Abstract:
:The aim of the present study was to provide reliable experimental evidence for the application of autologous skin fibroblasts (asFbs) in the repair of depressed scars. In the experiments, depressed trauma was induced in male Wistar rats, and fibroblasts were separated from the removed skin tissues to culture in medium. In vitro cultured asFbs were injected into the depressed scar sites of rats, and the repair function of asFbs in the depressed scars was then examined at the cellular and whole-animal levels. The expression levels of type I and type III collagen in the dermal layer of the skin injected with asFb cells were significantly higher, as compared with those of the control, and type I collagen expression was significantly higher compared with Type III. Re-injection of asFbs into the dermal layer of depressed scars can markedly improve their repair. These results may prove useful for skin repair in clinical settings.
journal_name
Exp Ther Medjournal_title
Experimental and therapeutic medicineauthors
Zhao J,Liu YC,Shi YH,Xie YQ,Cui HP,Li Y,Li XJ,Ren LQdoi
10.3892/etm.2016.3442subject
Has Abstractpub_date
2016-08-01 00:00:00pages
945-950issue
2eissn
1792-0981issn
1792-1015pii
ETM-0-0-3442journal_volume
12pub_type
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