Population pharmacokinetics of tacrolimus in pediatric refractory nephrotic syndrome and a summary of other pediatric disease models.

abstract：:Paraneoplastic autoimmune multiorgan syndrome (PAMS), also known as paraneoplasic pemphigus, involves the skin, internal organs and mucosa. PAMS-associated mortality may occur as a result of autoantibody formation against internal tumors and their infiltration into organs other than the skin lesions that characterize ...

journal_title：Experimental and therapeutic medicine

authors： Lee SY,Kim JH,Cho DH

更新日期：2016-09-01 00:00:00

abstract：:The objective of this study was to investigate the effects of leukotriene B4 (LTB4) on the expression of interleukin-32 (IL-32) interferon-γ (IFN-γ) and chemokine monocyte chemoattractant protein (MCP-1) and macrophage inhibitory protein (MIP-1α) in rheumatoid arthritis (RA). The rat model of RA collagen induced-arthr...

journal_title：Experimental and therapeutic medicine

authors： Bi D,Bi D,Zhong M,Zhang H,Jin S,Ma S,Luo H

更新日期：2017-10-01 00:00:00

abstract：:The presence of an occluded culprit artery or collaterals in non-ST-segment elevation myocardial infarction (NSTEMI) is relatively common; however, limited data are available regarding their clinical significance. The aim of the current study was to determine the clinical characteristics of occluded culprit arteries a...

journal_title：Experimental and therapeutic medicine

authors： Hwang HJ,Park CB,Cho JM,Jin ES,Sohn IS,Kim DH,Kim CJ

更新日期：2018-10-01 00:00:00

abstract：:Undaria pinnatifida (U. pinnatifida) polysaccharides (UPPS) are considered to be the major bioactive components of U. pinnatifida. The aim of the present study was to investigate the separation, sulfated modification, characterization and monosaccharide composition of UPPS. The optimal processing conditions were as fo...

journal_title：Experimental and therapeutic medicine

authors： Wang FL,Ji YB,Yang B

更新日期：2020-07-01 00:00:00

abstract：:Peripheral nerve predegeneration has been used as a tool to improve the in vitro cultivation of Schwann cells. The process of predegeneration may be accomplished either in vivo or in vitro. In previously published studies, various predegeneration periods were used, ranging from a few days until up to 5 weeks. The pres...

journal_title：Experimental and therapeutic medicine

authors： Tomko P,Slovinská L,Vanický I

更新日期：2019-01-01 00:00:00

abstract：:Previous studies have demonstrated that autophagy induced by caloric restriction (CR) is neuroprotective against cerebral ischemia. However, it has not been determined whether intermittent fasting (IF), a variation of CR, can exert autophagy-related neuroprotection against cerebral ischemia. Therefore, the neuroprotec...

journal_title：Experimental and therapeutic medicine

authors： Jeong JH,Yu KS,Bak DH,Lee JH,Lee NS,Jeong YG,Kim DK,Kim JJ,Han SY

更新日期：2016-11-01 00:00:00

abstract：:The clinical effects were compared and analyzed of traditional Chinese medicine (TCM) 'Ling Gui Long Mu soup' combined with the conventional Western medications in treating child typhoid complicated by myocarditis. From July, 2010 to May, 2014, 54 children suffering from typhoid complicated by myocarditis were enrolle...

journal_title：Experimental and therapeutic medicine

authors： Tian J,An X,Fu M,Wang Q

更新日期：2016-12-01 00:00:00

abstract：:The study aims to investigate the clinical significance of regulating the expression of 25-hydroxyvitamin D (25-OH-VD) via microRNA (miRNA)-376c in the occurrence and development of preeclampsia (PE) in pregnant women. Peripheral blood and placental tissues were collected from pregnant women in 4 groups, including 67 ...

journal_title：Experimental and therapeutic medicine

authors： Li J,Du J,Wang Z,Wang C,Bai J,Zhang S

更新日期：2018-09-01 00:00:00

abstract：:The aim of this study was to investigate the effects of heat stress on the expression of the coxsackievirus and adenovirus receptor (CAR) in mouse skin keratinocytes. Twenty BALB/c mice were randomly divided into two groups: the sham heat (control) and scald groups. Skin specimens were obtained 6 h after the treatment...

journal_title：Experimental and therapeutic medicine

authors： Deng X,Jia C,Chen F,Liu J,Zhou Z

更新日期：2013-10-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) accounts for ~80% of all types of lung cancer, which has the highest morbidity and mortality of all types of cancer worldwide. It is important to identify novel biomarkers and the molecular mechanism of NSCLC to improve current treatments of NSCLC. The present study aimed to investig...

journal_title：Experimental and therapeutic medicine

authors： Luo H,Liang C

更新日期：2018-04-01 00:00:00

abstract：:The present study described the characteristics of three cases of Creutzfeldt-Jakob disease (CJD) in China and analyzed their clinical presentations. The clinical information of the three cases was collected and analyzed. Blood and cerebrospinal fluid (CSF) specimens of the patients were collected for detection of the...

journal_title：Experimental and therapeutic medicine

authors： Wang X,Li N,Liu A,Ma L,Shan P,Jiang W,Zhang Q

更新日期：2017-09-01 00:00:00

abstract：:The present study reports the case of a 33-year-old male who presented with Terson syndrome with no cerebral hemorrhage secondary to traumatic brain injury (TBI). A computed tomography scan of the patient, who had sustained an impact injury to the right occipital region, showed no cerebral lesion. Ophthalmoscopy clear...

journal_title：Experimental and therapeutic medicine

authors： Jing XB,Sun LQ

更新日期：2014-01-01 00:00:00

abstract：:The present study investigated the role of runt-related transcription factor 2 (Runx2) in regulating the differentiation of human dental pulp stem cells (hDPSCs) into odontoblasts under the mediation of the Rho/Rho-associated protein kinase (ROCK) signaling pathway. hDPSCs and human bone marrow mesenchymal stem cells ...

journal_title：Experimental and therapeutic medicine

authors： Huang X,Chen X,Chen H,Xu D,Lin C,Peng B

更新日期：2018-05-01 00:00:00

abstract：:Matrix metalloproteases (MMPs) are a family of zinc-dependent endopeptidases that degrade extracellular matrix proteins. MMP-1 and MMP-2 are produced by endothelial cells and are involved in specific vascular pathologies, including atherosclerosis and aortal aneurysm. One of the most important differences between thes...

journal_title：Experimental and therapeutic medicine

authors： Siemianowicz K,Gminski J,Goss M,Francuz T,Likus W,Jurczak T,Garczorz W

更新日期：2010-11-01 00:00:00

abstract：:This study aimed to investigate the correlations between the detection rate of mural coronary artery (MCA) by 128-slice CT and the MCA compression extent in systole with myocardial bridge (MB) length and thickness. A retrospective analysis was conducted for 580 patients receiving multislicespiral CT coronary angiograp...

journal_title：Experimental and therapeutic medicine

authors： Niu YJ,Zhang XL,Cao AD,Leng B

更新日期：2013-03-01 00:00:00

abstract：:The aim of this study was to evaluate the safety of the continuous administration of recombinant human endostatin (Endostar) in healthy mice. A total of 16 nude mice were randomly divided into four treatment groups: a continuous administration group injected intraperitoneally (i.p.) with 14 mg/kg Endostar over seven d...

journal_title：Experimental and therapeutic medicine

authors： Huang R,Zhan Q,Zhou X,Chu Z,Jiang J,Liang X

更新日期：2012-06-01 00:00:00

abstract：:Cardiovascular disease is the main cause of morbidity and mortality in end-stage renal disease (ESRD) patients. Recent population based epidemiological studies demonstrated a correlation between reduced renal function and risk for all causes and cardiovascular mortality, 50% of patients dying before the commencement o...

journal_title：Experimental and therapeutic medicine

authors： Timofte D,Dragoș D,Balcangiu-Stroescu AE,Tănăsescu MD,Gabriela Bălan D,Răducu L,Tulin A,Stiru O,Ionescu D

更新日期：2020-07-01 00:00:00

abstract：:Postoperative cognitive dysfunction (POCD) is common in elderly patients. Senegenin, an active component of extracts from Polygala tenuifolia root, a traditional Chinese medicine, has neuroprotective and neuroregenerative effects. However, the mechanism underlying the effects of senegenin against postoperative cogniti...

journal_title：Experimental and therapeutic medicine

authors： Yu L,Sun L,Chen S

更新日期：2014-04-01 00:00:00

abstract：:The present study performed a meta-analysis of randomized controlled trials in multiple sclerosis (MS) patients to evaluate the efficacy and safety of anti-B-cell monoclonal antibodies (mAbs). To the best of our knowledge, no previous meta-analysis has evaluated this. Relevant studies published until March 2015 were r...

journal_title：Experimental and therapeutic medicine

authors： Xie Q,Li X,Sun J,Yuan B,Li Y,Wang L,Wang M

更新日期：2017-06-01 00:00:00

abstract：:LipoxinA4 (LXA4) is a well-known key mediator of endogenous anti-inflammation and of the resolution of inflammation. Considerable oxidative stress occurs during inflammation due to the generation of reactive oxidative species (ROS). Moreover, high levels of uric acid (UA) contribute to endothelial cell dysfunction, wh...

journal_title：Experimental and therapeutic medicine

authors： Zhou Y,You H,Zhang A,Jiang X,Pu Z,Xu G,Zhao M

更新日期：2020-08-01 00:00:00

abstract：:Compared with traditional imaging techniques, multimodal imaging obtains more accurate images that may increase disease detection rates. The present study prepared stromal cell-derived factor 1 (SDF-1)-loaded, targeted nanoparticles coated with iron (II,III) oxide and perfluorohexane (PFH) to be used as polymer-shelle...

journal_title：Experimental and therapeutic medicine

authors： Wang F,Wang Z,Pang L,Wan S,Qiu L

更新日期：2020-09-01 00:00:00

abstract：:Hyponatremia is a risk factor associated with poor prognosis in patients with heart failure (HF) with reduced ejection fraction. However, whether hyponatremia has a similar role in patients with HF with preserved ejection fraction (HFpEF) has remained controversial. Therefore, the present study aimed to investigate th...

journal_title：Experimental and therapeutic medicine

authors： Su Y,Ma M,Zhang H,Pan X,Zhang X,Zhang F,Lv Y,Yan C

更新日期：2020-11-01 00:00:00

abstract：:The aim of the present study was to investigate the roles of matrix metalloproteinase 14 (MMP-14) in corneal inflammatory lymphangiogenesis. The expression of MMP-14 in vivo was detected by immunohistochemistry, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot assays, under vario...

journal_title：Experimental and therapeutic medicine

authors： Du HT,Liu P

更新日期：2016-10-01 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1) has been demonstrated to affect the oxidative stress status in several in vitro, in vivo and clinical studies. The aim of the present study was to evaluate the effect of a GLP-1 analogue, exenatide, on oxidative stress parameters and apoptotic markers in testicular cells in an iron over...

journal_title：Experimental and therapeutic medicine

authors： Yesil S,Sungu N,Kilicarslan A,Kuskonmaz SM,Kara H,Kucuk A,Polat F,Kavutcu M,Arslan M

更新日期：2018-12-01 00:00:00

abstract：:The present study aimed to investigate the influence of mouse nerve growth factor (mNGF) on glial fibrillary acidic protein (GFAP) expression in neonatal rats with hypoxic-ischemic brain damage (HIBD). A total of 60 7-day-old neonatal rats were randomly divided into control, HIBD and mNGF groups (n=20). The rats in th...

journal_title：Experimental and therapeutic medicine

authors： Yin X,Dong L,Wei W,Wang Y,Chai Y,Feng Z

更新日期：2013-02-01 00:00:00

abstract：:We previously demonstrated that vitamin B6 suppresses tumorigenesis in the colon of mice and exerts an anti-inflammatory effect through the inhibition of NF-κB activation. As these effects resemble the pharmacological properties of thiazolidinedione (TZD), a synthetic peroxisome proliferator-activated receptor-γ (PPAR...

journal_title：Experimental and therapeutic medicine

authors： Yanaka N,Kanda M,Toya K,Suehiro H,Kato N

更新日期：2011-05-01 00:00:00

abstract：:The aim of the present study was to evaluate the expression of vascular endothelial growth factor (VEGF) and hypoxia inducible factor-1 (HIF-1), and to investigate the role of the HIF-1/VEGF signaling pathway following spinal cord injury (SCI). A total of 90 12-week-old Sprague Dawley rats were randomly divided into t...

journal_title：Experimental and therapeutic medicine

authors： Chen H,Li J,Liang S,Lin B,Peng Q,Zhao P,Cui J,Rao Y

更新日期：2017-03-01 00:00:00

abstract：:The present study aimed to investigate whether serum interleukin-6 (IL-6) expression levels were associated with the onset and progression of intervertebral disc degeneration (IDD). A comprehensive meta-analysis of the scientific literature from numerous electronic databases was performed, in order to obtain published...

journal_title：Experimental and therapeutic medicine

authors： Deng X,Zhao F,Kang B,Zhang X

更新日期：2016-04-01 00:00:00

abstract：:This study aimed to isolate rabbit adipose-derived stem cells (ADSCs) and explore the potential of platelet-rich plasma (PRP) in the chondrogenic differentiation of ADSCs, thereby potentially providing a new approach for the repair and regeneration of cartilage injury. Rabbit ADSCs were isolated and characterized by i...

journal_title：Experimental and therapeutic medicine

authors： Tang XB,Dong PL,Wang J,Zhou HY,Zhang HX,Wang SZ

更新日期：2015-08-01 00:00:00

abstract：:Clobetasol propionate (Clo) is a potent topical glucocorticoid and a potential remyelinating agent that has been approved by the U.S. Food and Drug Administration. However, the effect of Clo on neural stem cells (NSCs) remains largely unknown. The aim of the present study was to investigate the effect of Clo on the di...

journal_title：Experimental and therapeutic medicine

authors： Shi W,Bi S,Dai Y,Yang K,Zhao Y,Zhang Z

更新日期：2019-08-01 00:00:00