Effects of curcumin on artery blood gas index of rats with pulmonary fibrosis caused by paraquat poisoning and the expression of Smad 4, Smurf 2, interleukin-4 and interferon-γ.

abstract：:Hepatic stellate cells (HSCs) have been demonstrated to have immunoinhibitory activity. The aim of this study was to investigate the role of HSCs in the development of immunotolerance following liver transplantation. A rat liver transplantation tolerance model [donor Lewis into recipient Dark Agouti (DA)] and rejectio...

journal_title：Experimental and therapeutic medicine

authors： Jiang Z,Chen Y,Feng X,Jiang J,Chen T,Xie H,Zhou L,Zheng S

更新日期：2013-01-01 00:00:00

abstract：:An increasing number of cancer patients receive outpatient chemotherapy as an alternative to inpatient chemotherapy. The aim of this study was to investigate whether quality of life (QOL) during outpatient chemotherapy was better than QOL prior to hospital discharge, and to explore possible related factors prior to ho...

journal_title：Experimental and therapeutic medicine

authors： Matsuda A,Kobayashi M,Sakakibara Y,Tamaoka M,Furuiye M,Inase N,Matsushima E

更新日期：2011-03-01 00:00:00

abstract：:The aim of this study is to determine the accuracy rate of bronchopulmonary dysplasia (BPD) diagnosis and risk factors of short-term poor prognosis for premature infants. This study analyzed the clinical data of 81 premature infants (<32 weeks gestational age) with BPD, who were on oxygen therapy >28 days, and survive...

journal_title：Experimental and therapeutic medicine

authors： Du Z,Kong X,Ren Y,Feng Z,Huang J,Chen J,Wang R

更新日期：2017-10-01 00:00:00

abstract：:Psoriasis is a T cell mediated, chronic inflammatory autoimmune skin disease that affects up to 2-3% of the global population and leads to a decrease in quality of life. Experimental data accumulated in recent years highlighted the important role played by the immune system in the pathogenesis of this disease. Non-hum...

journal_title：Experimental and therapeutic medicine

authors： Surcel M,Huică RI,Munteanu AN,Isvoranu G,Pîrvu IR,Ciotaru D,Constantin C,Bratu O,Căruntu C,Neagu M,Ursaciuc C

更新日期：2019-02-01 00:00:00

abstract：:The universal endocrine pathological state affecting young individuals and adults is type 2 diabetes mellitus, which has seen a significant increase in the last 30 years, particularly in children. Genetic and evnironmental factors are the causative agents for this pathological state in children. This rapid and wide sp...

journal_title：Experimental and therapeutic medicine

authors： Xue Y,Gao M,Gao Y

更新日期：2016-10-01 00:00:00

abstract：:In the present study, we demonstrate that the degeneration of intervertebral discs is caused by ageing and apoptosis of matrix cells. Apoptosis is as essential as the function of proteoglycan synthesis in assessing the possible degeneration of intervertebral discs; paeoniflorin (PF) induces cytoprotective effects on v...

journal_title：Experimental and therapeutic medicine

authors： Chen SQ,Lin JP,Zheng QK,Chen SJ,Li M,Lin XZ,Wang SZ

更新日期：2015-12-01 00:00:00

abstract：:Lung cancer is an aggressive type of cancer that is associated with a high mortality rate. Lung cancer-initiating cells are populations of self-renewing cancer cells with pluripotent differentiation ability. Cancers typically originate from multiple phenotypically distinct cancer-initiating cells. CD133 and CD44 are s...

journal_title：Experimental and therapeutic medicine

authors： Huang X,Wan J,Leng D,Zhang Y,Yang S

更新日期：2020-01-01 00:00:00

abstract：:Immunomodulatory or immunosuppressive properties of bone marrow-derived mesenchymal stem cells (BM-MSCs) facilitate the treatment of acute respiratory distress syndrome and acute lung injury (ALI). Dysregulated miRNA (miRNA or miR) expression associated with the effects of BM-MSCs was assessed in a rat model of lipopo...

journal_title：Experimental and therapeutic medicine

authors： Park J,Jeong S,Park K,Yang K,Shin S

更新日期：2018-06-01 00:00:00

abstract：:This study aimed to investigate the reliability of ultrasound two-dimensional speckle tracking imaging (2D-STI) for the evaluation of myocardial ischemia in familial hypercholesterolemia (FH) patients. We recruited 28 patients clinically diagnosed with homozygous familial hypercholesterolemia (HoFH) and subjected them...

journal_title：Experimental and therapeutic medicine

authors： Song Y,Zhang RF,Liu Y

更新日期：2017-08-01 00:00:00

abstract：:Effects of ropivacaine at different concentrations on intrapartum fever, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in parturient with epidural labor analgesia were compared to provide reference for the rational selection of anesthetics in clinic. Medical records of 198 cases of primi-paras admitted to t...

journal_title：Experimental and therapeutic medicine

authors： Zhou X,Li J,Deng S,Xu Z,Liu Z

更新日期：2019-03-01 00:00:00

abstract：:The present study analyzed the ultrasonic features of papillary thyroid microcarcinoma (PTMC) and papillary thyroid non-microcarcinoma (non-PTMC) with the aim of improving the diagnostic value of ultrasonography. The ultrasonic features of 328 patients with papillary thyroid carcinoma (PTC), as confirmed by pathology,...

journal_title：Experimental and therapeutic medicine

authors： Zhang XL,Qian LX

更新日期：2014-10-01 00:00:00

abstract：:The present study was designed to observe the initiation of mitophagy in tumor cells after ultrasound treatment in the presence of curcumin under transmission electron microscopy. Nasopharyngeal carcinoma CNE2 cells were incubated with 10 μM curcumin and then exposed to ultrasound for 8 sec at an intensity of 0.46 W/c...

journal_title：Experimental and therapeutic medicine

authors： Wang X,Leung AW,Luo J,Xu C

更新日期：2012-01-01 00:00:00

abstract：:The present study aimed to investigate whether serum interleukin-6 (IL-6) expression levels were associated with the onset and progression of intervertebral disc degeneration (IDD). A comprehensive meta-analysis of the scientific literature from numerous electronic databases was performed, in order to obtain published...

journal_title：Experimental and therapeutic medicine

authors： Deng X,Zhao F,Kang B,Zhang X

更新日期：2016-04-01 00:00:00

abstract：:The therapeutic effect of saikosaponin a (SSa) on hyperlipidemic pancreatitis (HP) is not completely understood. The aim of the present study was to investigate the therapeutic effect and the underlying mechanism of SSa using a rat model of HP. Following successful establishment of the HP rat model, different doses of...

journal_title：Experimental and therapeutic medicine

authors： Feng P,Xu Y,Tong B,Tong X,Bian Y,Zhao S,Shen H

更新日期：2020-02-01 00:00:00

abstract：:Effects of dexmedetomidine on postoperative cognitive function in patients undergoing coronary artery bypass grafting were investigated. Eighty patients undergoing systemic anesthesia with extracorporeal coronary artery bypass grafting in The People's Hospital of Guangxi Zhuang Autonomous Region from January 2015 to A...

journal_title：Experimental and therapeutic medicine

authors： Gong Z,Li J,Zhong Y,Guan X,Huang A,Ma L

更新日期：2018-12-01 00:00:00

abstract：:To investigate the in vivo and in vitro inhibitory effects of deuterium-depleted water (DDW) on human lung cancer and the possible mechanisms underlying these effects, we cultured and treated human lung carcinoma cell line A549 and human embryonic lung fibroblasts HLF-1 with various concentrations of DDW from 2 to 72 ...

journal_title：Experimental and therapeutic medicine

authors： Cong FS,Zhang YR,Sheng HC,Ao ZH,Zhang SY,Wang JY

更新日期：2010-03-01 00:00:00

abstract：:The aim of the present study was to examine the effects of phacoemulsification and intraocular lens implantation combined with ciliarotomy in the treatment of angle-closure glaucoma with cataract in the elderly. A total of 68 patients were consecutively selected and divided into the control group with 33 cases (48 eye...

journal_title：Experimental and therapeutic medicine

authors： Li B,Wang FY,Lv TL,Zhu Y

更新日期：2016-10-01 00:00:00

abstract：:17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) is a water soluble, semisynthetic derivative of endotoxin that has anticancer effects. The aim of the present study was to determine whether 17-DMAG enhances the apoptosis of lymphoma cells in diffuse large B-cell lymphoma. Apoptosis was induced in SU-DHL-4...

journal_title：Experimental and therapeutic medicine

authors： Li JJ,Zhang JJ,Wang X,Sun ZM

更新日期：2017-10-01 00:00:00

abstract：:The aim of this study was to analyze the concentration changes of nuclear factor-κB (NF-κB) and the related inflammatory factors of pre-treatment and post-treatment in children with viral encephalitis, to examine the mechanism of NF-κB in the pathogenesis of child viral encephalitis. Twenty-two children with severe vi...

journal_title：Experimental and therapeutic medicine

authors： Zhang D,Zheng N,Liu X

更新日期：2017-06-01 00:00:00

abstract：:Cytomegalovirus (CMV) infection is the most common congenital infection worldwide, and remains a significant cause of the neurological deficiency and sensory deafness in developed countries. Maternal primary infection, reactivation or reinfection during pregnancy may lead to fetal infection and congenital CMV syndrome...

journal_title：Experimental and therapeutic medicine

authors： Gorun F,Motoi S,Malita D,Navolan DB,Nemescu D,Olariu TR,Craina M,Vilibic-Cavlek T,Ciohat I,Boda D,Dobrescu A

更新日期：2020-09-01 00:00:00

abstract：:In the present study, we studied the influence of serum high-molecular weight adiponectin (HMWA) levels in patients with pregnancy-induced hypertension (PIH) on the occurrence of eclampsia in secondary pregnancy and its related mechanisms. In total, 130 patients who were diagnosed with PIH for the first time were sele...

journal_title：Experimental and therapeutic medicine

authors： Xu Q,Fan D,Li F,Zhang Z

更新日期：2017-11-01 00:00:00

abstract：:Ischemic heart disease is a major cause of mortality and disability worldwide. Timely reperfusion is currently the most effective method of treating ischemic heart disease; however, abrupt reperfusion may cause ischemia/reperfusion (I/R) injury. Apoptosis serves an important role in the progression of myocardial I/R i...

journal_title：Experimental and therapeutic medicine

authors： Tan H,Chen L,Ma J

更新日期：2017-11-01 00:00:00

abstract：:The present study aimed to evaluate the impact of small interfering RNA (siRNA) targeting of the survivin gene in human tumor cells and the effect of decreased survivin expression on the proliferation and apoptosis of tumor cells. Human tumor cell lines (MSA-MB-231, SGC-7901, HeLa, A549, SK-OV-3 and Raji, PC-3) were c...

journal_title：Experimental and therapeutic medicine

authors： Zhang Z,Wang T,Liu Z,Tang S,Yue M,Feng S,Hu M,Xuan L,Chen Y

更新日期：2017-07-01 00:00:00

abstract：:The aim of the present study was to investigate the ability of bone marrow-derived mesenchymal stem cells (BMSCs) to repair radiation-induced acute intestinal injury, and to elucidate the underlying repair mechanism. Male Sprague-Dawley rats were subjected to whole abdominal irradiation using a single medical linear a...

journal_title：Experimental and therapeutic medicine

authors： Zheng K,Wu W,Yang S,Huang L,Chen J,Gong C,Fu Z,Lin R,Tan J

更新日期：2016-06-01 00:00:00

abstract：:In vitro differentiation of human embryonic stem cells (hESCs) into endometrium-like cells may provide a useful tool for clinical treatment. The aim of the present study was to investigate the differentiation potential of hESCs into endometrium-like cells using three methods, which included induction by feeder cells, ...

journal_title：Experimental and therapeutic medicine

authors： Yu W,Niu W,Wang S,Chen X,Sun BO,Wang F,Sun Y

更新日期：2015-07-01 00:00:00

abstract：:Hepatitis B virus (HBV) can establish a lifelong chronic infection in humans, leading to liver cirrhosis, liver failure and hepatocellular carcinoma. Patients with chronic hepatitis B (CHB) exhibit a weak virus-specific immune response. Regulatory T cells (Tregs) play a key role in regulating the immune response in pa...

journal_title：Experimental and therapeutic medicine

authors： Tang R,Lei Z,Wang X,Qi Q,He J,Liu D,Wang X,Chen X,Zhu J,Li Y,Zhou S,Su C

更新日期：2020-10-01 00:00:00

abstract：:The application of lidocaine can lead to nerve damage. Evidence suggests that patients with diabetic neuropathy are at a higher risk for neurotoxicity. In the present study, the successful induction of diabetic neuropathic pain (DNP) in rats via a high-sugar, high-fat diet and intraperitoneal injection of 1% streptozo...

journal_title：Experimental and therapeutic medicine

authors： Zheng X,Chen L,Du X,Cai J,Yu S,Wang H,Xu G,Luo Z

更新日期：2017-06-01 00:00:00

abstract：:Paeoniflorin serves important cellular roles, exerting anti-cancer, anti-inflammatory and anti-pulmonary fibrosis effects and possesses immune-modulatory properties. However, the exact role of paeoniflorin in the pathogenesis of osteoarthritis (OA) remains unclear. The aim of the present study was to investigate the e...

journal_title：Experimental and therapeutic medicine

authors： Hu PF,Sun FF,Jiang LF,Bao JP,Wu LD

更新日期：2018-08-01 00:00:00

abstract：:The objective of this study was to investigate the protective effects of scopolamine and penehyclidine hydrochloride on acute cerebral ischemia-reperfusion injury after cardiopulmonary resuscitation, and the effect on cytokine levels. Eighty patients with cardiac arrest admitted to our hospital from June 2011 to Decem...

journal_title：Experimental and therapeutic medicine

authors： Wang D,Jiang Q,Du X

更新日期：2018-02-01 00:00:00

abstract：:The aim of the present study was to investigate the protective effects of ischemic preconditioning on rats with renal ischemia-reperfusion injury and the effects on the expression of Bcl-2 and Bax. Thirty-six SD rats were randomly divided into three groups (n=12) including sham operation (S) group, ischemia-reperfusio...

journal_title：Experimental and therapeutic medicine

authors： Shen S,Zhou J,Meng S,Wu J,Ma J,Zhu C,Deng G,Liu D

更新日期：2017-11-01 00:00:00