Pyoderma gangrenosum and suppurative hidradenitis association, overlap or spectrum of the same disease? Case report and discussion.

abstract：:Endostatin (ES) is an endogenous angiogenesis inhibitor that has the ability to inhibit tumor growth and metastasis. However, its clinical application is limited by a number of disadvantages, such as poor stability, short half-life and the requirement of high doses to maintain its efficacy. The chemical modification o...

journal_title：Experimental and therapeutic medicine

authors： Li ZN,Yuan ZF,Mu GY,Hu M,Cao LJ,Zhang YL,Ge MX

更新日期：2015-09-01 00:00:00

abstract：:LipoxinA4 (LXA4) is a well-known key mediator of endogenous anti-inflammation and of the resolution of inflammation. Considerable oxidative stress occurs during inflammation due to the generation of reactive oxidative species (ROS). Moreover, high levels of uric acid (UA) contribute to endothelial cell dysfunction, wh...

journal_title：Experimental and therapeutic medicine

authors： Zhou Y,You H,Zhang A,Jiang X,Pu Z,Xu G,Zhao M

更新日期：2020-08-01 00:00:00

abstract：:Systemic sclerosis (SSc) is a relatively rare autoimmune disease with skin and visceral involvement, having a yet unknown etiopathogenesis. Research has shown that professional exposure to various polluting chemicals such as dyes, aliphatic and aromatic organic solvents, inhalable silica dust or certain heavy metals, ...

journal_title：Experimental and therapeutic medicine

authors： Bobeica C,Niculet E,Craescu M,Halip AI,Popescu IA,Draganescu ML,Onisor C,Stefanescu B,Gheuca-Solovastru L

更新日期：2021-01-01 00:00:00

abstract：:Limited data exist concerning the long-term (≥5 year) survival rates of patients with stage IIIB and IV non-small cell lung carcinoma (NSCLC) receiving chemotherapy. We aimed to determine the long-term results of cisplatin plus third-generation (vinorelbine or gemcitabine) cytotoxic chemotherapy in patients with local...

journal_title：Experimental and therapeutic medicine

authors： Ozkaya S,Findik S,Dirican A,Atici AG

更新日期：2012-12-01 00:00:00

abstract：:S-allyl-L-cysteine (SAC) is a sulfur-containing amino acid present in garlic and exhibits a wide range of biological activities such as antioxidant, anti-inflammatory, and anticancer agent. An earlier study demonstrated that SAC ameliorates oxidative damage in a model of experimental stroke. However, the antioxidant p...

journal_title：Experimental and therapeutic medicine

authors： Kosuge Y

更新日期：2020-02-01 00:00:00

abstract：:Emodin, an anthraquinone derivative isolated mainly from the root and rhizome of the medicinal plant Rheum palmatum L., was found to exert anticancer effects on various cultured cancer cells. Phosphatase of regenerating liver-3 (PRL-3), a novel gene, has been known to play an important role in the promotion of cellula...

journal_title：Experimental and therapeutic medicine

authors： Sun ZH,Bu P

更新日期：2012-06-01 00:00:00

abstract：:This study aimed to investigate the effect of ambroxol on the concentration of cefotaxime in the bronchioalveolar lavage fluid of rats with bleomycin-induced pulmonary fibrosis. A total of 54 Wistar male rats were randomly divided into three groups, namely the normal control group, model group and ambroxol group. On e...

journal_title：Experimental and therapeutic medicine

authors： Chen F,Zhang YX,Zhang CQ

更新日期：2015-02-01 00:00:00

abstract：:MicroRNA-155 (miR-155) is overexpressed in numerous human cancer types and has an oncogenic role. Previous study has revealed that miR-155 serves an important role in the progression of clear-cell renal cell carcinoma (ccRCC); however, the underlying mechanism was not completely clarified. The present study aimed to i...

journal_title：Experimental and therapeutic medicine

authors： Ji H,Tian D,Zhang B,Zhang Y,Yan D,Wu S

更新日期：2017-05-01 00:00:00

abstract：:The present study aimed to investigate the effects of mechanical stretch and lipopolysaccharides (LPS) on the expression of transforming growth factor-β1 (TGF-β1) and collagen and viscoelasticity in human embryonic MRC-5 lung fibroblasts cultured in vitro and to assess the mechanisms of ARDS-associated ventilator-indu...

journal_title：Experimental and therapeutic medicine

authors： Xie Y,Qian Y,Wang Y,Liu K,Li X

更新日期：2020-11-01 00:00:00

abstract：:Clinical efficacy of octreotide acetate combined with thrombin in the treatment of liver cirrhosis complicated with gastrointestinal hemorrhage was investigated. A retrospective analysis of 157 patients with liver cirrhosis and gastrointestinal hemorrhage admitted to Weifang People's Hospital from March 2012 to Septem...

journal_title：Experimental and therapeutic medicine

authors： Wang X,Liu Y,Zhao J,Zhang J

更新日期：2019-05-01 00:00:00

abstract：:Postmenopausal osteoporosis is a degenerative disease caused by lack of estrogen whereby bone degeneration exceeds bone formation, resulting in loss of bone mass. Various drugs have been utilized in an attempt to ameliorate bone strength in such patients. The aim of the present study was to compare the effects of vita...

journal_title：Experimental and therapeutic medicine

authors： Huang Y

更新日期：2018-01-01 00:00:00

abstract：:MiR-216a-5p has been acknowledged as an oncogene and is known to be involved in the progression and metastasis of numerous cancer subtypes. However, the potential role of miR-216a-5p in renal cell carcinoma (RCC) remains to be elucidated. In the present study, reverse transcription-quantitative polymerase chain reacti...

journal_title：Experimental and therapeutic medicine

authors： Chen P,Quan J,Jin L,Lin C,Xu W,Xu J,Guan X,Chen Z,Ni L,Yang S,Chen Y,Lai Y

更新日期：2018-04-01 00:00:00

abstract：:The aim of the present study was to investigate the correlation between the protein expression of A-kinase anchor protein 95 (AKAP95), cyclin D3 and AKT with pathological indicators in lung cancer tissues. Immunohistochemistry was used to detect the protein expression levels of the proteins in 51 lung cancer tissue sa...

journal_title：Experimental and therapeutic medicine

authors： Yu X,Yuan Y,Zhi X,Teng B,Chen X,Huang Q,Chen Y,Guan Z,Zhang Y

更新日期：2015-09-01 00:00:00

abstract：:Assisted reproductive technology (ART) including in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) have been shown to be associated with abnormal genomic imprinting, thus increasing the incidence of imprinting disorders such as Beckwith-Wiedemann syndrome (BWS) and Angelman syndrome (AS) in ART-...

journal_title：Experimental and therapeutic medicine

authors： Zheng HY,Shi XY,Wang LL,Wu YQ,Chen SL,Zhang L

更新日期：2011-07-01 00:00:00

abstract：:There are limited data available on the regression of fibrosis in hepatitis C virus (HCV) patients who have achieved sustained virologic response (SVR) after interferon-free treatments. Moreover, a perfect method for assessing liver fibrosis and its dynamics has not been established yet. The main objective of this stu...

journal_title：Experimental and therapeutic medicine

authors： Leuştean A,Popescu C,Nichita L,Tilişcan C,Aramă V

更新日期：2021-01-01 00:00:00

abstract：:Schwannomas are benign encapsulated tumors arising from Schwann cells in the peripheral nervous system. Between 25 and 45% of schwannomas occur in the head and neck region. Schwannomas of the larynx are extremely rare with an incidence of 0.1-1.5% in all benign laryngeal tumors. Laryngeal schwannomas usually occur in ...

journal_title：Experimental and therapeutic medicine

authors： Wang B,Dong P,Shen B,Xu H,Zheng J

更新日期：2014-04-01 00:00:00

abstract：:Cardiac fibrosis is a common phenomenon in different types of heart diseases, such as ischemic heart disease, inherited cardiomyopathy mutations, diabetes, and ageing and is associated with morbidity and mortality. Increased accumulation of extracellular matrix (ECM) that impacts cardiac function, is the underlying ca...

journal_title：Experimental and therapeutic medicine

authors： Tian J,An X,Niu L

更新日期：2017-05-01 00:00:00

abstract：:It is well established that altered expression of microRNAs (miRs) is critical in numerous human cancer types. Nevertheless, the molecular mechanisms of many miRs are yet to be elucidated. In the present study, reverse transcription-quantitative polymerase chain reaction and western blot analyses, and cell migration a...

journal_title：Experimental and therapeutic medicine

authors： Bai X,Yang M,Xu Y

更新日期：2018-12-01 00:00:00

abstract：:The aim of the present study was to investigate the protective effects of ischemic preconditioning on rats with renal ischemia-reperfusion injury and the effects on the expression of Bcl-2 and Bax. Thirty-six SD rats were randomly divided into three groups (n=12) including sham operation (S) group, ischemia-reperfusio...

journal_title：Experimental and therapeutic medicine

authors： Shen S,Zhou J,Meng S,Wu J,Ma J,Zhu C,Deng G,Liu D

更新日期：2017-11-01 00:00:00

abstract：:Lung cancer is among the most common causes of cancer-related mortality. It has a high mortality rate and resistance to chemotherapy due to its high metastatic potential. Naringenin, a bioactive compound identified in several fruits, displays anti-inflammatory and antitumor effects. Furthermore, naringenin mitigates t...

journal_title：Experimental and therapeutic medicine

authors： Chang HL,Chang YM,Lai SC,Chen KM,Wang KC,Chiu TT,Chang FH,Hsu LS

更新日期：2017-02-01 00:00:00

abstract：:The treatment of lymphatic malformations (LMs) represents a great clinical challenge. The present study reported on the treatment of 68 infants with cervical macrocystic LMs using surgical resection. The cases were retrospectively analyzed. All patients underwent pre-operative ultrasonography, computed tomography (CT)...

journal_title：Experimental and therapeutic medicine

authors： Ma J,Biao R,Lou F,Lin K,Gao YQ,Wang ML,Yang YL,Zhang TS

更新日期：2017-08-01 00:00:00

abstract：:Gastrointestinal (GI) mucormycosis is a rare and life-threatening invasive fungal infection. GI mucormycosis occur in all parts of the alimentary tract, with the stomach being the most common site. Diabetes mellitus and other types of conditions associated with immunodeficiency, including hematologic malignancies, sol...

journal_title：Experimental and therapeutic medicine

authors： Lee SH,Son YG,Sohn SS,Ryu SW

更新日期：2014-08-01 00:00:00

abstract：:To suppress the invasion of hepatocellular carcinoma (HCC) cells into surrounding connective tissues during metastasis, we investigated the usefulness of sorafenib. In order to search for model cell lines, cell numbers were counted to reveal cell lines with the potential to proliferate in serum-free media. Cell prolif...

journal_title：Experimental and therapeutic medicine

authors： Tomizawa M,Shinozaki F,Sugiyama T,Yamamoto S,Sueishi M,Yoshida T

更新日期：2010-09-01 00:00:00

abstract：:The aim of this study was to investigate the clinical features of ulcerative colitis (UC) combined with acute interstitial lung disease (ILD). One case with acute UC combined with ILD and airway disease was reported, and the pathological diagnosis of previous cases of UC combined with ILD was retrospectively analyzed ...

journal_title：Experimental and therapeutic medicine

authors： Xu L,Xiao W,Ma D,Zhou S,Zhang Q

更新日期：2014-10-01 00:00:00

abstract：:Activated T cells rely on aerobic glycolysis and glutaminolysis in order to proliferate and differentiate into effector cells. Therefore, intervention in these metabolic pathways inhibits proliferation. The aim of the present study was to evaluate the effects of Krebs' cycle inhibition at the level of malate dehydroge...

journal_title：Experimental and therapeutic medicine

authors： Eleftheriadis T,Pissas G,Antoniadi G,Liakopoulos V,Stefanidis I

更新日期：2015-11-01 00:00:00

abstract：:Oxidative stress has been reported to serve an important role in the development and progression of diabetic nephropathy (DN). Epithelial-mesenchymal transition (EMT) of renal tubular epithelial cells promotes renal fibrosis in DN, while the mechanism of reactive oxygen species (ROS)-mediated EMT is not fully understo...

journal_title：Experimental and therapeutic medicine

authors： Lu Q,Wang WW,Zhang MZ,Ma ZX,Qiu XR,Shen M,Yin XX

更新日期：2019-01-01 00:00:00

abstract：:There is currently no available cure or universally effective treatment for dry eye (DE). The aim of the present study was to investigate the clinical efficacy of transcutaneous electrical stimulation (TES) combined with artificial tears in treating DE. Patients diagnosed with DE were referred for therapy with TES com...

journal_title：Experimental and therapeutic medicine

authors： Cai MM,Zhang J

更新日期：2020-12-01 00:00:00

abstract：:Somatostatin has been extensively studied for the prophylaxis of pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP). However, the results remain controversial. The present retrospective cohort study aimed to investigate the efficacy of pre- and post-ERCP somatostatin administration in the pre...

journal_title：Experimental and therapeutic medicine

authors： Zhao LN,Yu T,Li CQ,Lai Y,Chen QK

更新日期：2014-08-01 00:00:00

abstract：:It is firmly established that smoking is a risk factor of cardiovascular disease, stroke and peripheral vascular disease. Although smoking alters the hemostatic process, the influence of smoking on human platelet activation remains controversial. For patients undergoing surgery, cessation of smoking prior to the proce...

journal_title：Experimental and therapeutic medicine

authors： Kito Y,Iida M,Tanabe K,Onuma T,Tsujimoto M,Nagase K,Tokuda H,Iwama T,Kozawa O,Iida H

更新日期：2019-11-01 00:00:00

abstract：:Examination of predictive effect of five hepatitis B virus (HBV) markers on the re-vaccination time of hepatitis B vaccine was assessed. A total of 3,243 patients examined by five HBV markers in Women and Children's Health Care Hospital of Linyi from January 2015 to December 2017 were selected as the subjects and anal...

journal_title：Experimental and therapeutic medicine

authors： Jia Q,Yu F,Zhou Q,Chen X,Gu Z,Ma C

更新日期：2020-08-01 00:00:00