Effect of neuromedin U on allergic airway inflammation in an asthma model.

abstract：:It is firmly established that smoking is a risk factor of cardiovascular disease, stroke and peripheral vascular disease. Although smoking alters the hemostatic process, the influence of smoking on human platelet activation remains controversial. For patients undergoing surgery, cessation of smoking prior to the proce...

journal_title：Experimental and therapeutic medicine

authors： Kito Y,Iida M,Tanabe K,Onuma T,Tsujimoto M,Nagase K,Tokuda H,Iwama T,Kozawa O,Iida H

更新日期：2019-11-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is one of the most common urological malignancies occurring in adult human kidneys worldwide. Recent research on antitumor drugs has focused on plant extracts, a class of compounds that play critical roles in cancer treatment. The present study aimed to investigate the potential antitumor ef...

journal_title：Experimental and therapeutic medicine

authors： Zhu C,Na N,Sheng H,Feng B,Wang H,Zhu P,Zhang W,Zhang M,Deng Z

更新日期：2020-04-01 00:00:00

abstract：:Suppurative hidradenitis and pyoderma gangrenosum are rare disorders that can be seen isolated or even more rare, as part of different autoinflammatory syndromes: Pyoderma gangrenosum, acne, and hidradenitis suppurativa (PASH), pyoderma gangrenosum, acne, pyogenic arthritis, and hidradenitis suppurativa (PAPASH) or ps...

journal_title：Experimental and therapeutic medicine

authors： Turcu G,Ioana Nedelcu R,Teodora Nedelcu I,Hodorogea A,Balaban M,Brinzea A,Nichita L,Gabriela Popp C,Andrada Zurac S,Theodor Andrei R

更新日期：2020-07-01 00:00:00

abstract：:Acute myocardial infarction (AMI) remains one of the leading causes of mortality worldwide; however, endothelial progenitor cell (EPC) transplantation has been proposed as a promising treatment strategy for EPC. High levels of tumor necrosis factor-related weak inducer of apoptosis (TWEAK) have been reported in AMI, a...

journal_title：Experimental and therapeutic medicine

authors： Sheng Z,Ju C,Li B,Chen Z,Pan X,Yan G,He Y,Yao Y,Ma G

更新日期：2018-11-01 00:00:00

abstract：:The aim of this study was to investigate the surgical methods and efficacies for cervicothoracolumbar spinal schwannoma (CSS). A total of 52 patients who had undergone treatment for schwannoma were retrospectively analyzed. Two methods were employed for the surgical resection of the thoracic and lumbar schwannomas: Ty...

journal_title：Experimental and therapeutic medicine

authors： Deng Q,Tian Z,Sheng W,Guo H,Dan ME

更新日期：2015-12-01 00:00:00

abstract：:The present study reported two cases of cystic meningioma. The clinical manifestations, magnetic resonance imaging (MRI) scan and histological aspects of the lesion and the associated cyst were examined. The classification of cystic meningioma was also discussed. The present study focused on the formation, diagnosis a...

journal_title：Experimental and therapeutic medicine

authors： Wang P,Han S,Liu N,Yu C,Qi X,Zhu M,Zhang X,Wang LI,Yan C

更新日期：2016-03-01 00:00:00

abstract：:Here, we present a case of post-operative liver metastases from pancreatic head cancer in a patient with leukocytopenia, who was safely treated by hepatic arterial infusion (HAI) chemotherapy consisting of gemcitabine and 5-FU. The patient was a 61-year-old woman who underwent pancreaticoduodenectomy for pancreatic he...

journal_title：Experimental and therapeutic medicine

authors： Tajima H,Ohta T,Kitagawa H,Sakai S,Makino I,Hayashi H,Nakagawara H,Onishi I,Takamura H,Ninomiya I,Fushida S,Tani T,Fujimura T,Kayahara M,Koda W,Minami T,Ryu Y,Sanada J,Matsui O

更新日期：2010-11-01 00:00:00

abstract：:Secreted frizzled-related protein 1 (SFRP1), which is an extracellular inhibitor involved in Wnt signalling, is downregulated by promoter hypermethylation in the early stages of colorectal tumorigenesis. Polycomb (PCG) and methyl-CpG-binding domain (MBD) proteins that serve a role in epigenetic gene regulation. The ai...

journal_title：Experimental and therapeutic medicine

authors： Yu J,Xie Y,Liu Y,Wang F,Li M,Qi J

更新日期：2020-12-01 00:00:00

abstract：:As an atherosclerotic disease, the process of peripheral arterial disease (PAD) is complicated and includes the abnormal proliferation of vascular smooth muscle. The current study aimed to determine the role of microRNA-15b (miR-15b) in the development of PAD and its associated mechanisms. Human vascular smooth muscle...

journal_title：Experimental and therapeutic medicine

authors： Sun Y,Gao Y,Song T,Yu C,Nie Z,Wang X

更新日期：2019-07-01 00:00:00

abstract：:Eugenol is a naturally occurring compound that is present in a variety of plants and has previous been demonstrated to exert a number of bioactivities. However, the potential effects of Eugenol on cellular protection against oxidative stress remain poorly understood. In the present study, HEK-293 cells and the mouse f...

journal_title：Experimental and therapeutic medicine

authors： Ma L,Liu J,Lin Q,Gu Y,Yu W

更新日期：2021-02-01 00:00:00

abstract：:The knowledge of the expected time-to-positivity (TTP) of blood cultures by major pathogens is essential both clinically and economically. To this end, we conducted the present two-year study in our Institution, aiming to assess the TTP of all the major microorganisms including Enterobacteriaceae, Pseudomonas aerugino...

journal_title：Experimental and therapeutic medicine

authors： Moustos E,Staphylaki D,Christidou A,Spandidos DA,Neonakis IK

更新日期：2017-12-01 00:00:00

abstract：:Kidney morphology has been used to estimate renal functions. The present study investigated the usefulness of kidney length and renal parenchymal volume (RPV) measured using three-dimensional ultrasonography (3-D USG) in estimating renal pathological findings, and the outcome in patients with nephropathy who underwent...

journal_title：Experimental and therapeutic medicine

authors： Xu J,Hwang SI,Lee HJ,Chin HJ

更新日期：2018-02-01 00:00:00

abstract：:The present study examined the expression of microRNA (miRNA or miR)-204 in pulp tissues, blood and saliva from pediatric patients with pulpitis and an underlying Helicobacter pylori (Hp) infection in the stomach, and the mechanism of the associated regulation by miR-204 was assessed. A total of 26 children with pulpi...

journal_title：Experimental and therapeutic medicine

authors： Zhou S,Xu J

更新日期：2019-07-01 00:00:00

abstract：:Breast cancer remains a worldwide public-health issue. Novel drugs that increase the sensitivity and reduce the toxic side effects of chemotherapeutic agents are urgently required. The present study investigated the effect and mechanism of the short-term intermittent administration of an anticancer bioactive peptide (...

journal_title：Experimental and therapeutic medicine

authors： Li X,Gao B,Su X

更新日期：2020-09-01 00:00:00

abstract：:The present study aimed to determine whether nimotuzumab enhances the effect of radiochemotherapy in malignant gliomas. Patients (n=41) with malignant gliomas were divided into 20 cases (treatment group) in which nimotuzumab plus radiochemotherapy were offered and 21 cases (control group) in which placebo and radioche...

journal_title：Experimental and therapeutic medicine

authors： Hong J,Peng Y,Liao Y,Jiang W,Wei R,Huo L,Han Z,Duan C,Zhong M

更新日期：2012-07-01 00:00:00

abstract：:Shikonin (SK), a naturally occurring naphthoquinone, exhibits antitumor activity. However, its precise mechanisms of action are unknown. In the present study, the effects of SK on NCI-H460 human lung cancer cells were investigated. It was found that SK reduced cell viability and induced apoptosis in the NCI-H460 cells...

journal_title：Experimental and therapeutic medicine

authors： Qu D,Chen YU,Xu XM,Zhang M,Zhang YI,Li SQ

更新日期：2015-04-01 00:00:00

abstract：:Avicularin (AL), quercetin-3-α-L-arabinofuranoside, has various pharmacological properties such as anticancer and anti-infective effects. However, the potential molecular mechanism via which AL exerts its anticancer activity is not fully understood. Cutaneous squamous cell carcinoma (CSCC) is the second most common sk...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Liu M,Chen S,Wu Q

更新日期：2020-02-01 00:00:00

abstract：:Lung cancer, a major health problem affecting the epithelial lining of the lower respiratory tract, is considered to be one of the deadliest types of cancer in males and females and it is well-known that smoking is the chief cause of lung cancer. In addition to smoking and environmental factors, genetic susceptibility...

journal_title：Experimental and therapeutic medicine

authors： Baykara O,Tansarikaya M,Demirkaya A,Kaynak K,Tanju S,Toker A,Buyru N

更新日期：2013-02-01 00:00:00

abstract：:Primary congenital glaucoma (PCG) is one of the primary causes of blindness in children and is characterized by congenital trabecular meshwork and anterior chamber angle dysplasia. While being a rare condition, PCG severely impairs the quality of life of affected patients. However, the pathogenesis of PCG remains to b...

journal_title：Experimental and therapeutic medicine

authors： Ling C,Zhang D,Zhang J,Sun H,Du Q,Li X

更新日期：2020-08-01 00:00:00

abstract：:Sodium 4-phenylbutyrate (PBA) exerts therapeutic effects in a wide range of pathologies. A previous study by the present authors revealed that intraperitoneal administration of PBA suppresses the onset of dextran sulfate sodium (DSS)-induced colitis in mice. In the present study, the effects of orally administered PBA...

journal_title：Experimental and therapeutic medicine

authors： Ono K,Nimura S,Hideshima Y,Nabeshima K,Nakashima M

更新日期：2017-12-01 00:00:00

abstract：:Scabies is a contagious skin disease that causes extremely itching. It is a parasitic disease caused by the mite Sarcoptes scabiei and characterized by polymorphous lesions. Vesicular and bullous lesions in cases of scabies are rather rare. Bullous scabies has a pemphigoid presentation. Crusted scabies, also known as ...

journal_title：Experimental and therapeutic medicine

authors： Su WJ,Fang S,Chen AJ,Shan K

更新日期：2015-10-01 00:00:00

abstract：:The aim of this study was to evaluate the therapeutic value of pathological indicators to predict the efficacy of endoscopic sinus surgery (ESS) in patients with chronic rhinosinusitis (CRS) with nasal polyps. A total of 53 patients with CRS with nasal polyps, who had undergone endoscopic surgery at least one year bef...

journal_title：Experimental and therapeutic medicine

authors： Tang J,Liu S,Zhang L,Chen W,Shi S,Yu Q,Tang C,Wang Y

更新日期：2013-07-01 00:00:00

abstract：:Traumatic brain injury (TBI) is among the leading causes of irreversible neurological damage and death worldwide. The aim of the present study was to investigate whether edaravone (EDA) had a neuroprotective effect on TBI as well as to identify the potential mechanism. Results demonstrated that EDA suppressed inflamma...

journal_title：Experimental and therapeutic medicine

authors： Zhang M,Teng CH,Wu FF,Ge LY,Xiao J,Zhang HY,Chen DQ

更新日期：2019-07-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/etm.2015.2860.]. ...

journal_title：Experimental and therapeutic medicine

authors： Liu Y,Xiao J,Shi X,Hao G,Chen Q,Zhou J,Wei X

更新日期：2019-04-01 00:00:00

abstract：:Polygoni Multiflori Radix is a traditional Chinese medicine used clinically to support the functions of the liver and kidneys and to treatment hyperlipidemia. In previous studies, an effective fraction, rich in 2,3,5,4'-tetrahydroxy stilbene-2-O-β-D-glucoside (TSG), was separated from Polygoni Multiflori Radix and dem...

journal_title：Experimental and therapeutic medicine

authors： Lou Z,Xia B,Su J,Yu J,Yan M,Huang Y,Lv G

更新日期：2017-11-01 00:00:00

abstract：:Bone cancer pain commonly occurs when tumors originating in the breast, prostate or lung metastasize to long bones, spinal vertebrae and/or the pelvis. However, the underlying mechanisms of bone cancer pain remain largely unknown. The present study aimed to determine the role of spinal tumor necrosis factor-α (TNF-α) ...

journal_title：Experimental and therapeutic medicine

authors： Yang Y,Zhang J,Gao Q,Bo J,Ma Z

更新日期：2017-05-01 00:00:00

abstract：:The aim of the present study was to determine the function of human amniotic epithelial cell transplantation (hAECT) in promoting the healing of rats with stage III pressure ulcer (PU) and to initially investigate its possible mechanisms. A total of 96 Sprague Dawley rats were allocated at random into the model, hAECT...

journal_title：Experimental and therapeutic medicine

authors： Zhou A,Zheng X,Yu L,Quan M,Shao X,Jiang Z

更新日期：2015-12-01 00:00:00

abstract：:Chronic rhinosinusitis with nasal polyps (CRSwNP) refers to chronic inflammation of the sinonasal mucosa. It can either be eosinophilic (ECRSwNP) or non-eosinophilic (non-ECRSwNP). However, immune cell infiltration in the microenvironment and pathogenesis of ECRSwNP and non-ECRSwNP are still unclear. The aim of the pr...

journal_title：Experimental and therapeutic medicine

authors： Xiong G,Xie X,Wang Q,Zhang Y,Ge Y,Lin W,Li M

更新日期：2020-12-01 00:00:00

abstract：:Diffuse ganglioneuromatosis (DG) of the gastrointestinal tract is a rare condition that is closely associated with neurofibromatosis type 1 and multiple endocrine neoplasia type 2B. The occurrence of DG with multiple schwannomas, which, of the GI tract, usually affect the stomach, is considerably more rare. The presen...

journal_title：Experimental and therapeutic medicine

authors： Lu C,Qiu Y,Lu X,Li G,Bu H

更新日期：2015-03-01 00:00:00

abstract：:Schwannomas may arise from any peripheral nerve containing Schwann cells. However, sural nerve schwannoma is extremely rare. In this study, a case of solitary schwannoma originating from the sural nerve in a 42-year-old male is presented. Physical examination revealed a 3-cm, elastic-hard, mobile, non-tender mass, whi...

journal_title：Experimental and therapeutic medicine

authors： Yamamoto K,Nishio J,Yano S,Naito M

更新日期：2014-01-01 00:00:00