Clinical analysis and prognostic significance of hepatitis B virus infections for diffuse large B-cell lymphoma with or without rituximab therapy.

Abstract:

:The aim of this study was to analyze the clinical features of hepatitis B surface antigen (HBsAg)-positive and negative diffuse large B-cell lymphomas (DLBCLs) and to compare the outcomes and serum hepatitis B virus (HBV)-DNA loads of patients treated with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) regimens with rituximab (RCHOP) or without. A total of 451 DLBCL patients, of which 90 were HBsAg-positive and 361 were HBsAg-negative, were retrospectively reviewed. We compared onset age, gender, Ann Arbor stage, international prognostic index (IPI), lactate dehydrogenase (LDH) and β2-microglobulin (β2-M) levels, as well as overall survival (OS) rates and HBV-DNA loads under CHOP or RCHOP regimens. The OS rate of the HBsAg-positive DLBCL patients was significantly lower than that of HBsAg-negative DLBCL patients and the HBsAg-positive DLBCL patients had an earlier median onset age. HBsAg-positive DLBCL patients had poorer OS rates compared with HBsAg-negative patients (62.2% HBsAg-positive vs. 76.2% HBsAg-negative, P=0.018). HBsAg-positive DLBCL patients with HBV-DNA loads >103 cps/ml during chemotherapy had significantly lower OS rates than those with lower HBV-DNA loads (48.4% HBV-DNA elevated vs. 71.2% HBV-DNA normal, P=0.037). HBsAg-positive DLBCL patients treated with RCHOP had a significantly higher OS rate (79.6%) compared with the 41 CHOP-treated patients (43.9%; P<0.001). HBsAg-positive DLBCL patients with an earlier median onset age and elevated HBV-DNA during chemotherapy had poorer prognoses. HBsAg and HBV-DNA during chemotherapy may be used as prognostic indicators for patients with DLBCL. Rituximab improves the outcome of HBsAg-positive DLBCL patients when administered in combination with anti-viral lamivudine.

journal_name

Exp Ther Med

authors

Xie W,Zhou D,Hu K,Xiao X,Huang W,He J,Shi J,Luo Y,Zhang J,Lin M,Cai Z,Huang H,Ye X

doi

10.3892/etm.2013.1079

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

109-114

issue

1

eissn

1792-0981

issn

1792-1015

pii

etm-06-01-0109

journal_volume

6

pub_type

杂志文章
  • Role of miR-145 in chronic constriction injury in rats.

    abstract::The present study aims to investigate the effects and underlying mechanisms of miRNA-145 (miR-145) in rat models of chronic constriction injury (CCI). Rats were randomly divided into control, sham, CCI, agomiRNA (agomiR)-normal control (NC) and agomiR-145 groups (n=25 in each group); in addition, 30 rats with CCI were...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2016.3900

    authors: Pang X,Tang Y,Zhang D

    更新日期:2016-12-01 00:00:00

  • Metformin in combination with rosiglitazone contribute to the increased serum adiponectin levels in people with type 2 diabetes mellitus.

    abstract::To evaluate how metformin plus rosiglitazone affect serum adiponectin levels in people suffering from type 2 diabetes mellitus (T2DM), 240 patients having T2DM were selected in this cohort study. Included subjects were randomly and equally separated into three subsets: i) Group A (rosiglitazone group); ii) group B (me...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4823

    authors: Nie JM,Li HF

    更新日期:2017-09-01 00:00:00

  • FABP4 alleviates endoplasmic reticulum stress-mediated ischemia-reperfusion injury in PC12 cells via regulation of PPARγ.

    abstract::Ischemic stroke is a life-threatening complication with a high rate of morbidity. Circulating fatty acid binding protein 4 (FABP4) has been reported to be associated with the outcome of acute ischemic stroke. The present study aimed to illustrate the function of FABP4 in ischemic stroke. PC12 cells exposed to oxygen g...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2021.9612

    authors: Yang XL,Mi JH,Dong Q

    更新日期:2021-03-01 00:00:00

  • Combination of ketamine and xylazine exacerbates cardiac dysfunction in severely scalded rats during the shock stage.

    abstract::Cardiac inhibition due to burn injury and anesthetics have been documented previously. However, little is known about their combined effects on cardiac function. The aim of the present study was to observe the effects of a ketamine/xylazine (K/X) combination on the cardiac function of rats with severe scalds and compa...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2013.1213

    authors: Feng Y,Chai J,Chu W,Ma L,Zhang P,Duan H

    更新日期:2013-09-01 00:00:00

  • miR-216a-5p acts as an oncogene in renal cell carcinoma.

    abstract::MiR-216a-5p has been acknowledged as an oncogene and is known to be involved in the progression and metastasis of numerous cancer subtypes. However, the potential role of miR-216a-5p in renal cell carcinoma (RCC) remains to be elucidated. In the present study, reverse transcription-quantitative polymerase chain reacti...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.5881

    authors: Chen P,Quan J,Jin L,Lin C,Xu W,Xu J,Guan X,Chen Z,Ni L,Yang S,Chen Y,Lai Y

    更新日期:2018-04-01 00:00:00

  • Detection and analysis of hepatitis C virus in HIV-infected patients in the Guangxi province of China.

    abstract::The aim of the present study was to investigate the prevalence rate of hepatitis C virus (HCV) infection in human immunodeficiency virus (HIV)-positive individuals and to study the infection status of HCV RNA in HIV-infected individuals who did not have anti-HCV antibodies in the Guangxi province of China, in order to...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4067

    authors: Wu SZ,Wei JL,Xu B,Wei PH,Yang Y,Qin B,Xie ZC

    更新日期:2017-03-01 00:00:00

  • Thalidomide and its analogues: A review of the potential for immunomodulation of fibrosis diseases and opthalmopathy.

    abstract::The US Food and Drug Administration approved thalidomide and its analogues for the treatment of erythema nodosum leprosum, in spite of the notoriety of reports of severe birth defects in the middle of the last century. As immunomodulatory drugs, thalidomide and its analogues have been used to effectively treat various...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.5209

    authors: Liu T,Guo F,Zhu X,He X,Xie L

    更新日期:2017-12-01 00:00:00

  • Cardiotoxicity and lung toxicity in male rats induced by long-term exposure to iron oxide and silver nanoparticles.

    abstract::Engineered nanoparticles (NPs) have been increasingly used in numerous fields over the last decade. In particular, iron oxide NPs (Fe2O3NPs) and silver NPs (AgNPs) have contributed to the current increase in NP usage. However, the possible side effects of increased NP exposure remain not fully elucidated. The present ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2019.8108

    authors: Yousef MI,Abuzreda AA,Kamel MA

    更新日期:2019-12-01 00:00:00

  • Effects of propofol on LC3II and mTOR/p-mTOR expression during ischemia-reperfusion myocardium injury in rats with type 2 diabetes mellitus.

    abstract::To investigate the effects of propofol on myocardial ischemia reperfusion in rats with type 2 diabetes, male adult rats were divided into five groups: Sham-operation (CC), ischemia-reperfusion (CI), low-dose propofol (LP), moderate-dose propofol (MP) and high-dose propofol (HP). The LP, MP and HP groups were administe...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2020.8499

    authors: Wang Y,Zhang K,Qi X,Yang G,Wang H,Zhang Z,Yang B

    更新日期:2020-04-01 00:00:00

  • Efficacy of hyperbaric oxygen treatment for depression in the convalescent stage following cerebral hemorrhage.

    abstract::The present study aimed to evaluate the clinical efficacy of hyperbaric oxygen (HBO) treatment for depression in the convalescent stage following cerebral hemorrhage. A total of 60 cases of patients with depression in the convalescent stage following cerebral hemorrhage (2-6 months) were randomly divided into the trea...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2013.1043

    authors: Cao H,Ju K,Zhong L,Meng T

    更新日期:2013-06-01 00:00:00

  • Influence of biomechanical and biochemical stimulation on the proliferation and differentiation of bone marrow stromal cells seeded on polyurethane scaffolds.

    abstract::The aim of the present investigation was to compare the effects of cyclic compression, perfusion, dexamethasone (DEX) and bone morphogenetic protein-7 (BMP-7) on the proliferation and differentiation of human bone marrow stromal cells (hBMSCs) in polyurethane scaffolds in a perfusion bioreactor. Polyurethane scaffolds...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2016.3206

    authors: Teng S,Liu C,Guenther D,Omar M,Neunaber C,Krettek C,Jagodzinski M

    更新日期:2016-06-01 00:00:00

  • Preparation of a new composite combining strengthened β-tricalcium phosphate with platelet-rich plasma as a potential scaffold for the repair of bone defects.

    abstract::β-tricalcium phosphate (β-TCP) and platelet-rich plasma (PRP) are commonly used in bone tissue engineering. In the present study, a new composite combining strengthened β-TCP and PRP was prepared and its morphological and mechanical properties were investigated by scanning electron microscopy (SEM) and material testin...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2014.1912

    authors: Wang C,Zhong D,Zhou X,Yin K,Liao Q,Kong L,Liu A

    更新日期:2014-10-01 00:00:00

  • Aberrant expression of miR-4728 in patients with non-small cell lung cancer and its regulatory effects on tumor progression in tumor cells.

    abstract::Non-small cell lung cancer (NSCLC) is a common malignant tumor with poor prognosis and an increasing number of cases. MicroRNA (miR)-4728 is related with the progression of various types of cancer, and is dysregulated in NSCLC, which indicates that miR-4728 may serve as a biomarker for NSCLC. The present study aimed t...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2020.9141

    authors: Hu Y,Zhang X,Gong C,Li J

    更新日期:2020-11-01 00:00:00

  • microRNA-192, -194 and -215 are frequently downregulated in colorectal cancer.

    abstract::microRNAs (miRNAs) are small, non-coding RNAs of endogenous origin. They have been increasingly shown to have aberrant expression in a number of tumor types. miR-192, -194 and -215 have not been comprehensively investigated using a large number of cases in colorectal cancer (CRC). We extracted total RNA from 107 CRC t...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2011.436

    authors: Chiang Y,Song Y,Wang Z,Liu Z,Gao P,Liang J,Zhu J,Xing C,Xu H

    更新日期:2012-03-01 00:00:00

  • Patient outcome prediction using multiple biomarkers in human melanoma: A clinicopathological study of 118 cases.

    abstract::The application of biomarkers in melanoma prognosis has been well recognized. However the ability of a single biomarker to predict melanoma patient outcome is usually limited. We previously examined the expression of ten biomarkers (Bim, BRG1, BRMS1, CTHRC1, ING4, NQO1, NF-κB-p50, PUMA, SNF5 and SOX4) in melanomas. To...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2010.169

    authors: Li J,Zhang Z,Li G

    更新日期:2011-01-01 00:00:00

  • Correlation of vitamin D receptor with bronchial asthma in children.

    abstract::This study was designed to investigate the correlation of vitamin D receptor (VDR) gene polymorphism with bronchial asthma in children. Seventy patients admitted to Daqing Longnan Hospital and diagnosed as bronchial asthma for the first time from April 2015 to May 2017 were selected as observation group. Patients rece...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.5739

    authors: Hou C,Zhu X,Chang X

    更新日期:2018-03-01 00:00:00

  • Recurrent pulmonary synovial sarcoma effectively treated with amrubicin: A case report.

    abstract::Pulmonary synovial sarcoma is a rare but aggressive disease. The present study describes the case of a 68-year-old female with pulmonary synovial sarcoma. The patient was mistakenly treated for small cell lung cancer due to false-positive staining for synaptophysin and cluster of differentiation 56. Despite severe mye...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2015.2308

    authors: Satoh H,Takayashiki N,Shiozawa T,Miyazaki K,Ohara G,Kagohashi K,Kurishima K,Sugita S,Aoyama T,Hasegawa T,Hizawa N

    更新日期:2015-05-01 00:00:00

  • Potential role of probiotics in the management of gastric ulcer.

    abstract::Gastric ulcer is one of the most common chronic gastrointestinal diseases characterized by a significant defect in the mucosal barrier. Helicobacter pylori (H. pylori) infection and the frequent long-term use of non-steroidal anti-inflammatory drugs are major factors involved in gastric ulcer development. Acid inhibit...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2016.3293

    authors: Khoder G,Al-Menhali AA,Al-Yassir F,Karam SM

    更新日期:2016-07-01 00:00:00

  • Rhynchophylline attenuates allergic bronchial asthma by inhibiting transforming growth factor-β1-mediated Smad and mitogen-activated protein kinase signaling transductions in vivo and in vitro.

    abstract::Rhynchophylline (Rhy) is a major active component of Uncaria rhynchophylla and exhibits the potential to inhibit the proliferation of airway smooth muscle cells (ASMCs). In the current study, it was hypothesized that Rhy serves a key role in the anti-asthma effect of Uncaria rhynchophylla by inhibiting transforming gr...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.6909

    authors: Wang M,Li H,Zhao Y,Lv C,Zhou G

    更新日期:2019-01-01 00:00:00

  • Effects of hypoxia on the proliferation, mineralization and ultrastructure of human periodontal ligament fibroblasts in vitro.

    abstract::This study aimed to investigate the effects of hypoxia on the proliferation, mineralization and ultrastructure of human periodontal ligament fibroblasts (HPLFs) at various times in vitro in order to further study plateau-hypoxia-induced periodontal disease. HPLFs (fifth passage) cultured by the tissue culture method w...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2013.1349

    authors: Zhang HY,Liu R,Xing YJ,Xu P,Li Y,Li CJ

    更新日期:2013-12-01 00:00:00

  • Systemic bioinformatics analysis of skeletal muscle gene expression profiles of sepsis.

    abstract::Sepsis is a type of systemic inflammatory response syndrome with high morbidity and mortality. Skeletal muscle dysfunction is one of the major complications of sepsis that may also influence the outcome of sepsis. The aim of the present study was to explore and identify potential mechanisms and therapeutic targets of ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.6026

    authors: Yang F,Wang Y

    更新日期:2018-06-01 00:00:00

  • Significance of human epidermal growth factor receptor 2 expression in colorectal cancer.

    abstract::The aim of the present study was to evaluate the protein expression level of human epidermal growth factor receptor 2 (HER-2) using immunohistochemistry (IHC), and assess the association with clinicopathological parameters and the prognosis of patients with colorectal cancer (CRC). In addition, the current study obser...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2014.2063

    authors: Tu J,Yu Y,Liu W,Chen S

    更新日期:2015-01-01 00:00:00

  • Metabolomic changes in patients with chronic obstructive pulmonary disease with abnormal Savda syndrome.

    abstract::The aim of this study was to determine the metabolic biomarkers for abnormal Savda syndrome in patients with chronic obstructive pulmonary disease (COPD). Based on Traditional Uyghur Medicine (TUM) theory, a total of 103 patients with COPD were classified into abnormal Savda and non-abnormal Savda syndrome groups and ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2014.2085

    authors: Xu WF,Upur H,Wu YH,Mamtimin B,Yang J,Ga YJ,You L

    更新日期:2015-02-01 00:00:00

  • Peritumoral cystic meningioma: A report of two cases and review of the literature.

    abstract::The present study reported two cases of cystic meningioma. The clinical manifestations, magnetic resonance imaging (MRI) scan and histological aspects of the lesion and the associated cyst were examined. The classification of cystic meningioma was also discussed. The present study focused on the formation, diagnosis a...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2016.2999

    authors: Wang P,Han S,Liu N,Yu C,Qi X,Zhu M,Zhang X,Wang LI,Yan C

    更新日期:2016-03-01 00:00:00

  • Subtraction CT angiography for the detection of intracranial aneurysms: A meta-analysis.

    abstract::The aim of this meta-analysis was to investigate the accuracy of subtraction computed tomography angiography (CTA) for diagnosing intracranial aneurysms. A systematic literature search up to January 1, 2013 was performed in PubMed. Two independent reviewers selected 8 studies that compared subtraction CTA with digital...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2016.3166

    authors: Feng TY,Han XF,Lang R,Wang F,Wu Q

    更新日期:2016-05-01 00:00:00

  • Supraorbital eyebrow keyhole approach for microsurgical management of ruptured anterior communicating artery aneurysm.

    abstract::The mortality and disability rate of patients with ruptured anterior communicating artery (AComA) aneurysm after bleeding is high. Even with the most advanced treatment methods, the incidence of complications remains high. The purpose of the present study was to determine the efficacy of microsurgery via supraorbital ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2020.8909

    authors: Bhattarai R,Liang C,Chen C,Wang H,Huang T,Ning X,Guo Y

    更新日期:2020-09-01 00:00:00

  • Anxiety and depression in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: Results from a Chinese survey.

    abstract::Limited studies have focused on mental symptoms (anxiety and depression) and their impact on quality of life (QoL) in patients with pulmonary hypertension (PH). The objective of the present study was to assess the prevalence of anxiety and depression and their association with QoL in patients with pulmonary arterial h...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2020.8566

    authors: Zhou X,Shi H,Yang Y,Zhang Z,Zhai Z,Wang C

    更新日期:2020-04-01 00:00:00

  • Long non-coding RNA LINC00707 acts as a competing endogenous RNA to enhance cell proliferation in colorectal cancer.

    abstract::Long non-coding RNAs (lncRNAs) have been indicated to serve critical roles in cancer development and progression. Long intergenic non-protein coding RNA 70 (LINC00707) was recently reported to be an oncogene involved in the tumorigenesis of several types of human cancer. However, the clinical role, biological function...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2019.8350

    authors: Wang H,Luan H,Zhan T,Liu X,Song J,Dai H

    更新日期:2020-02-01 00:00:00

  • Vascular endothelial growth factor +936C/T polymorphism and gastric cancer risk: A meta-analysis.

    abstract::The aim of this study was to determine whether the vascular endothelial growth factor (VEGF) +936C/T polymorphism confers susceptibility to gastric cancer (GC) by conducting a meta-analysis. Publications addressing the association between the VEGF +936C/T polymorphism and GC risk were selected from the Pubmed, Embase ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2011.278

    authors: Zhou LP,Luan H,Dong XH,Jin GJ,Man DL,Shang H

    更新日期:2011-09-01 00:00:00

  • Effects of ozone stimulation of bronchial epithelial cells on proliferation and collagen synthesis of co-cultured lung fibroblasts.

    abstract::Ozone (O3) as a major air pollutant is widely recognized for causing pathological changes of the airway system. However, it is not clear whether O3 exposure of bronchial epithelial cells (BECs) influences the proliferation and collagen synthesis of submucosal fibroblasts and contributes to the pathogenesis of airway r...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.6122

    authors: Wang Y,Tan M,Ouyang H,Deng L

    更新日期:2018-06-01 00:00:00