Abstract:
:Multiple cellular components are involved in the complex pathological process following central nervous system (CNS) injury, including neurons, glial cells and endothelial cells. Previous studies and neurotherapeutic clinical trials have assessed the molecular mechanisms that underlie neuronal cell death following CNS injury. However, this approach has largely failed to reduce CNS damage or improve the functional recovery of patients. Erythropoietin-producing human hepatocellular (Eph) receptors and ephrin ligands have attracted considerable attention since their discovery, due to their extensive distribution and unique bidirectional signaling between astrocytes and neurons. Previous studies have investigated the roles of Eph/ephrin bidirectional signaling in the developing central nervous system. It was determined that Eph/ephrin bidirectional signaling is expressed in various CNS regions and cell types, and that it serves diverse roles in the adult CNS. In the present review, the roles of Eph/ephrin bidirectional signaling in CNS injuries are assessed.
journal_name
Exp Ther Medjournal_title
Experimental and therapeutic medicineauthors
Yang JS,Wei HX,Chen PP,Wu Gdoi
10.3892/etm.2018.5702subject
Has Abstractpub_date
2018-03-01 00:00:00pages
2219-2227issue
3eissn
1792-0981issn
1792-1015pii
ETM-0-0-5702journal_volume
15pub_type
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doi:10.3892/etm.2013.1349
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journal_title:Experimental and therapeutic medicine
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doi:10.3892/etm.2018.7122
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journal_title:Experimental and therapeutic medicine
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