The value of serum amyloid A for predicting the severity and recovery of COVID-19.

abstract：:Traumatic brain injury (TBI) is among the leading causes of irreversible neurological damage and death worldwide. The aim of the present study was to investigate whether edaravone (EDA) had a neuroprotective effect on TBI as well as to identify the potential mechanism. Results demonstrated that EDA suppressed inflamma...

journal_title：Experimental and therapeutic medicine

authors： Zhang M,Teng CH,Wu FF,Ge LY,Xiao J,Zhang HY,Chen DQ

更新日期：2019-07-01 00:00:00

abstract：:The present study evaluated the value of black-blood high-resolution magnetic resonance imaging (HRMRI) for the visualization of intracranial atherosclerosis (ICAS) plaques. A total of 110 patients with cerebral artery or vertebrobasilar stenosis, vessel occlusion or a significantly weakened signal in black-blood magn...

journal_title：Experimental and therapeutic medicine

authors： Yang H,Zhu Y,Geng Z,Li C,Zhou L,Liu QI

更新日期：2015-07-01 00:00:00

abstract：:Different neoadjuvant therapy regimens are available for rectal cancer, but the relative effects are controversial. The aim of the present network meta-analysis (NMA) was to estimate the relative efficacy and safety of neoadjuvant therapies for resectable rectal cancer. MEDLINE, EMBASE and Cochrane Central Registry of...

journal_title：Experimental and therapeutic medicine

authors： Zhong W,Xue X,Dai L,Li R,Nie K,Zhou S

更新日期：2020-04-01 00:00:00

abstract：:Human osteoarthritis (OA) has been reclassified as a systemic musculoskeletal disorder involving activation of the innate and adaptive immune systems. Elevated pro-inflammatory cytokines may serve a key function in the development of the disease. 1,25-Dihydroxyvitamin D3 and dexamethasone (vitD3/Dex) may inhibit infla...

journal_title：Experimental and therapeutic medicine

authors： Wang G,Zhang J,Fang Y,Cao W,Xu B,Chen X

更新日期：2019-01-01 00:00:00

abstract：:The mortality and disability rate of patients with ruptured anterior communicating artery (AComA) aneurysm after bleeding is high. Even with the most advanced treatment methods, the incidence of complications remains high. The purpose of the present study was to determine the efficacy of microsurgery via supraorbital ...

journal_title：Experimental and therapeutic medicine

authors： Bhattarai R,Liang C,Chen C,Wang H,Huang T,Ning X,Guo Y

更新日期：2020-09-01 00:00:00

abstract：:Honokiol, a potent radical scavenger, has been demonstrated to ameliorate cerebral infarction following ischemia/reperfusion (I/R) injury. However, its effects on myocardial I/R injury remain unclear. The present study aimed to examine the effects of honokiol on myocardial I/R injury and to investigate its potential c...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Zhang ZZ,Wu Y,Zhan J,He XH,Wang YL

更新日期：2013-01-01 00:00:00

abstract：:Hericium erinaceus (HEP) is a notable medicinal fungus grown in China and other oriental countries. Polysaccharides from HEP have recently attracted considerable attention due to their numerous physiological activities. The objective of this study was to evaluate the anti-fatigue activity of HEP in a mouse model. Afte...

journal_title：Experimental and therapeutic medicine

authors： Liu J,DU C,Wang Y,Yu Z

更新日期：2015-02-01 00:00:00

abstract：:The aim of this study is to determine the accuracy rate of bronchopulmonary dysplasia (BPD) diagnosis and risk factors of short-term poor prognosis for premature infants. This study analyzed the clinical data of 81 premature infants (<32 weeks gestational age) with BPD, who were on oxygen therapy >28 days, and survive...

journal_title：Experimental and therapeutic medicine

authors： Du Z,Kong X,Ren Y,Feng Z,Huang J,Chen J,Wang R

更新日期：2017-10-01 00:00:00

abstract：:Activated T cells rely on aerobic glycolysis and glutaminolysis in order to proliferate and differentiate into effector cells. Therefore, intervention in these metabolic pathways inhibits proliferation. The aim of the present study was to evaluate the effects of Krebs' cycle inhibition at the level of malate dehydroge...

journal_title：Experimental and therapeutic medicine

authors： Eleftheriadis T,Pissas G,Antoniadi G,Liakopoulos V,Stefanidis I

更新日期：2015-11-01 00:00:00

abstract：:Kawasaki disease (KD) is the leading cause of acquired heart disease in pediatric patients in developed countries. Coronary artery aneurysms and myocardial infarction may occur if the disease remains untreated. An estimated 10-20% of KD patients do not respond to intravenous gamma globulin (IVIG), and thus, alternativ...

journal_title：Experimental and therapeutic medicine

authors： Dai N,Zhao C,Kong Q,Li D,Cai Z,Wang M

更新日期：2019-05-01 00:00:00

abstract：:Temozolomide (TMZ) resistance is a complication of treatment of glioma, and new strategies are urgently required to overcome chemoresistance in glioma cells. In the present study, it was demonstrated that tripartite motif-containing 31 (TRIM31) was abnormally upregulated in glioma tissues and cell lines compared with ...

journal_title：Experimental and therapeutic medicine

authors： Fan MD,Zhao XY,Qi JN,Jiang Y,Liu BY,Dun ZP,Zhang R,Wang CW,Pang Q

更新日期：2020-08-01 00:00:00

abstract：:Bone cancer pain commonly occurs when tumors originating in the breast, prostate or lung metastasize to long bones, spinal vertebrae and/or the pelvis. However, the underlying mechanisms of bone cancer pain remain largely unknown. The present study aimed to determine the role of spinal tumor necrosis factor-α (TNF-α) ...

journal_title：Experimental and therapeutic medicine

authors： Yang Y,Zhang J,Gao Q,Bo J,Ma Z

更新日期：2017-05-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a progressive disease with a high mortality rate. Previous studies have revealed the important function of the β3 adrenergic receptor (β3-AR) in cardiovascular diseases, and the potential beneficial effects of numerous β3-AR agonists on pulmonary vasodilation. Conversely, a num...

journal_title：Experimental and therapeutic medicine

authors： Sun J,Cheng J,Ding X,Chi J,Yang J,Li W

更新日期：2020-01-01 00:00:00

abstract：:The main function of adipocyte fatty acid-binding protein (A-FABP) is to regulate fatty acid metabolism as its molecular chaperone. The clinical significance of A-FABP in hypoxic-ischemic brain damage (HIBD) neonates is not yet clear. Free fatty acid (FFA) in cerebral cortex increases along with hypoxia ischemia degre...

journal_title：Experimental and therapeutic medicine

authors： Li M,Jiang L,Zhang H,Wang D,Zhang M,Zhang L

更新日期：2016-08-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is one of the most common cancer types worldwide. Previous studies have indicated that TOR signaling pathway regulator (TIPRL) is involved in the progression of NSCLC. However, the underlying mechanisms of the role of TIPRL in regulating NSCLC metastasis have remained largely elusive...

journal_title：Experimental and therapeutic medicine

authors： Xu X,Zhu H,Yang M,Zheng E,Zhou Y,Ni J,Li R,Yang Z,He T,Zhao G

更新日期：2020-03-01 00:00:00

abstract：:The aim of the present study was to investigate the feasibility of using composite scaffolds of poly(lactic-co-glycolic acid) (PLGA) and bioactive glass (BG) to repair bone defects. PLGA/BG composite scaffolds were prepared by thermally-induced phase separation. Scanning electron microscopy (SEM) was used to study the...

journal_title：Experimental and therapeutic medicine

authors： Yang L,Liu S,Fang W,Chen J,Chen Y

更新日期：2019-12-01 00:00:00

abstract：:Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide with high morbidity and mortality. Glomerular mesangial cell (MC) proliferation, inflammatory cell infiltration and extracellular matrix (ECM) accumulation are the main pathological characteristics of DN. A previous study revealed that...

journal_title：Experimental and therapeutic medicine

authors： Xiao L,Chen Y,Yuan Y,Xu B,Gao Q,Chen P,Zhang T,Guan T

更新日期：2019-09-01 00:00:00

abstract：:The aim of the present study was to investigate the expression profiles of cyclooxygenase (COX)-2 and microRNA (miRNA)-143 in the tumor tissue and blood samples of patients with osteosarcoma, and their involvement in the disease pathogenesis. Tumor tissue and blood samples were obtained from 46 patients with osteosarc...

journal_title：Experimental and therapeutic medicine

authors： Fang Y,Zhang Z,Wang Q,Zhao J

更新日期：2015-06-01 00:00:00

abstract：:Atherosclerosis is caused by various factors, and Glabridin may have protective effects on the cardiovascular system. The purpose of the present study was to evaluate the effects of Glabridin on atherosclerosis and evaluate whether Glabridin attenuates arteriosclerosis and endothelial permeability by suppressing the m...

journal_title：Experimental and therapeutic medicine

authors： Wang G,Sun G,Wang Y,Yu P,Wang X,Zhou B,Zhu H

更新日期：2019-01-01 00:00:00

abstract：:Obstructive salivary gland diseases are common conditions that arise following the disruption of the secretary ductal system and usually results in the swelling and pain of the affected gland(s). There has been an increase in the use of sialendoscopy for the treatment and diagnosis of obstructive salivary gland infect...

journal_title：Experimental and therapeutic medicine

authors： Ding YF,Tseng H,Su CH,Tai CC,Wu YY,Haung CJ,Lee CS,Hung SH

更新日期：2019-04-01 00:00:00

abstract：:Chronic exposure of workers to powder containing crystalline silica (Silicon dioxide; SiO2) can lead to chronic lung diseases (lung cancer, silicosis, etc.). Aim of this study was to evaluate the exposure of Greek construction workers to SiO2 and describe their pulmonary function. The study involved 86 outdoor and und...

journal_title：Experimental and therapeutic medicine

authors： Keramydas D,Bakakos P,Alchanatis M,Papalexis P,Konstantakopoulos I,Tavernaraki K,Dracopoulos V,Papadakis A,Pantazi E,Chelidonis G,Chaidoutis E,Constantinidis TC,Tsitsimpikou C,Kavantzas N,Patsouris E,Tsarouhas K,Spandidos

更新日期：2020-08-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is a component of metabolic syndrome that significantly increases the cardiovascular risk of patients with glucose metabolism alterations. This study identified the prevalence of NAFLD, predictors of NAFLD and explored the link between insulin sensitivity, insulin resistance a...

journal_title：Experimental and therapeutic medicine

authors： Vesa CM,Behl T,Nemeth S,Bratu OG,Diaconu CC,Moleriu RD,Negrut N,Zaha DC,Bustea C,Radu FI,Bungau S

更新日期：2020-12-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/etm.2019.8114.]. ...

journal_title：Experimental and therapeutic medicine

authors： Fang L,Xu Z,Lu J,Hong L,Qiao S,Liu L,An J

更新日期：2021-02-01 00:00:00

abstract：:Oxidative stress has been reported to serve an important role in the development and progression of diabetic nephropathy (DN). Epithelial-mesenchymal transition (EMT) of renal tubular epithelial cells promotes renal fibrosis in DN, while the mechanism of reactive oxygen species (ROS)-mediated EMT is not fully understo...

journal_title：Experimental and therapeutic medicine

authors： Lu Q,Wang WW,Zhang MZ,Ma ZX,Qiu XR,Shen M,Yin XX

更新日期：2019-01-01 00:00:00

abstract：:Chronic hepatitis B virus (CHB) infection is a burden on global healthcare and is associated with a higher risk of serious sequelae, including cirrhosis and hepatocellular carcinoma. The clinical application of entecavir as a treatment for CHB has produced positive outcomes, and so is an attractive form of pharmacolog...

journal_title：Experimental and therapeutic medicine

authors： Gai XD,Wu WF

更新日期：2017-10-01 00:00:00

abstract：:The classical analgesic pathway of opioids by binding their receptors in the nervous system is well known. However, little is known regarding opioid analgesia through the anti-inflammatory pathway. The present study aimed to investigate the analgesic and anti-inflammatory effect of β-endorphin on inflammatory pain. A ...

journal_title：Experimental and therapeutic medicine

authors： He X,Huang L,Qiu S,Yin X,Shen Y,Wu Y,Jiang Y,Fang J

更新日期：2018-04-01 00:00:00

abstract：:The present retrospective study aimed to investigate the prognostic factors for critically ill patients with an Acinetobacter baumannii (A. baumannii) infection. A total of 37 patients from the intensive care unit (ICU) were enrolled in the study. Data was collected from patients, including age, gender, ethnicity, A. ...

journal_title：Experimental and therapeutic medicine

authors： Xiao D,Wang L,Zhang D,Xiang D,Liu Q,Xing X

更新日期：2017-04-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/etm.2018.6297.]. ...

journal_title：Experimental and therapeutic medicine

authors： Jia L,Wang L,Liu W,Qian G,Jiang X,Zhang Z

更新日期：2018-12-01 00:00:00

abstract：:Eosinophilia has been implicated in the pathophysiology of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, the role of eosinophil activation in the development of AECOPD remains unclear. In the present study, the reliability of plasma levels of eosinophil activation markers, including eo...

journal_title：Experimental and therapeutic medicine

authors： Yang QF,Lu TT,Shu CM,Feng LF,Chang HT,Ji QY

更新日期：2017-10-01 00:00:00

abstract：:The epileptic state, or status epilepticus (SE), is the most serious situation manifested by individuals with epilepsy, and SE events can lead to neuronal damage. An understanding of the molecular, biochemical and physiopathological mechanisms involved in this type of neurological disease will enable the identificatio...

journal_title：Experimental and therapeutic medicine

authors： Carmona-Aparicio L,Zavala-Tecuapetla C,González-Trujano ME,Sampieri AI,Montesinos-Correa H,Granados-Rojas L,Floriano-Sánchez E,Coballase-Urrutía E,Cárdenas-Rodríguez N

更新日期：2016-10-01 00:00:00