PC-1 NF suppresses high glucose-stimulated inflammation and extracellular matrix accumulation in glomerular mesangial cells via the Wnt/β-catenin signaling.

abstract：:Shen-Zhi-Ling (SZL) oral liquid is a traditional Chinese medicine formula that is mainly used for the clinical treatment of mild to moderate Alzheimer's disease (AD). The aim of the present study was to investigate the effects and underlying mechanisms of SZL treatment on AD. APP/PS1 transgenic mice were utilized to e...

journal_title：Experimental and therapeutic medicine

authors： Xing S,Shen D,Chen C,Wu B,Chi H

更新日期：2017-09-01 00:00:00

abstract：:We previously reported on single-incision laparoscopic surgery applied to laparoscopically assisted vaginal hysterectomy (LAVH) cases. We accumulated single-incision LAVH cases to evaluate this operation, including its learning curve. Since July 2009, we planned to perform single-incision LAVH in 50 cases. Operative t...

journal_title：Experimental and therapeutic medicine

authors： Koyanagi T,Motomura S

更新日期：2011-09-01 00:00:00

abstract：:Chronic heart disease contributes to the mortality of patients with AIDS. Although studies of left ventricular function in patients with acquired immune deficiency syndrome (AIDS) have been conducted, studies of right ventricular function are rare. The present study aimed to characterize the tricuspid annulus movement...

journal_title：Experimental and therapeutic medicine

authors： Zhu H,Yuan J,Wei C,Chen J,Wang Y

更新日期：2014-03-01 00:00:00

abstract：:Bone cancer pain commonly occurs when tumors originating in the breast, prostate or lung metastasize to long bones, spinal vertebrae and/or the pelvis. However, the underlying mechanisms of bone cancer pain remain largely unknown. The present study aimed to determine the role of spinal tumor necrosis factor-α (TNF-α) ...

journal_title：Experimental and therapeutic medicine

authors： Yang Y,Zhang J,Gao Q,Bo J,Ma Z

更新日期：2017-05-01 00:00:00

abstract：:Harlequin ichthyosis (HI) is a genetic skin disorder characterized by thickening and splitting of the skin. In fetuses presenting with the disorder, the mortality rate is markedly high. A number of fetal HI cases have been documented. The present study reports a case of a pregnant woman who underwent two successive pr...

journal_title：Experimental and therapeutic medicine

authors： Liang Q,Xiong F,Liang X,Zheng D,Su S,Wen Y,Wang X

更新日期：2019-01-01 00:00:00

abstract：:The transient receptor potential melastatin 2 (TRPM2) channel, a Ca2+ permeable channel activated by cAMP, is expressed on pancreatic β-cells and is responsible for the regulation of insulin secretion. It is known that glucose-stimulated insulin secretion (GSIS) can be potentiated by glucagon like peptide-1 (GLP-1), a...

journal_title：Experimental and therapeutic medicine

authors： Pang B,Kim S,Li D,Ma Z,Sun B,Zhang X,Wu Z,Chen L

更新日期：2017-11-01 00:00:00

abstract：:To exploit a cross passive immunotherapy for enterovirus-induced hand-foot-and-mouth disease (HFMD), the cross antiviral activity of a neutralizing antibody against enterovirus 71 (EV71) and coxsackievirus A16 (CVA16) was investigated in vitro. White Leghorn specific-pathogen-free chickens were immunized with EV71 ant...

journal_title：Experimental and therapeutic medicine

authors： Gao E,Wu S,Xu Q,Zeng Y,Tan N,He S,Yang Y,Wei J

更新日期：2019-07-01 00:00:00

abstract：:Schisandrin B (SchB) is one of the primary active components of Schisandra chinensis (Turcz.) Baill., a traditional Chinese herb that has been used to treat insomnia for hundreds of years. Our previous studies revealed that SchB exerts sedative and hypnotic effects, increasing the content of γ-aminobutyric acid (GABA)...

journal_title：Experimental and therapeutic medicine

authors： Wang M,Li N,Jing S,Wang C,Sun J,Li H,Liu J,Chen J

更新日期：2020-12-01 00:00:00

abstract：:The main function of adipocyte fatty acid-binding protein (A-FABP) is to regulate fatty acid metabolism as its molecular chaperone. The clinical significance of A-FABP in hypoxic-ischemic brain damage (HIBD) neonates is not yet clear. Free fatty acid (FFA) in cerebral cortex increases along with hypoxia ischemia degre...

journal_title：Experimental and therapeutic medicine

authors： Li M,Jiang L,Zhang H,Wang D,Zhang M,Zhang L

更新日期：2016-08-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a rare but highly aggressive type of malignancy. MicroRNA (miR)-25 has been demonstrated to be involved in the genesis of numerous cancer types. The aim of the present study was to investigate the prognostic value and functional role of miR-25 in CCA. The expression of miR-25 was determined...

journal_title：Experimental and therapeutic medicine

authors： Liu H,Ma L,Wang J

更新日期：2019-10-01 00:00:00

abstract：:LipoxinA4 (LXA4) is a well-known key mediator of endogenous anti-inflammation and of the resolution of inflammation. Considerable oxidative stress occurs during inflammation due to the generation of reactive oxidative species (ROS). Moreover, high levels of uric acid (UA) contribute to endothelial cell dysfunction, wh...

journal_title：Experimental and therapeutic medicine

authors： Zhou Y,You H,Zhang A,Jiang X,Pu Z,Xu G,Zhao M

更新日期：2020-08-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy due to its broad resistance to chemotherapy. Gemcitabine is used as a standard chemotherapeutic drug for PDAC treatment, either alone or in combination with other chemotherapeutics. However, in patients with advanced disease, survival is rarely ...

journal_title：Experimental and therapeutic medicine

authors： Yao M,Hong Y,Liu Y,Chen W,Wang W

更新日期：2017-09-01 00:00:00

abstract：:There is currently no available cure or universally effective treatment for dry eye (DE). The aim of the present study was to investigate the clinical efficacy of transcutaneous electrical stimulation (TES) combined with artificial tears in treating DE. Patients diagnosed with DE were referred for therapy with TES com...

journal_title：Experimental and therapeutic medicine

authors： Cai MM,Zhang J

更新日期：2020-12-01 00:00:00

abstract：:This study aimed to investigate the reliability of ultrasound two-dimensional speckle tracking imaging (2D-STI) for the evaluation of myocardial ischemia in familial hypercholesterolemia (FH) patients. We recruited 28 patients clinically diagnosed with homozygous familial hypercholesterolemia (HoFH) and subjected them...

journal_title：Experimental and therapeutic medicine

authors： Song Y,Zhang RF,Liu Y

更新日期：2017-08-01 00:00:00

abstract：:The aim of the present study was to investigate the protective effects of sodium ferulate (SF) on HT22 hippocampal cells under a high glucose concentration. Cells were cultured in normal glucose (25 mM D-glucose) or high glucose (50 mM D-glucose) with various concentrations of SF (50, 100, 250 or 500 µM) for 0, 48 and...

journal_title：Experimental and therapeutic medicine

authors： Zhao J,Liu L,Zhang L,Lv J,Guo X,Li X,Zhao T

更新日期：2019-09-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase (IDO) is an immunoregulatory enzyme. It plays a key role in various malignancies, infection and autoimmune diseases. IDO induces immunosuppression through the depletion of tryptophan and its downstream metabolites. Hepatitis C virus (HCV) has infected more than 12 million individuals in Pak...

journal_title：Experimental and therapeutic medicine

authors： Asghar K,Ashiq MT,Zulfiqar B,Mahroo A,Nasir K,Murad S

更新日期：2015-03-01 00:00:00

abstract：:The aim of the present study was to examine whether the expression of focal adhesion kinase (FAK) is altered in the eutopic endometrium of female patients with adenomyosis, as compared with that of females without adenomyosis. The expression of FAK was assessed by immunohistochemical, western blot and reverse transcri...

journal_title：Experimental and therapeutic medicine

authors： Mu L,Chen W,Ma Y,Zheng W

更新日期：2015-11-01 00:00:00

abstract：:A previous study by our group found that electro-acupuncture (EA) at the Shenting (DU24) and Baihui (DU20) acupoints ameliorates cognitive impairment in rats with cerebral ischemia-reperfusion (I/R) injury. However, the precise mechanism of action has remained largely unknown. The present study investigated whether br...

journal_title：Experimental and therapeutic medicine

authors： Lin R,Li X,Liu W,Chen W,Yu K,Zhao C,Huang J,Yang S,Peng H,Tao J,Chen L

更新日期：2017-09-01 00:00:00

abstract：:Corneal astigmatism significantly compromises uncorrected visual acuity (UCVA) after phacoemulsification with implantation of traditional spherical or non-spherical monofocal intraocular lens (IOL). Toric IOL provides an effective way to gain favorable postoperative UCVA for the patients with cataracts with corneal as...

journal_title：Experimental and therapeutic medicine

authors： Yang JJ,Qin YZ,Qin L,Li JM

更新日期：2020-11-01 00:00:00

abstract：:Compared with traditional imaging techniques, multimodal imaging obtains more accurate images that may increase disease detection rates. The present study prepared stromal cell-derived factor 1 (SDF-1)-loaded, targeted nanoparticles coated with iron (II,III) oxide and perfluorohexane (PFH) to be used as polymer-shelle...

journal_title：Experimental and therapeutic medicine

authors： Wang F,Wang Z,Pang L,Wan S,Qiu L

更新日期：2020-09-01 00:00:00

abstract：:Different neoadjuvant therapy regimens are available for rectal cancer, but the relative effects are controversial. The aim of the present network meta-analysis (NMA) was to estimate the relative efficacy and safety of neoadjuvant therapies for resectable rectal cancer. MEDLINE, EMBASE and Cochrane Central Registry of...

journal_title：Experimental and therapeutic medicine

authors： Zhong W,Xue X,Dai L,Li R,Nie K,Zhou S

更新日期：2020-04-01 00:00:00

abstract：:The present study aimed to investigate the effect of triptolide (TL) on ulcerative colitis (UC) and explore the potential association between the therapeutic effects of TL and IL-1β expression using a 4,4-dimethyl-4-silapentane-1-sulfonic acid (DSS)-induced mouse model to simulate human UC. A total of 70 BALB/c female...

journal_title：Experimental and therapeutic medicine

authors： Zhang H,Gong C,Qu L,Ding X,Cao W,Chen H,Zhang B,Zhou G

更新日期：2016-09-01 00:00:00

abstract：:Silk fibroin (SF), chitosan (CS) and nano-hydroxyapatite (nHA) possess excellent biocompatibility, thus, these were used to construct a SF/CS/nHA composite scaffold. Previously published results identified that this material exhibited satisfactory physical and chemical properties, and therefore qualified as a repair m...

journal_title：Experimental and therapeutic medicine

authors： Ye P,Yu B,Deng J,She RF,Huang WL

更新日期：2017-12-01 00:00:00

abstract：:Rapamycin has been reported to be immunosuppressive and anti-proliferative towards vascular endothelial and smooth muscle cells. The purpose of the present study was to investigate the effects of rapamycin on the biological behaviors of endothelial cells that have been separated from the deformed vein in human venous ...

journal_title：Experimental and therapeutic medicine

authors： Si Y,Chu H,Zhu W,Xiao T,Shen X,Fu Y,Xu R,Jiang H

更新日期：2018-12-01 00:00:00

abstract：:The aim of the present study was to investigate the expression levels and clinical significance of Toll-like receptor (TLR) 3 and 4 in peripheral blood mononuclear cells (PBMCs) collected from children with Henoch-Schönlein purpura (HSP) nephritis. The randomized controlled trial was conducted between August 2011 and ...

journal_title：Experimental and therapeutic medicine

authors： Chang H,Yu DS,Liu XQ,Zhang QY,Cheng N,Zhang SQ,Qu ZH

更新日期：2014-06-01 00:00:00

abstract：:Erythropoietin (EPO), a glycoprotein originally known for its important role in the stimulation of erythropoiesis, has recently been shown to have significant protective effects in animal models of kidney and intestinal ischemia-reperfusion injury (IRI). However, the mechanism underlying these protective effects remai...

journal_title：Experimental and therapeutic medicine

authors： Rong R,Xijun X

更新日期：2015-08-01 00:00:00

abstract：:Neuregulin-1 (NRG-1) is a cardioactive growth factor released from endothelial cells. However, the effect of NRG-1 on ventricular remodeling in diabetic cardiomyopathy (DCM) remains unclear. The aim of the present study was to investigate the pathophysiological role of NRG-1 in a rat model of DCM. Rat cardiac microvas...

journal_title：Experimental and therapeutic medicine

authors： Li B,Xiao J,Li Y,Zhang J,Zeng M

更新日期：2013-11-01 00:00:00

abstract：:Obstructive salivary gland diseases are common conditions that arise following the disruption of the secretary ductal system and usually results in the swelling and pain of the affected gland(s). There has been an increase in the use of sialendoscopy for the treatment and diagnosis of obstructive salivary gland infect...

journal_title：Experimental and therapeutic medicine

authors： Ding YF,Tseng H,Su CH,Tai CC,Wu YY,Haung CJ,Lee CS,Hung SH

更新日期：2019-04-01 00:00:00

abstract：:Chronic hepatitis B virus (CHB) infection is a burden on global healthcare and is associated with a higher risk of serious sequelae, including cirrhosis and hepatocellular carcinoma. The clinical application of entecavir as a treatment for CHB has produced positive outcomes, and so is an attractive form of pharmacolog...

journal_title：Experimental and therapeutic medicine

authors： Gai XD,Wu WF

更新日期：2017-10-01 00:00:00

abstract：:The aim of this study was to evaluate the diagnostic value of 64-multislice spiral computed tomography (64-MSCT) for coronary stenosis compared with selective X-ray coronary angiography (SCA). Patients with chest pain, chest tightness or coronary stenosis received SCA and they acted as the controls. The sensitivity an...

journal_title：Experimental and therapeutic medicine

authors： Cheng L,Jing S,Zhang Y

更新日期：2013-03-01 00:00:00