Large scale ex vivo expansion of clinical-grade effector cells for adoptive immunotherapy.

abstract：:Adipose-derived stem cells (ADSCs) possess good proliferative and differentiative abilities, making then a promising candidate for the treatment of cartilage defects. However, local ischemia often causes apoptosis in ADSCs. Transforming growth factor-β3 (TGF-β3) is often used as a chondrogenic differentiation cytokine...

journal_title：Experimental and therapeutic medicine

authors： Wu F,Ye H,Lin J,Xu Y,Zhang Z,Xiong H,Laing M,Zhen Y,Chen S

更新日期：2018-05-01 00:00:00

abstract：:Ischemia-reperfusion (I/R) injury of the kidneys is commonly encountered in the clinic. The present study assessed the efficacy of simvastatin in preventing I/R-induced renal injury in a rat model and investigated the corresponding molecular mechanisms. Rats were divided into 3 groups, including a sham, I/R and I/R + ...

journal_title：Experimental and therapeutic medicine

authors： Zhang Y,Rong S,Feng Y,Zhao L,Hong J,Wang R,Yuan W

更新日期：2017-11-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is an inflammatory condition caused by hepatic lipid accumulation that is associated with insulin resistance, diabetes and metabolic syndrome. Although statins should be used with caution in liver diseases, they are increasingly investigated as a possible treatment for NAFLD. ...

journal_title：Experimental and therapeutic medicine

authors： Alkhatatbeh MJ,Lincz LF,Thorne RF

更新日期：2016-04-01 00:00:00

abstract：:Recurrent patellar dislocations were treated via knee arthroscopy combined with C-arm fluoroscopy, and reconstruction of the medial patellofemoral ligaments. Between October 2013 and March 2017, 52 cases of recurrent patellar dislocation [27 males and 25 females; age, 16-47 years (mean, 21.90 years)] were treated. Art...

journal_title：Experimental and therapeutic medicine

authors： Li L,Wang H,He Y,Si Y,Zhou H,Wang X

更新日期：2018-06-01 00:00:00

abstract：:The present study aimed to investigate the practicability and clinical value of applying laparotomy biliary lithotomy forceps to laparoscopic bile duct exploration (LCBDE) for the surgical treatment of incarcerated calculi. A total of 63 patients were diagnosed with cholecystolithiasis and choledocholithiasis. The pre...

journal_title：Experimental and therapeutic medicine

authors： Jiang H,Wang SY,Jin XL,Jin JC,Gu HB,Zhang FM

更新日期：2016-10-01 00:00:00

abstract：:Previous studies by our group demonstrated that radix Sophorae tonkinensis could induce hepatotoxicity. However, it remains unclear which components of this herb may be responsible for its hepatotoxicity. The present study aimed to investigate the hepatic toxicity of treatment with matrine (MT) and oxymatrine (OMT) al...

journal_title：Experimental and therapeutic medicine

authors： Gu Y,Lu J,Sun W,Jin R,Ohira T,Zhang Z,Tian X

更新日期：2019-04-01 00:00:00

abstract：:Effects of curcumin on artery blood gas index of rats with pulmonary fibrosis caused by paraquat poisoning and the expression of Mothers against decapentaplegic homolog 4 (Smad4), Smad ubiquitination regulatory factor 2 (Smurf2), interleukin-4 (IL-4) and interferon-γ (IFN-γ) were explored. A total of 54 Wistar rats we...

journal_title：Experimental and therapeutic medicine

authors： Chen H,Yang R,Tang Y,Fu X

更新日期：2019-05-01 00:00:00

abstract：:The aim of the present study was to investigate the effect of Forkhead family transcription factor P3 (Foxp3) knockdown on the function of cluster of differentiation (CD)4+CD25+ regulatory T cell (Tregs) and the tumor growth of a hepatocellular carcinoma (HCC) mouse model. CD4+CD25+ Tregs and CD4+CD25- T cells were so...

journal_title：Experimental and therapeutic medicine

authors： Shi C,Zhang Y,Yang H,Dong T,Chen Y,Xu Y,Yang X,Liu P

更新日期：2018-01-01 00:00:00

abstract：:The new enzyme-targeting radiosensitization treatment, Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas, type II (KORTUC II), markedly enhances the radiotherapeutic effect of treatment for various types of locally advanced malignant neoplasms. Patients who had declined surgical treatment and systemic chemoth...

journal_title：Experimental and therapeutic medicine

authors： Hitomi J,Kubota K,Ogawa Y,Hamada N,Murata Y,Nishioka A

更新日期：2010-09-01 00:00:00

abstract：:The present study aimed to investigate the capabilities of the cardiovascular virtual endoscopy (VE) system in diagnosing tetralogy of Fallot (TOF) and performing measurements. A total of 37 patients underwent two-dimensional echocardiography (2-DE) and multi-detector computed tomography (MDCT) examinations. The obtai...

journal_title：Experimental and therapeutic medicine

authors： Yao LP,Zhang L,Mei J,Ding FB,Li HM,Ding M,Yang X,Li XM,Sun K

更新日期：2018-02-01 00:00:00

abstract：:Ischemic heart diseases are a serious health problem worldwide. The transplantation of mesenchymal stem cells (MSCs) has been investigated in numerous clinical trials on various other diseases due to the self-renewal capacity of these cells and their potential to differentiate into a variety of cell types. The presenc...

journal_title：Experimental and therapeutic medicine

authors： Nimsanor N,Phetfong J,Plabplueng C,Jangpatarapongsa K,Prachayasittikul V,Supokawej A

更新日期：2017-12-01 00:00:00

abstract：:In patients with chronic kidney disease (CKD), hypertension (HP) is associated with the development of left ventricular (LV) diastolic dysfunction. However, the impact of antihypertensive treatment on LV diastolic function has not been well studied in CKD patients. Recently, two-dimensional speckle-tracking echocardio...

journal_title：Experimental and therapeutic medicine

authors： Li KL,Wang RX,Dai M,Lu J,Xue J,Yang XJ

更新日期：2015-05-01 00:00:00

abstract：:The aim of the present study was to explore the association between the M235T polymorphism of the angiotensinogen (AGT) gene and cytokines in patients with essential hypertension (EH). A total of 300 patients with EH and an age-matched control group of 150 individuals without EH, secondary hypertension, myocardial inf...

journal_title：Experimental and therapeutic medicine

authors： Cheng JL,Wang AL,Wan J

更新日期：2012-03-01 00:00:00

abstract：:Cardiovascular disease is the main cause of morbidity and mortality in end-stage renal disease (ESRD) patients. Recent population based epidemiological studies demonstrated a correlation between reduced renal function and risk for all causes and cardiovascular mortality, 50% of patients dying before the commencement o...

journal_title：Experimental and therapeutic medicine

authors： Timofte D,Dragoș D,Balcangiu-Stroescu AE,Tănăsescu MD,Gabriela Bălan D,Răducu L,Tulin A,Stiru O,Ionescu D

更新日期：2020-07-01 00:00:00

abstract：:Cell-based tissue engineering has the potential to restore cartilage defects. Induced pluripotent stem cells (iPSCs) are regarded as an alternative cell source in regenerative medicine. The purpose of the present study was to evaluate the use of mesenchymal stem cells (MSCs) derived from human iPSCs (hiPSCs) for the r...

journal_title：Experimental and therapeutic medicine

authors： Xu X,Shi D,Liu Y,Yao Y,Dai J,Xu Z,Chen D,Teng H,Jiang Q

更新日期：2017-07-01 00:00:00

abstract：:Immunomodulatory or immunosuppressive properties of bone marrow-derived mesenchymal stem cells (BM-MSCs) facilitate the treatment of acute respiratory distress syndrome and acute lung injury (ALI). Dysregulated miRNA (miRNA or miR) expression associated with the effects of BM-MSCs was assessed in a rat model of lipopo...

journal_title：Experimental and therapeutic medicine

authors： Park J,Jeong S,Park K,Yang K,Shin S

更新日期：2018-06-01 00:00:00

abstract：:UNBS5162, a naphthalimide derivative, has a strong anticancer effect and low clinical hematological toxicity. UNBS5162 has been shown to have an anticancer effect in numerous cancer types, except triple negative breast cancer (TNBC). To explore this issue, TNBC MDA-MB-231 cells were selected, and the effect of UNBS516...

journal_title：Experimental and therapeutic medicine

authors： Yue X,Li M,Chen D,Xu Z,Sun S

更新日期：2018-11-01 00:00:00

abstract：:Studies performed previously have indicated that long non-coding RNAs (lncRNAs) may be involved in skeletal muscle regeneration; however, the roles of lncRNAs during the repair of skeletal muscle contusion remain unclear. The present study established a mouse skeletal muscle contusion injury model to identify the role...

journal_title：Experimental and therapeutic medicine

authors： Zheng L,Liu X,Chen P,Xiao W

更新日期：2019-10-01 00:00:00

abstract：:The aim of this study was to evaluate the clincal value of multi-slice spiral computed tomography (MSCT) in the diagnosis of double aortic arch (DAA) and analyze the associated angiography and 3D reconstruction imaging to increase the accuracy of DAA diagnosis. Clinical and imaging data from 15 patients diagnosed with...

journal_title：Experimental and therapeutic medicine

authors： Chen X,Qu Y,Peng ZY,Lu J,Ma X,Hu W

更新日期：2014-08-01 00:00:00

abstract：:Genome wide association studies have revealed that the zinc finger MIZ-type containing 1 (ZMIZ1) is involved in the pathogenesis of vitiligo; however, the underlying mechanism remains unclear. The present study aimed to investigate the effects of ZMIZ1 on the proliferation, apoptosis and migration of the human melanoc...

journal_title：Experimental and therapeutic medicine

authors： Li M,Fan Y,Wang Y,Xu J,Xu H

更新日期：2020-08-01 00:00:00

abstract：:Eosinophilia has been implicated in the pathophysiology of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, the role of eosinophil activation in the development of AECOPD remains unclear. In the present study, the reliability of plasma levels of eosinophil activation markers, including eo...

journal_title：Experimental and therapeutic medicine

authors： Yang QF,Lu TT,Shu CM,Feng LF,Chang HT,Ji QY

更新日期：2017-10-01 00:00:00

abstract：:The present study aimed to investigate the role of plasminogen activator inhibitor-1 (PAI-1) in drug-induced early cognitive impairment and the underlying mechanism concerning microRNA (miR)-30b. A mouse model of cognitive impairment was established by intraperitoneal injection of scopolamine (2 mg/kg body weight) for...

journal_title：Experimental and therapeutic medicine

authors： Li X,Gao Y,Meng Z,Zhang C,Qi Q

更新日期：2016-05-01 00:00:00

abstract：:The present study aimed to investigate whether c-mesenchymal epithelial transition factor (C-MET) overexpression combined with RAS (including KRAS, NRAS and HRAS) or BRAF mutations were associated with late distant metastases and the prognosis of patients with colorectal cancer (CRC). A total of 374 patients with stag...

journal_title：Experimental and therapeutic medicine

authors： Liu J,Zeng W,Huang C,Wang J,Xu L,Ma D

更新日期：2018-05-01 00:00:00

abstract：:Atherosclerosis is caused by various factors, and Glabridin may have protective effects on the cardiovascular system. The purpose of the present study was to evaluate the effects of Glabridin on atherosclerosis and evaluate whether Glabridin attenuates arteriosclerosis and endothelial permeability by suppressing the m...

journal_title：Experimental and therapeutic medicine

authors： Wang G,Sun G,Wang Y,Yu P,Wang X,Zhou B,Zhu H

更新日期：2019-01-01 00:00:00

abstract：:The aim of the present study was to investigate the possible mechanism of Janus kinase (JAK)-signal transduction and activator of transcription (STAT)/PSMβ3 signaling in the occurrence of asthenozoospermia. We examined seminal fluid samples from 30 cases of asthenozoospermia and 30 healthy controls. Sperm was collecte...

journal_title：Experimental and therapeutic medicine

authors： Li J,Zhang L,Li B

更新日期：2017-01-01 00:00:00

abstract：:Infantile neuroaxonal dystrophy (INAD) is a rare neurodegenerative disorder. Phospholipase A2 group VI (PLA2G6) gene mutations have been identified in the majority of individuals with INAD. The present case report is on a Chinese female pediatric patient (age, 18 months) diagnosed with INAD with deafness. To date, onl...

journal_title：Experimental and therapeutic medicine

authors： Wang B,Wu,Tang J

更新日期：2018-08-01 00:00:00

abstract：:Endotoxin tolerance is an immunohomeostatic reaction to reiterant lipopolysaccharide (LPS) exposure that maintains a state of altered responsiveness in immune cells, resulting in the inhibition of the pro-inflammatory response and the resolution of inflammation. Microglia constitutes the first line of defense against ...

journal_title：Experimental and therapeutic medicine

authors： Sun X,Sun J,Shao X,Feng J,Yan J,Qin Y

更新日期：2018-06-01 00:00:00

abstract：:The present study was designed to evaluate the effects of steady and fluctuant inhibition of acetylcholinesterase (AChE) activity on neurotrophic factors in the hippocampus of juvenile mice. Steady inhibition of AChE activity was induced by an intramuscular injection of huperizine A (HupA) sustained-release microspher...

journal_title：Experimental and therapeutic medicine

authors： Li C,Wang T,Jiang N,Yu P,DU Y,Ren R,Fu F

更新日期：2012-02-01 00:00:00

abstract：:Systemic sclerosis (SSc) is a relatively rare autoimmune disease with skin and visceral involvement, having a yet unknown etiopathogenesis. Research has shown that professional exposure to various polluting chemicals such as dyes, aliphatic and aromatic organic solvents, inhalable silica dust or certain heavy metals, ...

journal_title：Experimental and therapeutic medicine

authors： Bobeica C,Niculet E,Craescu M,Halip AI,Popescu IA,Draganescu ML,Onisor C,Stefanescu B,Gheuca-Solovastru L

更新日期：2021-01-01 00:00:00

abstract：:Carotid artery stenosis is a notable cause of ocular ischemic disease. To analyze the ocular ischemic diseases caused by carotid artery stenosis and to seek effective treatment, a retrospective review of 182 patients with carotid artery stenosis was performed. These patients were administered medical treatment, caroti...

journal_title：Experimental and therapeutic medicine

authors： Yan Y,Zhang X,Yang Y,Han L,Wang H,Hu J

更新日期：2013-05-01 00:00:00