Intra-articular, single-shot co-injection of hyaluronic acid and corticosteroids in knee osteoarthritis: A randomized controlled trial.

Abstract:

:The aim of the present study was to investigate whether the co-injection of hyaluronic acid (HA) and corticosteroids (CS) was superior to HA alone in the treatment of knee OA. A total of 120 participants with symptomatic knee OA were recruited and formed the intention-to-treat population for a 6-month follow-up. In the HA group, patients received a single-shot injection of 4 ml HA. In the HA&CS group, patients received a co-injection of 3 ml compound betamethasone solution and 4 ml HA. Visual analog scale (VAS), Western Ontario and McMaster University Osteoarthritis Index (WOMAC) and knee flexion motion were assessed as primary outcomes. Patients in the HA&CS group exhibited better pain relief and knee function at the time points of week 1, month 1 and month 3 (P<0.05). For the last follow-up at month 6, the values did not differ significantly between these two groups. Patients in both groups exhibited improvement in pain, knee function, and range of motion following injection. For the final follow-up at month 6, the mean VAS score, WOMAC score and knee flexion motion were still superior to that prior to treatment, but the values did not differ significantly. The co-injection of HA and CS provided a rapid improvement in pain relief, knee function, and range of motion, but did not differ significantly from that of HA alone in the long term effect.

journal_name

Exp Ther Med

authors

Wang SZ,Wu DY,Chang Q,Guo YD,Wang C,Fan WM

doi

10.3892/etm.2018.6371

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

1928-1934

issue

3

eissn

1792-0981

issn

1792-1015

pii

ETM-0-0-6371

journal_volume

16

pub_type

杂志文章
  • Stimulation of tolerogenic dendritic cells using dexamethasone and 1,25-dihydroxyvitamin D3 represses autologous T cell activation and chondrocyte inflammation.

    abstract::Human osteoarthritis (OA) has been reclassified as a systemic musculoskeletal disorder involving activation of the innate and adaptive immune systems. Elevated pro-inflammatory cytokines may serve a key function in the development of the disease. 1,25-Dihydroxyvitamin D3 and dexamethasone (vitD3/Dex) may inhibit infla...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.7036

    authors: Wang G,Zhang J,Fang Y,Cao W,Xu B,Chen X

    更新日期:2019-01-01 00:00:00

  • Risk factors and the clinical and surgical features of fungal prosthetic joint infections: A retrospective analysis of eight cases.

    abstract::Fungal prosthetic joint infections (PJI) and reports of their clinical investigation are rare. In addition, there has been little evidence regarding the outcome of the two-stage exchange protocol for the treatment of fungal PJI. In order to investigate the risk factors and clinical, microbiological and pathological fe...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2016.3353

    authors: Geng L,Xu M,Yu L,Li J,Zhou Y,Wang Y,Chen J

    更新日期:2016-08-01 00:00:00

  • Dendrobium candidum Wall. ex Lindl. attenuates CCl4-induced hepatic damage in imprinting control region mice.

    abstract::The aim of the present study was to determine the preventive effect of the traditional Chinese medicine, Dendrobium candidum Wall ex Lindl. (D. candidum), on CCl4-induced hepatic damage in mice. The CCl4-induced hepatic damage mice were treated with D. candidum, and the serum levels of aspartate aminotransferase (AST)...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2014.1834

    authors: Li GJ,Sun P,Wang Q,Qian Y,Zhu K,Zhao X

    更新日期:2014-09-01 00:00:00

  • Predictive value of p53 expression in the risk of malignant gastrointestinal stromal tumors: Evidence from 19 studies.

    abstract::The current published data on p53 expression and its predictive value in the risk of malignant gastrointestinal stromal tumors (GIST) has are inconclusive. To derive a more precise estimation of the correlation between p53 and the biological behavior of GIST, a meta-analysis was performed. Studies were identified by s...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2011.369

    authors: Zong L,Chen P,Jiang J,Wang L,Li QG

    更新日期:2012-01-01 00:00:00

  • Low simvastatin concentrations reduce oleic acid-induced steatosis in HepG2 cells: An in vitro model of non-alcoholic fatty liver disease.

    abstract::Non-alcoholic fatty liver disease (NAFLD) is an inflammatory condition caused by hepatic lipid accumulation that is associated with insulin resistance, diabetes and metabolic syndrome. Although statins should be used with caution in liver diseases, they are increasingly investigated as a possible treatment for NAFLD. ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2016.3069

    authors: Alkhatatbeh MJ,Lincz LF,Thorne RF

    更新日期:2016-04-01 00:00:00

  • Brain-derived neurotrophic factor exerts neuroprotective actions against amyloid β-induced apoptosis in neuroblastoma cells.

    abstract::Alzheimer's disease (AD) brains demonstrate decreased levels of brain-derived neurotrophic factor (BDNF) and increased levels of β-amyloid peptide (Aβ), which is neurotoxic. The present study assessed the impact of BDNF on the toxic effects of Aβ25-35-induced apoptosis and the effects on BDNF-mediated signaling using ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2014.2033

    authors: Kim JH

    更新日期:2014-12-01 00:00:00

  • Combination of ketamine and xylazine exacerbates cardiac dysfunction in severely scalded rats during the shock stage.

    abstract::Cardiac inhibition due to burn injury and anesthetics have been documented previously. However, little is known about their combined effects on cardiac function. The aim of the present study was to observe the effects of a ketamine/xylazine (K/X) combination on the cardiac function of rats with severe scalds and compa...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2013.1213

    authors: Feng Y,Chai J,Chu W,Ma L,Zhang P,Duan H

    更新日期:2013-09-01 00:00:00

  • The future of medical education in neonatology, paediatrics and paediatric virology: An interview with Professor Alan Michael Weindling, Professor of Perinatal Medicine at the University of Liverpool.

    abstract::Professor Alan Michael Weindling, Emeritus Professor of Perinatal Medicine at the University of Liverpool in the UK, is one of the pioneers of modern neonatal care worldwide with an enormous contribution to the care of premature babies in the city of Liverpool. During the last 3 decades, his contributions focused on t...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.6547

    authors: Mammas IN,Spandidos DA

    更新日期:2018-09-01 00:00:00

  • Diagnostic value of OMOM capsule endoscopy for small bowel diseases in adults.

    abstract::The present study aimed to determine the diagnostic yield of OMOM capsule endoscopy for small bowel diseases in adults. A total of 89 patients, including 45 cases of obscure abdominal pain, 22 of chronic diarrhea, 18 of obscure gastrointestinal bleeding and 4 of obscure anemia were enrolled in the present study. The t...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.5864

    authors: Zhang L,Shen J,Guo L,Cheng F,Fan Q,Ni K,Xia S,Zhou D

    更新日期:2018-04-01 00:00:00

  • Protective effect of senegenin on splenectomy-induced postoperative cognitive dysfunction in elderly rats.

    abstract::Postoperative cognitive dysfunction (POCD) is common in elderly patients. Senegenin, an active component of extracts from Polygala tenuifolia root, a traditional Chinese medicine, has neuroprotective and neuroregenerative effects. However, the mechanism underlying the effects of senegenin against postoperative cogniti...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2014.1501

    authors: Yu L,Sun L,Chen S

    更新日期:2014-04-01 00:00:00

  • miR-216a-5p acts as an oncogene in renal cell carcinoma.

    abstract::MiR-216a-5p has been acknowledged as an oncogene and is known to be involved in the progression and metastasis of numerous cancer subtypes. However, the potential role of miR-216a-5p in renal cell carcinoma (RCC) remains to be elucidated. In the present study, reverse transcription-quantitative polymerase chain reacti...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.5881

    authors: Chen P,Quan J,Jin L,Lin C,Xu W,Xu J,Guan X,Chen Z,Ni L,Yang S,Chen Y,Lai Y

    更新日期:2018-04-01 00:00:00

  • BIIB021, an Hsp90 inhibitor, effectively kills a myelodysplastic syndrome cell line via the activation of caspases and inhibition of PI3K/Akt and NF-κB pathway proteins.

    abstract::The novel orally available inhibitor of the molecular chaperone heat shock protein 90 (Hsp90), BIIB021, induces the apoptosis of various types of tumor cell in vitro and in vivo. However, the effects and mechanisms of this agent on myelodysplastic syndrome (MDS) cell lines remain unknown. The aim of this study was to ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2014.1651

    authors: Lin S,Li J,Zhou W,Qian W,Wang B,Chen Z

    更新日期:2014-06-01 00:00:00

  • Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate.

    abstract::Mevalonate kinase (MVK) mutations were previously identified in disseminated superficial actinic porokeratosis. However, the role of MVK in differentiation, apoptosis and prenylation of keratinocytes requires further investigation. Farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP) of the mevalonate ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2020.8569

    authors: Li M,Min W,Wang J,Wang L,Li Y,Zhou N,Yang Z,Qian Q

    更新日期:2020-04-01 00:00:00

  • Enhanced plasma miR-142-5p promotes the progression of intrahepatic cholangiocarcinoma via targeting PTEN.

    abstract::The aim of the present study was to evaluate the expression and specific role of microRNA (miR)-142-5p in the progression of intrahepatic cholangiocarcinoma (ICC). Reverse transcription-quantitative polymerase chain reaction was performed to evaluate miR-142-5p expression in patients with ICC and healthy control subje...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2019.7438

    authors: Wei G,Yuan Y,He X,Jin L,Jin D

    更新日期:2019-05-01 00:00:00

  • Clinical value of Pro-GRP and T lymphocyte subpopulation for the assessment of immune functions of lung cancer patients after DC-CIK biological therapy.

    abstract::The present study investigated the aptness of assessing the levels of progastrin-releasing peptide (Pro-GRP) in addition to the T lymphocyte subpopulation in lung cancer patients prior to and after therapy for determining immune function. A total of 45 patients with lung cancer were recruited and stratified in to a no...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.5520

    authors: He L,Wang J,Chang D,Lv D,Li H,Zhang H

    更新日期:2018-02-01 00:00:00

  • Value of Dyna CT in guiding embolization during transarterial uterine artery embolization of fibroids.

    abstract::The present study aimed to assess the usefulness of Dyna CT during transarterial uterine artery embolization (UAE) of fibroids. A total of 65 patients with symptomatic submucosal and intramural fibroids scheduled for transarterial UAE at the First People's Hospital of Changhou between May 2016 and September 2018 were ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2020.8875

    authors: Wang CY,Xia JG,Chen WH,Lu YF,Han ZH,Wang Q

    更新日期:2020-08-01 00:00:00

  • Evaluation of right ventricular function by Doppler tissue imaging of the tricuspid annulus in patients with acquired immune deficiency syndrome.

    abstract::Chronic heart disease contributes to the mortality of patients with AIDS. Although studies of left ventricular function in patients with acquired immune deficiency syndrome (AIDS) have been conducted, studies of right ventricular function are rare. The present study aimed to characterize the tricuspid annulus movement...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2014.1480

    authors: Zhu H,Yuan J,Wei C,Chen J,Wang Y

    更新日期:2014-03-01 00:00:00

  • Effects of forkhead box protein M1 on trophoblast invasion and its role in preeclampsia development.

    abstract::The present study aimed to investigate the expression of the forkhead box protein M1 (FOXM1) in the placenta of patients with preeclampsia, and its effect on trophoblasts. A total of 28 patients with preeclampsia and 30 patients without preeclampsia (controls) who underwent cesarean section and were admitted to the Af...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.6195

    authors: Cui X,Xu J,Ji Y,Song X,Wang J,Zhang L,Yang S,Ye Y

    更新日期:2018-07-01 00:00:00

  • Insight into the binding interaction of kaempferol-7-O-α-L-rhamnopyranoside with human serum albumin by multiple fluorescence spectroscopy and molecular modeling.

    abstract::Human serum albumin (HSA) is a transporting protein that has multiple functions. The binding interaction between HSA and small molecules affects its function and efficacy of small molecules. The present study reports that kaempferol-7-O-α-L-rhamnopyranoside (KR) interacts with HSA as indicated by multiple fluorescence...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4427

    authors: Zhang W,Chen C,Zhang C,Duan J,Yao H,Li Y,Meng A,Shi J

    更新日期:2017-06-01 00:00:00

  • GATA4 is upregulated in nasopharyngeal cancer and facilitates epithelial-mesenchymal transition and metastasis through regulation of SLUG.

    abstract::GATA4, a member of the GATA family, serves a key function in several types of cancer, including hepatoblastoma, gastric cancer and breast cancer. However, the function of GATA4 in nasopharyngeal cancer (NPC) is largely unknown. The present study revealed that GATA4 was upregulated in NPC tissue samples and the NPC cel...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.6826

    authors: Zhou Y,Chang H,Yang B

    更新日期:2018-12-01 00:00:00

  • Anxiety and depression in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: Results from a Chinese survey.

    abstract::Limited studies have focused on mental symptoms (anxiety and depression) and their impact on quality of life (QoL) in patients with pulmonary hypertension (PH). The objective of the present study was to assess the prevalence of anxiety and depression and their association with QoL in patients with pulmonary arterial h...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2020.8566

    authors: Zhou X,Shi H,Yang Y,Zhang Z,Zhai Z,Wang C

    更新日期:2020-04-01 00:00:00

  • Expression of miR-376 in blood of pregnant women with preeclampsia and its effect on 25-hydroxyvitamin D.

    abstract::The study aims to investigate the clinical significance of regulating the expression of 25-hydroxyvitamin D (25-OH-VD) via microRNA (miRNA)-376c in the occurrence and development of preeclampsia (PE) in pregnant women. Peripheral blood and placental tissues were collected from pregnant women in 4 groups, including 67 ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.6394

    authors: Li J,Du J,Wang Z,Wang C,Bai J,Zhang S

    更新日期:2018-09-01 00:00:00

  • ERCC1 protein as a guide for individualized therapy of late-stage advanced non-small cell lung cancer.

    abstract::Excision repair cross-complementation group 1 (ERCC1) protein has been associated with cisplatin resistance. The objective of this study was to investigate the correlation between ERCC1 protein levels and the therapeutic effect of individualized therapy in advanced non-small cell lung cancer (NSCLC). A total of 190 ad...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2011.276

    authors: Gao Z,Han B,Shen J,Gu A,Qi D,Huang J,Shi C,Xiong L,Zhao Y,Jiang L,Wang H,Chen Y

    更新日期:2011-09-01 00:00:00

  • Curative effect of minimally invasive surgery on palmar and foot hyperhidrosis and its influence on serum-related cytokines and immunoglobulins.

    abstract::The curative effect of minimally invasive surgery on palmar and foot hyperhidrosis and its influence on serum-related cytokines and immunoglobulins were investigated. Seventy-six patients with palmar and foot hyperhidrosis admitted to Yunnan University Hospital from August 2014 to July 2016 were selected and randomly ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.5873

    authors: Li WX,Li YK,Lin HT

    更新日期:2018-04-01 00:00:00

  • A decreasing trend in toxoplasma gondii seroprevalence among pregnant women in Romania - results of a large scale study.

    abstract::Toxoplasmosis is a zoonotic infection caused by the obligate intracellular apicomplexan parasite Toxoplasma gondii (T. gondii). T. gondii infection is a cause of congenital infection worldwide. Primary infection or the reactivation of latent infection during pregnancy may lead to fetal infection and to congenital toxo...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2020.9012

    authors: Motoi S,Navolan DB,Malita D,Ciohat I,Nemescu D,Manciuc C,Gorun F,Vilibic-Cavlek T,Boda D,Craina M,Dobrescu A

    更新日期:2020-10-01 00:00:00

  • Orally administered sodium 4-phenylbutyrate suppresses the development of dextran sulfate sodium-induced colitis in mice.

    abstract::Sodium 4-phenylbutyrate (PBA) exerts therapeutic effects in a wide range of pathologies. A previous study by the present authors revealed that intraperitoneal administration of PBA suppresses the onset of dextran sulfate sodium (DSS)-induced colitis in mice. In the present study, the effects of orally administered PBA...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.5251

    authors: Ono K,Nimura S,Hideshima Y,Nabeshima K,Nakashima M

    更新日期:2017-12-01 00:00:00

  • Bayesian network meta-analysis of the effects of single-incision laparoscopic surgery, conventional laparoscopic appendectomy and open appendectomy for the treatment of acute appendicitis.

    abstract::The present study aimed to systematically evaluate the effectiveness of single-incision laparoscopic surgery (SILS), conventional laparoscopic appendectomy (CLA) and open appendectomy (OA) for the treatment of acute appendicitis. PubMed and Embase databases were systematically searched to identify relevant studies com...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.5343

    authors: Feng J,Cui N,Wang Z,Duan J

    更新日期:2017-12-01 00:00:00

  • Vascular repair and anti-inflammatory effects of soluble epoxide hydrolase inhibitor.

    abstract::Kawasaki disease (KD) is the leading cause of acquired heart disease in pediatric patients in developed countries. Coronary artery aneurysms and myocardial infarction may occur if the disease remains untreated. An estimated 10-20% of KD patients do not respond to intravenous gamma globulin (IVIG), and thus, alternativ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2019.7396

    authors: Dai N,Zhao C,Kong Q,Li D,Cai Z,Wang M

    更新日期:2019-05-01 00:00:00

  • MicroRNA-519a inhibits the proliferation and promotes the apoptosis of ovarian cancer cells through targeting signal transducer and activator of transcription 3.

    abstract::Ovarian cancer is a highly prevalent cancer among women. Recent studies have indicated that microRNAs (miRs) may serve important roles in the pathogenesis of ovarian cancer. miR-519a was observed to be downregulated in tissue samples of patients with ovarian cancer; however, its role in ovarian cancer requires further...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.5600

    authors: Tian F,Jia L,Chu Z,Han H,Zhang Y,Cai J

    更新日期:2018-02-01 00:00:00

  • Effects of recombinant adeno-associated virus-mediated CD151 gene transfer on the expression of rat vascular endothelial growth factor in ischemic myocardium.

    abstract::The aim of this study was to observe the effects of cluster of differentiation (CD) 151 on the expression of vascular endothelial growth factor (VEGF) in ischemic myocardium by the injection of a recombinant adeno-associated virus (rAAV) vector carrying the human CD151 gene. A rat acute myocardial infarction model was...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2014.2079

    authors: Fu H,Tan J,Yin Q

    更新日期:2015-01-01 00:00:00