Endocrinological analysis of endothelium-dependent vasodilation in middle-aged patients with impaired glucose tolerance during prediabetes mellitus.

abstract：:A major consequence of obstructive jaundice (OJ) in clinical practice is the development of severe liver injury, and at present, no effective treatments have been developed to protect against it. Preconditioning with damage-associated molecular pattern (DAMP) molecules has been demonstrated to protect multiple organs ...

journal_title：Experimental and therapeutic medicine

authors： Zhou YX,Ni Y,Liu YB,Liu X

更新日期：2014-07-01 00:00:00

abstract：:The functions of telomeric repeat-binding factor 1 (TRF1) and 2 (TRF2) in oral carcinogenesis are largely unexplored. This study examined the relationship between the expression of TRF1 and TRF2 and clinicopathological variables and survival in oral cavity squamous cell carcinoma (OCSCC). Western blotting and immunohi...

journal_title：Experimental and therapeutic medicine

authors： Chuang HC,Chen CH,Huang CC,Fang FM,Tsai HT,Chien CY

更新日期：2011-01-01 00:00:00

abstract：:The present study aimed to investigate the effect of glutathione S-transferase A1 (GSTA1) on lung cancer cell viability, invasion and adhesion in the presence of nicotine in vitro. Furthermore, the effect of GSTA1 on the epithelial-mesenchymal transition (EMT), a process strongly associated with lung cancer metastasis...

journal_title：Experimental and therapeutic medicine

authors： Wang W,Liu F,Wang C,Wang C,Tang Y,Jiang Z

更新日期：2017-08-01 00:00:00

abstract：:A 58-year-old female exhibited the onset of symmetrical sensory abnormalities of the face and extremities. The neurological examination revealed normal muscle strength with abated or absent tendon reflexes. The patient experienced symmetrical glove- and stocking-type pinprick sensations in the distal extremities and a...

journal_title：Experimental and therapeutic medicine

authors： Zhang J,Liu N,Zhang ZC,Zheng RZ,Li Q

更新日期：2014-12-01 00:00:00

abstract：:The present study aimed to investigate the effects of glycerol on the physical properties and release of an insulin-loaded polyvinyl alcohol (PVA) hydrogel film. The insulin-loaded hydrogel composite film was produced using the freeze-thawing method, after which the in vitro swelling ratio, transmittance and insulin r...

journal_title：Experimental and therapeutic medicine

authors： Cai Y,Che J,Yuan M,Shi X,Chen W,Yuan WE

更新日期：2016-10-01 00:00:00

abstract：:Ginsenoside Rb1 (GRb1), which is one of the main ingredients derived from Panax ginseng, has been widely used to treat various gastrointestinal disorders. The present study aimed to determine whether GRb1 was able to prevent intestinal mucosal barrier damage in rats following peritoneal air exposure for 3 h. GRb1 (5, ...

journal_title：Experimental and therapeutic medicine

authors： Zhou F,Zhang P,Chen X,Yan J,Yao J,Yu Z,Chen X

更新日期：2016-10-01 00:00:00

abstract：:Chronic heart disease contributes to the mortality of patients with AIDS. Although studies of left ventricular function in patients with acquired immune deficiency syndrome (AIDS) have been conducted, studies of right ventricular function are rare. The present study aimed to characterize the tricuspid annulus movement...

journal_title：Experimental and therapeutic medicine

authors： Zhu H,Yuan J,Wei C,Chen J,Wang Y

更新日期：2014-03-01 00:00:00

abstract：:Effect of total glucosides of paeony on the changes of IL-4 and ICAM-1 levels in eczema mouse model serum was investigated. A total of 38 KM mice of SPF grade were divided into 3 groups: the control group (n=10), the model group (n=15) and the treatment group (n=13). The pathological model of chronic eczema in mouse r...

journal_title：Experimental and therapeutic medicine

authors： Zhou M,Sui H

更新日期：2019-03-01 00:00:00

abstract：:The present study aimed to investigate the influence of mouse nerve growth factor (mNGF) on glial fibrillary acidic protein (GFAP) expression in neonatal rats with hypoxic-ischemic brain damage (HIBD). A total of 60 7-day-old neonatal rats were randomly divided into control, HIBD and mNGF groups (n=20). The rats in th...

journal_title：Experimental and therapeutic medicine

authors： Yin X,Dong L,Wei W,Wang Y,Chai Y,Feng Z

更新日期：2013-02-01 00:00:00

abstract：:The hypoxia-reoxygenation process of obstructive sleep apnea (OSA) may cause oxidative stress injury of the kidney, but the molecular mechanisms are not clear. The present study aimed to investigate whether high mobility group box 1 protein (HMGB1) and its subsequent inflammatory pathway served a role in kidney injury...

journal_title：Experimental and therapeutic medicine

authors： Zhang C,Dong H,Chen F,Wang Y,Ma J,Wang G

更新日期：2019-01-01 00:00:00

abstract：:The present study aimed to investigate the clinical characteristics of von Hippel-Lindau (VHL) disease and the clinical significance of VHL gene detection. The clinical materials of patients with VHL disease were collected from 3 different families between May 1985 and October 2017. A systematic pedigree study and VHL...

journal_title：Experimental and therapeutic medicine

authors： Lin G,Zhao Y,Zhang Z,Zhang H

更新日期：2020-08-01 00:00:00

abstract：:Thymic carcinoma is a rare thymic epithelial tumor in which chemotherapy for advanced disease has not yet been established. Thymidylate synthase (TS) and orotate phosphoribosyltransferase (OPRT) protein expression levels in thymic carcinoma were evaluated as possible indicators of the anticancer activity of 5-fluorour...

journal_title：Experimental and therapeutic medicine

authors： Yokota K,Sasaki H,Okuda K,Shitara M,Hikosaka Y,Moriyama S,Yano M,Fujii Y

更新日期：2012-10-01 00:00:00

abstract：:The present multicentre, prospective, open-label, single treatment arm study (Val-Perfect) examined the efficacy and tolerability of once-daily valsartan monotherapy (80 mg for two weeks, followed by 160 mg for eight weeks) in 195 Chinese patients with mild to moderate hypertension, using office, home, and ambulatory ...

journal_title：Experimental and therapeutic medicine

authors： Sun N,Feng Y,Gao P,Chen X,Qi L,Zhang S,Dong Y,Yang X,Li X,Chen Y,Liu L

更新日期：2017-03-01 00:00:00

abstract：:The present study investigated the characteristic features of cancer stem cells (CSCs) using an aggressive human osteosarcoma cell line OS-65. Hoechst 33342 dye exclusion was used to distinguish the cancer stem-like side population (SP) cells from OS-65 cells. Furthermore, the SP cells were characterized via chemoresi...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Teng JS

更新日期：2016-07-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of S-adenosyl methionine (SAMe) on infectious premature inflammatory factors and uterine contraction, and to further explore its mechanism of action via the transient receptor protein 3 (TRPC3)/protein kinase Cβ (PKCβ)/C-kinase-activated protein phosphatase-1...

journal_title：Experimental and therapeutic medicine

authors： Ge J,Han T,Li X,Shan L,Zhang J,Hong Y,Xia Y,Wang J,Hou M

更新日期：2018-07-01 00:00:00

abstract：:A standard systemic therapy for patients with human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer (ABC) is yet to be identified. Sorafenib has been developed for the treatment of solid tumors, including breast cancer, as an oral multikinase inhibitor with antiangiogenic and antiproliferativ...

journal_title：Experimental and therapeutic medicine

authors： Tan QX,Qin QH,Lian B,Yang WP,Wei CY

更新日期：2014-05-01 00:00:00

abstract：:The initiation and progression of various types of tumors, such as lung neoplasms, are driven by a population of cells with stem cell properties and their microenvironment. Bone marrow mesenchymal stem cells (BM-MSCs) in long-term in vitro culture may exhibit spontaneous changes in stem cell biological properties, inc...

journal_title：Experimental and therapeutic medicine

authors： Zhang YM,Zhang ZM,Guan QL,Liu YQ,Wu ZW,Li JT,Su Y,Yan CL,Luo YL,Qin J,Wang Q,Xie XD

更新日期：2017-10-01 00:00:00

abstract：:Chemotherapy-induced anorexia (CIA), which may lead to severe nutrition-associated problems, is a common complication associated with anti-cancer therapies. In the present study, the anti-anorexigenic effect of electroacupuncture (EA) was explored through assessing a change in appetite-associated peptides and c-Fos ex...

journal_title：Experimental and therapeutic medicine

authors： Kang KS,Huh W,Bang Y,Choi HJ,Baek JY,Song JH,Kang JW,Kim TH

更新日期：2019-04-01 00:00:00

abstract：:β-elemene is a novel, plant-derived anticancer drug, which has been used to target multiple solid tumor types. Hyperthermia is an adjuvant therapeutic modality to treat cancer. However, the underlying mechanisms associated with the efficacy of these two treatments are largely unknown. The aim of the present study was ...

journal_title：Experimental and therapeutic medicine

authors： Wu Z,Wang T,Zhang Y,Zheng Z,Yu S,Jing S,Chen S,Jiang H,Ma S

更新日期：2017-06-01 00:00:00

abstract：:Expression of TGF-β1 and miR-99a in patients with early spontaneous abortion and correlation with hormone levels during pregnancy were investigated. A total of 70 pregnant women with early spontaneous abortion diagnosed in Jining No. 1 People's Hospital from February 1, 2015 to May 1, 2018 were selected as the study g...

journal_title：Experimental and therapeutic medicine

authors： Xie J,Cao Y

更新日期：2019-06-01 00:00:00

abstract：:Schwannomas are benign encapsulated tumors arising from Schwann cells in the peripheral nervous system. Between 25 and 45% of schwannomas occur in the head and neck region. Schwannomas of the larynx are extremely rare with an incidence of 0.1-1.5% in all benign laryngeal tumors. Laryngeal schwannomas usually occur in ...

journal_title：Experimental and therapeutic medicine

authors： Wang B,Dong P,Shen B,Xu H,Zheng J

更新日期：2014-04-01 00:00:00

abstract：:Diagnostic value between IL-17 combined with IL-18 and CT angiography in carotid atherosclerosis was evaluated. A total of 158 patients with suspected carotid artery stenosis in People's Hospital of Dongying from March 2014 to April 2017 were selected as the subjects. One hundred and two patients with carotid atherosc...

journal_title：Experimental and therapeutic medicine

authors： Suo F,Jiang F,Fang X,Ma A,Ma L

更新日期：2019-02-01 00:00:00

abstract：:The Chinese population are at an increased risk of autoimmune hepatitis (AIH). The aims of this study were to determine the demographic and clinical features of AIH in China. A total of 83 patients with AIH diagnosed by the revised scoring system were re-analyzed, and the clinical presentations among the different age...

journal_title：Experimental and therapeutic medicine

authors： Peng M,Li Y,Zhang M,Jiang Y,Xu Y,Tian Y,Peng F,Gong G

更新日期：2014-01-01 00:00:00

abstract：:The aim of this study was to validate the feasibility of modified frontolateral partial laryngectomy without tracheotomy using animal experiments. The glottic area before and after surgery of 6 excised canine larynges and 10 canine larynges in vivo were compared to observe whether the glottic area following modified f...

journal_title：Experimental and therapeutic medicine

authors： Xu H,Dong P,Sun Z,Xie J

更新日期：2013-02-01 00:00:00

abstract：:The association between Helicobacter pylori (H. pylori) infection and metabolic syndrome (MetS) determined in different cohorts from different countries is currently inconclusive. In the majority of previous studies, H. pylori infection was diagnosed based on the presence of H. pylori IgG antibody in the serum. Howeve...

journal_title：Experimental and therapeutic medicine

authors： Yu Y,Cai J,Song Z,Wang J,Wu L

更新日期：2019-06-01 00:00:00

abstract：:Certain microRNAs (miRs) regulate the progression and metastasis of various cancer types. In the present study, the role of miR-370 in the progression and proliferation of human astrocytoma and glioblastoma cells was assessed and the underlying molecular mechanism was investigated. miR-370 levels in clinical specimens...

journal_title：Experimental and therapeutic medicine

authors： Lu M,Wang Y,Zhou S,Xu J,Li J,Tao R,Zhu Y

更新日期：2018-01-01 00:00:00

abstract：:The complex network of etiological factors, signals and tissue responses involved in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) cannot be successfully targeted by a single therapeutic agent. Multimodal approaches to the therapy of CP/CPPS have been and are currently being tested, as in the frame of com...

journal_title：Experimental and therapeutic medicine

authors： Magri V,Marras E,Restelli A,Wagenlehner FM,Perletti G

更新日期：2015-03-01 00:00:00

abstract：:The present study reported a case of portopulmonary hypertension (POPH) that was secondary to underlying liver cirrhosis in a 58-year-old woman, who was successfully treated with low-dose tolvaptan. The patient had suffered from refractory peripheral edema and electrolyte abnormalities, including severe hypokalemia, u...

journal_title：Experimental and therapeutic medicine

authors： Ogihara Y,Yamada N,Dohi K,Matsuda A,Ota S,Ishikura K,Nakamura M,Ito M

更新日期：2017-01-01 00:00:00

abstract：:Thyroid hormone receptor-interacting protein 6 (TRIP6), a member of the zyxin family of Lin-Isl-Mec (LIM) proteins, is an adaptor protein primarily expressed in epithelial cells. TRIP6 can regulate a variety of cellular responses, such as actin cytoskeletal reorganization and cell adhesion. However, to the best of our...

journal_title：Experimental and therapeutic medicine

authors： Liu W,Cheng L,Li Q,Jing J

更新日期：2020-03-01 00:00:00

abstract：:The universal endocrine pathological state affecting young individuals and adults is type 2 diabetes mellitus, which has seen a significant increase in the last 30 years, particularly in children. Genetic and evnironmental factors are the causative agents for this pathological state in children. This rapid and wide sp...

journal_title：Experimental and therapeutic medicine

authors： Xue Y,Gao M,Gao Y

更新日期：2016-10-01 00:00:00