In silico insight into EGFR treatment in patients with lung carcinoma and T790M mutations.

abstract：:We generated replication-defective adenovirus Ad-p53AIP1 and studied its anti-tumor efficacy both in vitro and in vivo. We demonstrated that Ad-p53AIP1 infection elicited high levels of p53AIP1 expression in cancer cells. We also found that Ad-p53AIP1 expression induced marked apoptosis and cell cycle arrest in HepG2 ...

journal_title：Experimental and therapeutic medicine

authors： Jiang Y,Chen H,Jia H,Xu Y,Liu G,Wang Y,Yang X,Lu Y

更新日期：2010-03-01 00:00:00

abstract：:An accessory middle cerebral artery (AMCA), which mainly acts in the collateral circulation of the middle cerebral artery (MCA), is a rare anatomic malformation. Similar to other intracranial vessels, cerebrovascular disease can occur in the AMCA. However, the development of an arteriovenous malformation (AVM) in the ...

journal_title：Experimental and therapeutic medicine

authors： Li K,Guo Y,Qu L,Xu B,Xu K,Yu J

更新日期：2018-09-01 00:00:00

abstract：:The present study aimed to investigate the capabilities of the cardiovascular virtual endoscopy (VE) system in diagnosing tetralogy of Fallot (TOF) and performing measurements. A total of 37 patients underwent two-dimensional echocardiography (2-DE) and multi-detector computed tomography (MDCT) examinations. The obtai...

journal_title：Experimental and therapeutic medicine

authors： Yao LP,Zhang L,Mei J,Ding FB,Li HM,Ding M,Yang X,Li XM,Sun K

更新日期：2018-02-01 00:00:00

abstract：:Diabetic nephropathy (DN) is currently a major public health problem worldwide. The objective of the present study was to evaluate the clinical effect of breviscapine injections in patients with DN. A meta-analysis was performed using the following databases to obtain published reports in any language: PubMed/MEDLINE,...

journal_title：Experimental and therapeutic medicine

authors： Liu X,Yao L,Sun D,Zhu X,Liu Q,Xu T,Wang L

更新日期：2016-09-01 00:00:00

abstract：:MicroRNAs (miRs) are a class of endogenous small non-coding RNAs that have been revealed to negatively mediate the expression of their target genes at the post-transcriptional level. Recently, particular miRs have demonstrated an involvement in the pathogenesis of Alzheimer's disease (AD). However, the specific role o...

journal_title：Experimental and therapeutic medicine

authors： Zhang Y,Xing H,Guo S,Zheng Z,Wang H,Xu D

更新日期：2016-08-01 00:00:00

abstract：:The present study was conducted to investigate the effects of minocycline on the expression of selected transcriptional and translational profiles in the rat spinal cord following sciatic nerve (SNR) transection and microsurgical coaptation. The mRNA and protein expression levels of B cell lymphoma-2 (Bcl-2), Bcl-2-as...

journal_title：Experimental and therapeutic medicine

authors： Keilhoff G,Lucas B,Uhde K,Fansa H

更新日期：2016-05-01 00:00:00

abstract：:The underlying mechanisms of arterial remodeling (AR) remain unclear. Studies have indicated that decellularized scaffolds stimulate the differentiation of fibroblasts into myofibroblasts and promote the accumulation of the extracellular matrix (ECM). In the present study, the impact of ECM changes following AR on vas...

journal_title：Experimental and therapeutic medicine

authors： Xin H,Wang Z,Wu S,Wang P,Tao X,Xu C,You L

更新日期：2019-07-01 00:00:00

abstract：:This study aimed to investigate the correlations between the detection rate of mural coronary artery (MCA) by 128-slice CT and the MCA compression extent in systole with myocardial bridge (MB) length and thickness. A retrospective analysis was conducted for 580 patients receiving multislicespiral CT coronary angiograp...

journal_title：Experimental and therapeutic medicine

authors： Niu YJ,Zhang XL,Cao AD,Leng B

更新日期：2013-03-01 00:00:00

abstract：:Psoriasis affects 2-4% of the population worldwide and its treatment is currently far from satisfactory. Calcipotriol and Portulaca oleracea have been reported to exhibit the capacity to inhibit inflammation in psoriatic patients and improve their clinical condition. However, the efficacy of a combination regimen of t...

journal_title：Experimental and therapeutic medicine

authors： Zhao H,Li S,Luo F,Tan Q,Li H,Zhou W

更新日期：2015-02-01 00:00:00

abstract：:Metastatic breast cancer is one of the most common metastatic tumors. Although studies have validated the role of β-inducible gene-h3 (βig-h3) in human biology and disease, the detailed mechanisms mediated by βig-h3 in breast carcinoma metastasis remain unclear. Thus, the present study investigated the role and potent...

journal_title：Experimental and therapeutic medicine

authors： Zhang J,Li Z

更新日期：2018-03-01 00:00:00

abstract：:Obstructive sleep apnoea (OSA) is a very common sleep and breathing disorder that occurs in worldwide. It is important to develop a more effective treatment for OSA to overcome lung cell apoptosis during intermittent hypoxia (IH). A mitochondrial separation protein inhibitor (Mdivi-1) has been demonstrated to be a pow...

journal_title：Experimental and therapeutic medicine

authors： Zhao D,Yin CY,Ye XW,Wan ZF,Zhao DG,Zhang XY

更新日期：2019-03-01 00:00:00

abstract：:Hepatitis B virus (HBV) can establish a lifelong chronic infection in humans, leading to liver cirrhosis, liver failure and hepatocellular carcinoma. Patients with chronic hepatitis B (CHB) exhibit a weak virus-specific immune response. Regulatory T cells (Tregs) play a key role in regulating the immune response in pa...

journal_title：Experimental and therapeutic medicine

authors： Tang R,Lei Z,Wang X,Qi Q,He J,Liu D,Wang X,Chen X,Zhu J,Li Y,Zhou S,Su C

更新日期：2020-10-01 00:00:00

abstract：:Stem cells represent an old niche with various new potential therapeutics. Besides drug treatment, reperfusion procedures and surgical revascularization, stem cell therapy could be a good option in ischemic cardiac diseases. A study was performed on a small group of cases who died of cardiac arrhythmia secondary to sc...

journal_title：Experimental and therapeutic medicine

authors： Ceausu Z,Socea B,Dimitriu MCT,Predescu D,Constantin VD,Bacalbaşa N,Cîrstoveanu C,Costache M,Ceausu M

更新日期：2020-10-01 00:00:00

abstract：:This prospective study explored the link between values of C-reactive protein (CRP) in patients with SpA (ankylosing spondylitis, psoriatic arthritis, reactive arthritis, or arthritis-related inflammatory bowel disease) and functional disability in order to derive an algorithm that may predict functional disability ba...

journal_title：Experimental and therapeutic medicine

authors： Catan L,Boariu M,Amaricai E,Popa D,Puenea G,Drăgoi M,Stratul Ș,Drăgoi RG

更新日期：2021-01-01 00:00:00

abstract：:This study explored the effect of pidotimod combined with azithromycin on children with mycoplasma pneumonia and the expression of interleukin-10 (IL-10) and granulocyte colony-stimulating factor (G-CSF) in serum. The clinical data of 149 children with mycoplasma pneumonia from May 2014 to May 2018 in Zhangqiu Distric...

journal_title：Experimental and therapeutic medicine

authors： Shi H,Lan L,Lv X,Sun L

更新日期：2019-09-01 00:00:00

abstract：:Breast cancer remains a worldwide public-health issue. Novel drugs that increase the sensitivity and reduce the toxic side effects of chemotherapeutic agents are urgently required. The present study investigated the effect and mechanism of the short-term intermittent administration of an anticancer bioactive peptide (...

journal_title：Experimental and therapeutic medicine

authors： Li X,Gao B,Su X

更新日期：2020-09-01 00:00:00

abstract：:Tanshinone IIA (TSIIA) is a major component of Salvia miltiorrhiza, a Chinese herb that exhibits a therapeutic effect on polycystic ovary syndrome (PCOS). The present study replicated PCOS via the neonatal treatment of estradiol in mice. Estrous cycles, body and ovarian weight, serum levels of testosterone and estradi...

journal_title：Experimental and therapeutic medicine

authors： Jin J,Hu QY,Xu WW,Zhu WJ,Liu B,Liu J,Wang W,Zhou HF

更新日期：2019-05-01 00:00:00

abstract：:Subclinical hypothyroidism (SCH) is becoming a global health problem due to its increasing prevalence and potential adverse effects, including cardiovascular diseases and nonalcoholic fatty liver disease (NAFLD). However, the association between SCH and NAFLD remains controversial. MicroRNAs (miRNAs/miRs) have been re...

journal_title：Experimental and therapeutic medicine

authors： Zhang L,Wu K,Bo T,Zhou L,Gao L,Zhou X,Chen W

更新日期：2020-02-01 00:00:00

abstract：:Cardiovascular ischemic disease refers to a large class of conditions that are harmful to human health. A number of previous studies have demonstrated that microRNAs (miRs) have notable roles in regulating cardiac injury. miR-144 is influential in the differentiation, growth, and metastatic processes of cells; however...

journal_title：Experimental and therapeutic medicine

authors： E L,Jiang H,Lu Z

更新日期：2019-03-01 00:00:00

abstract：:Adipose-derived stem cells (ADSCs) possess good proliferative and differentiative abilities, making then a promising candidate for the treatment of cartilage defects. However, local ischemia often causes apoptosis in ADSCs. Transforming growth factor-β3 (TGF-β3) is often used as a chondrogenic differentiation cytokine...

journal_title：Experimental and therapeutic medicine

authors： Wu F,Ye H,Lin J,Xu Y,Zhang Z,Xiong H,Laing M,Zhen Y,Chen S

更新日期：2018-05-01 00:00:00

abstract：:Chinese herbal extracts are being used increasingly to treat osteoarthritis (OA) in recent years. Baicalin (BA) is an active component of Scutellaria baicalensis Georgi extracts and protects chondrocytes against damage. The aim of the present study was to examine the mechanism of action of BA on chondrocytes from mous...

journal_title：Experimental and therapeutic medicine

authors： Wang P,Zhu P,Liu R,Meng Q,Li S

更新日期：2020-12-01 00:00:00

abstract：:Accumulating evidence has demonstrated that the Rho/Rho-associated protein kinase (Rho/ROCK) and nuclear factor κB (NF-κB) signaling pathways are involved in the pathogenesis of diabetic vascular injury. In this study, we investigated the beneficial effects of fasudil, a ROCK inhibitor, on vascular endothelial injury ...

journal_title：Experimental and therapeutic medicine

authors： Lu Y,Li H,Jian W,Zhuang J,Wang K,Peng W,Xu Y

更新日期：2013-08-01 00:00:00

abstract：:Extramedullary hematopoiesis (EMH) is defined as hematopoiesis occurring in organs outside of the bone marrow. The present report describes two cases of thalassemic patients with paraspinal medullary hematopoiesis and analyzes the clinical manifestations, imaging, pathology, diagnosis and treatment of EMH. In addition...

journal_title：Experimental and therapeutic medicine

authors： Zhang HZ,Li Y,Liu X,Chen BR,Yao GH,Peng YN

更新日期：2016-12-01 00:00:00

abstract：:The aim of this study was to observe the effects of different types of fluid resuscitation on hepatic mitochondria and apoptosis in hemorrhagic shock, and the corresponding mechanisms. Forty rats were divided into five groups: Sham surgery (Sham group), shock (Shock group), Ringer's lactate resuscitation (RL group), h...

journal_title：Experimental and therapeutic medicine

authors： Cheng Q,Yang G,Ma J,Li J,Shan Q

更新日期：2014-02-01 00:00:00

abstract：:Endometriosis (EM) is associated with oxidative stress. Advanced oxidation protein products (AOPPs) are novel markers of oxidative stress, which serve an important role as an inflammatory mediator in various chronic diseases. In order to examine the role of AOPPs in infertile women with EM, the present study analyzed ...

journal_title：Experimental and therapeutic medicine

authors： Song Y,Liu J,Qiu Z,Chen D,Luo C,Liu X,Hua R,Zhu X,Lin Y,Li L,Liu W,Quan S

更新日期：2018-01-01 00:00:00

abstract：:We report a case of a 10-year-old female patient who survived ring-sling complex without surgery. The patient had congenital wheezing from the neonatal period and was treated after a tentative diagnosis of infantile asthma. The patient suffered from allergy and was hospitalized several times due to severe wheezing, an...

journal_title：Experimental and therapeutic medicine

authors： Fukuda H,Imataka G,Drago F,Maeda K,Yoshihara S

更新日期：2017-09-01 00:00:00

abstract：:The Philips Intellivue MP50 monitor provides a method for non-invasive, near-continuous blood pressure (BP) monitoring and is designed to be an alternative to direct intra-arterial BP (IABP) measurement. However, no studies have specifically compared non-invasive and invasive BP measurements using the monitor. The pre...

journal_title：Experimental and therapeutic medicine

authors： Meng X,Zang G,Fan L,Zheng L,Dai J,Wang X,Xia W,Liu J,Zhang C

更新日期：2013-07-01 00:00:00

abstract：:The aim of this study was to analyze the changes in serum protein levels in the progression of hepatitis B using isobaric tags for relative and absolute quantitation (iTRAQ) analysis, in addition to comparing the serum protein levels of patients with chronic hepatitis B (CHB), patients with hepatitis B virus-induced a...

journal_title：Experimental and therapeutic medicine

authors： Peng L,Liu J,Li YM,Huang ZL,Wang PP,Gu YR,Zheng YB,Gao ZL

更新日期：2013-11-01 00:00:00

abstract：:The present study aimed to evaluate the anti-cancer effect of ellagic acid in human non-small cell lung cancer (NSCLC) A549 cells and to reveal the potential underlying mechanism. The effects of ellagic acid on the cell proliferation of A549 cells were determined by MTT assay. Cell cycle and apoptosis were measured wi...

journal_title：Experimental and therapeutic medicine

authors： Liu Q,Liang X,Niu C,Wang X

更新日期：2018-07-01 00:00:00

abstract：:The present study reported a case of portopulmonary hypertension (POPH) that was secondary to underlying liver cirrhosis in a 58-year-old woman, who was successfully treated with low-dose tolvaptan. The patient had suffered from refractory peripheral edema and electrolyte abnormalities, including severe hypokalemia, u...

journal_title：Experimental and therapeutic medicine

authors： Ogihara Y,Yamada N,Dohi K,Matsuda A,Ota S,Ishikura K,Nakamura M,Ito M

更新日期：2017-01-01 00:00:00