Langerhans' cell histiocytosis of the temporal bone: A case report.

abstract：:Special AT-rich sequence binding protein 2 (SATB2) is a member of the special family of AT-rich binding transcription factors and has a critical role in osteoblast differentiation and craniofacial patterning. However, the expression and distribution of SATB2 in tooth development is largely unknown. The aim of the pres...

journal_title：Experimental and therapeutic medicine

authors： He L,Liu H,Shi L,Pan S,Yang X,Zhang L,Niu Y

更新日期：2017-10-01 00:00:00

abstract：:Diabetes may affect myocardial fibrosis through oxidative stress. Trimetazidine (TMZ) is an anti-anginal agent. The present study aimed to determine the modulatory effect of TMZ on reactive oxygen species (ROS) and connective tissue growth factor (CTGF) expression and to evaluate the potential of TMZ to improve diasto...

journal_title：Experimental and therapeutic medicine

authors： Zhao Y,Li S,Quan E,Zhang H,Wu Y,Luo Y,Peng L,Wang J,Zhu J,Liu J

更新日期：2019-08-01 00:00:00

abstract：:Homeobox D10 (HOXD10) belongs to the human homeobox (HOX) gene family, and the homologous protein encoded by HOX primarily controls cell differentiation and morphogenesis during embryonic development. The current study aimed to explore the roles and mechanisms of HOXD10 in the migration of human fibroblast-like synovi...

journal_title：Experimental and therapeutic medicine

authors： Luan L,Ma Y,Zhang L

更新日期：2018-09-01 00:00:00

abstract：:The T790M mutational basis of treatment failure, following treatment via alteration of the epidermal growth factor receptor (EGFR) pathway, is a well-known anomaly in patients with non-small cell lung cancer (NSCLC). The T790M mutation activates the kinase domain, causing tyrosine kinase inhibitors, such as gefitinib,...

journal_title：Experimental and therapeutic medicine

authors： Zang SZ,Yang YR,Zhao SS,Li YX,Gao XY,Zhong CL

更新日期：2017-05-01 00:00:00

abstract：:In recent years accumulating evidence has indicated that tocotrienol exhibits an oxidation resistance function, decreased cholesterol function, inhibits cancer function and has unique physiological functions, including anti-inflammatory, anti-apoptotic and anti-oxidative properties. The present study investigated the ...

journal_title：Experimental and therapeutic medicine

authors： Xun C,Mamat M,Guo H,Mamati P,Sheng J,Zhang J,Xu T,Liang W,Cao R,Sheng W

更新日期：2017-07-01 00:00:00

abstract：:Melatonin is a darkness hormone secreted by the pineal gland, which serves a role in idiopathic oligoasthenoteratozoospermia (iOAT). The present study aimed to evaluate the seminal plasma and serum melatonin levels of 50 patients with iOAT and 50 normal fertile controls and the effects of exposure to light at night on...

journal_title：Experimental and therapeutic medicine

authors： H Hassan M,A El-Taieb M,N Fares N,M Fayed H,Toghan R,M Ibrahim H

更新日期：2020-07-01 00:00:00

abstract：:Bisphenol A (BPA) is an environmental pollutant that is widely produced throughout the world. It is primarily used in the manufacture of polycarbonate plastics, epoxy resins, paints and dental materials. BPA has been reported to promote hepatotoxicity and cardiotoxicity. The antioxidant activity of sesame lignans is w...

journal_title：Experimental and therapeutic medicine

authors： Eweda SM,Newairy ASA,Abdou HM,Gaber AS

更新日期：2020-01-01 00:00:00

abstract：:Shen-Zhi-Ling (SZL) oral liquid is a traditional Chinese medicine formula that is mainly used for the clinical treatment of mild to moderate Alzheimer's disease (AD). The aim of the present study was to investigate the effects and underlying mechanisms of SZL treatment on AD. APP/PS1 transgenic mice were utilized to e...

journal_title：Experimental and therapeutic medicine

authors： Xing S,Shen D,Chen C,Wu B,Chi H

更新日期：2017-09-01 00:00:00

abstract：:The aim of the present study was to screen differentially co-expressed genes and the involved transcription factors (TFs) and microRNAs (miRNAs) in venous thromboembolism (VTE). Microarray data of GSE19151 were downloaded from Gene Expression Omnibus, including 70 patients with VTE and 63 healthy controls. Principal c...

journal_title：Experimental and therapeutic medicine

authors： Ming Z,Ding W,Yuan R,Jin J,Li X

更新日期：2016-06-01 00:00:00

abstract：:Conjunctivitis associated systemic lupus erythematosus (caSLE) is a connective tissue autoimmune disease with a large spectrum of clinical manifestations. The disease may lead to ocular complications and in severe cases may be sight-threatening. This study investigated the expression of vascular adhesion protein-1 (VA...

journal_title：Experimental and therapeutic medicine

authors： Liu H,Zhang J,Zhou P,Sun H,Katsarou M,Drakoulis N

更新日期：2019-12-01 00:00:00

abstract：:Relative changes in B-type natriuretic peptide (BNP) and amino terminal pro-BNP (NT-proBNP) levels may help to assess the risk of congestive heart failure (CHF). However, whether these levels at the time of admission enable the prediction of outcomes with acute exacerbation remains unknown. The current study determine...

journal_title：Experimental and therapeutic medicine

authors： Dai Y,Yang J,Takagi A,Konishi H,Miyazaki T,Masuda H,Shimada K,Miyauchi K,Daida H

更新日期：2017-08-01 00:00:00

abstract：:MicroRNA (miR) are short non-coding RNA that bind to the 3'-untranslational region of their target genes, inhibiting translation and causing mRNA degradation. miR deregulation has been implicated in human cancer; however, the detailed regulatory mechanism of miR-137 in osteosarcoma (OS) remains largely unknown. In the...

journal_title：Experimental and therapeutic medicine

authors： Feng Q,Wu Q,Liu X,Xiong Y,Li H

更新日期：2017-06-01 00:00:00

abstract：:The present study investigated the aptness of assessing the levels of progastrin-releasing peptide (Pro-GRP) in addition to the T lymphocyte subpopulation in lung cancer patients prior to and after therapy for determining immune function. A total of 45 patients with lung cancer were recruited and stratified in to a no...

journal_title：Experimental and therapeutic medicine

authors： He L,Wang J,Chang D,Lv D,Li H,Zhang H

更新日期：2018-02-01 00:00:00

abstract：:3-Hydroxy-3-methylglutaric aciduria (3-HMG, OMIN 246450) is a rare autosomal recessive metabolic disorder caused by a deficiency of 3-hydroxy-3-methylglutaryl-CoA lyase, a key enzyme in leucine metabolism and ketone body synthesis. Acute episodes of 3-HMG may be triggered by fasting or infection, and symptoms include ...

journal_title：Experimental and therapeutic medicine

authors： Hao X,Wang J,Liu S,Chen Y,Zhang Y,Hao Y

更新日期：2016-06-01 00:00:00

abstract：:Human serum albumin (HSA) is a transporting protein that has multiple functions. The binding interaction between HSA and small molecules affects its function and efficacy of small molecules. The present study reports that kaempferol-7-O-α-L-rhamnopyranoside (KR) interacts with HSA as indicated by multiple fluorescence...

journal_title：Experimental and therapeutic medicine

authors： Zhang W,Chen C,Zhang C,Duan J,Yao H,Li Y,Meng A,Shi J

更新日期：2017-06-01 00:00:00

abstract：:Effects of propofol, midazolam and dexmedetomidine on patients with sepsis in intensive care unit (ICU) and on arterial blood gas (ABG) were studied. In total 429 ICU patients with sepsis, admitted to Renji Hospital, School of Medicine, Shanghai Jiaotong University from May 2015 to January 2019, were selected as resea...

journal_title：Experimental and therapeutic medicine

authors： Ding J,Chen Y,Gao Y

更新日期：2019-12-01 00:00:00

abstract：:Herpes Zoster (HZ) is reported as the most prevalent viral infection in patients with systemic lupus erythematosus (SLE). The aim of the present study was to investigate the clinical features, complications, and potential risk factors of HZ in patients with SLE from Southern China. A retrospective study was performed ...

journal_title：Experimental and therapeutic medicine

authors： Chen D,Li H,Xie J,Zhan Z,Liang L,Yang X

更新日期：2017-12-01 00:00:00

abstract：:Doxorubicin (DOX), a potent and widely used anticancer agent, can give rise to severe cardiotoxicity that limits its clinical use by inducing oxidative stress. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the central regulator of cellular responses to electrophilic/oxidative stress, which serves a critical ro...

journal_title：Experimental and therapeutic medicine

authors： Guo Z,Yan M,Chen L,Fang P,Li Z,Wan Z,Cao S,Hou Z,Wei S,Li W,Zhang B

更新日期：2018-10-01 00:00:00

abstract：:Extramedullary hematopoiesis (EMH) is defined as hematopoiesis occurring in organs outside of the bone marrow. The present report describes two cases of thalassemic patients with paraspinal medullary hematopoiesis and analyzes the clinical manifestations, imaging, pathology, diagnosis and treatment of EMH. In addition...

journal_title：Experimental and therapeutic medicine

authors： Zhang HZ,Li Y,Liu X,Chen BR,Yao GH,Peng YN

更新日期：2016-12-01 00:00:00

abstract：:Nuclear receptor related-1 protein (Nurr1) is a novel orphan member of the nuclear receptor superfamily (the NR4A family) involved in tumorigenesis. The aim of the present study was to investigate the expression and possible function of Nurr1 in pancreatic ductal adenocarcinoma (PDAC). The expression pattern of Nurr1 ...

journal_title：Experimental and therapeutic medicine

authors： Ji L,Gong C,Ge L,Song L,Chen F,Jin C,Zhu H,Zhou G

更新日期：2017-02-01 00:00:00

abstract：:Various microRNAs (miRs) have been demonstrated to serve important roles in gastric cancer (GC). miR-153 in particular has been reported to serve a suppressive role in GC; however, the underlying mechanism remains unclear. In the present study Reverse transcription-quantitative polymerase chain reaction and western bl...

journal_title：Experimental and therapeutic medicine

authors： Ouyang Y,Yuan W,Qiu S

更新日期：2018-08-01 00:00:00

abstract：:Curcumin is a natural polyphenol with powerful antioxidant and anti-inflammatory properties. The present study evaluated the protective effect of curcumin on myocardial injury in rats as well as the mechanisms underlying these effects, and examined the expression of nuclear factor-κB (NF-κB), peroxisome proliferator-a...

journal_title：Experimental and therapeutic medicine

authors： Lv FH,Yin HL,He YQ,Wu HM,Kong J,Chai XY,Zhang SR

更新日期：2016-12-01 00:00:00

abstract：:Uterine carcinosarcoma (UCS) is a rare but very aggressive cancer of the female reproductive tract with an extremely poor prognosis. With the goal of understanding the role of microRNA (miRNA) dysregulation in these tumors, we profiled the expression of 667 human miRNAs in a panel of eight UCS patients and five benign...

journal_title：Experimental and therapeutic medicine

authors： Devor EJ,DE Mik JN,Ramachandran S,Goodheart MJ,Leslie KK

更新日期：2012-04-01 00:00:00

abstract：:Pulmonary mucormycosis, a relatively rare pulmonary fungal disease, is difficult to diagnose and lacks effective treatment. The present study reports the case of a 64-year-old patient who was treated successfully for pulmonary mucormycosis in Xuan Wu Hospital. The patient presented with low-grade fever and a productiv...

journal_title：Experimental and therapeutic medicine

authors： Luo Z,Zhang L

更新日期：2017-10-01 00:00:00

abstract：:The present study aimed to investigate changes of T-regulatory (Treg) and T-helper (Th)17 cells as well as cytokines in peripheral blood of children with acute bronchitis, and to explore the roles of these cells in the pathogenesis of acute bronchitis. A total of 126 children who had presented at Renji Hospital (Shang...

journal_title：Experimental and therapeutic medicine

authors： Tu Z,Xue H,Chen W,Cao L,Zhang W

更新日期：2017-10-01 00:00:00

abstract：:The present study analyzed the ultrasonic features of papillary thyroid microcarcinoma (PTMC) and papillary thyroid non-microcarcinoma (non-PTMC) with the aim of improving the diagnostic value of ultrasonography. The ultrasonic features of 328 patients with papillary thyroid carcinoma (PTC), as confirmed by pathology,...

journal_title：Experimental and therapeutic medicine

authors： Zhang XL,Qian LX

更新日期：2014-10-01 00:00:00

abstract：:The action mechanism of long non-coding ribonucleic acid-homeobox transcript antisense ribonucleic acid (lncRNA-HOTAIR) in the regulation of the Wnt signaling pathway on the drug resistance of non-small cell lung cancer was investigated. Forty eight patients with non-small cell lung cancer, who were treated with cispl...

journal_title：Experimental and therapeutic medicine

authors： Guo F,Cao Z,Guo H,Li S

更新日期：2018-06-01 00:00:00

abstract：:In the present study the preventive effect of polysaccharides from the large yellow croaker swim bladder (PLYCSB) on HCl/ethanol-induced gastric injury in ICR mice was investigated. A high dose of PLYCSB (50 mg/kg) was found to reduce the levels of the serum proinflammatory cytokines interleukin (IL)-1β, IL-6, IL-8, a...

journal_title：Experimental and therapeutic medicine

authors： Chen S,Zhu K,Wang R,Zhao X

更新日期：2014-07-01 00:00:00

abstract：:The aim of the present study was to investigate the role and mechanism of vascular cell adhesion molecule-1 (VCAM-1) in the development of rheumatoid arthritis (RA). One hundred and twenty patients with RA who had been admitted to the Huaihe Hospital of Henan University between January and December 2013 were enrolled ...

journal_title：Experimental and therapeutic medicine

authors： Wang L,Ding Y,Guo X,Zhao Q

更新日期：2015-09-01 00:00:00

abstract：:The present study aimed to determine the diagnostic yield of OMOM capsule endoscopy for small bowel diseases in adults. A total of 89 patients, including 45 cases of obscure abdominal pain, 22 of chronic diarrhea, 18 of obscure gastrointestinal bleeding and 4 of obscure anemia were enrolled in the present study. The t...

journal_title：Experimental and therapeutic medicine

authors： Zhang L,Shen J,Guo L,Cheng F,Fan Q,Ni K,Xia S,Zhou D

更新日期：2018-04-01 00:00:00