Behavioral and biochemical effects of a formulation of the traditional Chinese medicine, Kai-Xin-San, in fatigued rats.

abstract：:This study aimed to investigate the influence of intrathecal injection with dexmedetomidine on the behavioral ability and analgesic effects of rat models with chronic neuropathic pain. It also discusses the role that the expression of protein kinase C (PKC) in the spinal dorsal horn plays in the analgesic mechanism of...

journal_title：Experimental and therapeutic medicine

authors： Li X,Zhang W

更新日期：2018-11-01 00:00:00

abstract：:Hepatic stellate cells (HSCs) have been demonstrated to have immunoinhibitory activity. The aim of this study was to investigate the role of HSCs in the development of immunotolerance following liver transplantation. A rat liver transplantation tolerance model [donor Lewis into recipient Dark Agouti (DA)] and rejectio...

journal_title：Experimental and therapeutic medicine

authors： Jiang Z,Chen Y,Feng X,Jiang J,Chen T,Xie H,Zhou L,Zheng S

更新日期：2013-01-01 00:00:00

abstract：:Cardiac inhibition due to burn injury and anesthetics have been documented previously. However, little is known about their combined effects on cardiac function. The aim of the present study was to observe the effects of a ketamine/xylazine (K/X) combination on the cardiac function of rats with severe scalds and compa...

journal_title：Experimental and therapeutic medicine

authors： Feng Y,Chai J,Chu W,Ma L,Zhang P,Duan H

更新日期：2013-09-01 00:00:00

abstract：:Chemotherapeutic drug resistance is an obstacle for the successful therapy of prostate cancer. The aim of the present study was to identify the effects of proto-oncogene serine/threonine-protein kinase pim-1 (pim-1) in the proliferation of chemotherapeutic drug-resistant prostate cancer cells. Androgen-independent hum...

journal_title：Experimental and therapeutic medicine

authors： Zhang X,Sun Y,Wang P,Yang C,Li S

更新日期：2019-10-01 00:00:00

abstract：:The present study reported a case of portopulmonary hypertension (POPH) that was secondary to underlying liver cirrhosis in a 58-year-old woman, who was successfully treated with low-dose tolvaptan. The patient had suffered from refractory peripheral edema and electrolyte abnormalities, including severe hypokalemia, u...

journal_title：Experimental and therapeutic medicine

authors： Ogihara Y,Yamada N,Dohi K,Matsuda A,Ota S,Ishikura K,Nakamura M,Ito M

更新日期：2017-01-01 00:00:00

abstract：:The alleviation of brain injury is a key issue following cardiopulmonary resuscitation (CPR). Hydrogen sulfide (H2S) is hypothesized to be involved in the pathophysiological process of ischemia-reperfusion injury, and exerts a protective effect on neurons. The aim of the present study was to investigate the effects of...

journal_title：Experimental and therapeutic medicine

authors： Lin JY,Zhang MW,Wang JG,Li H,Wei HY,Liu R,Dai G,Liao XX

更新日期：2016-02-01 00:00:00

abstract：:In the present study, we investigated the effects of hydroxyethyl starch (HES) 130/0.4 on serum pro-inflammatory variables, immunologic variables, fluid balance (FB)-negative(-) rate and renal function in severe acute pancreatitis (SAP) patients. From October, 2007 to November, 2008, a total of 120 SAP patients were e...

journal_title：Experimental and therapeutic medicine

authors： Chen QJ,Yang ZY,Wang CY,Dong LM,Zhang YS,Xie C,Chen CZ,Zhu SK,Yang HJ,Wu HS,Yang C

更新日期：2016-11-01 00:00:00

abstract：:The present study aimed to summarize the clinical characteristics and experiences of misdiagnoses of cerebral venous thrombosis (CVT). A total of 18 patients with CVT who received treatment between September 2009 and August 2011 were enrolled. Of the patients, 13 were females and 5 were males with an average age of 39...

journal_title：Experimental and therapeutic medicine

authors： Wang X,Sun X,Liu H

更新日期：2012-11-01 00:00:00

abstract：:In spite of the favorable prognosis of early gastric cancer (EGC), recurrence or second primary cancers present in certain patients after curative surgery. It is crucial to identify who are at high risk and when. In the present study, 323 patients with EGC who underwent curative surgery were studied. A total of 22 pat...

journal_title：Experimental and therapeutic medicine

authors： Huang B,Wang Z,Xing C,Sun Z,Zhao B,Xu H

更新日期：2011-11-01 00:00:00

abstract：:The aim of the present study was to investigate the roles of matrix metalloproteinase 14 (MMP-14) in corneal inflammatory lymphangiogenesis. The expression of MMP-14 in vivo was detected by immunohistochemistry, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot assays, under vario...

journal_title：Experimental and therapeutic medicine

authors： Du HT,Liu P

更新日期：2016-10-01 00:00:00

abstract：:Cyclic adenosine monophosphate (cAMP) is an important secondary messenger that has long been recognized to control the initiation of meiosis through the activation of protein kinase A (PKA) in mammalian oocytes. However, PKA is not the only target for cAMP. Recent studies on cAMP-dependent and PKA-independent pathways...

journal_title：Experimental and therapeutic medicine

authors： Wang JC,Geng Y,Han Y,Luo HN,Zhang YS

更新日期：2018-08-01 00:00:00

abstract：:The aim of the present study was to investigate the expression levels and clinical significance of Toll-like receptor (TLR) 3 and 4 in peripheral blood mononuclear cells (PBMCs) collected from children with Henoch-Schönlein purpura (HSP) nephritis. The randomized controlled trial was conducted between August 2011 and ...

journal_title：Experimental and therapeutic medicine

authors： Chang H,Yu DS,Liu XQ,Zhang QY,Cheng N,Zhang SQ,Qu ZH

更新日期：2014-06-01 00:00:00

abstract：:The present study aimed to apply the best single-energy (SE) scanning in energy spectrum computed tomography (CT) to evaluate the usefulness of lower extremity arterial angiography imaging in patients with lower extremity arterial occlusive disease. A total of 64 patients diagnosed with lower extremity arterial occlus...

journal_title：Experimental and therapeutic medicine

authors： Wang G,Zhao D,Ling Z,Wang H,Yu S,Zhang J

更新日期：2019-08-01 00:00:00

abstract：:MicroRNAs (miRs), a class of small non-coding RNAs, function as key regulators in gene expression through binding to the 3'-untranslated region (UTR) of their target mRNA, which further leads to translational repression or mRNA degradation. Recently, miR-138 has been found to have a tumor suppressive role in a variety...

journal_title：Experimental and therapeutic medicine

authors： Yuan Z,Mo H,Mo L,He J,Wu Z,Lin X

更新日期：2017-06-01 00:00:00

abstract：:Studies performed previously have indicated that long non-coding RNAs (lncRNAs) may be involved in skeletal muscle regeneration; however, the roles of lncRNAs during the repair of skeletal muscle contusion remain unclear. The present study established a mouse skeletal muscle contusion injury model to identify the role...

journal_title：Experimental and therapeutic medicine

authors： Zheng L,Liu X,Chen P,Xiao W

更新日期：2019-10-01 00:00:00

abstract：:Cell-based adoptive immunotherapy for the treatment of various cancer types has attracted the attention of scientists. However, due to the absence of unitary standard protocols to produce large quantities of clinical-grade effector cells, it remains challenging to translate the experimental findings into clinical appl...

journal_title：Experimental and therapeutic medicine

authors： Yu H,Chen W,Li C,Lin D,Liu J,Yang Z,Yang J,Sun Y,Ma D

更新日期：2017-12-01 00:00:00

abstract：:The aim of the present study was to explore the association between the M235T polymorphism of the angiotensinogen (AGT) gene and cytokines in patients with essential hypertension (EH). A total of 300 patients with EH and an age-matched control group of 150 individuals without EH, secondary hypertension, myocardial inf...

journal_title：Experimental and therapeutic medicine

authors： Cheng JL,Wang AL,Wan J

更新日期：2012-03-01 00:00:00

abstract：:The present study aimed to systematically evaluate the effectiveness of single-incision laparoscopic surgery (SILS), conventional laparoscopic appendectomy (CLA) and open appendectomy (OA) for the treatment of acute appendicitis. PubMed and Embase databases were systematically searched to identify relevant studies com...

journal_title：Experimental and therapeutic medicine

authors： Feng J,Cui N,Wang Z,Duan J

更新日期：2017-12-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) has become a significant public health risk. Long non-coding RNAs (lncRNAs) have been identified as important factors involved in the proliferation, apoptosis and inflammatory cytokine expression of lung cells. Peripheral blood samples from 66 subjects (18 non-smokers, 24 s...

journal_title：Experimental and therapeutic medicine

authors： Lei Z,Guo H,Zou S,Jiang J,Kui Y,Song J

更新日期：2021-01-01 00:00:00

abstract：:While previous trials have indicated that the use of corticosteroids for patients with acute respiratory distress syndrome (ARDS) is effective, the dosage and time-course for the use of corticosteroids remain a subject of controversy. The present study aimed to address and resolve these problems. PubMed, Embase and th...

journal_title：Experimental and therapeutic medicine

authors： Sun S,Liu D,Zhang H,Zhang X,Wan B

更新日期：2019-12-01 00:00:00

abstract：:Endometriosis is a common reproductive disorder in women, with a global prevalence of 10-15%. Long noncoding RNAs (lncRNAs) are critical to gene transcription, cell cycle modulation and immune response. The lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) reportedly mediates autophagy of endometr...

journal_title：Experimental and therapeutic medicine

authors： Liu X,Zhang P,Li Y,Zhao N,Han H

更新日期：2021-01-01 00:00:00

abstract：:The aim of the present study was to provide reliable experimental evidence for the application of autologous skin fibroblasts (asFbs) in the repair of depressed scars. In the experiments, depressed trauma was induced in male Wistar rats, and fibroblasts were separated from the removed skin tissues to culture in medium...

journal_title：Experimental and therapeutic medicine

authors： Zhao J,Liu YC,Shi YH,Xie YQ,Cui HP,Li Y,Li XJ,Ren LQ

更新日期：2016-08-01 00:00:00

abstract：:In acute aortic dissection (AD) in pregnancy, increased cardiovascular stress due to pregnancy is an important factor leading to an emergent aortic event. It is rare but often results in a devastating event for both the pregnant patient and the foetus. Two cases of acute AD (Stanford type A) in pregnant females are pr...

journal_title：Experimental and therapeutic medicine

authors： Lei Y,Jiang Z,Chen J,Wang D,Hong G,Chen S

更新日期：2018-12-01 00:00:00

abstract：:Transvaginal ultrasound (TVUS) is a standard imaging modality for differentiating patients with benign or malignant suspected adnexal mass. To date, numerous studies have assessed the diagnostic accuracy of TVUS in various settings but with variable results. Therefore, the purpose of the present study was to perform a...

journal_title：Experimental and therapeutic medicine

authors： Zhang X,Meng X,Dou T,Sun H

更新日期：2020-12-01 00:00:00

abstract：:The aim of this study was to observe the effects of cluster of differentiation (CD) 151 on the expression of vascular endothelial growth factor (VEGF) in ischemic myocardium by the injection of a recombinant adeno-associated virus (rAAV) vector carrying the human CD151 gene. A rat acute myocardial infarction model was...

journal_title：Experimental and therapeutic medicine

authors： Fu H,Tan J,Yin Q

更新日期：2015-01-01 00:00:00

abstract：:The aim of this study was to analyze the changes in serum protein levels in the progression of hepatitis B using isobaric tags for relative and absolute quantitation (iTRAQ) analysis, in addition to comparing the serum protein levels of patients with chronic hepatitis B (CHB), patients with hepatitis B virus-induced a...

journal_title：Experimental and therapeutic medicine

authors： Peng L,Liu J,Li YM,Huang ZL,Wang PP,Gu YR,Zheng YB,Gao ZL

更新日期：2013-11-01 00:00:00

abstract：:One of the most prevalent diseases affecting humans are those which affect the oral cavity. Several diseases can affect the mouth, such as oral cancer, dental caries, Lichen Planus and, of course, periodontal disease with its variants. This review discusses gingivitis, periodontitis and peri-implantitis with a brief f...

journal_title：Experimental and therapeutic medicine

authors： Mann J,Bernstein Y,Findler M

更新日期：2020-02-01 00:00:00

abstract：:Kawasaki disease (KD) is the leading cause of acquired heart disease in pediatric patients in developed countries. Coronary artery aneurysms and myocardial infarction may occur if the disease remains untreated. An estimated 10-20% of KD patients do not respond to intravenous gamma globulin (IVIG), and thus, alternativ...

journal_title：Experimental and therapeutic medicine

authors： Dai N,Zhao C,Kong Q,Li D,Cai Z,Wang M

更新日期：2019-05-01 00:00:00

abstract：:Intervertebral disc degeneration (IDD) is considered to be the main cause of many spinal disorders; however, its underlying pathophysiology is not clearly understood. Recent studies indicate that excessive mechanical loading may serve a major role in the initiation of IDD. The aim of the present study was to explore t...

journal_title：Experimental and therapeutic medicine

authors： Bai X,Wang D,Zhou M,Xu C,Li W,Tao H,He Q,Ruan D

更新日期：2017-04-01 00:00:00

abstract：:The aim of the present study was to investigate whether the co-injection of hyaluronic acid (HA) and corticosteroids (CS) was superior to HA alone in the treatment of knee OA. A total of 120 participants with symptomatic knee OA were recruited and formed the intention-to-treat population for a 6-month follow-up. In th...

journal_title：Experimental and therapeutic medicine

authors： Wang SZ,Wu DY,Chang Q,Guo YD,Wang C,Fan WM

更新日期：2018-09-01 00:00:00