Two successive cases of fetal harlequin ichthyosis: A case report.

abstract：:The herbal medicine Yin Huang Mixture (YHHJ; patent no. 200910031240.7) is an aqueous extract composed from various herbs, including Artemisia capillaries Thunb, Hypericum japonicum Thunb, Eucommia ulmoides Oliver, Rheum officinale Baill, Gardenia jasminoides Ellis, Poria cocos Wolf and Dictamnus dasycarpus Turcz. Pre...

journal_title：Experimental and therapeutic medicine

authors： Liu J,Hou LL,Zhao CY

更新日期：2018-04-01 00:00:00

abstract：:Tools to define the active ingredients and flavors of Traditional Chinese Medicines (TCMs) are limited by long analysis times, complex sample preparation and a lack of multiplexed analysis. The aim of the present study was to optimize and validate an electronic tongue (E-tongue) methodology to analyze the bitterness o...

journal_title：Experimental and therapeutic medicine

authors： Li X,Gao X,Liu R,Wang J,Wu Z,Zhang L,Li H,Gui X,Kang B,Shi J

更新日期：2016-11-01 00:00:00

abstract：:Effects of simvastatin-loaded PLGA sustained release microspheres on the treatment of rats with intervertebral disk degeneration (IVDD) and on 6-keto-prostaglandin F1α (6-K-PGF1α) and hypoxia inducible factor-1α (HIF-1α) were investigated. Eighty female rats were selected and randomized into a model group (modeled for...

journal_title：Experimental and therapeutic medicine

authors： Zhu K,Zhao F,Yang Y,Mu W

更新日期：2020-01-01 00:00:00

abstract：:Ginsenoside Rg3 has been demonstrated to inhibit tumor cell proliferation and angiogenesis. However, its effect on liver tumors when administered via the hepatic artery has not been investigated. The purpose of this study was to evaluate the therapeutic effect of hepatic artery administration of Rg3 combined with tran...

journal_title：Experimental and therapeutic medicine

authors： Yu Y,Zhang C,Liu L,Li X

更新日期：2013-03-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) accounts for ~80% of all types of lung cancer, which has the highest morbidity and mortality of all types of cancer worldwide. It is important to identify novel biomarkers and the molecular mechanism of NSCLC to improve current treatments of NSCLC. The present study aimed to investig...

journal_title：Experimental and therapeutic medicine

authors： Luo H,Liang C

更新日期：2018-04-01 00:00:00

abstract：:Capillary density on nailfold capillaroscopy (NFC) is considered a promising instrument for assessing disease characteristics in patients with systemic sclerosis (SSc), however, there is no agreement yet over how to analyze and interpret the results. The objective of this study was to investigate the possible associat...

journal_title：Experimental and therapeutic medicine

authors： Gheorghiu AM,Oneata R,Ancuta I,Enuica A,Linte O,Macovei L,Bojinca M,Stoica V,Mihai C

更新日期：2020-10-01 00:00:00

abstract：:Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a rare malignant tumor that accounts for 3% of all tumors of the nasal cavity. The incidence of ENB is 0.4 cases per million in the general population, and the most common symptoms are nasal obstruction and epistaxis. Previous studies have indicate...

journal_title：Experimental and therapeutic medicine

authors： Sabongi JG,Gonçalves MC,Alves CD,Alves J,Scapulatempo-Neto C,Moriguchi SM

更新日期：2016-11-01 00:00:00

abstract：:The aim of the present study was to determine the function of human amniotic epithelial cell transplantation (hAECT) in promoting the healing of rats with stage III pressure ulcer (PU) and to initially investigate its possible mechanisms. A total of 96 Sprague Dawley rats were allocated at random into the model, hAECT...

journal_title：Experimental and therapeutic medicine

authors： Zhou A,Zheng X,Yu L,Quan M,Shao X,Jiang Z

更新日期：2015-12-01 00:00:00

abstract：:The proliferation and migration of Schwann cells (SCs) are key events in the process of peripheral nerve repair. This is required to promote the growth of SCs and is a challenge during the treatment of peripheral nerve injury. Baicalin is a natural herb-derived flavonoid compound, which has been reported to possess ne...

journal_title：Experimental and therapeutic medicine

authors： Zuo W,Wu H,Zhang K,Lv P,Xu F,Jiang W,Zheng L,Zhao J

更新日期：2017-07-01 00:00:00

abstract：:Endostatin (ES) is an endogenous angiogenesis inhibitor that has the ability to inhibit tumor growth and metastasis. However, its clinical application is limited by a number of disadvantages, such as poor stability, short half-life and the requirement of high doses to maintain its efficacy. The chemical modification o...

journal_title：Experimental and therapeutic medicine

authors： Li ZN,Yuan ZF,Mu GY,Hu M,Cao LJ,Zhang YL,Ge MX

更新日期：2015-09-01 00:00:00

abstract：:Chrysin is a major active ingredient of flavonoids, known to exhibit protective effects against various types of cancer. However, the anticancer role of chrysin against hepatocellular carcinoma (HCC) and the underlying molecular mechanisms remain unclear. In order to evaluate the effects of chrysin on cell viability a...

journal_title：Experimental and therapeutic medicine

authors： Zhang Q,Ma S,Liu B,Liu J,Zhu R,Li M

更新日期：2016-07-01 00:00:00

abstract：:This study aims to investigate the function and related mechanism of P27 gene in intervertebral disc (IVD) degeneration of mice. X-ray, immunohistochemical staining, and alkaline phosphatase (ALP) histochemical staining were used to analyze the phenotypic difference of the intervertebral discs of 4-week-old mice with ...

journal_title：Experimental and therapeutic medicine

authors： Liu X,Wang D,Zhang Z,Zhu F,Yao A,Tian J,Miao D

更新日期：2017-08-01 00:00:00

abstract：:Female athletes may experience difficulties in achieving pregnancy due to athletic amenorrhea (AA); however, the underlying mechanisms of AA remain unknown. The present study focuses on the mitochondrial alteration and its function in detecting the possible mechanism of AA. An AA rat model was established by excessive...

journal_title：Experimental and therapeutic medicine

authors： Xiong RH,Wen SL,Wang Q,Zhou HY,Feng S

更新日期：2018-01-01 00:00:00

abstract：:This study was designed to assess the relationship between changes in peripheral inflammatory factors of patients complicated with non-alcoholic fatty liver disease (NAFLD) undergoing coronary artery bypass grafting (CABG) before and after operation, and their prognosis. A total of 68 patients with stable angina pecto...

journal_title：Experimental and therapeutic medicine

authors： Wang L,Li Y,Gong X

更新日期：2018-01-01 00:00:00

abstract：:The aim of the present study was to evaluate the expression and effect of rat mitofusin-2 (rMfn2) in the ovaries and other organs in rats. Rat models were developed by the intraovarian microinjection of an rMfn2-overexpressing lentiviral vector. Lenti-green fluorescent protein (GFP)-rMfn2 was microinjected into rat ov...

journal_title：Experimental and therapeutic medicine

authors： Hu X,Lei X,Wang J,Pan H,Li C,Yao Z

更新日期：2014-09-01 00:00:00

abstract：:A long-acting β2-agonist (LABA) combined with an inhaled corticosteroid (ICS) is frequently prescribed as initial therapy in steroid-naïve asthma patients because of its effective control of symptoms and improvement of pulmonary function. However, it is unclear which patients will be responsive to LABAs and whether br...

journal_title：Experimental and therapeutic medicine

authors： Ohwada A,Inami K,Onuma E,Matsumoto-Yamazaki M,Atsuta R,Takahashi K

更新日期：2011-07-01 00:00:00

abstract：:Donor organ rejection remains a significant problem. The present study aimed to assess whether transferring a donor's major histocompatibility complex (MHC) genes to the recipient could mitigate rejection in organ transplantation. Seven loci of MHC genes from donor mice were amplified and ligated into vectors; the vec...

journal_title：Experimental and therapeutic medicine

authors： Li T,Zhang W,Xu Q,Li S,Tong X,Ding J,Li H,Hou S,Xu Z,Jablons DM,You L

更新日期：2018-06-01 00:00:00

abstract：:The present study investigated the aptness of assessing the levels of progastrin-releasing peptide (Pro-GRP) in addition to the T lymphocyte subpopulation in lung cancer patients prior to and after therapy for determining immune function. A total of 45 patients with lung cancer were recruited and stratified in to a no...

journal_title：Experimental and therapeutic medicine

authors： He L,Wang J,Chang D,Lv D,Li H,Zhang H

更新日期：2018-02-01 00:00:00

abstract：:The association between Helicobacter pylori (H. pylori) infection and metabolic syndrome (MetS) determined in different cohorts from different countries is currently inconclusive. In the majority of previous studies, H. pylori infection was diagnosed based on the presence of H. pylori IgG antibody in the serum. Howeve...

journal_title：Experimental and therapeutic medicine

authors： Yu Y,Cai J,Song Z,Wang J,Wu L

更新日期：2019-06-01 00:00:00

abstract：:The present study investigated the role of runt-related transcription factor 2 (Runx2) in regulating the differentiation of human dental pulp stem cells (hDPSCs) into odontoblasts under the mediation of the Rho/Rho-associated protein kinase (ROCK) signaling pathway. hDPSCs and human bone marrow mesenchymal stem cells ...

journal_title：Experimental and therapeutic medicine

authors： Huang X,Chen X,Chen H,Xu D,Lin C,Peng B

更新日期：2018-05-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is a common malignant tumor with poor prognosis and an increasing number of cases. MicroRNA (miR)-4728 is related with the progression of various types of cancer, and is dysregulated in NSCLC, which indicates that miR-4728 may serve as a biomarker for NSCLC. The present study aimed t...

journal_title：Experimental and therapeutic medicine

authors： Hu Y,Zhang X,Gong C,Li J

更新日期：2020-11-01 00:00:00

abstract：:B-cell lymphoma 6 (BCL6), a proto-oncogene, is an evolutionarily conserved zinc finger protein that functions as a transcriptional repressor. BCL6 is the master regulator of B-lymphocyte development, and it has been reported that BCL6 may serve an important role in breast cancer progression. The aim of the present stu...

journal_title：Experimental and therapeutic medicine

authors： Ang L,Zheng L,Wang J,Huang J,Hu HG,Zou Q,Zhao Y,Liu QM,Zhao M,Wu ZS

更新日期：2017-11-01 00:00:00

abstract：:The aim of this study was to evaluate the clincal value of multi-slice spiral computed tomography (MSCT) in the diagnosis of double aortic arch (DAA) and analyze the associated angiography and 3D reconstruction imaging to increase the accuracy of DAA diagnosis. Clinical and imaging data from 15 patients diagnosed with...

journal_title：Experimental and therapeutic medicine

authors： Chen X,Qu Y,Peng ZY,Lu J,Ma X,Hu W

更新日期：2014-08-01 00:00:00

abstract：:Spinal cord injury (SCI) is a severe health problem and the mechanism involved remains elusive. The aim of the present study was to elucidate the role of C/EBP homologous protein (CHOP), a prominent protein of the endoplasmic reticulum (ER) stress-mediated apoptosis in SCI. A total of 20 adult male Sprague-Dawley rats...

journal_title：Experimental and therapeutic medicine

authors： Wang Z,Zhang C,Hong Z,Chen H,Chen W,Chen G

更新日期：2013-01-01 00:00:00

abstract：:Previous studies have demonstrated that aripiprazole (APZ), a third-generation atypical antipsychotic drug, exhibits anti-depressant and neuroprotective effects by promoting dopaminergic neuronal cell recovery in stroke. To investigate the neuroprotective effects of APZ, behavioral and histopathological experiments we...

journal_title：Experimental and therapeutic medicine

authors： Gil CH,Kim YR,Lee HJ,Jung DH,Shin HK,Choi BT

更新日期：2018-01-01 00:00:00

abstract：:Ventilator-associated pneumonia (VAP) is a common nosocomial infection in neonatal intensive care units with high morbidity and mortality. Bacterial biofilm in the endotracheal tube (ET) provides a notable and persistent source of pathogens that may cause VAP, and thus is important for VAP detection. However, during i...

journal_title：Experimental and therapeutic medicine

authors： Pan Y,Du L,Ai Q,Song S,Tang X,Zhu D,Yu J

更新日期：2017-08-01 00:00:00

abstract：:The present study aimed to determine the clinical characteristics and perinatal outcomes of females with severe preeclampsia according to their pre-pregnancy body mass index (BMI). Data from 233 patients with severe preeclampsia were reviewed from the Inpatient Obstetrics Department. The data were divided into 3 group...

journal_title：Experimental and therapeutic medicine

authors： Jiang L,Lin J,Yan J,Lin X,Han Q,Zhang H

更新日期：2020-07-01 00:00:00

abstract：:The Philips Intellivue MP50 monitor provides a method for non-invasive, near-continuous blood pressure (BP) monitoring and is designed to be an alternative to direct intra-arterial BP (IABP) measurement. However, no studies have specifically compared non-invasive and invasive BP measurements using the monitor. The pre...

journal_title：Experimental and therapeutic medicine

authors： Meng X,Zang G,Fan L,Zheng L,Dai J,Wang X,Xia W,Liu J,Zhang C

更新日期：2013-07-01 00:00:00

abstract：:The T790M mutational basis of treatment failure, following treatment via alteration of the epidermal growth factor receptor (EGFR) pathway, is a well-known anomaly in patients with non-small cell lung cancer (NSCLC). The T790M mutation activates the kinase domain, causing tyrosine kinase inhibitors, such as gefitinib,...

journal_title：Experimental and therapeutic medicine

authors： Zang SZ,Yang YR,Zhao SS,Li YX,Gao XY,Zhong CL

更新日期：2017-05-01 00:00:00

abstract：:Previous studies have indicated pro-tumor functions of macrophages in tumor progression in different types of malignant tumors. The detailed mechanisms of cell-cell interaction between macrophages and tumor cells have been investigated by means of in vitro co-culture experiments. The present study developed magnetite ...

journal_title：Experimental and therapeutic medicine

authors： Komohara Y,Kawauchi R,Makiyama E,Mikami K,Horlad H,Fujiwara Y,Kida T,Takeya M,Niidome T

更新日期：2017-08-01 00:00:00