DC-CIK biotherapy for a recurrent benign lymphoepithelial lesion of the salivary gland: A case report and literature review.

Abstract:

:A benign lymphoepithelial lesion (BLEL) is an idiopathic inflammation of the parotid gland, characterized by hyperplasia, lymphocyte infiltration and the formation of epimyoepithelial islands, as well as atrophy of the gland parenchyma. Common treatment methods include immunosuppression and glucocorticoid therapies, in addition to surgical dissections. Cytokine-induced killer (CIK) cells sensitized to specific antigens by dendritic cells (DCs) are used in DC-CIK biotherapy. The present study reports the case of a 22-year-old female suffering from a postoperative recurrent BLEL on the left parotid gland, which was gradually increasing. Following initial unsuccessful conservative treatment attempts, a 10-day course of DC-CIK therapy was initiated, after which the lesion in the gland area was reduced in size and local infection and skin ulcerations were improved. DC-CIK biotherapy was continued for three months (four sessions of 10-day treatments with a 10-day break in between) until the lesion disappeared and the skin ulceration was healed. Computerized tomography scans of the parotid gland revealed complete remission of the primary lesion and recovery of the bone destruction. The patient was discharged and remained stable with no sign of recurrence during a 10-month follow-up period. In the present case report, a successful DC-CIK adoptive cellular immunotherapy treatment for a BLEL was described for the first time.

journal_name

Exp Ther Med

authors

Xing D,Zhao Y

doi

10.3892/etm.2014.1937

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

1565-1568

issue

5

eissn

1792-0981

issn

1792-1015

pii

etm-08-05-1565

journal_volume

8

pub_type

杂志文章
  • Expression of miR-376 in blood of pregnant women with preeclampsia and its effect on 25-hydroxyvitamin D.

    abstract::The study aims to investigate the clinical significance of regulating the expression of 25-hydroxyvitamin D (25-OH-VD) via microRNA (miRNA)-376c in the occurrence and development of preeclampsia (PE) in pregnant women. Peripheral blood and placental tissues were collected from pregnant women in 4 groups, including 67 ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.6394

    authors: Li J,Du J,Wang Z,Wang C,Bai J,Zhang S

    更新日期:2018-09-01 00:00:00

  • Histological aspects of the small intestine under variable feed restriction: The effects of short and intense restriction on a growing rabbit model.

    abstract::The objective of this study was to investigate the effect of seven days of feed restriction (between days 42 and 49) on the morphology of the small intestine in experimental rabbit models. Sixty weaned Hyplus rabbits (35 days old) were included in the experiment and split into three groups of 20 rabbits. The first con...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2014.1924

    authors: Makovicky P,Tumova E,Volek Z,Makovicky P,Vodicka P

    更新日期:2014-11-01 00:00:00

  • Efficacies of minimally invasive puncture and small bone window craniotomy for hypertensive intracerebral hemorrhage, evaluation of motor-evoked potentials and comparison of postoperative rehemorrhage between the two methods.

    abstract::Application value of the minimally invasive puncture and small bone window craniotomy in hypertensive intracerebral hemorrhage was investigated to explore the effects of the above treatment methods on motor-evoked potentials (MEPs) and postoperative rehemorrhage. Patients with hypertensive intracerebral hemorrhage who...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.7094

    authors: Luan L,Li M,Sui H,Li G,Pan W

    更新日期:2019-02-01 00:00:00

  • Probiotic and glutamine treatments attenuate alcoholic liver disease in a rat model.

    abstract::The pathogenesis underlying alcoholic liver disease (ALD), which is often a result of alcohol abuse, currently remains unclear. Previous studies have reported that enteric dysbiosis serves an important role in the pathogenesis of ALD. The present study aimed to investigate the effects of glutamine and probiotics on a ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2019.8123

    authors: Huang H,Lin Z,Zeng Y,Lin X,Zhang Y

    更新日期:2019-12-01 00:00:00

  • Effect of AXL on the epithelial-to-mesenchymal transition in non-small cell lung cancer.

    abstract::Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-associated mortality in the United States. AXL, which is a member of the receptor tyrosine kinases, has been established as a strong candidate for the targeted therapy of cancer. Therefore, the present study aimed to investigate the role of AXL in NSCLC...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4532

    authors: Ying X,Chen J,Huang X,Huang P,Yan S

    更新日期:2017-07-01 00:00:00

  • Antiosteoporotic effect of icariin in ovariectomized rats is mediated via the Wnt/β-catenin pathway.

    abstract::Icariin (ICA), the main active flavonoid glucoside isolated from Herba Epimedii, has been shown to prevent postmenopausal bone loss in vitro. However, the mechanisms by which ICA prevents bone loss in vivo remain poorly understood. In the present study, the effect of ICA in an ovariectomized (OVX) rat model of osteopo...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2016.3333

    authors: Chen G,Wang C,Wang J,Yin S,Gao H,Xiang LU,Liu H,Xiong Y,Wang P,Zhu X,Yang LI,Zhang R

    更新日期:2016-07-01 00:00:00

  • Antiosteoporotic effects of Polycan in combination with calcium lactate-gluconate in ovariectomized rats.

    abstract::The aim of the present study was to investigate the optimum composition of Polycan (β-glucan complex) and calcium lactate-gluconate (CaLG) that exhibited the most beneficial effects in ovariectomy (OVX)-induced osteoporotic rats. Polycan and CaLG single formulas (100 mg/kg each), and three doses (50, 100 and 200 mg/kg...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2014.1793

    authors: Choi JS,Kim JW,Kim KY,Cho HR,Choi IS,Ku SK

    更新日期:2014-09-01 00:00:00

  • Solitary schwannoma of the sural nerve: An unusual clinical presentation.

    abstract::Schwannomas may arise from any peripheral nerve containing Schwann cells. However, sural nerve schwannoma is extremely rare. In this study, a case of solitary schwannoma originating from the sural nerve in a 42-year-old male is presented. Physical examination revealed a 3-cm, elastic-hard, mobile, non-tender mass, whi...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2013.1395

    authors: Yamamoto K,Nishio J,Yano S,Naito M

    更新日期:2014-01-01 00:00:00

  • Paeoniflorin inhibits IL-1β-induced MMP secretion via the NF-κB pathway in chondrocytes.

    abstract::Paeoniflorin serves important cellular roles, exerting anti-cancer, anti-inflammatory and anti-pulmonary fibrosis effects and possesses immune-modulatory properties. However, the exact role of paeoniflorin in the pathogenesis of osteoarthritis (OA) remains unclear. The aim of the present study was to investigate the e...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.6325

    authors: Hu PF,Sun FF,Jiang LF,Bao JP,Wu LD

    更新日期:2018-08-01 00:00:00

  • Synchronous diffuse ganglioneuromatosis and multiple schwannomas of the colon: A case report and literature review.

    abstract::Diffuse ganglioneuromatosis (DG) of the gastrointestinal tract is a rare condition that is closely associated with neurofibromatosis type 1 and multiple endocrine neoplasia type 2B. The occurrence of DG with multiple schwannomas, which, of the GI tract, usually affect the stomach, is considerably more rare. The presen...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2015.2212

    authors: Lu C,Qiu Y,Lu X,Li G,Bu H

    更新日期:2015-03-01 00:00:00

  • Efficacy of several biological therapies for treating moderate to severe psoriasis: A network meta-analysis.

    abstract::The aim of the present meta-analysis was to systematically assess the efficacy of the various treatments available for moderate to severe psoriasis. PubMed and Embase databases were systematically searched to select relevant studies up to February 2015. Odds ratios (ORs) and their 95% confidence intervals (CIs) were u...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.6859

    authors: Geng W,Zhao J,Fu J,Zhang H,Qiao S

    更新日期:2018-12-01 00:00:00

  • Effects of heat stress on the expression of the coxsackievirus and adenovirus receptor in mouse skin keratinocytes.

    abstract::The aim of this study was to investigate the effects of heat stress on the expression of the coxsackievirus and adenovirus receptor (CAR) in mouse skin keratinocytes. Twenty BALB/c mice were randomly divided into two groups: the sham heat (control) and scald groups. Skin specimens were obtained 6 h after the treatment...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2013.1230

    authors: Deng X,Jia C,Chen F,Liu J,Zhou Z

    更新日期:2013-10-01 00:00:00

  • Hepcidin in non-alcoholic fatty liver disease regulated by the TLR4/NF-κB signaling pathway.

    abstract::The aim of our study was to analyze the role of toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB signal pathway on Hepcidin regulation in non-alcoholic fatty liver disease (NAFLD). A total of 60 male Sprague-Dawley rats were randomly divided into the control, NAFLD and intervention groups. Rats in the control group ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2015.2873

    authors: Chen W,Wang X,Huang LI,Liu BO

    更新日期:2016-01-01 00:00:00

  • Treatment of recurrent patellar dislocation via knee arthroscopy combined with C-arm fluoroscopy and reconstruction of the medial patellofemoral ligament.

    abstract::Recurrent patellar dislocations were treated via knee arthroscopy combined with C-arm fluoroscopy, and reconstruction of the medial patellofemoral ligaments. Between October 2013 and March 2017, 52 cases of recurrent patellar dislocation [27 males and 25 females; age, 16-47 years (mean, 21.90 years)] were treated. Art...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.6055

    authors: Li L,Wang H,He Y,Si Y,Zhou H,Wang X

    更新日期:2018-06-01 00:00:00

  • Risk factors and the clinical and surgical features of fungal prosthetic joint infections: A retrospective analysis of eight cases.

    abstract::Fungal prosthetic joint infections (PJI) and reports of their clinical investigation are rare. In addition, there has been little evidence regarding the outcome of the two-stage exchange protocol for the treatment of fungal PJI. In order to investigate the risk factors and clinical, microbiological and pathological fe...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2016.3353

    authors: Geng L,Xu M,Yu L,Li J,Zhou Y,Wang Y,Chen J

    更新日期:2016-08-01 00:00:00

  • Body surface area as a key determinant of aortic root and arch dimensions in a population-based study.

    abstract::The associations between the aortic dimensions (of the aortic sinus, aortic annulus and aortic arch) and physiological variables have not been established in the Chinese population. The present study examined the associations among physiological variables to determine the aortic root and arch dimensions echocardiograp...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2012.839

    authors: Wang YL,Wang QL,Wang L,Wu YB,Wang ZB,Cameron J,Liang YL

    更新日期:2013-02-01 00:00:00

  • Differential co-expression analysis of venous thromboembolism based on gene expression profile data.

    abstract::The aim of the present study was to screen differentially co-expressed genes and the involved transcription factors (TFs) and microRNAs (miRNAs) in venous thromboembolism (VTE). Microarray data of GSE19151 were downloaded from Gene Expression Omnibus, including 70 patients with VTE and 63 healthy controls. Principal c...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2016.3208

    authors: Ming Z,Ding W,Yuan R,Jin J,Li X

    更新日期:2016-06-01 00:00:00

  • High lncRNA MEG3 expression is associated with high mortality rates in patients with sepsis and increased lipopolysaccharide-induced renal epithelial cell and cardiomyocyte apoptosis.

    abstract::Long non-coding RNA (lncRNA) maternally expressed 3 (MEG3) has been reported to be a key component in cancer biology. Preliminary microarray data from a previous study indicated that lncRNA MEG3 expression was altered in plasma of patients with sepsis. The present study found that the plasma levels of lncRNA MEG3 were...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2019.8049

    authors: Chen K,Shi X,Jin Y,Wang F,Shen Q,Xu W

    更新日期:2019-11-01 00:00:00

  • Denitrase activity of Debaryomyces hansenii reduces the oxidized compound 3-nitrotyrosine in mice liver with colitis.

    abstract::The oxidation of tyrosine to 3-nitrotyrosine is irreversible, and due to this characteristic, 3-nitrotyrosine is used as a marker for oxidative stress in a range of diverse chronic and degenerative diseases. It has been established that the yeast Debaryomyces hansenii (D. hansenii) can assimilate free 3-nitrotyrosine ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2019.7395

    authors: Calderón-Torres CM,Sarabia-Curz L,Ledesma-Soto Y,Murguía-Romero M,Terrazas LI

    更新日期:2019-05-01 00:00:00

  • Irradiation facilitates the inhibitory effect of the heat shock protein 90 inhibitor NVP-BEP800 on the proliferation of malignant glioblastoma cells through attenuation of the upregulation of heat shock protein 70.

    abstract::The present study aimed to investigate the effect of NVP-BEP800, a novel heat shock protein (Hsp) 90 inhibitor of the 2-aminothieno[2,3-d]pyrimidine class, in combination with radiation on glioblastoma cells. T98G human glioblastoma cells were treated with dimethyl sulfoxide (DMSO), NVP-BEP800, NVP-BEP800 in combinati...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2014.1800

    authors: Wu J,Wang W,Shao Q,Xiao G,Cheng J,Yuan Y,Zhang M

    更新日期:2014-09-01 00:00:00

  • Global dysregulation of the chromosome 14q32 imprinted region in uterine carcinosarcoma.

    abstract::Uterine carcinosarcoma (UCS) is a rare but very aggressive cancer of the female reproductive tract with an extremely poor prognosis. With the goal of understanding the role of microRNA (miRNA) dysregulation in these tumors, we profiled the expression of 667 human miRNAs in a panel of eight UCS patients and five benign...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2012.458

    authors: Devor EJ,DE Mik JN,Ramachandran S,Goodheart MJ,Leslie KK

    更新日期:2012-04-01 00:00:00

  • Comparative study of computed tomography of normal and lymphoid follicular hyperplasia thymus in myasthenia gravis patients.

    abstract::The aim of the present study was to evaluate the thymuses of non-thymomatous myasthenia gravis (MG) patients by computed tomography (CT) for differentiating lymphoid follicular hyperplasia (LFH) thymus from normal/involuted thymus in order to assist surgeons in determining whether a non-thymomatous MG patient requires...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.6948

    authors: Zhang H,Zhang P,Yu TL

    更新日期:2019-01-01 00:00:00

  • Decreased microRNA-140-5p contributes to respiratory syncytial virus disease through targeting Toll-like receptor 4.

    abstract::The abnormal expression of miRNAs (miRs) has previously been reported in respiratory syncytial virus (RSV) disease. However, to the best of our knowledge, the expression of miR-140-5p in patients with an RSV infection has never been explored. Reverse transcription-quantitative polymerase chain reaction was performed t...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.6272

    authors: Zhang Y,Shao L

    更新日期:2018-08-01 00:00:00

  • Clinical value of black-blood high-resolution magnetic resonance imaging for intracranial atherosclerotic plaques.

    abstract::The present study evaluated the value of black-blood high-resolution magnetic resonance imaging (HRMRI) for the visualization of intracranial atherosclerosis (ICAS) plaques. A total of 110 patients with cerebral artery or vertebrobasilar stenosis, vessel occlusion or a significantly weakened signal in black-blood magn...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2015.2469

    authors: Yang H,Zhu Y,Geng Z,Li C,Zhou L,Liu QI

    更新日期:2015-07-01 00:00:00

  • Diagnostic accuracy of transvaginal ultrasound examination for assigning a specific diagnosis to adnexal masses: A meta-analysis.

    abstract::Transvaginal ultrasound (TVUS) is a standard imaging modality for differentiating patients with benign or malignant suspected adnexal mass. To date, numerous studies have assessed the diagnostic accuracy of TVUS in various settings but with variable results. Therefore, the purpose of the present study was to perform a...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2020.9395

    authors: Zhang X,Meng X,Dou T,Sun H

    更新日期:2020-12-01 00:00:00

  • Enhancement of humoral and cell mediated immune response to HPV16 L1-derived peptides subsequent to vaccination with prophylactic bivalent HPV L1 virus-like particle vaccine in healthy females.

    abstract::Currently prophylactic HPV16/18 L1 virus-like particle (VLP) vaccines are employed with great success for the prevention of HPV infection. However, limited information is available regarding the immune responses against human papillomavirus (HPV) 16/18 L1 subsequent to HPV16/18 L1 VLP vaccination, primarily due to the...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4150

    authors: Yokomine M,Matsueda S,Kawano K,Sasada T,Fukui A,Yamashita T,Komatsu N,Shichijo S,Tasaki K,Matsukuma K,Itoh K,Kamura T,Ushijima K

    更新日期:2017-04-01 00:00:00

  • Safety of tirofiban for patients with acute ischemic stroke in routine clinical practice.

    abstract::The aim of the present study was to investigate the safety of tirofiban alone and in combination with various treatments in acute ischemic stroke (AIS). A total of 120 patients with AIS were included in the study, and these patients were divided into three treatment groups: Group A (tirofiban alone, n=68), group B (ti...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2015.2495

    authors: Zhu YQ,Zhang YJ,Ruan HL,Liu Q,Zhan Q,Li Q

    更新日期:2015-07-01 00:00:00

  • Adult cervicomedullary pilocytic astrocytoma: A case report.

    abstract::Pilocytic astrocytoma (PA) is a rare glioma, which generally occurs in children and young adults. In adult patients, the majority of PA tumors are supratentorial. Due to the low morbidity rate of the disease in adults, PA is frequently misdiagnosed and mistreated. In the present study, this rare disease was successful...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2015.2828

    authors: Zhao Y,Feng L,Wei Q,Gao L

    更新日期:2015-12-01 00:00:00

  • Ultrasonic features of papillary thyroid microcarcinoma and non-microcarcinoma.

    abstract::The present study analyzed the ultrasonic features of papillary thyroid microcarcinoma (PTMC) and papillary thyroid non-microcarcinoma (non-PTMC) with the aim of improving the diagnostic value of ultrasonography. The ultrasonic features of 328 patients with papillary thyroid carcinoma (PTC), as confirmed by pathology,...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2014.1910

    authors: Zhang XL,Qian LX

    更新日期:2014-10-01 00:00:00

  • Effect of stromal cell-derived factor-1 on myocardial apoptosis and cardiac function recovery in rats with acute myocardial infarction.

    abstract::The aim of the study was to investigate the effect of stromal cell-derived factor-1 (SDF-1) on myocardial apoptosis and cardiac function recovery in rats with acute myocardial infarction (AMI) and the mechanism of the Toll-like receptor (TLR)-4/nuclear factor-κB (NF-κB) signaling pathway. A total of 64 healthy male F3...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2016.3770

    authors: Liu Y,Gao S,Wang Z,Yang Y,Huo H,Tian X

    更新日期:2016-11-01 00:00:00