Abstract:
:MicroRNAs (miRs) are have been demonstrated to serve important functions in the genesis of human cancer, including colorectal cancer (CRC). The role of miR-6852 in CRC remains unknown. In this study, it was demonstrated that miR-6852 was underexpressed in CRC tissues compared with adjacent normal tissues. Moreover, the expression of miR-6852 was negatively correlated with CRC metastasis, whereas positively correlated with patient prognosis. It was revealed that the overexpression of miR-6852 significantly inhibited the proliferation and invasion of CRC cells. miR-6852 overexpression reduced CRC cells in the S phase. TCF7 was identified to be a direct target of miR-6852 in CRC cells. Overexpression of miR-6852 significantly inhibited the mRNA and protein levels of TCF7 in CRC cells. Furthermore, TCF7 was highly expressed in CRC tissues and cell lines. TCF7 expression was negatively correlated with miR-6852 levels in CRC tissues. Finally, knockdown of TCF7 significantly suppressed the proliferation and invasion of CRC cells. Taken together, the results of the present study indicated that miR-6852 serves as a tumor suppressor in CRC through targeting TCF7.
journal_name
Exp Ther Medjournal_title
Experimental and therapeutic medicineauthors
Cui BH,Hong Xdoi
10.3892/etm.2018.6259subject
Has Abstractpub_date
2018-08-01 00:00:00pages
879-885issue
2eissn
1792-0981issn
1792-1015pii
ETM-0-0-6259journal_volume
16pub_type
杂志文章abstract::Alteration of behavior and PSD proteins in cerebral cortex and hippocampal synaptosome in the Alzheimer's disease (AD) mouse model were determined. AD was established by intraperitoneal injection of streptozotocin (STZ) in neonatal mice (intraperitoneal AD group) or intracerebroventricular injection of STZ in adult mi...
journal_title:Experimental and therapeutic medicine
pub_type: 杂志文章
doi:10.3892/etm.2018.6487
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abstract::Intactable epilepsy (IE) is relatively common in pediatric epilepsy. The resistance mechanism of IE has been previously investigated. Multidrug-resistant associated protein 1 (MRP1) and MRP2 are associated with drug transport. The aim of the present study was to investigate the expression of MRP1 and MRP2 in periphera...
journal_title:Experimental and therapeutic medicine
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journal_title:Experimental and therapeutic medicine
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journal_title:Experimental and therapeutic medicine
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journal_title:Experimental and therapeutic medicine
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journal_title:Experimental and therapeutic medicine
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journal_title:Experimental and therapeutic medicine
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更新日期:2020-08-01 00:00:00
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journal_title:Experimental and therapeutic medicine
pub_type: 杂志文章
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journal_title:Experimental and therapeutic medicine
pub_type: 杂志文章
doi:10.3892/etm.2015.2762
更新日期:2015-11-01 00:00:00
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journal_title:Experimental and therapeutic medicine
pub_type: 杂志文章
doi:10.3892/etm.2014.1711
更新日期:2014-07-01 00:00:00
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journal_title:Experimental and therapeutic medicine
pub_type: 杂志文章
doi:10.3892/etm.2019.8208
更新日期:2020-01-01 00:00:00
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journal_title:Experimental and therapeutic medicine
pub_type: 杂志文章
doi:10.3892/etm.2015.2736
更新日期:2015-11-01 00:00:00
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journal_title:Experimental and therapeutic medicine
pub_type: 杂志文章
doi:10.3892/etm.2013.992
更新日期:2013-05-01 00:00:00
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journal_title:Experimental and therapeutic medicine
pub_type: 杂志文章
doi:10.3892/etm.2018.6761
更新日期:2018-12-01 00:00:00
abstract::[This corrects the article DOI: 10.3892/etm.2018.6297.]. ...
journal_title:Experimental and therapeutic medicine
pub_type: 杂志文章,已发布勘误
doi:10.3892/etm.2018.6881
更新日期:2018-12-01 00:00:00
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journal_title:Experimental and therapeutic medicine
pub_type: 杂志文章
doi:10.3892/etm.2016.3959
更新日期:2017-01-01 00:00:00
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journal_title:Experimental and therapeutic medicine
pub_type: 杂志文章
doi:10.3892/etm.2018.5702
更新日期:2018-03-01 00:00:00
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journal_title:Experimental and therapeutic medicine
pub_type: 杂志文章
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journal_title:Experimental and therapeutic medicine
pub_type: 杂志文章,评审
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更新日期:2020-07-01 00:00:00
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journal_title:Experimental and therapeutic medicine
pub_type: 杂志文章
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更新日期:2012-03-01 00:00:00
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journal_title:Experimental and therapeutic medicine
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更新日期:2018-09-01 00:00:00
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journal_title:Experimental and therapeutic medicine
pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
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journal_title:Experimental and therapeutic medicine
pub_type: 杂志文章
doi:10.3892/etm.2020.9305
更新日期:2020-12-01 00:00:00
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journal_title:Experimental and therapeutic medicine
pub_type: 杂志文章
doi:10.3892/etm.2019.8266
更新日期:2020-01-01 00:00:00
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journal_title:Experimental and therapeutic medicine
pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00
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journal_title:Experimental and therapeutic medicine
pub_type: 杂志文章
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更新日期:2017-04-01 00:00:00
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journal_title:Experimental and therapeutic medicine
pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00