Malate dehydrogenase-2 inhibitor LW6 promotes metabolic adaptations and reduces proliferation and apoptosis in activated human T-cells.

abstract：:[This corrects the article DOI: 10.3892/etm.2019.8114.]. ...

journal_title：Experimental and therapeutic medicine

authors： Fang L,Xu Z,Lu J,Hong L,Qiao S,Liu L,An J

更新日期：2021-02-01 00:00:00

abstract：:Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide with high morbidity and mortality. Glomerular mesangial cell (MC) proliferation, inflammatory cell infiltration and extracellular matrix (ECM) accumulation are the main pathological characteristics of DN. A previous study revealed that...

journal_title：Experimental and therapeutic medicine

authors： Xiao L,Chen Y,Yuan Y,Xu B,Gao Q,Chen P,Zhang T,Guan T

更新日期：2019-09-01 00:00:00

abstract：:Forkhead box P3 (FOXP3), which is a transcription factor, has a primary role in the development and function of regulatory T cells, and thus contributes to homeostasis of the immune system. A previous study generated a cell-permeable fusion protein of mouse FOXP3 conjugated to a protein transduction domain (PTD-mFOXP3...

journal_title：Experimental and therapeutic medicine

authors： Liu X,Wang J,Wang H,Zhou C,Yu Q,Yin L,Wu W,Xia S,Shao Q

更新日期：2017-02-01 00:00:00

abstract：:The effectiveness of therapy combining dihydroartemisinin (DHA) and small interfering RNA targeting Notch1 (siNotch1) in T-cell lymphoma remains unknown. The present study explored the potential and possible mechanisms of combined dihydroarteminin, and siNotch1 therapy for T-cell lymphoma. It was demonstrated that the...

journal_title：Experimental and therapeutic medicine

authors： Huo L,Wei W,Wu S,Zhao X,Zhao C,Zhao H,Sun L

更新日期：2018-03-01 00:00:00

abstract：:There are limited data available on the regression of fibrosis in hepatitis C virus (HCV) patients who have achieved sustained virologic response (SVR) after interferon-free treatments. Moreover, a perfect method for assessing liver fibrosis and its dynamics has not been established yet. The main objective of this stu...

journal_title：Experimental and therapeutic medicine

authors： Leuştean A,Popescu C,Nichita L,Tilişcan C,Aramă V

更新日期：2021-01-01 00:00:00

abstract：:Human osteoarthritis (OA) has been reclassified as a systemic musculoskeletal disorder involving activation of the innate and adaptive immune systems. Elevated pro-inflammatory cytokines may serve a key function in the development of the disease. 1,25-Dihydroxyvitamin D3 and dexamethasone (vitD3/Dex) may inhibit infla...

journal_title：Experimental and therapeutic medicine

authors： Wang G,Zhang J,Fang Y,Cao W,Xu B,Chen X

更新日期：2019-01-01 00:00:00

abstract：:Angioimmunoblastic T cell lymphoma (AITL)-associated hemophagocytic lymphohistiocytosis (HLH) rarely occurs with annular erythema multiforme-like rashes. The present case report describes a patient who was misdiagnosed with erythema multiforme at an early stage of the disease due to annular erythema multiforme-like er...

journal_title：Experimental and therapeutic medicine

authors： Zhang L,Tong C,Tan Y,Peng S,He Y,Wang T

更新日期：2018-09-01 00:00:00

abstract：:The aim of the present study was to investigate the correlation between the protein expression of A-kinase anchor protein 95 (AKAP95), cyclin D3 and AKT with pathological indicators in lung cancer tissues. Immunohistochemistry was used to detect the protein expression levels of the proteins in 51 lung cancer tissue sa...

journal_title：Experimental and therapeutic medicine

authors： Yu X,Yuan Y,Zhi X,Teng B,Chen X,Huang Q,Chen Y,Guan Z,Zhang Y

更新日期：2015-09-01 00:00:00

abstract：:Neuroblastoma is a common tumor in childhood and exhibits heterogeneity and malignant progression. MYCN expression and amplification profiles are frequently correlated with the efficacy of therapy. Arsenic trioxide and imatinib mesylate (STI-571) have been suggested as promising therapeutic agents for neuroblastoma, w...

journal_title：Experimental and therapeutic medicine

authors： Kim KJ,Jung JM,Cho JY,Woo SY,Cho KA,Ryu KH,Yoo ES

更新日期：2011-05-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignant types of cancer, with a high mortality rate. Sorafenib is the sole approved oral clinical therapy against advanced HCC. However, individual patients exhibit varying responses to sorafenib and the development of sorafenib resistance has been a new chall...

journal_title：Experimental and therapeutic medicine

authors： Huang D,Yuan W,Li H,Li S,Chen Z,Yang H

更新日期：2018-09-01 00:00:00

abstract：:Resveratrol, a naturally occurring polyphenolic phytoalexin antioxidant compound present in grapes and red wine, has been reported to induce various biochemical responses. It has been shown to possess anti-aging, anti-inflammatory and anti-proliferative activities in several cell types. However, the effects of resvera...

journal_title：Experimental and therapeutic medicine

authors： Eo SH,Cho HS,Kim SJ

更新日期：2014-03-01 00:00:00

abstract：:Honokiol, a potent radical scavenger, has been demonstrated to ameliorate cerebral infarction following ischemia/reperfusion (I/R) injury. However, its effects on myocardial I/R injury remain unclear. The present study aimed to examine the effects of honokiol on myocardial I/R injury and to investigate its potential c...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Zhang ZZ,Wu Y,Zhan J,He XH,Wang YL

更新日期：2013-01-01 00:00:00

abstract：:This study aimed to investigate the effects of hypoxia on the proliferation, mineralization and ultrastructure of human periodontal ligament fibroblasts (HPLFs) at various times in vitro in order to further study plateau-hypoxia-induced periodontal disease. HPLFs (fifth passage) cultured by the tissue culture method w...

journal_title：Experimental and therapeutic medicine

authors： Zhang HY,Liu R,Xing YJ,Xu P,Li Y,Li CJ

更新日期：2013-12-01 00:00:00

abstract：:17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) is a water soluble, semisynthetic derivative of endotoxin that has anticancer effects. The aim of the present study was to determine whether 17-DMAG enhances the apoptosis of lymphoma cells in diffuse large B-cell lymphoma. Apoptosis was induced in SU-DHL-4...

journal_title：Experimental and therapeutic medicine

authors： Li JJ,Zhang JJ,Wang X,Sun ZM

更新日期：2017-10-01 00:00:00

abstract：:The aim of this meta-analysis was to investigate the accuracy of subtraction computed tomography angiography (CTA) for diagnosing intracranial aneurysms. A systematic literature search up to January 1, 2013 was performed in PubMed. Two independent reviewers selected 8 studies that compared subtraction CTA with digital...

journal_title：Experimental and therapeutic medicine

authors： Feng TY,Han XF,Lang R,Wang F,Wu Q

更新日期：2016-05-01 00:00:00

abstract：:Chronic antibody-mediated rejection (ABMR) is a major cause of the transplant renal interstitial fibrosis and transplanted kidney epithelial cell transdifferentiation is one of the main mechanisms. The transforming growth factor (TGF)-β1/integrin-linked kinase (ILK) signaling pathway has a significant role in the epit...

journal_title：Experimental and therapeutic medicine

authors： Yan Q,Luo H,Wang B,Sui W,Zou G,Chen H,Zou H

更新日期：2017-05-01 00:00:00

abstract：:In the present study, the thenar muscles were evaluated using magnetic resonance imaging (MRI), in addition, the correlations between thenar muscle changes, clinical findings and electrodiagnostic results from patients with carpal tunnel syndrome were investigated. The subjects were 13 patients (17 wrists) who were cl...

journal_title：Experimental and therapeutic medicine

authors： Dilokhuttakarn T,Naito K,Kinoshita M,Sugiyama Y,Goto K,Iwase Y,Kaneko K

更新日期：2017-09-01 00:00:00

abstract：:A combination of docetaxel (D) and cisplatin (P) is one of the standard regimens for the initial treatment of advanced non-small cell lung cancer (NSCLC). Yet, the toxicity of D administered at 75 mg/m(2) in three weekly doses to patients is a concern. The aim of this study was to assess the efficacy of a lower combin...

journal_title：Experimental and therapeutic medicine

authors： Kim KS,Oh IJ,Ban HJ,Cho HJ,Kwon YS,Kim YI,Lim SC,Na KJ,Song SY,Choi S,Choi YD,Kim YC

更新日期：2012-08-01 00:00:00

abstract：:Thyroid hormone receptor-interacting protein 6 (TRIP6), a member of the zyxin family of Lin-Isl-Mec (LIM) proteins, is an adaptor protein primarily expressed in epithelial cells. TRIP6 can regulate a variety of cellular responses, such as actin cytoskeletal reorganization and cell adhesion. However, to the best of our...

journal_title：Experimental and therapeutic medicine

authors： Liu W,Cheng L,Li Q,Jing J

更新日期：2020-03-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus, which causes coronavirus disease 2019 (COVID-19) and affects children less frequently than adults. According to Professor Vana Papaevangelou, Professor of Paediatrics at the University of Athens School of Medicine, children comprise o...

journal_title：Experimental and therapeutic medicine

authors： Mammas IN,Theodoridou M,Spandidos DA

更新日期：2020-12-01 00:00:00

abstract：:The efficacy of DNA vaccines may be improved by small interfering (si)RNA adjuvants targeting pro-apoptotic genes. The aim of the present study was to investigate the capacity of siRNAs targeting B-cell lymphoma 2 homologous antagonist killer (BAK) and B-cell lymphoma 2-associated X protein (BAX) to improve the effica...

journal_title：Experimental and therapeutic medicine

authors： Liu J,Feng K,Zhao L,Luo H,Zhu Y

更新日期：2017-06-01 00:00:00

abstract：:Neuregulin-1 (NRG-1) is a cardioactive growth factor released from endothelial cells. However, the effect of NRG-1 on ventricular remodeling in diabetic cardiomyopathy (DCM) remains unclear. The aim of the present study was to investigate the pathophysiological role of NRG-1 in a rat model of DCM. Rat cardiac microvas...

journal_title：Experimental and therapeutic medicine

authors： Li B,Xiao J,Li Y,Zhang J,Zeng M

更新日期：2013-11-01 00:00:00

abstract：:A benign lymphoepithelial lesion (BLEL) is an idiopathic inflammation of the parotid gland, characterized by hyperplasia, lymphocyte infiltration and the formation of epimyoepithelial islands, as well as atrophy of the gland parenchyma. Common treatment methods include immunosuppression and glucocorticoid therapies, i...

journal_title：Experimental and therapeutic medicine

authors： Xing D,Zhao Y

更新日期：2014-11-01 00:00:00

abstract：:The role of contaminated clothing in the transmission of influenza A virus during an epidemic period was investigated by examining the recovery of infectious influenza virus from experimentally virus-contaminated clothing, which had been subejected to routine wearing and washing for several months or years. The amount...

journal_title：Experimental and therapeutic medicine

authors： Ikeda K,Tsujimoto K,Suzuki Y,Koyama AH

更新日期：2015-04-01 00:00:00

abstract：:Macrophage autophagy has a protective role in the development of atherosclerosis; however, it turns dysfunctional in advanced lesions with an increase in p62/sequestosome-1 protein. Little is known about the role and significance of p62 accumulation in atherosclerosis. The present study investigated the association be...

journal_title：Experimental and therapeutic medicine

authors： Ning H,Liu D,Yu X,Guan X

更新日期：2017-12-01 00:00:00

abstract：:Ventilator-associated pneumonia (VAP) is a common and sometimes fatal complication in pediatric intensive care units (PICU). The aim of our study was to characterize the distribution and drug susceptibility of the pathogens isolated from the sputum of patients with VAP in the PICU of our hospital and to provide suppor...

journal_title：Experimental and therapeutic medicine

authors： Ning BT,Zhang CM,Liu T,Ye S,Yang ZH,Chen ZJ

更新日期：2013-01-01 00:00:00

abstract：:In the present study, the predictive value of glycosylated hemoglobin (HbA1c), microalbuminuria (24 h mAlb) and serum cystatin C (Cys-C) levels on the outcome of pregnancy in patients with gestational diabetes mellitus (GDM) was investigated. Samples of 144 females with GDM and 117 normal pregnant females as controls ...

journal_title：Experimental and therapeutic medicine

authors： Jin H

更新日期：2020-02-01 00:00:00

abstract：:This study demonstrates the removal of virus particles from B95-8 host cells that maintain normal activity under optimal osmotic pressure. After infecting B95-8 cells with Epstein-Barr virus (EBV) particles, the cells were treated with isosmotic solution [0.90% NaCl (330 mOsm/kg H(2)O)], hyposmotic solutions [0.36% Na...

journal_title：Experimental and therapeutic medicine

authors： Pan M,Shen J,Cai J

更新日期：2013-03-01 00:00:00

abstract：:Achondroplasia (ACH) is a hereditary dwarfism caused by the disturbed proliferation and differentiation of growth plate chondrocytes, followed by impaired endochondral bone growth. ACH is caused by mutations in the gene encoding the transmembrane receptor, fibroblast growth factor receptor 3 (FGFR3). In total, >90% of...

journal_title：Experimental and therapeutic medicine

authors： Liu J,Tang X,Cheng J,Wang L,Yang X,Wang Y

更新日期：2015-05-01 00:00:00

abstract：:The aim of this study was to systematically search literature and conduct a meta-analysis comparing the clinical efficacy and safety of Evolut R and Sapien 3 valves for transcatheter aortic valve implantation (TAVI). The PubMed, Biomed Central, Scopus, Cochrane library and Google scholar databases were searched for ar...

journal_title：Experimental and therapeutic medicine

authors： He C,Xiao L,Liu J

更新日期：2019-11-01 00:00:00