Abstract:
:Diabetes may affect myocardial fibrosis through oxidative stress. Trimetazidine (TMZ) is an anti-anginal agent. The present study aimed to determine the modulatory effect of TMZ on reactive oxygen species (ROS) and connective tissue growth factor (CTGF) expression and to evaluate the potential of TMZ to improve diastolic function in streptozotocin (STZ)-induced diabetic rats. After treating STZ-induced diabetic rats with TMZ for 16 weeks, a decrease in malondialdehyde levels, cardiac collagen volume fraction, left ventricular (LV) end-diastolic pressure and protein expression of collagen-I (Col I), Col III and CTGF compared with those in diabetic control rats was observed. In vitro, TMZ inhibited Col I, Col III and CTGF protein expression in cardiac fibroblasts treated with high glucose and decreased intracellular ROS generation and hydroxyproline content in the cell culture medium of cardiac fibroblasts. TMZ markedly improved cardiac fibrosis and diastolic function in diabetic rats. This effect was associated with a reduction in ROS production and CTGF expression in cardiac fibroblasts. The present study suggests that TMZ may be beneficial for protecting the hearts of diabetic patients.
journal_name
Exp Ther Medjournal_title
Experimental and therapeutic medicineauthors
Zhao Y,Li S,Quan E,Zhang H,Wu Y,Luo Y,Peng L,Wang J,Zhu J,Liu Jdoi
10.3892/etm.2019.7705subject
Has Abstractpub_date
2019-08-01 00:00:00pages
1477-1485issue
2eissn
1792-0981issn
1792-1015pii
ETM-0-0-7705journal_volume
18pub_type
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