Sorafenib suppresses the cell cycle and induces the apoptosis of hepatocellular carcinoma cell lines in serum-free media.

abstract：:Pontocerebellar hypoplasia type 6 (PCH6) is a rare autosomal recessive disease that occurs due to mutations in the mitochondrial arginyl-tRNA synthetase 2 (RARS2) gene. To the best of our knowledge, 23 cases with relatively complete clinical data have been reported thus far. In the present study, a case with PCH6 caus...

journal_title：Experimental and therapeutic medicine

authors： Zhang J,Zhang Z,Zhang Y,Wu Y

更新日期：2018-01-01 00:00:00

abstract：:Sjogren's syndrome type B (SSB)/La antibody is an autoantibody generally observed in connective tissue diseases whereas double-stranded deoxyribonucleic acid (dsDNA) antibodies are the most characteristic autoantibodies found in systemic lupus erythematosus (SLE) patients. The relationship of these autoantibodies rema...

journal_title：Experimental and therapeutic medicine

authors： Ding M,Zhang J

更新日期：2016-07-01 00:00:00

abstract：:Angelicin is an active compound isolated from the Chinese herb Angelica archangelica, which has been reported to exert antitumor effects by inhibiting malignant behaviors in several types of tumor, including proliferation, colony formation, migration and invasion. However, the effects of angelicin on human cervical ca...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Chen Y,Chen X,Liang Y,Yang D,Dong J,Yang N,Liang Z

更新日期：2019-11-01 00:00:00

abstract：:A mutation in the IIb sodium phosphate transporter SLC34A2 gene has recently been described in pulmonary alveolar microlithiasis (PAM) patients. Experiments in this study were aimed at confirming the role of the gene product in PAM by comparing phosphorylated products in extracellular fluid of alveolar epithelial cell...

journal_title：Experimental and therapeutic medicine

authors： Ma T,Qu D,Yan B,Zhang Q,Ren J,Hu Y

更新日期：2018-01-01 00:00:00

abstract：:The aim of the present study was to evaluate the expression and effect of rat mitofusin-2 (rMfn2) in the ovaries and other organs in rats. Rat models were developed by the intraovarian microinjection of an rMfn2-overexpressing lentiviral vector. Lenti-green fluorescent protein (GFP)-rMfn2 was microinjected into rat ov...

journal_title：Experimental and therapeutic medicine

authors： Hu X,Lei X,Wang J,Pan H,Li C,Yao Z

更新日期：2014-09-01 00:00:00

abstract：:Notch3 is a member of the Notch family and its mutations are known to cause a hereditary human disorder called cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). However, the specific function and signaling cascade initiated by CADASIL mutants remain unknown. To gain ...

journal_title：Experimental and therapeutic medicine

authors： Lin C,Huang Z,Zhou R,Zhou Y,Shentu Y,Yu K,Zhang Y

更新日期：2021-02-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is a component of metabolic syndrome that significantly increases the cardiovascular risk of patients with glucose metabolism alterations. This study identified the prevalence of NAFLD, predictors of NAFLD and explored the link between insulin sensitivity, insulin resistance a...

journal_title：Experimental and therapeutic medicine

authors： Vesa CM,Behl T,Nemeth S,Bratu OG,Diaconu CC,Moleriu RD,Negrut N,Zaha DC,Bustea C,Radu FI,Bungau S

更新日期：2020-12-01 00:00:00

abstract：:The present study aimed to evaluate the impact of small interfering RNA (siRNA) targeting of the survivin gene in human tumor cells and the effect of decreased survivin expression on the proliferation and apoptosis of tumor cells. Human tumor cell lines (MSA-MB-231, SGC-7901, HeLa, A549, SK-OV-3 and Raji, PC-3) were c...

journal_title：Experimental and therapeutic medicine

authors： Zhang Z,Wang T,Liu Z,Tang S,Yue M,Feng S,Hu M,Xuan L,Chen Y

更新日期：2017-07-01 00:00:00

abstract：:This review presents a systematic analysis of the literature regarding the pachychoroid disease spectrum nomenclature, diagnosis criteria and therapeutic options. Pachychoroid related diseases are a new concept, introduced into the ophthalmological nomenclature in 2013 and evolving both as concept and as classificatio...

journal_title：Experimental and therapeutic medicine

authors： Moraru AD,Costin D,Moraru RL,Costuleanu M,Brănișteanu DC

更新日期：2020-10-01 00:00:00

abstract：:Insulin is used in the treatment of type 2 diabetes, with its usage reaching 30-50% in Western countries. The aim of the present study was to determine the association between insulin dosage (ID)/insulin usage time (IT) and coronary artery lesions in patients of type 2 diabetes with coronary heart disease. Based on th...

journal_title：Experimental and therapeutic medicine

authors： Luo XL,Yan QK,Wang Y,Fang H,Wang HY,Bai Y,Zeng CY,Wang XK

更新日期：2016-05-01 00:00:00

abstract：:The present report describes the clinical course and treatment of a Mooren-like ulcer associated with abuse of topical anesthetics and dexamethasone. A 38-year-old male physician treated himself with lidocaine, tetracaine and dexamethasone (DEX) eye drops for severe pain and decline of vision in both eyes. After six m...

journal_title：Experimental and therapeutic medicine

authors： Wu H,Hu Y,Shi XR,Xu F,Jiang CY,Huang R,Jia H

更新日期：2016-07-01 00:00:00

abstract：:The present study aimed to investigate whether serum interleukin-6 (IL-6) expression levels were associated with the onset and progression of intervertebral disc degeneration (IDD). A comprehensive meta-analysis of the scientific literature from numerous electronic databases was performed, in order to obtain published...

journal_title：Experimental and therapeutic medicine

authors： Deng X,Zhao F,Kang B,Zhang X

更新日期：2016-04-01 00:00:00

abstract：:The aim of this study was to explore the effect of electroacupuncture (EA) on immune function in patients undergoing supratentorial craniotomy. We also examined whether point specificity in EA was present. The study involved 29 patients undergoing craniotomy. The patients were divided into three groups: a control (C, ...

journal_title：Experimental and therapeutic medicine

authors： Li G,Li S,Wang B,An L

更新日期：2013-09-01 00:00:00

abstract：:The present study aimed to systematically evaluate the effectiveness of single-incision laparoscopic surgery (SILS), conventional laparoscopic appendectomy (CLA) and open appendectomy (OA) for the treatment of acute appendicitis. PubMed and Embase databases were systematically searched to identify relevant studies com...

journal_title：Experimental and therapeutic medicine

authors： Feng J,Cui N,Wang Z,Duan J

更新日期：2017-12-01 00:00:00

abstract：:Hypertension is a very common cardiovascular disorder, however, the molecular mechanism underlying this disease remains poorly understood. Recently, an increasing number of studies have demonstrated that mitochondrial (mt)DNA mutations serve important roles in the pathogenesis of hypertension. The current study report...

journal_title：Experimental and therapeutic medicine

authors： Lin L,Cui P,Qiu Z,Wang M,Yu Y,Wang J,Sun Q,Zhao H

更新日期：2019-03-01 00:00:00

abstract：:The aim of this study was to isolate and purify Rhizoma Pinelliae trypsin inhibitor (RPTI), determine its N-terminal amino acid sequence and evaluate its inhibitory effect on the proliferation of poorly differentiated BGC-823 human gastric adenocarcinoma cells. RPTI was separated and purified from a 40% (NH4)2SO4 prec...

journal_title：Experimental and therapeutic medicine

authors： Zu G,Wang H,Wang J,Dou Y,Zhao W,Sun Y

更新日期：2014-07-01 00:00:00

abstract：:Langerhansmporal histiocytosis (LCH) refers to a group of diseases that are characterized by the primary pathogenesis of an abnormal polyclonal proliferation of Langerhans cells that affect different structures of the human body, including the temporal bone. Thus far, the etiology of LCH remains unclear. Diagnosis of ...

journal_title：Experimental and therapeutic medicine

authors： Ni M,Yang X

更新日期：2017-03-01 00:00:00

abstract：:The aim of the present study was to characterize the effects of early growth response factor-1 DNA enzyme (EDRz) in a rat abdominal aortic aneurysm (AAA) model to determine the mechanism by which EDRz inhibits AAA and affects the formation of AAA by regulating the activity of matrix metalloproteinase (MMP)-2 and MMP-9...

journal_title：Experimental and therapeutic medicine

authors： Wang S,Dong H,Liu C,Xu G,Hu X,Fan Y,Chen L

更新日期：2018-07-01 00:00:00

abstract：:Cardiac fibrosis is a common phenomenon in different types of heart diseases, such as ischemic heart disease, inherited cardiomyopathy mutations, diabetes, and ageing and is associated with morbidity and mortality. Increased accumulation of extracellular matrix (ECM) that impacts cardiac function, is the underlying ca...

journal_title：Experimental and therapeutic medicine

authors： Tian J,An X,Niu L

更新日期：2017-05-01 00:00:00

abstract：:Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS2) deficiency is a metabolic disorder caused by mutations in the HMGCS2 gene. The present study describes the identification of four cases of HMGCS2 deficiency in Japan. Hepatomegaly and severe metabolic acidosis were observed in all cases. Fatty liver was id...

journal_title：Experimental and therapeutic medicine

authors： Ago Y,Otsuka H,Sasai H,Abdelkreem E,Nakama M,Aoyama Y,Matsumoto H,Fujiki R,Ohara O,Akiyama K,Fukui K,Watanabe Y,Nakajima Y,Ohnishi H,Ito T,Fukao T

更新日期：2020-11-01 00:00:00

abstract：:Therapy using acellular spinal cord (ASC) scaffolds seeded with bone marrow stromal cells (BMSCs) has previously been shown to restore function of the damaged spinal cord and improve functional recovery in a rat model of acute hemisected spinal cord injury (SCI). The aim of the present study was to determine whether B...

journal_title：Experimental and therapeutic medicine

authors： Wang YH,Chen J,Zhou J,Nong F,Lv JH,Liu J

更新日期：2017-01-01 00:00:00

abstract：:Functional dyspepsia (FD) is a non-organic gastrointestinal disorder that has a marked negative impact on quality of life. Compared with conventional pharmacological therapies, the traditional Chinese medicine weikangning (WKN) is a safe and effective treatment for FD. The present study aimed to determine the molecula...

journal_title：Experimental and therapeutic medicine

authors： Chang Y,Wei W,Tong L,Liu Y,Zhou A,Chen J,Wei R,Zhang P,Su X

更新日期：2017-10-01 00:00:00

abstract：:The present study investigated the characteristic features of cancer stem cells (CSCs) using an aggressive human osteosarcoma cell line OS-65. Hoechst 33342 dye exclusion was used to distinguish the cancer stem-like side population (SP) cells from OS-65 cells. Furthermore, the SP cells were characterized via chemoresi...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Teng JS

更新日期：2016-07-01 00:00:00

abstract：:Electrospinning using biocompatible polymer scaffolds, seeded with or without stem cells, is considered a promising technique for producing fibrous scaffolds with therapeutic possibilities for ischemic heart disease. However, no optimal scaffolds for treating ischemic heart disease have been identified thus far. In th...

journal_title：Experimental and therapeutic medicine

authors： Du M,Gu J,Wang J,Xue Y,Ma Y,Mo X,Xue S

更新日期：2019-05-01 00:00:00

abstract：:The transformation of prostate cancer from an androgen-dependent state to an androgen-independent state is a lethal progression. Alterations in transcriptional programs are the basis of prostate cancer deterioration. The androgen receptor (AR), a member of the nuclear hormone receptor superfamily, mediates prostate ca...

journal_title：Experimental and therapeutic medicine

authors： Cheng Y,Yu P,Duan X,Liu C,Xu S,Chen Y,Tan Y,Qiang Y,Shen J,Tao Z

更新日期：2015-06-01 00:00:00

abstract：:The aim of this study was to analyze the concentration changes of nuclear factor-κB (NF-κB) and the related inflammatory factors of pre-treatment and post-treatment in children with viral encephalitis, to examine the mechanism of NF-κB in the pathogenesis of child viral encephalitis. Twenty-two children with severe vi...

journal_title：Experimental and therapeutic medicine

authors： Zhang D,Zheng N,Liu X

更新日期：2017-06-01 00:00:00

abstract：:Simple bone cysts (SBCs) are uncommon lesions that usually occur in the long bones of the skeleton and in the body of the mandible. Displacement of the mandibular canal due to cystic lesions have been reported previously. However, there have been no reports in which endoscopy has been utilized to observe an inferior a...

journal_title：Experimental and therapeutic medicine

authors： Matsuda S,Yoshimura H,Sano K

更新日期：2019-06-01 00:00:00

abstract：:Neuregulin-1 (NRG-1) is a cardioactive growth factor released from endothelial cells. However, the effect of NRG-1 on ventricular remodeling in diabetic cardiomyopathy (DCM) remains unclear. The aim of the present study was to investigate the pathophysiological role of NRG-1 in a rat model of DCM. Rat cardiac microvas...

journal_title：Experimental and therapeutic medicine

authors： Li B,Xiao J,Li Y,Zhang J,Zeng M

更新日期：2013-11-01 00:00:00

abstract：:Ischemic heart diseases are a serious health problem worldwide. The transplantation of mesenchymal stem cells (MSCs) has been investigated in numerous clinical trials on various other diseases due to the self-renewal capacity of these cells and their potential to differentiate into a variety of cell types. The presenc...

journal_title：Experimental and therapeutic medicine

authors： Nimsanor N,Phetfong J,Plabplueng C,Jangpatarapongsa K,Prachayasittikul V,Supokawej A

更新日期：2017-12-01 00:00:00

abstract：:Uterine cervical adenocarcinoma has a poor clinical prognosis when compared with squamous cell carcinoma. Therefore, the development of new treatment strategies for uterine cervical adenocarcinoma is necessary. Src is a proto-oncogene that is important in cancer progression. Dasatinib is a Src inhibitor that has been ...

journal_title：Experimental and therapeutic medicine

authors： Takiguchi E,Nishimura M,Mineda A,Kawakita T,Abe A,Irahara M

更新日期：2017-11-01 00:00:00