Intermittent fasting is neuroprotective in focal cerebral ischemia by minimizing autophagic flux disturbance and inhibiting apoptosis.

abstract：:Suppurative hidradenitis and pyoderma gangrenosum are rare disorders that can be seen isolated or even more rare, as part of different autoinflammatory syndromes: Pyoderma gangrenosum, acne, and hidradenitis suppurativa (PASH), pyoderma gangrenosum, acne, pyogenic arthritis, and hidradenitis suppurativa (PAPASH) or ps...

journal_title：Experimental and therapeutic medicine

authors： Turcu G,Ioana Nedelcu R,Teodora Nedelcu I,Hodorogea A,Balaban M,Brinzea A,Nichita L,Gabriela Popp C,Andrada Zurac S,Theodor Andrei R

更新日期：2020-07-01 00:00:00

abstract：:The aim of this study was to investigate the effect of ouabain (EO) on myocardial remodeling. Twenty-two adult male Sprague-Dawley rats were randomly divided into two groups: the rats in the EO group (n=12) were intraperitoneally injected with EO daily and those in the control group (n=10) were injected with physiolog...

journal_title：Experimental and therapeutic medicine

authors： Ren Y,Zhang M,Zhang T,Huang R

更新日期：2013-07-01 00:00:00

abstract：:Female athletes may experience difficulties in achieving pregnancy due to athletic amenorrhea (AA); however, the underlying mechanisms of AA remain unknown. The present study focuses on the mitochondrial alteration and its function in detecting the possible mechanism of AA. An AA rat model was established by excessive...

journal_title：Experimental and therapeutic medicine

authors： Xiong RH,Wen SL,Wang Q,Zhou HY,Feng S

更新日期：2018-01-01 00:00:00

abstract：:A clinical requirement exists for early biomarkers that can predict the severity of acute pancreatitis (AP). In order to determine whether E-cadherin is associated with the severity of AP, a pancreatitic rat model was established and the expression levels of E-cadherin were detected. A study population of 24 Sprague D...

journal_title：Experimental and therapeutic medicine

authors： Yuan W,Pan QI,Chen G,Yan J,Xia J,Chen Y

更新日期：2015-12-01 00:00:00

abstract：:Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is closely associated with organ injury. The aim of the present study was to investigate the change of ALDH2 expression in a rat model of sepsis-induced acute renal injury, and to observe the effect of ALDH2 inhibition on the kidney. A model of sepsis syndrome was establi...

journal_title：Experimental and therapeutic medicine

authors： Hu JF,Wang HX,Li HH,Hu J,Yu Y,Gao Q

更新日期：2017-09-01 00:00:00

abstract：:MicroRNA (miR)-199b-5p has been reported to have a critical role in various types of malignancy. However, the exact function miR-199b-5p in renal cancer remains to be fully elucidated. The present study aimed to detect the expression levels of miR-199b-5p in renal cell carcinoma (RCC) tissues and RCC cell lines, and i...

journal_title：Experimental and therapeutic medicine

authors： Lai Y,Quan J,Lin C,Li H,Hu J,Chen P,Xu J,Guan X,Xu W,Lai Y,Ni L

更新日期：2018-07-01 00:00:00

abstract：:Various microRNAs (miRs) have been demonstrated to serve important roles in gastric cancer (GC). miR-153 in particular has been reported to serve a suppressive role in GC; however, the underlying mechanism remains unclear. In the present study Reverse transcription-quantitative polymerase chain reaction and western bl...

journal_title：Experimental and therapeutic medicine

authors： Ouyang Y,Yuan W,Qiu S

更新日期：2018-08-01 00:00:00

abstract：:The present study aimed to determine the expression of microRNA (miRNA or miR)-145 in hypertrophic scars at the tissue and cellular levels, and to investigate its biological functions and mechanism of action. A total of 36 patients who were diagnosed with hypertrophic scar were included in the present study. Reverse t...

journal_title：Experimental and therapeutic medicine

authors： Wang S,Li C,Yu Y,Qiao J

更新日期：2019-11-01 00:00:00

abstract：:Capillary density on nailfold capillaroscopy (NFC) is considered a promising instrument for assessing disease characteristics in patients with systemic sclerosis (SSc), however, there is no agreement yet over how to analyze and interpret the results. The objective of this study was to investigate the possible associat...

journal_title：Experimental and therapeutic medicine

authors： Gheorghiu AM,Oneata R,Ancuta I,Enuica A,Linte O,Macovei L,Bojinca M,Stoica V,Mihai C

更新日期：2020-10-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is one of the most common cancer types worldwide. Previous studies have indicated that TOR signaling pathway regulator (TIPRL) is involved in the progression of NSCLC. However, the underlying mechanisms of the role of TIPRL in regulating NSCLC metastasis have remained largely elusive...

journal_title：Experimental and therapeutic medicine

authors： Xu X,Zhu H,Yang M,Zheng E,Zhou Y,Ni J,Li R,Yang Z,He T,Zhao G

更新日期：2020-03-01 00:00:00

abstract：:The present study aimed to investigate the effects of glycerol on the physical properties and release of an insulin-loaded polyvinyl alcohol (PVA) hydrogel film. The insulin-loaded hydrogel composite film was produced using the freeze-thawing method, after which the in vitro swelling ratio, transmittance and insulin r...

journal_title：Experimental and therapeutic medicine

authors： Cai Y,Che J,Yuan M,Shi X,Chen W,Yuan WE

更新日期：2016-10-01 00:00:00

abstract：:Arteriovenous fistula (AVF) thrombosis is a common complication in patients undergoing hemodialysis, and early intervention is required. Urokinase has been used as a thrombolytic agent for declotting the thrombosed access. However, the optimal route for infusing urokinase remains to be determined. In the present retro...

journal_title：Experimental and therapeutic medicine

authors： Wan Z,Xiang R,Wang H,Zhong Q,Tu B

更新日期：2019-05-01 00:00:00

abstract：:Temozolomide (TMZ) resistance is a complication of treatment of glioma, and new strategies are urgently required to overcome chemoresistance in glioma cells. In the present study, it was demonstrated that tripartite motif-containing 31 (TRIM31) was abnormally upregulated in glioma tissues and cell lines compared with ...

journal_title：Experimental and therapeutic medicine

authors： Fan MD,Zhao XY,Qi JN,Jiang Y,Liu BY,Dun ZP,Zhang R,Wang CW,Pang Q

更新日期：2020-08-01 00:00:00

abstract：:Compared to other diseases, early or atypical spinal tuberculosis (TB) is prone to being misdiagnosed due to the lack of specific clinical manifestations and misleading negative results of various laboratory analyses and imaging examinations. Various methods for diagnosing spinal TB have become research hotspots. Rece...

journal_title：Experimental and therapeutic medicine

authors： Pu F,Feng J,Yang L,Zhang L,Xia P

更新日期：2019-11-01 00:00:00

abstract：:Oxidative stress and apoptosis serve an essential role in cisplatin-induced cardiotoxicity, which limits its clinical use, and increases the risk of cardiovascular disease. As a natural drug, the antioxidant and antitumor effects of cyanidin have been recognized, but its protective effect on cisplatin-induced cardiomy...

journal_title：Experimental and therapeutic medicine

authors： Qian P,Yan LJ,Li YQ,Yang HT,Duan HY,Wu JT,Fan XW,Wang SL

更新日期：2018-02-01 00:00:00

abstract：:The aim of the present study was to investigate the correlation between the protein expression of A-kinase anchor protein 95 (AKAP95), cyclin D3 and AKT with pathological indicators in lung cancer tissues. Immunohistochemistry was used to detect the protein expression levels of the proteins in 51 lung cancer tissue sa...

journal_title：Experimental and therapeutic medicine

authors： Yu X,Yuan Y,Zhi X,Teng B,Chen X,Huang Q,Chen Y,Guan Z,Zhang Y

更新日期：2015-09-01 00:00:00

abstract：:Homeobox D10 (HOXD10) belongs to the human homeobox (HOX) gene family, and the homologous protein encoded by HOX primarily controls cell differentiation and morphogenesis during embryonic development. The current study aimed to explore the roles and mechanisms of HOXD10 in the migration of human fibroblast-like synovi...

journal_title：Experimental and therapeutic medicine

authors： Luan L,Ma Y,Zhang L

更新日期：2018-09-01 00:00:00

abstract：:Action potential (AP) contours vary considerably between the fibers of normal adult and aged left atria. The underlying ionic and molecular mechanisms that mediate these differences remain unknown. The aim of the present study was to investigate whether the L-type calcium current (ICa.L) and the L-type Ca2+ channel of...

journal_title：Experimental and therapeutic medicine

authors： Gan TY,Qiao W,Xu GJ,Zhou XH,Tang BP,Song JG,Li YD,Zhang J,Li FP,Mao T,Jiang T

更新日期：2013-10-01 00:00:00

abstract：:Lung cancer is among the most common causes of cancer-related mortality. It has a high mortality rate and resistance to chemotherapy due to its high metastatic potential. Naringenin, a bioactive compound identified in several fruits, displays anti-inflammatory and antitumor effects. Furthermore, naringenin mitigates t...

journal_title：Experimental and therapeutic medicine

authors： Chang HL,Chang YM,Lai SC,Chen KM,Wang KC,Chiu TT,Chang FH,Hsu LS

更新日期：2017-02-01 00:00:00

abstract：:The aim of this study was to explore the clinical characteristics of and treatment strategies for interstitial pneumonia induced by gefitinib in patients with advanced non-small cell lung cancer (NSCLC). The detailed clinical data of one patient with NSCLC and gefitinib-induced interstitial pneumonia were compiled and...

journal_title：Experimental and therapeutic medicine

authors： Luo C,Lv M,Li Y,Liu P,Yang J

更新日期：2014-04-01 00:00:00

abstract：:Previous studies by our group demonstrated that radix Sophorae tonkinensis could induce hepatotoxicity. However, it remains unclear which components of this herb may be responsible for its hepatotoxicity. The present study aimed to investigate the hepatic toxicity of treatment with matrine (MT) and oxymatrine (OMT) al...

journal_title：Experimental and therapeutic medicine

authors： Gu Y,Lu J,Sun W,Jin R,Ohira T,Zhang Z,Tian X

更新日期：2019-04-01 00:00:00

abstract：:Excision repair cross-complementation group 1 (ERCC1) protein has been associated with cisplatin resistance. The objective of this study was to investigate the correlation between ERCC1 protein levels and the therapeutic effect of individualized therapy in advanced non-small cell lung cancer (NSCLC). A total of 190 ad...

journal_title：Experimental and therapeutic medicine

authors： Gao Z,Han B,Shen J,Gu A,Qi D,Huang J,Shi C,Xiong L,Zhao Y,Jiang L,Wang H,Chen Y

更新日期：2011-09-01 00:00:00

abstract：:The aim of the present study was to investigate the effect of microRNA (miR)-92a on cystatin C expression in patients with type II diabetes and lower limb ischemia. A total of 199 patients diagnosed with type II diabetes were included in the study and divided into three experimental groups: Simple type II diabetes mel...

journal_title：Experimental and therapeutic medicine

authors： Zhang Y,Guan Q,Jin X

更新日期：2015-06-01 00:00:00

abstract：:E-cadherin is a key cell adhesion molecule implicated in tumor suppression that is frequently altered in hepatocellular carcinoma (HCC), particularly in hepatitis B virus-related tumors. Here, we report that the epigenetic drugs 5-azacytidine and trichostatin A up-regulated E-cadherin expression in HCC cells. The depl...

journal_title：Experimental and therapeutic medicine

authors： Qiu X,Qiao F,Su X,Zhao Z,Fan H

更新日期：2010-05-01 00:00:00

abstract：:Oxidative stress results in damage to cellular structures and has been linked to numerous diseases, including cancer. Extracellular superoxide dismutase (EC-SOD) is a principal enzymatic antioxidant in extracellular space. The purpose of this study was to determine whether the expression of EC-SOD protein is altered i...

journal_title：Experimental and therapeutic medicine

authors： Yokoe H,Nomura H,Yamano Y,Fushimi K,Sakamoto Y,Ogawara K,Shiiba M,Bukawa H,Uzawa K,Takiguchi Y,Tanzawa H

更新日期：2010-07-01 00:00:00

abstract：:The aim of the present study was to clarify the association between lipid metabolism and the atherosclerosis in early-stage chronic renal failure at the molecular level and to explore the efficacy of decorin on chronic renal failure. Sprague Dawley rats receiving 5/6 nephrectomy and Sham surgery were divided into cont...

journal_title：Experimental and therapeutic medicine

authors： Ma HB,Wang R,Yu KZ,Yu C

更新日期：2015-02-01 00:00:00

abstract：:To investigate the effects of propofol on myocardial ischemia reperfusion in rats with type 2 diabetes, male adult rats were divided into five groups: Sham-operation (CC), ischemia-reperfusion (CI), low-dose propofol (LP), moderate-dose propofol (MP) and high-dose propofol (HP). The LP, MP and HP groups were administe...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Zhang K,Qi X,Yang G,Wang H,Zhang Z,Yang B

更新日期：2020-04-01 00:00:00

abstract：:Cardiopulmonary resuscitation (CPR) after cardiac arrest (CA) often leads to neurological deficits in the absence of effective treatment. The aim of the present basic research study was to investigate the effects of human urine-derived stem cells (hUSCs) on the recovery of neurological function in rats after CA/CPR. h...

journal_title：Experimental and therapeutic medicine

authors： Pan C,Zheng X,Wang L,Chen Q,Lin Q

更新日期：2020-11-01 00:00:00

abstract：:Sepsis is a serious condition characterized by an infectious process that induces a severe systemic inflammatory response. In this study, the effects of gemfibrozil (GFZ) on the inflammatory response associated with abdominal sepsis were investigated using a rat model of cecal-ligation and puncture (CLP). Male Wistar ...

journal_title：Experimental and therapeutic medicine

authors： Cámara-Lemarroy CR,Guzman-DE LA Garza FJ,Cordero-Perez P,Ibarra-Hernandez JM,Muñoz-Espinosa LE,Fernandez-Garza NE

更新日期：2015-03-01 00:00:00

abstract：:Macrophage autophagy has a protective role in the development of atherosclerosis; however, it turns dysfunctional in advanced lesions with an increase in p62/sequestosome-1 protein. Little is known about the role and significance of p62 accumulation in atherosclerosis. The present study investigated the association be...

journal_title：Experimental and therapeutic medicine

authors： Ning H,Liu D,Yu X,Guan X

更新日期：2017-12-01 00:00:00