Mechanisms of human amniotic epithelial cell transplantation in treating stage III pressure ulcer in a rat model.

abstract：:The aim of this study was to investigate the effects of heat stress on the expression of the coxsackievirus and adenovirus receptor (CAR) in mouse skin keratinocytes. Twenty BALB/c mice were randomly divided into two groups: the sham heat (control) and scald groups. Skin specimens were obtained 6 h after the treatment...

journal_title：Experimental and therapeutic medicine

authors： Deng X,Jia C,Chen F,Liu J,Zhou Z

更新日期：2013-10-01 00:00:00

abstract：:Melatonin is a darkness hormone secreted by the pineal gland, which serves a role in idiopathic oligoasthenoteratozoospermia (iOAT). The present study aimed to evaluate the seminal plasma and serum melatonin levels of 50 patients with iOAT and 50 normal fertile controls and the effects of exposure to light at night on...

journal_title：Experimental and therapeutic medicine

authors： H Hassan M,A El-Taieb M,N Fares N,M Fayed H,Toghan R,M Ibrahim H

更新日期：2020-07-01 00:00:00

abstract：:Recurrent patellar dislocations were treated via knee arthroscopy combined with C-arm fluoroscopy, and reconstruction of the medial patellofemoral ligaments. Between October 2013 and March 2017, 52 cases of recurrent patellar dislocation [27 males and 25 females; age, 16-47 years (mean, 21.90 years)] were treated. Art...

journal_title：Experimental and therapeutic medicine

authors： Li L,Wang H,He Y,Si Y,Zhou H,Wang X

更新日期：2018-06-01 00:00:00

abstract：:Cisplatin (DDP) is a commonly used chemotherapy drug; however, the side effects associated with its use, particularly acute kidney injury (AKI), limit its clinical application. Puerarin is a natural flavonoid extracted from the Chinese medical herb Radix puerariae, which has been reported to alleviate DDP-induced neph...

journal_title：Experimental and therapeutic medicine

authors： Wu Z,Li C,Li Q,Li J,Lu X

更新日期：2020-10-01 00:00:00

abstract：:MicroRNAs (miRs) are have been demonstrated to serve important functions in the genesis of human cancer, including colorectal cancer (CRC). The role of miR-6852 in CRC remains unknown. In this study, it was demonstrated that miR-6852 was underexpressed in CRC tissues compared with adjacent normal tissues. Moreover, th...

journal_title：Experimental and therapeutic medicine

authors： Cui BH,Hong X

更新日期：2018-08-01 00:00:00

abstract：:Simple bone cysts (SBCs) are uncommon lesions that usually occur in the long bones of the skeleton and in the body of the mandible. Displacement of the mandibular canal due to cystic lesions have been reported previously. However, there have been no reports in which endoscopy has been utilized to observe an inferior a...

journal_title：Experimental and therapeutic medicine

authors： Matsuda S,Yoshimura H,Sano K

更新日期：2019-06-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is a common malignant tumor with poor prognosis and an increasing number of cases. MicroRNA (miR)-4728 is related with the progression of various types of cancer, and is dysregulated in NSCLC, which indicates that miR-4728 may serve as a biomarker for NSCLC. The present study aimed t...

journal_title：Experimental and therapeutic medicine

authors： Hu Y,Zhang X,Gong C,Li J

更新日期：2020-11-01 00:00:00

abstract：:The present study aimed to investigate the effects of levodopa (LEV) on cellular apoptosis in a rabbit model of steroid-associated necrosis of the femoral head (SANFH). A total of 44 healthy adult Chinese rabbits were randomly divided into three groups: Group A (n=15), administered a combination of lipopolysaccharide ...

journal_title：Experimental and therapeutic medicine

authors： Xi H,Tao W,Jian Z,Sun X,Gong X,Huang L,Dong T

更新日期：2017-01-01 00:00:00

abstract：:Many studies have focused on the identification of therapeutic targets for the treatment of certain types of cancer. Wogonin is a natural flavonoid compound that exhibits a potent anti-cancer effect. The underlying mechanism of wogonin may therefore reveal an effective way to identify novel therapeutic targets. In the...

journal_title：Experimental and therapeutic medicine

authors： Wang SJ,Zhao JK,Ren S,Sun WW,Zhang WJ,Zhang JN

更新日期：2019-01-01 00:00:00

abstract：:Organic cation transporter member 2 (OCT2) is an N-glycosylated transporter that has been shown to be closely associated with the transport of antitumor drugs. Oxaliplatin, a platinum-based drug, is used for the chemotherapy of colorectal cancer (CRC). However, oxaliplatin resistance is a major challenge in the treatm...

journal_title：Experimental and therapeutic medicine

authors： Cong X,Liu X,Dong X,Fang S,Sun Z,Fan J

更新日期：2021-02-01 00:00:00

abstract：:Metabolic acidosis has been proved to be a risk factor for the progression of chronic kidney disease, but its relation to acute kidney injury (AKI) has not been investigated. In general, a diagnosis of metabolic acidosis is based on arterial blood gas (ABG) analysis, but the diagnostic role of carbon dioxide combining...

journal_title：Experimental and therapeutic medicine

authors： Hu J,Wang Y,Geng X,Chen R,Xu X,Zhang X,Lin J,Teng J,Ding X

更新日期：2017-05-01 00:00:00

abstract：:This study was designed to investigate the correlation of vitamin D receptor (VDR) gene polymorphism with bronchial asthma in children. Seventy patients admitted to Daqing Longnan Hospital and diagnosed as bronchial asthma for the first time from April 2015 to May 2017 were selected as observation group. Patients rece...

journal_title：Experimental and therapeutic medicine

authors： Hou C,Zhu X,Chang X

更新日期：2018-03-01 00:00:00

abstract：:Identifying the predominant microbial species in patients with ethmoidal sinusitis is conducive to its successful treatment. The aim of the present study was to determine the microbial composition and the predominant fungal and bacterial species in patients with ethmoidal sinusitis. A sample was obtained from 3 patien...

journal_title：Experimental and therapeutic medicine

authors： Zhang J,He S,Li Y,Lv M,Wei H,Qu B,Zheng Y,Hu C

更新日期：2018-11-01 00:00:00

abstract：:Phthalates are confirmed to have toxic effects on the reproductive system and are likely to have further damaging actions in humans. The present study explored the molecular mechanisms of the toxic effect of mono-(2-ethylhexyl) phthalate (MEHP) on mouse Sertoli cells. Cell apoptosis and proliferation assays were used ...

journal_title：Experimental and therapeutic medicine

authors： Wang L,Dou T,Li S,Liu Y

更新日期：2019-04-01 00:00:00

abstract：:The anticancer properties of epigallocatechin-3-gallate (EGCG) are documented in the treatment of several types of cancer; however, there is no relevant evidence for its efficacy in the treatment of renal cell carcinoma (RCC). In the present study, the therapeutic effects of EGCG in vitro were investigated, with parti...

journal_title：Experimental and therapeutic medicine

authors： Chen SJ,Yao XD,Peng BO,Xu YF,Wang GC,Huang J,Liu M,Zheng JH

更新日期：2016-04-01 00:00:00

abstract：:The present investigation explored the in vitro culture, isolation and characterization of hair follicle cell differentiation from umbilical cord blood mesenchymal stem cells (MSCs). Flow cytometry was used to obtain MSCs from the isolation and purification of human umbilical cord blood MSCs. Culture suspension of hai...

journal_title：Experimental and therapeutic medicine

authors： Bu ZY,Wu LM,Yu XH,Zhong JB,Yang P,Chen J

更新日期：2017-07-01 00:00:00

abstract：:In patients with chronic kidney disease (CKD), hypertension (HP) is associated with the development of left ventricular (LV) diastolic dysfunction. However, the impact of antihypertensive treatment on LV diastolic function has not been well studied in CKD patients. Recently, two-dimensional speckle-tracking echocardio...

journal_title：Experimental and therapeutic medicine

authors： Li KL,Wang RX,Dai M,Lu J,Xue J,Yang XJ

更新日期：2015-05-01 00:00:00

abstract：:Stress-related mucosal disease (SRMD) is a common complication in patients in the intensive care unit (ICU). The aim of the present study was to investigate the possible mechanisms for the pathogenesis of SRMD. In total, 38 patients with SRMD were enrolled from an ICU, as well as 15 healthy volunteers. The disease sev...

journal_title：Experimental and therapeutic medicine

authors： Wang X,Zhao Q,Shi H,Qi F,Shi N,Bai D,Li X,Yuan H,Zuo X

更新日期：2020-11-01 00:00:00

abstract：:Diabetes may affect myocardial fibrosis through oxidative stress. Trimetazidine (TMZ) is an anti-anginal agent. The present study aimed to determine the modulatory effect of TMZ on reactive oxygen species (ROS) and connective tissue growth factor (CTGF) expression and to evaluate the potential of TMZ to improve diasto...

journal_title：Experimental and therapeutic medicine

authors： Zhao Y,Li S,Quan E,Zhang H,Wu Y,Luo Y,Peng L,Wang J,Zhu J,Liu J

更新日期：2019-08-01 00:00:00

abstract：:Stromal cell-derived growth factor (SDF)-1α acts as a ligand to C-X-C chemokine receptors 4 (CXCR4) and 7 (CXCR7), which are involved in the formation of choroidal neovascularization. Previous studies have demonstrated crosstalk between the platelet-derived growth factor (PDGF)-BB/PDGF receptor (PDGFR)-β and SDF-1α/CX...

journal_title：Experimental and therapeutic medicine

authors： Xiang DN,Feng YF,Wang J,Zhang X,Shen JJ,Zou R,Yuan YZ

更新日期：2019-11-01 00:00:00

abstract：:MicroRNA (miR) are short non-coding RNA that bind to the 3'-untranslational region of their target genes, inhibiting translation and causing mRNA degradation. miR deregulation has been implicated in human cancer; however, the detailed regulatory mechanism of miR-137 in osteosarcoma (OS) remains largely unknown. In the...

journal_title：Experimental and therapeutic medicine

authors： Feng Q,Wu Q,Liu X,Xiong Y,Li H

更新日期：2017-06-01 00:00:00

abstract：:The present study aimed to analyze the imaging, clinical and pathological features of fungal infection involvement in primary biliary cirrhosis (PBC) by retrospectively analyzing and reviewing the features of two patients with fungal infection involvement in PBC. Both patients were female. One patient had a confirmed ...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Zhao Z,Lu H,Zhang J,Huang F

更新日期：2017-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a primary malignancy in the liver, which is a global health problem. The present study aimed to observe the apoptotic effects of berbamine on SMMC-7721 cell lines and to investigate the effects of berbamine on induction of the intrinsic apoptotic pathway. The human HCC SMMC-7721 cells...

journal_title：Experimental and therapeutic medicine

authors： Cao Y,Cao J,Yu B,Wang S,Liu L,Tao L,Sun W

更新日期：2018-02-01 00:00:00

abstract：:Chlorogenic acid (CGA) is the primary constituent of Caulis Lonicerae, a Chinese herb used for the treatment of rheumatoid arthritis (RA). The present study aimed to investigate whether CGA was able to inhibit the proliferation of the fibroblast-like synoviocyte cell line (RSC-364), stimulated by interleukin (IL)-6, t...

journal_title：Experimental and therapeutic medicine

authors： Lou L,Zhou J,Liu Y,Wei YI,Zhao J,Deng J,Dong B,Zhu L,Wu A,Yang Y,Chai L

更新日期：2016-05-01 00:00:00

abstract：:Dysregulation of microRNAs serves a crucial role in the chemosensitivity to cisplatin (DDP) in ovarian cancer (OVC). The abnormal expression of microRNA (miR)-654-3p has been reported in several types of human cancer. However, the association between miR-654-3p and cisplatin resistance in human OVC remains unclear. Th...

journal_title：Experimental and therapeutic medicine

authors： Niu YC,Tong J,Shi XF,Zhang T

更新日期：2020-08-01 00:00:00

abstract：:An increasing number of cancer patients receive outpatient chemotherapy as an alternative to inpatient chemotherapy. The aim of this study was to investigate whether quality of life (QOL) during outpatient chemotherapy was better than QOL prior to hospital discharge, and to explore possible related factors prior to ho...

journal_title：Experimental and therapeutic medicine

authors： Matsuda A,Kobayashi M,Sakakibara Y,Tamaoka M,Furuiye M,Inase N,Matsushima E

更新日期：2011-03-01 00:00:00

abstract：:The aim of the study was to investigate the possibility of human umbilical cord mesenchymal stem cells (UC-MSCs) surviving and differentiating into hepatocyte-like cells in partially hepatectomized model rats. MSCs were isolated from human umbilical cord and cultured with collagenase digestion. Cell surface markers we...

journal_title：Experimental and therapeutic medicine

authors： Chen Z,Kuang Q,Lao XJ,Yang J,Huang W,Zhou D

更新日期：2016-09-01 00:00:00

abstract：:Previous studies have indicated pro-tumor functions of macrophages in tumor progression in different types of malignant tumors. The detailed mechanisms of cell-cell interaction between macrophages and tumor cells have been investigated by means of in vitro co-culture experiments. The present study developed magnetite ...

journal_title：Experimental and therapeutic medicine

authors： Komohara Y,Kawauchi R,Makiyama E,Mikami K,Horlad H,Fujiwara Y,Kida T,Takeya M,Niidome T

更新日期：2017-08-01 00:00:00

abstract：:Doxorubicin (DOX), a potent and widely used anticancer agent, can give rise to severe cardiotoxicity that limits its clinical use by inducing oxidative stress. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the central regulator of cellular responses to electrophilic/oxidative stress, which serves a critical ro...

journal_title：Experimental and therapeutic medicine

authors： Guo Z,Yan M,Chen L,Fang P,Li Z,Wan Z,Cao S,Hou Z,Wei S,Li W,Zhang B

更新日期：2018-10-01 00:00:00

abstract：:A mutation in the IIb sodium phosphate transporter SLC34A2 gene has recently been described in pulmonary alveolar microlithiasis (PAM) patients. Experiments in this study were aimed at confirming the role of the gene product in PAM by comparing phosphorylated products in extracellular fluid of alveolar epithelial cell...

journal_title：Experimental and therapeutic medicine

authors： Ma T,Qu D,Yan B,Zhang Q,Ren J,Hu Y

更新日期：2018-01-01 00:00:00