Abstract:
:Stem cells represent an old niche with various new potential therapeutics. Besides drug treatment, reperfusion procedures and surgical revascularization, stem cell therapy could be a good option in ischemic cardiac diseases. A study was performed on a small group of cases who died of cardiac arrhythmia secondary to scarring myocardial infarctions. Tissue cardiac samples were taken from these cases (from the anterior and lateral wall of the left ventricle), for microscopy examination, in order to investigate the presence of cardiac stem cells (CSC). Multiple series of histological sections were also performed and examined, along with immunohistochemical analysis (IHC). The cells were identified in close contact with the residual ischemic cardiomyocytes, in the proximity of the myocardial collagenous scar, in old myocardial infarctions. They were activated by hypoxic ischemia and were influenced by the capillary microvascular density and the interstitial micro-environment conditions. In chronic intermittent ischemia they seem to turn themselves from dormant quiescent cells into activated progenitor committed cells.
journal_name
Exp Ther Medjournal_title
Experimental and therapeutic medicineauthors
Ceausu Z,Socea B,Dimitriu MCT,Predescu D,Constantin VD,Bacalbaşa N,Cîrstoveanu C,Costache M,Ceausu Mdoi
10.3892/etm.2020.9015subject
Has Abstractpub_date
2020-10-01 00:00:00pages
3452-3457issue
4eissn
1792-0981issn
1792-1015pii
ETM-0-0-9015journal_volume
20pub_type
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