Oxidized low-density lipoprotein-induced p62/SQSTM1 accumulation in THP-1-derived macrophages promotes IL-18 secretion and cell death.

abstract：:Hyperlipidemia is a risk factor of kidney damage that can lead to chronic kidney disease. Studies have shown that exercise reduces kidney damage; however, the specific mechanisms underlying the protective effects of exercise remain unclear. For 12 weeks, 8-week-old male apolipoprotein E-deficient (ApoE-/-) mice were r...

journal_title：Experimental and therapeutic medicine

authors： Qian C,Yang Q,Guo L,Zhu H,You X,Liu H,Sun Y

更新日期：2021-02-01 00:00:00

abstract：:Multi infarct dementia (MID) is a form of dementia that is preventable and treatable. However, at present, the drugs used in MID treatment were developed for Alzheimer's disease. While only a limited range of drugs is available, the incidence of MID is increasing year on year. The present study aimed to investigate th...

journal_title：Experimental and therapeutic medicine

authors： Fu Y,Wei J,Li B,Gao L,Xia P,Wen Y,Xu S

更新日期：2020-11-01 00:00:00

abstract：:The aim of the present study was to evaluate the expression and specific role of microRNA (miR)-142-5p in the progression of intrahepatic cholangiocarcinoma (ICC). Reverse transcription-quantitative polymerase chain reaction was performed to evaluate miR-142-5p expression in patients with ICC and healthy control subje...

journal_title：Experimental and therapeutic medicine

authors： Wei G,Yuan Y,He X,Jin L,Jin D

更新日期：2019-05-01 00:00:00

abstract：:Women with endometrial cancer often undergo hysteroscopy during their diagnostic work-up. Whether or not the duration of hysteroscopy affects the rate of positive peritoneal cells and the duration of recurrence-free survival is unknown. In a retrospective multi-centre study, the records of 552 patients with endometria...

journal_title：Experimental and therapeutic medicine

authors： Tempfer C,Froese G,Buerkle B,Polterauer S,Grimm C,Concin N,Hofstetter G,Weigert M,Oehler MK

更新日期：2011-09-01 00:00:00

abstract：:In spite of the favorable prognosis of early gastric cancer (EGC), recurrence or second primary cancers present in certain patients after curative surgery. It is crucial to identify who are at high risk and when. In the present study, 323 patients with EGC who underwent curative surgery were studied. A total of 22 pat...

journal_title：Experimental and therapeutic medicine

authors： Huang B,Wang Z,Xing C,Sun Z,Zhao B,Xu H

更新日期：2011-11-01 00:00:00

abstract：:The present study aimed to investigate changes of T-regulatory (Treg) and T-helper (Th)17 cells as well as cytokines in peripheral blood of children with acute bronchitis, and to explore the roles of these cells in the pathogenesis of acute bronchitis. A total of 126 children who had presented at Renji Hospital (Shang...

journal_title：Experimental and therapeutic medicine

authors： Tu Z,Xue H,Chen W,Cao L,Zhang W

更新日期：2017-10-01 00:00:00

abstract：:Collecting duct carcinoma (CDC), which is also known as Bellini duct carcinoma, accounts for less than 1% of all renal cell carcinoma, which has a poor prognosis. Predominantly, clinicians recognize this disease due to past experience and case reports, and a standard treatment is yet to be established. The present cas...

journal_title：Experimental and therapeutic medicine

authors： Zhu L,Wang Z,Pan C,Peng R,Wei X,Zhong Z

更新日期：2016-08-01 00:00:00

abstract：:Radiation pneumonitis is a clinical problem with a high incidence. Once the onset of radiation pneumonitis has occurred, the administration of antioxidants and anti-inflammatory agents is the most commonly used method of clinical treatment. Quercetin (Que) is a common flavonoid, with potent anti-inflammatory and anti-...

journal_title：Experimental and therapeutic medicine

authors： Qin M,Chen W,Cui J,Li W,Liu D,Zhang W

更新日期：2017-12-01 00:00:00

abstract：:The aim of this study was to determine whether the vascular endothelial growth factor (VEGF) +936C/T polymorphism confers susceptibility to gastric cancer (GC) by conducting a meta-analysis. Publications addressing the association between the VEGF +936C/T polymorphism and GC risk were selected from the Pubmed, Embase ...

journal_title：Experimental and therapeutic medicine

authors： Zhou LP,Luan H,Dong XH,Jin GJ,Man DL,Shang H

更新日期：2011-09-01 00:00:00

abstract：:Effects of antithrombotic agents on the bleeding risk after transurethral resection of the prostate (TURP) were assessed in patients with benign prostatic hyperplasia (BPH). Controlled clinical trials on the effects of perioperative anticoagulant therapy on postoperative bleeding in BPH patients published during Janua...

journal_title：Experimental and therapeutic medicine

authors： He Q,Yu Y,Gao F

更新日期：2020-10-01 00:00:00

abstract：:Tenosynovial chondromatosis is an extra-articular version of articular synovial chondromatosis and a relatively rare condition that can affect the tendon sheath, bursa, or joint synovial tissue. Tenosynovial chondromatosis is rarely reported in the literature and is often misdiagnosed. In the present study, a case of ...

journal_title：Experimental and therapeutic medicine

authors： Chen YX,Lu YX,Zhuang ZE,Li ZY

更新日期：2015-10-01 00:00:00

abstract：:Uterine leiomyoma is the most common benign tumor type of the female reproductive tract. Despite its high prevalence, the exact pathogenesis of the benign tumor remains unknown. In the present study, the effects of di-(2-ethylhexyl) phthalate (DEHP) on the proliferation and apoptosis rates and expression of inflammato...

journal_title：Experimental and therapeutic medicine

authors： Kim JH

更新日期：2018-06-01 00:00:00

abstract：:Cisplatin (DDP) is a commonly used chemotherapy drug; however, the side effects associated with its use, particularly acute kidney injury (AKI), limit its clinical application. Puerarin is a natural flavonoid extracted from the Chinese medical herb Radix puerariae, which has been reported to alleviate DDP-induced neph...

journal_title：Experimental and therapeutic medicine

authors： Wu Z,Li C,Li Q,Li J,Lu X

更新日期：2020-10-01 00:00:00

abstract：:The present study described the characteristics of three cases of Creutzfeldt-Jakob disease (CJD) in China and analyzed their clinical presentations. The clinical information of the three cases was collected and analyzed. Blood and cerebrospinal fluid (CSF) specimens of the patients were collected for detection of the...

journal_title：Experimental and therapeutic medicine

authors： Wang X,Li N,Liu A,Ma L,Shan P,Jiang W,Zhang Q

更新日期：2017-09-01 00:00:00

abstract：:We previously reported on single-incision laparoscopic surgery applied to laparoscopically assisted vaginal hysterectomy (LAVH) cases. We accumulated single-incision LAVH cases to evaluate this operation, including its learning curve. Since July 2009, we planned to perform single-incision LAVH in 50 cases. Operative t...

journal_title：Experimental and therapeutic medicine

authors： Koyanagi T,Motomura S

更新日期：2011-09-01 00:00:00

abstract：:The study was conducted to evaluate the relationship between the blood lactic acid (BLA) level, serum procalcitonin (PCT), C-reactive protein (CRP) and the severity and prognosis of neonatal sepsis. A retrospective analysis was conducted on 90 children with sepsis admitted into the Intensive Care Unit (ICU) of the Hub...

journal_title：Experimental and therapeutic medicine

authors： Jia Y,Wang Y,Yu X

更新日期：2017-09-01 00:00:00

abstract：:It is firmly established that smoking is a risk factor of cardiovascular disease, stroke and peripheral vascular disease. Although smoking alters the hemostatic process, the influence of smoking on human platelet activation remains controversial. For patients undergoing surgery, cessation of smoking prior to the proce...

journal_title：Experimental and therapeutic medicine

authors： Kito Y,Iida M,Tanabe K,Onuma T,Tsujimoto M,Nagase K,Tokuda H,Iwama T,Kozawa O,Iida H

更新日期：2019-11-01 00:00:00

abstract：:Impaired glucose tolerance (IGT) is a pre-diabetic metabolic state involving heterogeneous and dynamic changes between the normal and diabetic state. The present study aimed to investigate the endocrine regulation of endothelium-dependent dysfunction in middle-aged patients with IGT and in patients with a normal gluco...

journal_title：Experimental and therapeutic medicine

authors： Liu Y,Li J,Zhang Z,Tang Y,Chen Z,Wang Z

更新日期：2014-03-01 00:00:00

abstract：:The aim of this study was to analyze the clinical features of hepatitis B surface antigen (HBsAg)-positive and negative diffuse large B-cell lymphomas (DLBCLs) and to compare the outcomes and serum hepatitis B virus (HBV)-DNA loads of patients treated with cyclophosphamide, doxorubicin, vincristine and prednisone (CHO...

journal_title：Experimental and therapeutic medicine

authors： Xie W,Zhou D,Hu K,Xiao X,Huang W,He J,Shi J,Luo Y,Zhang J,Lin M,Cai Z,Huang H,Ye X

更新日期：2013-07-01 00:00:00

abstract：:Effects of curcumin on artery blood gas index of rats with pulmonary fibrosis caused by paraquat poisoning and the expression of Mothers against decapentaplegic homolog 4 (Smad4), Smad ubiquitination regulatory factor 2 (Smurf2), interleukin-4 (IL-4) and interferon-γ (IFN-γ) were explored. A total of 54 Wistar rats we...

journal_title：Experimental and therapeutic medicine

authors： Chen H,Yang R,Tang Y,Fu X

更新日期：2019-05-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) accounts for ~80% of all types of lung cancer, which has the highest morbidity and mortality of all types of cancer worldwide. It is important to identify novel biomarkers and the molecular mechanism of NSCLC to improve current treatments of NSCLC. The present study aimed to investig...

journal_title：Experimental and therapeutic medicine

authors： Luo H,Liang C

更新日期：2018-04-01 00:00:00

abstract：:Conjunctivitis associated systemic lupus erythematosus (caSLE) is a connective tissue autoimmune disease with a large spectrum of clinical manifestations. The disease may lead to ocular complications and in severe cases may be sight-threatening. This study investigated the expression of vascular adhesion protein-1 (VA...

journal_title：Experimental and therapeutic medicine

authors： Liu H,Zhang J,Zhou P,Sun H,Katsarou M,Drakoulis N

更新日期：2019-12-01 00:00:00

abstract：:The present study aims to investigate the effects and underlying mechanisms of miRNA-145 (miR-145) in rat models of chronic constriction injury (CCI). Rats were randomly divided into control, sham, CCI, agomiRNA (agomiR)-normal control (NC) and agomiR-145 groups (n=25 in each group); in addition, 30 rats with CCI were...

journal_title：Experimental and therapeutic medicine

authors： Pang X,Tang Y,Zhang D

更新日期：2016-12-01 00:00:00

abstract：:Pulmonary carcinoid tumors represent bronchopulmonary neuroendocrine neoplasms which might synthetize serotonin, histamine, bombesin or other types of hormones responsible for the development of a broad spectrum of signs and symptoms, known as carcinoid syndrome. Data of 98 patients submitted to surgery for bronchial ...

journal_title：Experimental and therapeutic medicine

authors： Savu C,Melinte A,Lukadi JL,Mirvald C,Savu C,Belu E,Diaconu C,Iliescu L,Balescu I,Stiru O,Bratu O,Gorecki G,Bacalbasa N

更新日期：2020-12-01 00:00:00

abstract：:Asthma is a major inflammatory airway disease with high incidence and mortality rates. The Global Initiative for Asthma released a report called 'The Global Burden of Asthma' in 2004. However, the specific pathogenesis of asthma remains unclear. An increasing number of studies have demonstrated that neuromedin U (NMU)...

journal_title：Experimental and therapeutic medicine

authors： Ren X,Dong F,Zhuang Y,Wang Y,Ma W

更新日期：2020-02-01 00:00:00

abstract：:It has been widely reported that the serum anion gap is significantly associated with mortality in intensive care unit (ICU); however, it remains unknown whether the association is present in aortic aneurysm (AA) patients. The present study aimed to investigate the association between the admission serum anion gap and...

journal_title：Experimental and therapeutic medicine

authors： Chen Q,Chen Q,Li L,Lin X,Chang SI,Li Y,Tian Z,Liu W,Huang K

更新日期：2018-09-01 00:00:00

abstract：:The interaction between TEM-1 β-lactamase and antibiotics is very important in the hydrolysis of antibiotics. In the present study, the recognition and binding of TEM-1 β-lactamase with three β-lactam antibiotics, including penicillin G, cefalexin and cefoxitin, was investigated by fluorescence and ultraviolet-visible...

journal_title：Experimental and therapeutic medicine

authors： Yang J,Li Q,Bian L

更新日期：2017-10-01 00:00:00

abstract：:The present study aimed to explore the effects of dexmedetomidine combined with etomidate on the expression levels of interleukin (IL)-17A and S-100β in rats with postoperative cognitive dysfunction (POCD). A total of 50 SD rats were randomly allocated into the control group, model group, etomidate group (Eto group), ...

journal_title：Experimental and therapeutic medicine

authors： Yu X,Xie Y

更新日期：2020-12-01 00:00:00

abstract：:The aim of the present study was to investigate the therapeutic effect of a combined treatment of Buyang Huanwu decoction (BYHWD), a well-known formula of traditional Chinese medicine, and neural stem cells (NSCs) on spinal cord injury (SCI) and the associated underlying mechanisms. A SCI model was established by surg...

journal_title：Experimental and therapeutic medicine

authors： Zhang M,Chai Y,Liu T,Xu N,Yang C

更新日期：2015-04-01 00:00:00

abstract：:Diffuse ganglioneuromatosis (DG) of the gastrointestinal tract is a rare condition that is closely associated with neurofibromatosis type 1 and multiple endocrine neoplasia type 2B. The occurrence of DG with multiple schwannomas, which, of the GI tract, usually affect the stomach, is considerably more rare. The presen...

journal_title：Experimental and therapeutic medicine

authors： Lu C,Qiu Y,Lu X,Li G,Bu H

更新日期：2015-03-01 00:00:00