Urantide improves atherosclerosis by controlling C-reactive protein, monocyte chemotactic protein-1 and transforming growth factor-β expression in rats.

abstract：:Mutations in the solute carrier family 25 (SLC25A13) gene may result in neonatal intrahepatic cholestasis caused by citrin deficiency and/or adult-onset type II citrullinemia. These conditions are inherited in an autosomal recessive manner. The current case report describes a 43-year-old man who presented with sudden ...

journal_title：Experimental and therapeutic medicine

authors： Tang L,Chen L,Wang H,Dai L,Pan S

更新日期：2016-07-01 00:00:00

abstract：:B-cell lymphoma 6 (BCL6), a proto-oncogene, is an evolutionarily conserved zinc finger protein that functions as a transcriptional repressor. BCL6 is the master regulator of B-lymphocyte development, and it has been reported that BCL6 may serve an important role in breast cancer progression. The aim of the present stu...

journal_title：Experimental and therapeutic medicine

authors： Ang L,Zheng L,Wang J,Huang J,Hu HG,Zou Q,Zhao Y,Liu QM,Zhao M,Wu ZS

更新日期：2017-11-01 00:00:00

abstract：:The aim of the present study was to examine the effects of phacoemulsification and intraocular lens implantation combined with ciliarotomy in the treatment of angle-closure glaucoma with cataract in the elderly. A total of 68 patients were consecutively selected and divided into the control group with 33 cases (48 eye...

journal_title：Experimental and therapeutic medicine

authors： Li B,Wang FY,Lv TL,Zhu Y

更新日期：2016-10-01 00:00:00

abstract：:Inflammatory diseases are an important health concern and have a growing incidence worldwide. Thus, developing novel and safe drugs to treat these disorders remains an important pursuit. Artemisia iwayomogi, locally known as Dowijigi (DJ), is a perennial herb found primarily in Korea and is used to treat various disea...

journal_title：Experimental and therapeutic medicine

authors： Kim SM,Vetrivel P,Kim HH,Ha SE,Saralamma VVG,Kim GS

更新日期：2020-03-01 00:00:00

abstract：:Cyclic adenosine monophosphate (cAMP) is an important secondary messenger that has long been recognized to control the initiation of meiosis through the activation of protein kinase A (PKA) in mammalian oocytes. However, PKA is not the only target for cAMP. Recent studies on cAMP-dependent and PKA-independent pathways...

journal_title：Experimental and therapeutic medicine

authors： Wang JC,Geng Y,Han Y,Luo HN,Zhang YS

更新日期：2018-08-01 00:00:00

abstract：:Secreted frizzled-related protein 1 (SFRP1), which is an extracellular inhibitor involved in Wnt signalling, is downregulated by promoter hypermethylation in the early stages of colorectal tumorigenesis. Polycomb (PCG) and methyl-CpG-binding domain (MBD) proteins that serve a role in epigenetic gene regulation. The ai...

journal_title：Experimental and therapeutic medicine

authors： Yu J,Xie Y,Liu Y,Wang F,Li M,Qi J

更新日期：2020-12-01 00:00:00

abstract：:There are limited data available on the regression of fibrosis in hepatitis C virus (HCV) patients who have achieved sustained virologic response (SVR) after interferon-free treatments. Moreover, a perfect method for assessing liver fibrosis and its dynamics has not been established yet. The main objective of this stu...

journal_title：Experimental and therapeutic medicine

authors： Leuştean A,Popescu C,Nichita L,Tilişcan C,Aramă V

更新日期：2021-01-01 00:00:00

abstract：:Increasing evidence connects gallstone disease (GD) to cardio-cerebrovascular disease (CVD). The aim of the present systematic review and meta-analysis was to determine whether and to what extent an association between GD and CVD existed. PubMed, EMBASE and the Cochrane Library were systemically searched up to March 3...

journal_title：Experimental and therapeutic medicine

authors： Zhao SF,Wang AM,Yu XJ,Wang LL,Xu XN,Shi GJ

更新日期：2019-04-01 00:00:00

abstract：:Effects of antithrombotic agents on the bleeding risk after transurethral resection of the prostate (TURP) were assessed in patients with benign prostatic hyperplasia (BPH). Controlled clinical trials on the effects of perioperative anticoagulant therapy on postoperative bleeding in BPH patients published during Janua...

journal_title：Experimental and therapeutic medicine

authors： He Q,Yu Y,Gao F

更新日期：2020-10-01 00:00:00

abstract：:Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene have previously been associated with a predisposition to pituitary adenomas. However, to the best of our knowledge, mutations in AIP that relate specifically to sporadic non-functioning pituitary adenomas (NFPAs) have yet to be reported. Therefo...

journal_title：Experimental and therapeutic medicine

authors： Hu Y,Yang J,Chang Y,Ma S,Qi J

更新日期：2016-03-01 00:00:00

abstract：:A standard systemic therapy for patients with human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer (ABC) is yet to be identified. Sorafenib has been developed for the treatment of solid tumors, including breast cancer, as an oral multikinase inhibitor with antiangiogenic and antiproliferativ...

journal_title：Experimental and therapeutic medicine

authors： Tan QX,Qin QH,Lian B,Yang WP,Wei CY

更新日期：2014-05-01 00:00:00

abstract：:One of the most prevalent diseases affecting humans are those which affect the oral cavity. Several diseases can affect the mouth, such as oral cancer, dental caries, Lichen Planus and, of course, periodontal disease with its variants. This review discusses gingivitis, periodontitis and peri-implantitis with a brief f...

journal_title：Experimental and therapeutic medicine

authors： Mann J,Bernstein Y,Findler M

更新日期：2020-02-01 00:00:00

abstract：:This study aims to investigate the function and related mechanism of P27 gene in intervertebral disc (IVD) degeneration of mice. X-ray, immunohistochemical staining, and alkaline phosphatase (ALP) histochemical staining were used to analyze the phenotypic difference of the intervertebral discs of 4-week-old mice with ...

journal_title：Experimental and therapeutic medicine

authors： Liu X,Wang D,Zhang Z,Zhu F,Yao A,Tian J,Miao D

更新日期：2017-08-01 00:00:00

abstract：:Dysregulation of microRNAs serves a crucial role in the chemosensitivity to cisplatin (DDP) in ovarian cancer (OVC). The abnormal expression of microRNA (miR)-654-3p has been reported in several types of human cancer. However, the association between miR-654-3p and cisplatin resistance in human OVC remains unclear. Th...

journal_title：Experimental and therapeutic medicine

authors： Niu YC,Tong J,Shi XF,Zhang T

更新日期：2020-08-01 00:00:00

abstract：:The pathogenesis of acute liver failure has not been fully elucidated. The present study investigated the effects of the serum from patients with hepatitis E virus (HEV)-related acute liver failure on human liver cell survival and apoptosis, and evaluated the protective effects of anti-lipopolysaccharide(LPS) antibody...

journal_title：Experimental and therapeutic medicine

authors： Wu F,Wang M,Tian D

更新日期：2014-01-01 00:00:00

abstract：:Fungal prosthetic joint infections (PJI) and reports of their clinical investigation are rare. In addition, there has been little evidence regarding the outcome of the two-stage exchange protocol for the treatment of fungal PJI. In order to investigate the risk factors and clinical, microbiological and pathological fe...

journal_title：Experimental and therapeutic medicine

authors： Geng L,Xu M,Yu L,Li J,Zhou Y,Wang Y,Chen J

更新日期：2016-08-01 00:00:00

abstract：:The diagnostic value of detection of serum β-human chorionic gonadotropin (β-HCG) and Chlamydia trachomatis immunoglobulin G (CT-IgG) combined with transvaginal ultrasonography in early tubal pregnancy was investigated. A total of 55 patients with early tubal pregnancy were selected as the tubal pregnancy group, while...

journal_title：Experimental and therapeutic medicine

authors： Xin H,Liu W,Li P

更新日期：2018-07-01 00:00:00

abstract：:We previously reported that cyclin E (CCNE1) amplification is strongly associated with resistance to treatment in serous ovarian cancer by high-resolution oligonucleotide copy number analysis. Dysregulation of cell cycle control has been implicated as the key event in human oncogenesis, and aberrant expression of G1-S...

journal_title：Experimental and therapeutic medicine

authors： Hashimoto T,Yanaihara N,Okamoto A,Nikaido T,Saito M,Takakura S,Yasuda M,Sasaki H,Ochiai K,Tanaka T

更新日期：2011-03-01 00:00:00

abstract：:Eosinophilia has been implicated in the pathophysiology of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, the role of eosinophil activation in the development of AECOPD remains unclear. In the present study, the reliability of plasma levels of eosinophil activation markers, including eo...

journal_title：Experimental and therapeutic medicine

authors： Yang QF,Lu TT,Shu CM,Feng LF,Chang HT,Ji QY

更新日期：2017-10-01 00:00:00

abstract：:Gastric carcinoma is one of the most common human cancers and has a poor prognosis. Receptor tyrosine kinase-like orphan receptor 2 (ROR2), which is a non-canonical receptor of the Wnt signaling pathway, has been reported to be deregulated in numerous types of human cancers, including gastric carcinoma. However, the e...

journal_title：Experimental and therapeutic medicine

authors： Yan L,Du Q,Yao J,Liu R

更新日期：2016-12-01 00:00:00

abstract：:Ischemia/reperfusion (I/R) injury during liver resection or transplantation for the treatment of hepatocellular carcinoma (HCC) may increase the risk of metastasis. Peroxisome proliferator-activated receptor-γ (PPARγ) activation has been observed to exert a protective effect against hepatic I/R injury. However, whethe...

journal_title：Experimental and therapeutic medicine

authors： Liu YI,Liu Z,Chen Y,Xu K,Dong J

更新日期：2016-02-01 00:00:00

abstract：:The aim of this meta-analysis was to investigate the accuracy of subtraction computed tomography angiography (CTA) for diagnosing intracranial aneurysms. A systematic literature search up to January 1, 2013 was performed in PubMed. Two independent reviewers selected 8 studies that compared subtraction CTA with digital...

journal_title：Experimental and therapeutic medicine

authors： Feng TY,Han XF,Lang R,Wang F,Wu Q

更新日期：2016-05-01 00:00:00

abstract：:The study was conducted to evaluate the relationship between the blood lactic acid (BLA) level, serum procalcitonin (PCT), C-reactive protein (CRP) and the severity and prognosis of neonatal sepsis. A retrospective analysis was conducted on 90 children with sepsis admitted into the Intensive Care Unit (ICU) of the Hub...

journal_title：Experimental and therapeutic medicine

authors： Jia Y,Wang Y,Yu X

更新日期：2017-09-01 00:00:00

abstract：:The Philips Intellivue MP50 monitor provides a method for non-invasive, near-continuous blood pressure (BP) monitoring and is designed to be an alternative to direct intra-arterial BP (IABP) measurement. However, no studies have specifically compared non-invasive and invasive BP measurements using the monitor. The pre...

journal_title：Experimental and therapeutic medicine

authors： Meng X,Zang G,Fan L,Zheng L,Dai J,Wang X,Xia W,Liu J,Zhang C

更新日期：2013-07-01 00:00:00

abstract：:The aim of the present study was to investigate the function of microRNA-146b on myocardial infarction and the mechanism. An MTT assay, Annexin V/propidium iodide (PI) apoptosis assay, ELISA kits, western blot analysis and a caspase-3/8 activity assay were used to measure cell growth, vascular apoptosis inflammatory f...

journal_title：Experimental and therapeutic medicine

authors： Zhao L,Yang XR,Han X

更新日期：2019-02-01 00:00:00

abstract：:The aim of this study was to investigate the effects of advanced glycation end-products (AGEs) on podocyte adhesion and the underlying mechanisms. Immortalized mouse podocytes were exposed to various conditions and podocyte adhesion was evaluated using a hexosaminidase assay. The expression levels of integrin-linked k...

journal_title：Experimental and therapeutic medicine

authors： Cheng C,Zheng Z,Shi C,Liu X,Ye Z,Lou T

更新日期：2013-12-01 00:00:00

abstract：:Shen-Zhi-Ling (SZL) oral liquid is a traditional Chinese medicine formula that is mainly used for the clinical treatment of mild to moderate Alzheimer's disease (AD). The aim of the present study was to investigate the effects and underlying mechanisms of SZL treatment on AD. APP/PS1 transgenic mice were utilized to e...

journal_title：Experimental and therapeutic medicine

authors： Xing S,Shen D,Chen C,Wu B,Chi H

更新日期：2017-09-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/etm.2018.6297.]. ...

journal_title：Experimental and therapeutic medicine

authors： Jia L,Wang L,Liu W,Qian G,Jiang X,Zhang Z

更新日期：2018-12-01 00:00:00

abstract：:Chemotherapeutic drug resistance is an obstacle for the successful therapy of prostate cancer. The aim of the present study was to identify the effects of proto-oncogene serine/threonine-protein kinase pim-1 (pim-1) in the proliferation of chemotherapeutic drug-resistant prostate cancer cells. Androgen-independent hum...

journal_title：Experimental and therapeutic medicine

authors： Zhang X,Sun Y,Wang P,Yang C,Li S

更新日期：2019-10-01 00:00:00

abstract：:Embelin is a small-molecule inhibitor extracted from plants of the Myrsinaceae family demonstrating specific inhibition of the X-linked inhibitor of apoptosis protein (XIAP) to affect the proliferation and apoptosis of various types of tumor cells. However, the mechanism of action for this effect remains unclear. The ...

journal_title：Experimental and therapeutic medicine

authors： Taghiyev A,Sun D,Gao ZM,Liang R,Wang L

更新日期：2012-10-01 00:00:00