Effect of the herbal formulation Shen-Zhi-Ling on an APP/PS1 mouse model of Alzheimer's disease by modulating the biliverdin reductase/heme oxygenase 1 system.

abstract：:The association between long non-coding RNA zinc finger antisense 1 (ZFAS1) and acute myeloid leukemia (AML) has not yet been investigated. The present study aimed to assess the potential role of ZFAS1 in AML cell proliferation and apoptosis. The expression of ZFAS1 mRNA in various AML cell lines (HL-60, KG-1, ML-1 an...

journal_title：Experimental and therapeutic medicine

authors： Guo H,Wu L,Zhao P,Feng A

更新日期：2017-07-01 00:00:00

abstract：:Radiation pneumonitis is a clinical problem with a high incidence. Once the onset of radiation pneumonitis has occurred, the administration of antioxidants and anti-inflammatory agents is the most commonly used method of clinical treatment. Quercetin (Que) is a common flavonoid, with potent anti-inflammatory and anti-...

journal_title：Experimental and therapeutic medicine

authors： Qin M,Chen W,Cui J,Li W,Liu D,Zhang W

更新日期：2017-12-01 00:00:00

abstract：:Many studies have focused on the identification of therapeutic targets for the treatment of certain types of cancer. Wogonin is a natural flavonoid compound that exhibits a potent anti-cancer effect. The underlying mechanism of wogonin may therefore reveal an effective way to identify novel therapeutic targets. In the...

journal_title：Experimental and therapeutic medicine

authors： Wang SJ,Zhao JK,Ren S,Sun WW,Zhang WJ,Zhang JN

更新日期：2019-01-01 00:00:00

abstract：:The present study described the characteristics of three cases of Creutzfeldt-Jakob disease (CJD) in China and analyzed their clinical presentations. The clinical information of the three cases was collected and analyzed. Blood and cerebrospinal fluid (CSF) specimens of the patients were collected for detection of the...

journal_title：Experimental and therapeutic medicine

authors： Wang X,Li N,Liu A,Ma L,Shan P,Jiang W,Zhang Q

更新日期：2017-09-01 00:00:00

abstract：:Vitiligo is an acquired pigmentary disorder characterized by the loss of skin color and functional melanocytes. The pathogenesis of vitiligo remains unclear, which means that effective clinical treatment is difficult. However, if melanocyte linkage-specific genes are identified in vitiligo lesions, the appropriate tre...

journal_title：Experimental and therapeutic medicine

authors： Xu W,Wang X

更新日期：2019-06-01 00:00:00

abstract：:Cytomegalovirus (CMV) infection is the most common congenital infection worldwide, and remains a significant cause of the neurological deficiency and sensory deafness in developed countries. Maternal primary infection, reactivation or reinfection during pregnancy may lead to fetal infection and congenital CMV syndrome...

journal_title：Experimental and therapeutic medicine

authors： Gorun F,Motoi S,Malita D,Navolan DB,Nemescu D,Olariu TR,Craina M,Vilibic-Cavlek T,Ciohat I,Boda D,Dobrescu A

更新日期：2020-09-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) has become a significant public health risk. Long non-coding RNAs (lncRNAs) have been identified as important factors involved in the proliferation, apoptosis and inflammatory cytokine expression of lung cells. Peripheral blood samples from 66 subjects (18 non-smokers, 24 s...

journal_title：Experimental and therapeutic medicine

authors： Lei Z,Guo H,Zou S,Jiang J,Kui Y,Song J

更新日期：2021-01-01 00:00:00

abstract：:The pathogenesis of acute liver failure has not been fully elucidated. The present study investigated the effects of the serum from patients with hepatitis E virus (HEV)-related acute liver failure on human liver cell survival and apoptosis, and evaluated the protective effects of anti-lipopolysaccharide(LPS) antibody...

journal_title：Experimental and therapeutic medicine

authors： Wu F,Wang M,Tian D

更新日期：2014-01-01 00:00:00

abstract：:Resveratrol, a naturally occurring polyphenolic phytoalexin antioxidant compound present in grapes and red wine, has been reported to induce various biochemical responses. It has been shown to possess anti-aging, anti-inflammatory and anti-proliferative activities in several cell types. However, the effects of resvera...

journal_title：Experimental and therapeutic medicine

authors： Eo SH,Cho HS,Kim SJ

更新日期：2014-03-01 00:00:00

abstract：:Diffuse ganglioneuromatosis (DG) of the gastrointestinal tract is a rare condition that is closely associated with neurofibromatosis type 1 and multiple endocrine neoplasia type 2B. The occurrence of DG with multiple schwannomas, which, of the GI tract, usually affect the stomach, is considerably more rare. The presen...

journal_title：Experimental and therapeutic medicine

authors： Lu C,Qiu Y,Lu X,Li G,Bu H

更新日期：2015-03-01 00:00:00

abstract：:B-cell lymphoma 6 (BCL6), a proto-oncogene, is an evolutionarily conserved zinc finger protein that functions as a transcriptional repressor. BCL6 is the master regulator of B-lymphocyte development, and it has been reported that BCL6 may serve an important role in breast cancer progression. The aim of the present stu...

journal_title：Experimental and therapeutic medicine

authors： Ang L,Zheng L,Wang J,Huang J,Hu HG,Zou Q,Zhao Y,Liu QM,Zhao M,Wu ZS

更新日期：2017-11-01 00:00:00

abstract：:Osteonecrosis is a condition that frequently affects patients with systemic lupus erythematosus (SLE). However, reports on severe multifocal osteonecrosis involving more than three anatomical sites in patients with SLE are scarce. The present study describes a case of SLE with multifocal osteonecrosis involving all fo...

journal_title：Experimental and therapeutic medicine

authors： Sun S,Wang Q,Gong Y,Qi X,Liu J

更新日期：2019-10-01 00:00:00

abstract：:Different tacrolimus (TAC) population pharmacokinetic (PPK) models have been established in various pediatric disease populations. However, a TAC PPK model for pediatric refractory nephrotic syndrome (PRNS) has not been well characterized. The current study aimed to establish a TAC PPK model in Chinese PRNS and provid...

journal_title：Experimental and therapeutic medicine

authors： Wang D,Lu J,Li Q,Li Z

更新日期：2019-05-01 00:00:00

abstract：:In patients undergoing off-pump coronary artery bypass surgery (OPCAB), it is important to attenuate myocardium injury during the surgery. The present study aimed to observe the cardioprotection induced by sevoflurane induction and maintenance compared with propofol intravenous anesthesia, and to detect its potential ...

journal_title：Experimental and therapeutic medicine

authors： Liu X,Liu X,Wang R,Luo H,Qin G,Wang LU,Ye Z,Guo Q,Wang E

更新日期：2016-06-01 00:00:00

abstract：:Chronic rhinosinusitis (CRS) is a heterogeneous disease, with varying immunological and histopathological features. The CC chemokine ligand 19 (CCL19) can stimulate T cells and antigen-presenting cells into secondary lymphoid node formation, as observed in allergic rhinitis, inflammatory bowel disease and other inflam...

journal_title：Experimental and therapeutic medicine

authors： Zou Y,Wang Y,Wang SB,Kong YG,Xu YU,Tao ZZ,Chen SM

更新日期：2016-01-01 00:00:00

abstract：:The aim of the present study was to evaluate the concentrations of fetuin-A, osteoprotegerin (OPG) and α-Klotho protein in patients with alcoholic cirrhosis at different stages of the disease, and to demonstrate that fetuin-A, osteoprotegin and α-Klotho may be used as markers of the severity of cirrhosis. A total of 5...

journal_title：Experimental and therapeutic medicine

authors： Prystupa A,Dąbrowska A,Sak JJ,Tarach J,Toruń-Jurkowska A,Lachowska-Kotowska P,Dzida G

更新日期：2016-11-01 00:00:00

abstract：:The present study was designed to evaluate the effects of steady and fluctuant inhibition of acetylcholinesterase (AChE) activity on neurotrophic factors in the hippocampus of juvenile mice. Steady inhibition of AChE activity was induced by an intramuscular injection of huperizine A (HupA) sustained-release microspher...

journal_title：Experimental and therapeutic medicine

authors： Li C,Wang T,Jiang N,Yu P,DU Y,Ren R,Fu F

更新日期：2012-02-01 00:00:00

abstract：:The present study investigated the role of runt-related transcription factor 2 (Runx2) in regulating the differentiation of human dental pulp stem cells (hDPSCs) into odontoblasts under the mediation of the Rho/Rho-associated protein kinase (ROCK) signaling pathway. hDPSCs and human bone marrow mesenchymal stem cells ...

journal_title：Experimental and therapeutic medicine

authors： Huang X,Chen X,Chen H,Xu D,Lin C,Peng B

更新日期：2018-05-01 00:00:00

abstract：:Simple bone cysts (SBCs) are uncommon lesions that usually occur in the long bones of the skeleton and in the body of the mandible. Displacement of the mandibular canal due to cystic lesions have been reported previously. However, there have been no reports in which endoscopy has been utilized to observe an inferior a...

journal_title：Experimental and therapeutic medicine

authors： Matsuda S,Yoshimura H,Sano K

更新日期：2019-06-01 00:00:00

abstract：:We generated replication-defective adenovirus Ad-p53AIP1 and studied its anti-tumor efficacy both in vitro and in vivo. We demonstrated that Ad-p53AIP1 infection elicited high levels of p53AIP1 expression in cancer cells. We also found that Ad-p53AIP1 expression induced marked apoptosis and cell cycle arrest in HepG2 ...

journal_title：Experimental and therapeutic medicine

authors： Jiang Y,Chen H,Jia H,Xu Y,Liu G,Wang Y,Yang X,Lu Y

更新日期：2010-03-01 00:00:00

abstract：:Homeobox protein Nxk-2.5 (Nkx2.5) is a homeobox transcription factor that promotes chamber-like myocardial gene expression. Data from a previous genome-wide association study suggested that Nkx2.5 may be associated with the genetic variation that underlies atrial fibrillation (AF). Nkx2.5 loss of function has been dem...

journal_title：Experimental and therapeutic medicine

authors： Chen J,Xu S,Li W,Wu L,Wang L,Li Y,Zhou W

更新日期：2019-12-01 00:00:00

abstract：:The present study aimed to analyze the imaging, clinical and pathological features of fungal infection involvement in primary biliary cirrhosis (PBC) by retrospectively analyzing and reviewing the features of two patients with fungal infection involvement in PBC. Both patients were female. One patient had a confirmed ...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Zhao Z,Lu H,Zhang J,Huang F

更新日期：2017-02-01 00:00:00

abstract：:It is firmly established that smoking is a risk factor of cardiovascular disease, stroke and peripheral vascular disease. Although smoking alters the hemostatic process, the influence of smoking on human platelet activation remains controversial. For patients undergoing surgery, cessation of smoking prior to the proce...

journal_title：Experimental and therapeutic medicine

authors： Kito Y,Iida M,Tanabe K,Onuma T,Tsujimoto M,Nagase K,Tokuda H,Iwama T,Kozawa O,Iida H

更新日期：2019-11-01 00:00:00

abstract：:Uterine cervical adenocarcinoma has a poor clinical prognosis when compared with squamous cell carcinoma. Therefore, the development of new treatment strategies for uterine cervical adenocarcinoma is necessary. Src is a proto-oncogene that is important in cancer progression. Dasatinib is a Src inhibitor that has been ...

journal_title：Experimental and therapeutic medicine

authors： Takiguchi E,Nishimura M,Mineda A,Kawakita T,Abe A,Irahara M

更新日期：2017-11-01 00:00:00

abstract：:Neuregulin-1 (NRG-1) is a cardioactive growth factor released from endothelial cells. However, the effect of NRG-1 on ventricular remodeling in diabetic cardiomyopathy (DCM) remains unclear. The aim of the present study was to investigate the pathophysiological role of NRG-1 in a rat model of DCM. Rat cardiac microvas...

journal_title：Experimental and therapeutic medicine

authors： Li B,Xiao J,Li Y,Zhang J,Zeng M

更新日期：2013-11-01 00:00:00

abstract：:The effects of human immunodeficiency virus (HIV) on the metabolic and biological pathways of cluster of differentiation (CD)4+ T lymphocytes were investigated. A total of 150 patients with acquired immune deficiency syndrome (AIDS) and 50 healthy individuals who were admitted to hospital for physical examination duri...

journal_title：Experimental and therapeutic medicine

authors： Ma Y,Zhao W,Shi C,Wang N,Fan T

更新日期：2018-03-01 00:00:00

abstract：:Sepsis is a complication of infection caused by disease or trauma. Increasing evidence have shown that long noncoding RNAs (lncRNAs) are involved in the regulation of sepsis. However, the mechanism of lncRNA nuclear enriched abundant transcript 1 (NEAT1) in the regulation of sepsis progression remains to be elucidated...

journal_title：Experimental and therapeutic medicine

authors： Liu L,Liu F,Sun Z,Peng Z,You T,Yu Z

更新日期：2020-10-01 00:00:00

abstract：:Endometriosis is a common reproductive disorder in women, with a global prevalence of 10-15%. Long noncoding RNAs (lncRNAs) are critical to gene transcription, cell cycle modulation and immune response. The lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) reportedly mediates autophagy of endometr...

journal_title：Experimental and therapeutic medicine

authors： Liu X,Zhang P,Li Y,Zhao N,Han H

更新日期：2021-01-01 00:00:00

abstract：:Cardiopulmonary resuscitation (CPR) after cardiac arrest (CA) often leads to neurological deficits in the absence of effective treatment. The aim of the present basic research study was to investigate the effects of human urine-derived stem cells (hUSCs) on the recovery of neurological function in rats after CA/CPR. h...

journal_title：Experimental and therapeutic medicine

authors： Pan C,Zheng X,Wang L,Chen Q,Lin Q

更新日期：2020-11-01 00:00:00

abstract：:Autophagy has been shown to be involved in the pathophysiology of developmental seizure-induced brain damage. The present study aimed to examine whether E-64d, an autophagy inhibitor, was able to facilitate developmental seizure-induced hippocampal mossy fiber sprouting, in particular sprouting-associated zinc transpo...

journal_title：Experimental and therapeutic medicine

authors： Ni H,Zhang LL,Ren SY,Sun BL

更新日期：2016-07-01 00:00:00