Chlorogenic acid induces apoptosis to inhibit inflammatory proliferation of IL-6-induced fibroblast-like synoviocytes through modulating the activation of JAK/STAT and NF-κB signaling pathways.

abstract：:Salivary gland malignant neoplasms (SGMNs) represent a group of malignant solid tumors with heterogeneity in their cellular make-up, which causes difficulty with regard to the immunohistochemical confirmation of their cytological features. In the present study, overexpression of the pituitary tumor transforming gene (...

journal_title：Experimental and therapeutic medicine

authors： Liu J,Wang Y,He H,Jin W,Zheng R

更新日期：2015-08-01 00:00:00

abstract：:Effects of paraquat (PQ) on interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in macrophages were investigated. Different concentrations of PQ were added to mouse macrophage RAW264.7 for culture. According to different concentrations of PQ, mice were divided into micro concentration (0.01 mmol/l), low concentra...

journal_title：Experimental and therapeutic medicine

authors： Huang J,Ning N,Zhang W

更新日期：2019-03-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial proliferation and inflammation. Intra-articular corticosteroid injections are commonly used for the treatment of arthritis affecting one or two joints. Although corticosteroid injections are fast-acting, repeated usage can result in se...

journal_title：Experimental and therapeutic medicine

authors： Cho HK,Park GY,Sung WJ,Kawk SG,Jung WB

更新日期：2020-11-01 00:00:00

abstract：:Point mutations in oncogenes and tumor suppressor genes occur at early stages in the carcinogenic process. Point mutations in ras family oncogenes are the most common mutational events in several types of human cancer, and are available as molecular markers for the detection of cancer cells in carcinogenicity bioassay...

journal_title：Experimental and therapeutic medicine

authors： Yano Y,Yano T,Kinoshita A,Matoba A,Hasuma T,Wanibuchi H,Morimura K,Otani S,Fukushima S

更新日期：2010-07-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) serve important roles in colorectal cancer. The aim of the present study was to investigate the expression and role of cervical carcinoma expressed PCNA regulatory (CCEPR) lncRNA in colorectal cancer progression. The results demonstrated that CCEPR expression was significantly higher in ...

journal_title：Experimental and therapeutic medicine

authors： Duan Y,Fang Z,Shi Z,Zhang L

更新日期：2019-11-01 00:00:00

abstract：:The mortality and disability rate of patients with ruptured anterior communicating artery (AComA) aneurysm after bleeding is high. Even with the most advanced treatment methods, the incidence of complications remains high. The purpose of the present study was to determine the efficacy of microsurgery via supraorbital ...

journal_title：Experimental and therapeutic medicine

authors： Bhattarai R,Liang C,Chen C,Wang H,Huang T,Ning X,Guo Y

更新日期：2020-09-01 00:00:00

abstract：:The aim of this study was to investigate the pathogenesis of autophagy and apoptosis mediated by Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signal pathway after the onset of acute spinal cord injury (ASCI). A total of 45 Sprague-Dawley adult rats of either sex were selected for this...

journal_title：Experimental and therapeutic medicine

authors： Xia Y,Xia H,Chen D,Liao Z,Yan Y

更新日期：2017-08-01 00:00:00

abstract：:Coronary artery disease (CAD) is a leading cause of death, and microRNAs (miRNAs) are widely involved in physiological and pathological processes of CAD. We chose the targetscore method calculated via the variational Bayesian Gaussian mixture model (VB-GMM) as the prediction method of target genes. By observing the de...

journal_title：Experimental and therapeutic medicine

authors： Ma XL,Yang X,Fan R

更新日期：2019-03-01 00:00:00

abstract：:The Krüppel-associated box zinc-finger protein 545 (ZNF545) was recently identified as a tumor suppressor in esophageal squamous cell carcinoma (ESCC). However, the role of ZNF545 in the tumorigenesis of esophageal cancer cells expressing loss-of-function mutant p53 has not been elucidated. In the present study, the r...

journal_title：Experimental and therapeutic medicine

authors： Fan Y,Wang Y,Fu S,Liu D,Lin S

更新日期：2019-09-01 00:00:00

abstract：:Clinical efficacy of octreotide acetate combined with thrombin in the treatment of liver cirrhosis complicated with gastrointestinal hemorrhage was investigated. A retrospective analysis of 157 patients with liver cirrhosis and gastrointestinal hemorrhage admitted to Weifang People's Hospital from March 2012 to Septem...

journal_title：Experimental and therapeutic medicine

authors： Wang X,Liu Y,Zhao J,Zhang J

更新日期：2019-05-01 00:00:00

abstract：:Chronic myelogenous leukemia (CML) is a condition characterized by a balanced genetic translocation, t (9;22) (q34;q11.2), which leads to a fusion of the Abelson oncogene (ABL) from chromosome 9q34 with the breakpoint cluster region (BCR) gene on chromosome 22q11.2. This rearrangement is referred to as the Philadelphi...

journal_title：Experimental and therapeutic medicine

authors： Shen X,Zhang M,Shen Y,Shi W,Liu W,Wei WU

更新日期：2015-10-01 00:00:00

abstract：:The ChrT gene encodes a chromate reductase enzyme which catalyzes the reduction of Cr(VI). The chromate reductase is also known as flavin mononucleotide (FMN) reductase (FMN_red). The aim of the present study was to clone the full-length ChrT DNA from Serratia sp. CQMUS2 and analyze the deduced amino acid sequence and...

journal_title：Experimental and therapeutic medicine

authors： Deng P,Tan X,Wu Y,Bai Q,Jia Y,Xiao H

更新日期：2015-03-01 00:00:00

abstract：:Successful islet isolation is crucial for islet transplantation and cell treatment for type 1 diabetes. Current isolation methods are able to obtain 500-1,000 islets per rat, which results in a waste of ≥50% of total islets. In the present study, a facile mechanical shaking method for improving islet yield (up to 1,50...

journal_title：Experimental and therapeutic medicine

authors： Yin N,Chen T,Yu Y,Han Y,Yan F,Zheng Z,Chen Z

更新日期：2016-12-01 00:00:00

abstract：:The aim of the present study was to explore the effects and mechanisms of insulin on mitochondrial oxidative stress in septic acute kidney injury (AKI). Male Sprague Dawley rats were divided randomly into four groups: Control group, sham surgery group, cecal ligation and puncture (CLP) group, and CLP plus insulin grou...

journal_title：Experimental and therapeutic medicine

authors： Chen GD,Zhang JL,Chen YT,Zhang JX,Wang T,Zeng QY

更新日期：2018-04-01 00:00:00

abstract：:The present study was to analyze the mechanism of cytomembrane ATP-sensitive K+ channels (KATP) in the neurovascular unit treatment of ischemic stroke in the recovery period. A total of 24 healthy adult male Wistar rats of 5-8 weeks age, weighing 160-200 g were randomly divided into the control (sham-operation group),...

journal_title：Experimental and therapeutic medicine

authors： Zhang Y,Pan S,Zheng X,Wan Q

更新日期：2016-08-01 00:00:00

abstract：:The aim of this study was to evaluate the efficacy and safety of polyethylene glycol 4000 (PEG 4000) for the treatment of constipation in children over 8 years of age. A total of 216 children from 7 hospitals were enrolled. A total of 105 patients received oral PEG 4000 (20 g/day) and 111 patients received oral lactul...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Wang B,Jiang X,Jiang M,Xu C,Shao C,Jia L,Huang Z,Xu X,Liu H,Shang L

更新日期：2012-05-01 00:00:00

abstract：:To evaluate how metformin plus rosiglitazone affect serum adiponectin levels in people suffering from type 2 diabetes mellitus (T2DM), 240 patients having T2DM were selected in this cohort study. Included subjects were randomly and equally separated into three subsets: i) Group A (rosiglitazone group); ii) group B (me...

journal_title：Experimental and therapeutic medicine

authors： Nie JM,Li HF

更新日期：2017-09-01 00:00:00

abstract：:The aim of the present study was to explore the effect of baicalin on liver hypoxia/reoxygenation (H/R) injury and the possible mechanism involved. A cellular H/R model was established and cells were treated with 50, 100 and 200 µmol/l baicalin. Following reoxygenation for 6 h, cell viability, lactate dehydrogenase (L...

journal_title：Experimental and therapeutic medicine

authors： Liu F,Zhang J,Qian J,Wu G,Ma Z

更新日期：2018-08-01 00:00:00

abstract：:The present study aimed to evaluate the value of serum amyloid A (SAA) in coronavirus disease 2019 (COVID-19) and compared the efficacy of SAA and C-reactive protein (CRP) in predicting the severity and recovery of COVID-19. A retrospective study was conducted on COVID-19 patients hospitalized in Wuhan No. 1 Hospital ...

journal_title：Experimental and therapeutic medicine

authors： Fu J,Huang PP,Zhang S,Yao QD,Han R,Liu HF,Yang Y,Zhang DY

更新日期：2020-10-01 00:00:00

abstract：:Previous research has shown that breathing exercises may improve the prognosis and health status in patients with lung cancer by enhancing pulmonary function and quality of life (QOL). However, individually published results are inconclusive. The aim of the present meta-analysis was to evaluate the clinical value of b...

journal_title：Experimental and therapeutic medicine

authors： Liu W,Pan YL,Gao CX,Shang Z,Ning LJ,Liu X

更新日期：2013-04-01 00:00:00

abstract：:The aim of the present study was to evaluate whether preoperative computed tomography (CT) is a useful modality for the diagnosis of axillary lymph node metastasis. The axillary lymph node status was examined in patients with primary breast cancer who had undergone surgery. In total, 75 patients were analyzed with pre...

journal_title：Experimental and therapeutic medicine

authors： Kutomi G,Ohmura T,Satomi F,Takamaru T,Shima H,Suzuki Y,Otokozawa S,Zembutsu H,Mori M,Hirata K

更新日期：2014-08-01 00:00:00

abstract：:The current study aimed to assess the repeatability and validity of cervical range of motion (CROM) measurements using an optical motion capture system (OMCS), compared with a CROM device. A total of 20 healthy volunteers were selected and enrolled in the current study after informed consent was received. The motion o...

journal_title：Experimental and therapeutic medicine

authors： Feng M,Liang L,Sun W,Liu GW,Yin X,Han T,Wei X,Zhu L

更新日期：2019-12-01 00:00:00

abstract：:Bone marrow stromal cells (MSCs) are a useful source of stem cells for the treatment of various brain injury diseases due to their abundant supply and fewer ethical problems compared with transplant treatment. However, the clinical application of MSCs is limited due to allograft rejection and immunosuppression in the ...

journal_title：Experimental and therapeutic medicine

authors： Yuan FY,Zhang MX,Shi YH,Li MH,Ou JY,Bai WF,Zhang MS

更新日期：2020-09-01 00:00:00

abstract：:Intrahepatic cholangiocarcinoma (ICC) is a cancer type with high malignancy and a current lack of biomarkers to predict recurrence. In the present study, to identify potential biomarkers, five ICC datasets from the Gene Expression Omnibus database were analyzed to construct initial datasets by using a robust rank aggr...

journal_title：Experimental and therapeutic medicine

authors： Chen FY,Zhou C,Zhang XY,Zhou KQ,Peng YF,Yu L,Fan J,Zhou J,Hu J,Wang Z

更新日期：2020-11-01 00:00:00

abstract：:Abnormalities in insulin hormone levels leads to a hyperglycemic condition of diabetic mellitus. Hyperglycemia seriously induces organ and system destructions. The excessive accumulation of collagen fiber deposits occurs in inflammatory and reorganization processes of chronic liver diseases in type I insulin-dependent...

journal_title：Experimental and therapeutic medicine

authors： Komolkriengkrai M,Nopparat J,Vongvatcharanon U,Anupunpisit V,Khimmaktong W

更新日期：2019-08-01 00:00:00

abstract：:The study aims to investigate the clinical significance of regulating the expression of 25-hydroxyvitamin D (25-OH-VD) via microRNA (miRNA)-376c in the occurrence and development of preeclampsia (PE) in pregnant women. Peripheral blood and placental tissues were collected from pregnant women in 4 groups, including 67 ...

journal_title：Experimental and therapeutic medicine

authors： Li J,Du J,Wang Z,Wang C,Bai J,Zhang S

更新日期：2018-09-01 00:00:00

abstract：:Lymphangioleiomyomatosis (LAM) is a progressive disorder of unknown etiology that predominantly affects the lungs, and the resulting respiratory failure can be fatal. Extrapulmonary LAM is a rare disease that often occurs concurrently with pulmonary LAM. Usually, extrapulmonary LAM presents as a localized, well-circum...

journal_title：Experimental and therapeutic medicine

authors： Fu W,Li Y,Li H,Yang P,Xing X

更新日期：2016-09-01 00:00:00

abstract：:Schwannomas may arise from any peripheral nerve containing Schwann cells. However, sural nerve schwannoma is extremely rare. In this study, a case of solitary schwannoma originating from the sural nerve in a 42-year-old male is presented. Physical examination revealed a 3-cm, elastic-hard, mobile, non-tender mass, whi...

journal_title：Experimental and therapeutic medicine

authors： Yamamoto K,Nishio J,Yano S,Naito M

更新日期：2014-01-01 00:00:00

abstract：:Sustained-release (SR) formulations of metoprolol succinate (MS) may minimize fluctuations in plasma concentration and decrease the resulting adverse events. The aim of the present study was to optimize the loading capacity of microcapsules and the SR of MS. A uniform design method was applied to optimize the formulat...

journal_title：Experimental and therapeutic medicine

authors： Song L,He S,Ping Q

更新日期：2017-05-01 00:00:00

abstract：:A major consequence of obstructive jaundice (OJ) in clinical practice is the development of severe liver injury, and at present, no effective treatments have been developed to protect against it. Preconditioning with damage-associated molecular pattern (DAMP) molecules has been demonstrated to protect multiple organs ...

journal_title：Experimental and therapeutic medicine

authors： Zhou YX,Ni Y,Liu YB,Liu X

更新日期：2014-07-01 00:00:00