Exercise reduces hyperlipidemia-induced kidney damage in apolipoprotein E-deficient mice.

abstract：:Hypertension is a very common cardiovascular disorder, however, the molecular mechanism underlying this disease remains poorly understood. Recently, an increasing number of studies have demonstrated that mitochondrial (mt)DNA mutations serve important roles in the pathogenesis of hypertension. The current study report...

journal_title：Experimental and therapeutic medicine

authors： Lin L,Cui P,Qiu Z,Wang M,Yu Y,Wang J,Sun Q,Zhao H

更新日期：2019-03-01 00:00:00

abstract：:This study aimed to analyze the correlation between single nucleotide polymorphisms (SNPs) of the actin, aortic smooth muscle (ACTA2) gene and coronary artery stenosis in patients with type 2 diabetes mellitus (T2DM). Eight SNPs from the promoter region of the ACTA2 gene were screened. Patients with T2DM (n=251) were ...

journal_title：Experimental and therapeutic medicine

authors： Fang H,Luo X,Wang Y,Liu N,Fu C,Wang H,Fang Y,Shi W,Zhang Y,Zeng C,Wang X

更新日期：2014-04-01 00:00:00

abstract：:Acute cerebral ischemia/reperfusion injury (ACIR) rat model was used to investigate the effect of spermine on oxidative stress and apoptosis. Sixty healthy and clean male Sprague-Dawley rats were randomly divided into 3 groups: The sham-operated group (n=12), the model group (n=12) and the experiment group (n=36). The...

journal_title：Experimental and therapeutic medicine

authors： Du H,Ming X,Zhou S

更新日期：2017-07-01 00:00:00

abstract：:The aim of the present investigation was to compare the effects of cyclic compression, perfusion, dexamethasone (DEX) and bone morphogenetic protein-7 (BMP-7) on the proliferation and differentiation of human bone marrow stromal cells (hBMSCs) in polyurethane scaffolds in a perfusion bioreactor. Polyurethane scaffolds...

journal_title：Experimental and therapeutic medicine

authors： Teng S,Liu C,Guenther D,Omar M,Neunaber C,Krettek C,Jagodzinski M

更新日期：2016-06-01 00:00:00

abstract：:The present study aimed to examine the effects of rivastigmine hydrogen tartrate and donepezil hydrochloride on the cognitive function and mental behavior of patients with Alzheimer's disease (AD). For this purpose, a total of 126 patients with AD admitted to Luoyang Central Hospital from January, 2018 to December, 20...

journal_title：Experimental and therapeutic medicine

authors： Zhang X,Yu R,Wang H,Zheng R

更新日期：2020-08-01 00:00:00

abstract：:Efficient apoptosis requires Bcl-2 family-mediated mitochondrial outer membrane permeabilization (MOMP), which releases pro-apoptotic proteins to the cytosol, activating apoptosis and inhibiting X-linked inhibitor of apoptosis protein (XIAP). XIAP is a member of the inhibitors of apoptosis protein family whose express...

journal_title：Experimental and therapeutic medicine

authors： Chen C,Liu TS,Zhao SC,Yang WZ,Chen ZP,Yan Y

更新日期：2018-05-01 00:00:00

abstract：:It is hypothesized that there may be common characteristics between the genetic regulatory networks of different diseases. To identify these potential similarities, analysis of overlapping differentially expressed genes (DEGs) in several diseases, which are believed to be associated in traditional Chinese medicine (TC...

journal_title：Experimental and therapeutic medicine

authors： Tang H,Zhang Y

更新日期：2018-06-01 00:00:00

abstract：:The current study assessed the association between toll-like receptor 9 (TLR9) and systemic lupus erythematosus (SLE) and subsequently determined the predictive value of TLR9 in assessing the prognosis of SLE. A total of 90 newly diagnosed patients with SLE and 49 healthy control subjects were enrolled in the current ...

journal_title：Experimental and therapeutic medicine

authors： Yuan Y,Zhao L,Ye Z,Ma H,Wang X,Jiang Z

更新日期：2019-04-01 00:00:00

abstract：:Ovarian cancer is a highly prevalent cancer among women. Recent studies have indicated that microRNAs (miRs) may serve important roles in the pathogenesis of ovarian cancer. miR-519a was observed to be downregulated in tissue samples of patients with ovarian cancer; however, its role in ovarian cancer requires further...

journal_title：Experimental and therapeutic medicine

authors： Tian F,Jia L,Chu Z,Han H,Zhang Y,Cai J

更新日期：2018-02-01 00:00:00

abstract：:The aim of the present study was to explore the effect of baicalin on liver hypoxia/reoxygenation (H/R) injury and the possible mechanism involved. A cellular H/R model was established and cells were treated with 50, 100 and 200 µmol/l baicalin. Following reoxygenation for 6 h, cell viability, lactate dehydrogenase (L...

journal_title：Experimental and therapeutic medicine

authors： Liu F,Zhang J,Qian J,Wu G,Ma Z

更新日期：2018-08-01 00:00:00

abstract：:Doxorubicin (DOX), a potent and widely used anticancer agent, can give rise to severe cardiotoxicity that limits its clinical use by inducing oxidative stress. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the central regulator of cellular responses to electrophilic/oxidative stress, which serves a critical ro...

journal_title：Experimental and therapeutic medicine

authors： Guo Z,Yan M,Chen L,Fang P,Li Z,Wan Z,Cao S,Hou Z,Wei S,Li W,Zhang B

更新日期：2018-10-01 00:00:00

abstract：:The present study evaluated the association between different Mycoplasma pneumoniae (M. pneumonia) genotypes and clinical features of pediatric patients. Subjects were children diagnosed with community-acquired pneumonia at the Children's Hospital of Soochow University (Suzhou, China) from January 2012 to December 201...

journal_title：Experimental and therapeutic medicine

authors： Fan L,Li D,Zhang L,Hao C,Sun H,Shao X,Xu J,Chen Z

更新日期：2017-09-01 00:00:00

abstract：:The diagnostic criteria of osteoporosis were established based on bone mineral density (BMD). Therefore, BMD measured by dual energy X-ray absorptiometry has been recognized as the gold standard to diagnose osteoporosis. However, discrepancies between fracture risk and BMD have been recognized. Bone is composed of col...

journal_title：Experimental and therapeutic medicine

authors： Suzuki Y,Maruyama-Nagao A,Sakuraba K,Kawai S

更新日期：2017-05-01 00:00:00

abstract：:The present study aimed to analyze the imaging, clinical and pathological features of fungal infection involvement in primary biliary cirrhosis (PBC) by retrospectively analyzing and reviewing the features of two patients with fungal infection involvement in PBC. Both patients were female. One patient had a confirmed ...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Zhao Z,Lu H,Zhang J,Huang F

更新日期：2017-02-01 00:00:00

abstract：:The aim of the present study was to investigate the effect of Forkhead family transcription factor P3 (Foxp3) knockdown on the function of cluster of differentiation (CD)4+CD25+ regulatory T cell (Tregs) and the tumor growth of a hepatocellular carcinoma (HCC) mouse model. CD4+CD25+ Tregs and CD4+CD25- T cells were so...

journal_title：Experimental and therapeutic medicine

authors： Shi C,Zhang Y,Yang H,Dong T,Chen Y,Xu Y,Yang X,Liu P

更新日期：2018-01-01 00:00:00

abstract：:The present study aimed to investigate whether serum interleukin-6 (IL-6) expression levels were associated with the onset and progression of intervertebral disc degeneration (IDD). A comprehensive meta-analysis of the scientific literature from numerous electronic databases was performed, in order to obtain published...

journal_title：Experimental and therapeutic medicine

authors： Deng X,Zhao F,Kang B,Zhang X

更新日期：2016-04-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are a novel class of transcripts, which are pervasively transcribed in the genome and a have greatly unknown biological function. Previous studies have identified that lncRNAs serve an important role in embryonic development. However, the function and mechanism of lncRNAs in the developm...

journal_title：Experimental and therapeutic medicine

authors： Gao L,Yin J,Wu W

更新日期：2016-06-01 00:00:00

abstract：:The aim of this study was to investigate and analyze the effects of human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) on the recovery of neurological function and telomerase reverse transcriptase (TERT) expression in brain tissue of rats with cerebral ischemia-reperfusion injury. A total of 100 healthy adu...

journal_title：Experimental and therapeutic medicine

authors： Huang X,Zhang S,Li F,Zhou Y,Wang X,Fu G,Ma X

更新日期：2017-12-01 00:00:00

abstract：:Extramedullary hematopoiesis (EMH) is defined as hematopoiesis occurring in organs outside of the bone marrow. The present report describes two cases of thalassemic patients with paraspinal medullary hematopoiesis and analyzes the clinical manifestations, imaging, pathology, diagnosis and treatment of EMH. In addition...

journal_title：Experimental and therapeutic medicine

authors： Zhang HZ,Li Y,Liu X,Chen BR,Yao GH,Peng YN

更新日期：2016-12-01 00:00:00

abstract：:Cutaneous squamous cell carcinoma (CSCC) is the second most common type of skin cancer with increasing incidence. In recent years, several microRNAs (miRs) have been demonstrated to serve an oncogenic or tumor suppressive role in CSCC. However, the exact role of miR-34a in CSCC and the underlying regulatory mechanism ...

journal_title：Experimental and therapeutic medicine

authors： Li S,Luo C,Zhou J,Zhang Y

更新日期：2017-12-01 00:00:00

abstract：:The aim of this study was to investigate the association between metabolic syndrome (MS) and vascular endothelial cell dysfunction (ECD) in adolescents. Sixty obese pediatric inpatients at the General Hospital of Tianjin Medical University from February 2011 to February 2012 were included. Among these, 30 patients wer...

journal_title：Experimental and therapeutic medicine

authors： Wei Y,Liu G,Yang J,Zheng R,Jiang L,Bao P

更新日期：2013-06-01 00:00:00

abstract：:The rabbit VX2 hepatic tumor model has been widely used for the investigation of liver cancer. The present study was designed to compare two inoculation methods in order to identify an improved modality for establishing rabbit hepatic tumors. A total of 44 rabbits were randomly divided into 2 groups. All inoculations ...

journal_title：Experimental and therapeutic medicine

authors： Sun JH,Zhang YL,Nie CH,Yu XB,Xie HY,Zhou L,Zheng SS

更新日期：2012-03-01 00:00:00

abstract：:Human serum albumin (HSA) is a transporting protein that has multiple functions. The binding interaction between HSA and small molecules affects its function and efficacy of small molecules. The present study reports that kaempferol-7-O-α-L-rhamnopyranoside (KR) interacts with HSA as indicated by multiple fluorescence...

journal_title：Experimental and therapeutic medicine

authors： Zhang W,Chen C,Zhang C,Duan J,Yao H,Li Y,Meng A,Shi J

更新日期：2017-06-01 00:00:00

abstract：:Activation of telomerase is involved in carcinogenesis in most types of cancers. However, the prognostic value of telomerase activity (TA) in patients with gastric carcinoma (GC) remains controversial. We conducted a meta-analysis to assess the relationship between TA and the clinical outcome of GC. A meta-analysis of...

journal_title：Experimental and therapeutic medicine

authors： Lü MH,Deng JQ,Cao YL,Fang DC,Zhang Y,Yang SM

更新日期：2012-04-01 00:00:00

abstract：:The aim of the present study was to establish a stem cell line for multi-mode imaging (in vivo fluorescence imaging, magnetic resonance imaging and 99mTc single-photon emission computed tomography) and to study the biological activity, stemness, proliferative activity and differentiation ability of superparamagnetic i...

journal_title：Experimental and therapeutic medicine

authors： Meng Y,Liu H,Bian N,Gong J,Zhong X,Huang C,Liang W,Xu H

更新日期：2018-09-01 00:00:00

abstract：:It is understood that mechanical loading may affect tendon properties. However, how different mechanical loading conditions may affect tendons remains unknown. The present study aimed to investigate the effect of treadmill running at various intensities on rat Achilles tendon. A total of 18 male Wistar rats were rando...

journal_title：Experimental and therapeutic medicine

authors： Xu SY,He YB,Deng SY,Liu SY,Xu L,Ni GX

更新日期：2018-06-01 00:00:00

abstract：:Endometriosis is a common reproductive disorder in women, with a global prevalence of 10-15%. Long noncoding RNAs (lncRNAs) are critical to gene transcription, cell cycle modulation and immune response. The lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) reportedly mediates autophagy of endometr...

journal_title：Experimental and therapeutic medicine

authors： Liu X,Zhang P,Li Y,Zhao N,Han H

更新日期：2021-01-01 00:00:00

abstract：:Compared with traditional imaging techniques, multimodal imaging obtains more accurate images that may increase disease detection rates. The present study prepared stromal cell-derived factor 1 (SDF-1)-loaded, targeted nanoparticles coated with iron (II,III) oxide and perfluorohexane (PFH) to be used as polymer-shelle...

journal_title：Experimental and therapeutic medicine

authors： Wang F,Wang Z,Pang L,Wan S,Qiu L

更新日期：2020-09-01 00:00:00

abstract：:Giant aneurysm of the posterior circulation is associated with a higher risk of rupture compared with that of the anterior circulation. Furthermore, surgical clipping and interventional embolization for giant aneurysm of the posterior circulation are more difficult and complex to perform. The present study reported on...

journal_title：Experimental and therapeutic medicine

authors： Zhang CL,Shi ZH,Yan ZZ,Ding CL,Cao JM,Wang YH,Zhang P

更新日期：2021-01-01 00:00:00

abstract：:E-cadherin is a key cell adhesion molecule implicated in tumor suppression that is frequently altered in hepatocellular carcinoma (HCC), particularly in hepatitis B virus-related tumors. Here, we report that the epigenetic drugs 5-azacytidine and trichostatin A up-regulated E-cadherin expression in HCC cells. The depl...

journal_title：Experimental and therapeutic medicine

authors： Qiu X,Qiao F,Su X,Zhao Z,Fan H

更新日期：2010-05-01 00:00:00