Safety and efficacy of self-expandable Evolut R vs. balloon-expandable Sapien 3 valves for transcatheter aortic valve implantation: A systematic review and meta-analysis.

Abstract:

:The aim of this study was to systematically search literature and conduct a meta-analysis comparing the clinical efficacy and safety of Evolut R and Sapien 3 valves for transcatheter aortic valve implantation (TAVI). The PubMed, Biomed Central, Scopus, Cochrane library and Google scholar databases were searched for articles published up to June, 2019. A total of 5 studies were included. In total, 795 patients underwent TAVI with Evolut R, while 665 patients received the Sapien 3 valve in the included studies. Overall device success with Evolut R was 95.7% and with Sapien 3 was 94.2%. Pooled data indicated no significant differences between the 2 valves (OR, 1.12; 95% CI, 0.66-1.89; P=0.68; I2=0%). No significant differences were observed in the incidence of none to mild paravalvular leakage between the 2 groups (OR, 1.71; 95% CI, 0.83-3.54; P=0.14; I2=0%). Both mean [random; mean difference (MD) = -3.96; 95% CI, -4.61 to -3.31; P<0.00001, I2=0%] and peak (random; MD = -6.85; 95% CI, -8.22 to -5.48; P<0.00001, I2=0%) aortic valve gradients were significantly lower with Evolut R. No significant differences were observed in the 30-day mortality (OR, 1.32; 95% CI, 0.45-3.87; P=0.62; I2=0%) or 30-day stroke outcomes (OR, 0.76; 95% CI, 0.32-1.81; P=0.54; I2=0%) between the 2 devices. On the whole, the findings of this study indicate that Evolut R and Sapien 3 valves may be comparable in terms of device success and short-term complications. The differences between the 2 devices for post-operative moderate to severe paravalvular leak and permanent pacemaker implantation remain unclear. There is thus a need for a large multi-center randomized controlled trial to provide stronger evidence on this subject.

journal_name

Exp Ther Med

authors

He C,Xiao L,Liu J

doi

10.3892/etm.2019.8000

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

3893-3904

issue

5

eissn

1792-0981

issn

1792-1015

pii

ETM-0-0-8000

journal_volume

18

pub_type

杂志文章
  • Treatment of a central venous perforation caused by dialysis intubation using coils and cyanoacrylate glue: A case report.

    abstract::Central venous catheter is one of the most commonly used vascular therapies in patients receiving hemodialysis and vascular perforation is a rare but serious complication. The present study reports on a case of a 64-year-old female who developed massive hemothorax and hemorrhagic shock after long-term dialysis due to ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2019.7923

    authors: Zhou CZ,Liu KC,Wang P,Ren W,Lv WF

    更新日期:2019-10-01 00:00:00

  • Principles of antibiotic application in children with lobar pneumonia: Step-up or step-down.

    abstract::In order to provide a scientific basis for rational use of antibiotics, we studied and compared the therapeutic effects of step-down and step-up antibiotic treatment schemes in children with lobar pneumonia. Eighty cases of children with lobar pneumonia were enrolled in this study and were randomly divided into two gr...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4319

    authors: Li Y,Han F,Yang Y,Chu J

    更新日期:2017-06-01 00:00:00

  • Metformin in combination with rosiglitazone contribute to the increased serum adiponectin levels in people with type 2 diabetes mellitus.

    abstract::To evaluate how metformin plus rosiglitazone affect serum adiponectin levels in people suffering from type 2 diabetes mellitus (T2DM), 240 patients having T2DM were selected in this cohort study. Included subjects were randomly and equally separated into three subsets: i) Group A (rosiglitazone group); ii) group B (me...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4823

    authors: Nie JM,Li HF

    更新日期:2017-09-01 00:00:00

  • Analysis of the in vitro effects of di-(2-ethylhexyl) phthalate exposure on human uterine leiomyoma cells.

    abstract::Uterine leiomyoma is the most common benign tumor type of the female reproductive tract. Despite its high prevalence, the exact pathogenesis of the benign tumor remains unknown. In the present study, the effects of di-(2-ethylhexyl) phthalate (DEHP) on the proliferation and apoptosis rates and expression of inflammato...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.6040

    authors: Kim JH

    更新日期:2018-06-01 00:00:00

  • Small interfering RNA targeting of the survivin gene inhibits human tumor cell growth in vitro.

    abstract::The present study aimed to evaluate the impact of small interfering RNA (siRNA) targeting of the survivin gene in human tumor cells and the effect of decreased survivin expression on the proliferation and apoptosis of tumor cells. Human tumor cell lines (MSA-MB-231, SGC-7901, HeLa, A549, SK-OV-3 and Raji, PC-3) were c...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4501

    authors: Zhang Z,Wang T,Liu Z,Tang S,Yue M,Feng S,Hu M,Xuan L,Chen Y

    更新日期:2017-07-01 00:00:00

  • Noninvasive cumulative axial load may induce intervertebral disc degeneration-A potential rabbit model.

    abstract::Intervertebral disc degeneration (IDD) is considered to be the main cause of many spinal disorders; however, its underlying pathophysiology is not clearly understood. Recent studies indicate that excessive mechanical loading may serve a major role in the initiation of IDD. The aim of the present study was to explore t...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4148

    authors: Bai X,Wang D,Zhou M,Xu C,Li W,Tao H,He Q,Ruan D

    更新日期:2017-04-01 00:00:00

  • Effect of glabridin on collagen deposition in liver and amelioration of hepatocyte destruction in diabetes rats.

    abstract::Abnormalities in insulin hormone levels leads to a hyperglycemic condition of diabetic mellitus. Hyperglycemia seriously induces organ and system destructions. The excessive accumulation of collagen fiber deposits occurs in inflammatory and reorganization processes of chronic liver diseases in type I insulin-dependent...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2019.7664

    authors: Komolkriengkrai M,Nopparat J,Vongvatcharanon U,Anupunpisit V,Khimmaktong W

    更新日期:2019-08-01 00:00:00

  • Development of a sustained-release microcapsule for delivery of metoprolol succinate.

    abstract::Sustained-release (SR) formulations of metoprolol succinate (MS) may minimize fluctuations in plasma concentration and decrease the resulting adverse events. The aim of the present study was to optimize the loading capacity of microcapsules and the SR of MS. A uniform design method was applied to optimize the formulat...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4247

    authors: Song L,He S,Ping Q

    更新日期:2017-05-01 00:00:00

  • Improvement of cytomegalovirus pp65 DNA vaccine efficacy by co-administration of siRNAs targeting BAK and BAX.

    abstract::The efficacy of DNA vaccines may be improved by small interfering (si)RNA adjuvants targeting pro-apoptotic genes. The aim of the present study was to investigate the capacity of siRNAs targeting B-cell lymphoma 2 homologous antagonist killer (BAK) and B-cell lymphoma 2-associated X protein (BAX) to improve the effica...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4385

    authors: Liu J,Feng K,Zhao L,Luo H,Zhu Y

    更新日期:2017-06-01 00:00:00

  • Decrease of γ-aminobutyric acid and zinc ions in the islet periportal circulation stimulates glucagon secretion during hypoglycemia.

    abstract::The present study assessed the effects of γ-aminobutyric acid (GABA) from β-cells on glucose levels and glucagon secretion, and identified channels via which glucagon secretion is initiated. An in vivo experiment was performed containing three groups: Intrapancreatic artery infusion of GABA alone, GABA plus insulin or...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.5670

    authors: Yu T,Jiang Z,Liu L,Fan Z

    更新日期:2018-03-01 00:00:00

  • Nilotinib rapidly reverses breakpoint cluster region-Abelson oncogene fusion gene and M244V mutations in a patient with chronic myelogenous leukemia: A case report.

    abstract::Chronic myelogenous leukemia (CML) is a condition characterized by a balanced genetic translocation, t (9;22) (q34;q11.2), which leads to a fusion of the Abelson oncogene (ABL) from chromosome 9q34 with the breakpoint cluster region (BCR) gene on chromosome 22q11.2. This rearrangement is referred to as the Philadelphi...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2015.2707

    authors: Shen X,Zhang M,Shen Y,Shi W,Liu W,Wei WU

    更新日期:2015-10-01 00:00:00

  • β3 adrenergic receptor antagonist SR59230A exerts beneficial effects on right ventricular performance in monocrotaline-induced pulmonary arterial hypertension.

    abstract::Pulmonary arterial hypertension (PAH) is a progressive disease with a high mortality rate. Previous studies have revealed the important function of the β3 adrenergic receptor (β3-AR) in cardiovascular diseases, and the potential beneficial effects of numerous β3-AR agonists on pulmonary vasodilation. Conversely, a num...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2019.8236

    authors: Sun J,Cheng J,Ding X,Chi J,Yang J,Li W

    更新日期:2020-01-01 00:00:00

  • Clinical value of black-blood high-resolution magnetic resonance imaging for intracranial atherosclerotic plaques.

    abstract::The present study evaluated the value of black-blood high-resolution magnetic resonance imaging (HRMRI) for the visualization of intracranial atherosclerosis (ICAS) plaques. A total of 110 patients with cerebral artery or vertebrobasilar stenosis, vessel occlusion or a significantly weakened signal in black-blood magn...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2015.2469

    authors: Yang H,Zhu Y,Geng Z,Li C,Zhou L,Liu QI

    更新日期:2015-07-01 00:00:00

  • Antiproliferative effect and characterization of a novel antifungal peptide derived from human Chromogranin A.

    abstract::CGA-N46 is a novel antifungal peptide derived from the N-terminus of human Chromogranin A, corresponding to the 31st to 76th amino acids. Further research on its activities and characteristics may be helpful for the application of CGA-N46 in medical or other situations. In the present study, the antifungal spectrum an...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2015.2838

    authors: Li RF,Lu YL,Lu YB,Zhang HR,Huang L,Yin Y,Zhang L,Liu S,Lu Z,Sun Y

    更新日期:2015-12-01 00:00:00

  • Comparison of the clinical efficacy of AcrySof® IQ and TECNIS® toric intraocular lenses: A real-world study.

    abstract::Corneal astigmatism significantly compromises uncorrected visual acuity (UCVA) after phacoemulsification with implantation of traditional spherical or non-spherical monofocal intraocular lens (IOL). Toric IOL provides an effective way to gain favorable postoperative UCVA for the patients with cataracts with corneal as...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2020.9153

    authors: Yang JJ,Qin YZ,Qin L,Li JM

    更新日期:2020-11-01 00:00:00

  • Sensitive quantitative assay for point mutations in the rat H-ras gene based on single nucleotide primer extension.

    abstract::Point mutations in oncogenes and tumor suppressor genes occur at early stages in the carcinogenic process. Point mutations in ras family oncogenes are the most common mutational events in several types of human cancer, and are available as molecular markers for the detection of cancer cells in carcinogenicity bioassay...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm_00000103

    authors: Yano Y,Yano T,Kinoshita A,Matoba A,Hasuma T,Wanibuchi H,Morimura K,Otani S,Fukushima S

    更新日期:2010-07-01 00:00:00

  • Qingre Baidu mixture-induced effect of AI-2 on Staphylococcus aureus and Pseudomonas aeruginosa biofilms in chronic and refractory wounds.

    abstract::The present study aimed to investigate the effect of the traditional Chinese medicine Qingre Baidu mixture (QBM) on the regulation of various parameters, including the morphology of bacterial biofilms, the bacterial density sensing system, the self-induction of the molecule autoinducer (AI)-2 and the hypoxia-inducible...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2019.7391

    authors: Shan W,Wang Y,Zhang Z,Xing J,Xu J,Xiao W,Shen Y,Guo S,Que H

    更新日期:2019-05-01 00:00:00

  • Trimetazidine inhibits cardiac fibrosis by reducing reactive oxygen species and downregulating connective tissue growth factor in streptozotocin-induced diabetic rats.

    abstract::Diabetes may affect myocardial fibrosis through oxidative stress. Trimetazidine (TMZ) is an anti-anginal agent. The present study aimed to determine the modulatory effect of TMZ on reactive oxygen species (ROS) and connective tissue growth factor (CTGF) expression and to evaluate the potential of TMZ to improve diasto...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2019.7705

    authors: Zhao Y,Li S,Quan E,Zhang H,Wu Y,Luo Y,Peng L,Wang J,Zhu J,Liu J

    更新日期:2019-08-01 00:00:00

  • Probiotic and glutamine treatments attenuate alcoholic liver disease in a rat model.

    abstract::The pathogenesis underlying alcoholic liver disease (ALD), which is often a result of alcohol abuse, currently remains unclear. Previous studies have reported that enteric dysbiosis serves an important role in the pathogenesis of ALD. The present study aimed to investigate the effects of glutamine and probiotics on a ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2019.8123

    authors: Huang H,Lin Z,Zeng Y,Lin X,Zhang Y

    更新日期:2019-12-01 00:00:00

  • Effect of hypoxia-inducible factor-1/vascular endothelial growth factor signaling pathway on spinal cord injury in rats.

    abstract::The aim of the present study was to evaluate the expression of vascular endothelial growth factor (VEGF) and hypoxia inducible factor-1 (HIF-1), and to investigate the role of the HIF-1/VEGF signaling pathway following spinal cord injury (SCI). A total of 90 12-week-old Sprague Dawley rats were randomly divided into t...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4049

    authors: Chen H,Li J,Liang S,Lin B,Peng Q,Zhao P,Cui J,Rao Y

    更新日期:2017-03-01 00:00:00

  • Glutathione S-transferase A1 mediates nicotine-induced lung cancer cell metastasis by promoting epithelial-mesenchymal transition.

    abstract::The present study aimed to investigate the effect of glutathione S-transferase A1 (GSTA1) on lung cancer cell viability, invasion and adhesion in the presence of nicotine in vitro. Furthermore, the effect of GSTA1 on the epithelial-mesenchymal transition (EMT), a process strongly associated with lung cancer metastasis...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4663

    authors: Wang W,Liu F,Wang C,Wang C,Tang Y,Jiang Z

    更新日期:2017-08-01 00:00:00

  • Vitamin B6 regulates mRNA expression of peroxisome proliferator-activated receptor-γ target genes.

    abstract::We previously demonstrated that vitamin B6 suppresses tumorigenesis in the colon of mice and exerts an anti-inflammatory effect through the inhibition of NF-κB activation. As these effects resemble the pharmacological properties of thiazolidinedione (TZD), a synthetic peroxisome proliferator-activated receptor-γ (PPAR...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2011.238

    authors: Yanaka N,Kanda M,Toya K,Suehiro H,Kato N

    更新日期:2011-05-01 00:00:00

  • Expression of CCR3, SOX5 and LC3 in patients with elderly onset rheumatoid arthritis and the clinical significance.

    abstract::This study investigated the expression of C-C chemokine receptor type 3 (CCR3), transcription factor SOX5 (SOX5) and microtubule-associated protein 1 light chain 3 (LC3) in patients with elderly onset rheumatoid arthritis (EORA) and the clinical significance. Ninety patients with elderly onset rheumatoid arthritis wer...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4961

    authors: Wang J,Zhao Q

    更新日期:2017-10-01 00:00:00

  • Multifocal osteonecrosis affecting all four limbs in systemic lupus erythematosus: A case report.

    abstract::Osteonecrosis is a condition that frequently affects patients with systemic lupus erythematosus (SLE). However, reports on severe multifocal osteonecrosis involving more than three anatomical sites in patients with SLE are scarce. The present study describes a case of SLE with multifocal osteonecrosis involving all fo...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2019.7829

    authors: Sun S,Wang Q,Gong Y,Qi X,Liu J

    更新日期:2019-10-01 00:00:00

  • Brain cell apoptosis inhibition by butylphthalide in Alzheimer's disease model in rats.

    abstract::The present study was designed to test the hypothesis that butylphthalide protects the brain of Alzheimer's disease (AD) model rats by inhibiting apoptosis. Ninety Sprague-Dawley rats were randomly divided into drug, control and blank groups of 30 rats in each. The rats in the drug and control groups were treated to i...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4322

    authors: Song FX,Wang L,Liu H,Wang YL,Zou Y

    更新日期:2017-06-01 00:00:00

  • Serum anion gap on admission predicts intensive care unit mortality in patients with aortic aneurysm.

    abstract::It has been widely reported that the serum anion gap is significantly associated with mortality in intensive care unit (ICU); however, it remains unknown whether the association is present in aortic aneurysm (AA) patients. The present study aimed to investigate the association between the admission serum anion gap and...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.6391

    authors: Chen Q,Chen Q,Li L,Lin X,Chang SI,Li Y,Tian Z,Liu W,Huang K

    更新日期:2018-09-01 00:00:00

  • MicroRNA-137 acts as a tumor suppressor in osteosarcoma by targeting enhancer of zeste homolog 2.

    abstract::MicroRNA (miR) are short non-coding RNA that bind to the 3'-untranslational region of their target genes, inhibiting translation and causing mRNA degradation. miR deregulation has been implicated in human cancer; however, the detailed regulatory mechanism of miR-137 in osteosarcoma (OS) remains largely unknown. In the...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4435

    authors: Feng Q,Wu Q,Liu X,Xiong Y,Li H

    更新日期:2017-06-01 00:00:00

  • Lipoxin A4 attenuates uric acid-activated, NADPH oxidase-dependent oxidative stress by interfering with translocation of p47phox in human umbilical vein endothelial cells.

    abstract::LipoxinA4 (LXA4) is a well-known key mediator of endogenous anti-inflammation and of the resolution of inflammation. Considerable oxidative stress occurs during inflammation due to the generation of reactive oxidative species (ROS). Moreover, high levels of uric acid (UA) contribute to endothelial cell dysfunction, wh...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2020.8812

    authors: Zhou Y,You H,Zhang A,Jiang X,Pu Z,Xu G,Zhao M

    更新日期:2020-08-01 00:00:00

  • Therapeutic effects of triptolide via the inhibition of IL-1β expression in a mouse model of ulcerative colitis.

    abstract::The present study aimed to investigate the effect of triptolide (TL) on ulcerative colitis (UC) and explore the potential association between the therapeutic effects of TL and IL-1β expression using a 4,4-dimethyl-4-silapentane-1-sulfonic acid (DSS)-induced mouse model to simulate human UC. A total of 70 BALB/c female...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2016.3490

    authors: Zhang H,Gong C,Qu L,Ding X,Cao W,Chen H,Zhang B,Zhou G

    更新日期:2016-09-01 00:00:00

  • Oxidized low-density lipoprotein-induced p62/SQSTM1 accumulation in THP-1-derived macrophages promotes IL-18 secretion and cell death.

    abstract::Macrophage autophagy has a protective role in the development of atherosclerosis; however, it turns dysfunctional in advanced lesions with an increase in p62/sequestosome-1 protein. Little is known about the role and significance of p62 accumulation in atherosclerosis. The present study investigated the association be...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.5221

    authors: Ning H,Liu D,Yu X,Guan X

    更新日期:2017-12-01 00:00:00