Relationship of renal morphology on 3-dimensional ultrasonography with renal pathologic findings and outcome in biopsy-proven nephropathy.

Abstract:

:Kidney morphology has been used to estimate renal functions. The present study investigated the usefulness of kidney length and renal parenchymal volume (RPV) measured using three-dimensional ultrasonography (3-D USG) in estimating renal pathological findings, and the outcome in patients with nephropathy who underwent renal biopsy. In this study, 94 adult patients who had native kidney biopsy with 3-D USG results were included. The mean kidney length and RPV were independent factors of, and positively correlated to the estimated glomerular filtration rate (eGFR). The mean kidney length and RPV had inverse associations with the percentage of global glomerulosclerosis. Higher mean RPV, other than longer kidney length, indicated a lower prevalence of tubular atrophy. During 63.3±19.3 months of follow-up, a mean RPV of <125 ml increased the risk of composite outcome by 4.287 fold (95% confidence interval, 1.133-16.227) as compared with a mean RPV of ≥125 ml (P=0.032). In conclusion, kidney size was inversely associated with certain nephronal damage and positively associated with eGFR in nephropathy. Furthermore, smaller RPVs predicted worse outcomes of nephropathy.

journal_name

Exp Ther Med

authors

Xu J,Hwang SI,Lee HJ,Chin HJ

doi

10.3892/etm.2017.5626

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

2088-2096

issue

2

eissn

1792-0981

issn

1792-1015

pii

ETM-0-0-5626

journal_volume

15

pub_type

杂志文章
  • N1-guanyl-1, 7-diaminoheptane enhances the sensitivity of pancreatic ductal adenocarcinoma cells to gemcitabine via the inhibition of eukaryotic translation initiation factor 5A2.

    abstract::Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy due to its broad resistance to chemotherapy. Gemcitabine is used as a standard chemotherapeutic drug for PDAC treatment, either alone or in combination with other chemotherapeutics. However, in patients with advanced disease, survival is rarely ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4740

    authors: Yao M,Hong Y,Liu Y,Chen W,Wang W

    更新日期:2017-09-01 00:00:00

  • Protective effects of paeoniflorin against FasL-induced apoptosis of intervertebral disc annulus fibrosus cells via Fas-FasL signalling pathway.

    abstract::In the present study, we demonstrate that the degeneration of intervertebral discs is caused by ageing and apoptosis of matrix cells. Apoptosis is as essential as the function of proteoglycan synthesis in assessing the possible degeneration of intervertebral discs; paeoniflorin (PF) induces cytoprotective effects on v...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2015.2776

    authors: Chen SQ,Lin JP,Zheng QK,Chen SJ,Li M,Lin XZ,Wang SZ

    更新日期:2015-12-01 00:00:00

  • Somatostatin administration prior to ERCP is effective in reducing the risk of post-ERCP pancreatitis in high-risk patients.

    abstract::Somatostatin has been extensively studied for the prophylaxis of pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP). However, the results remain controversial. The present retrospective cohort study aimed to investigate the efficacy of pre- and post-ERCP somatostatin administration in the pre...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2014.1733

    authors: Zhao LN,Yu T,Li CQ,Lai Y,Chen QK

    更新日期:2014-08-01 00:00:00

  • Retinoid acid receptors in human colorectal cancer: An unexpected link with patient outcome.

    abstract::The status of the three retinoic acid receptors (RARs) α, β and γ in human colorectal cancer (CRC) has not as yet been examined. RARs are in part responsible for the actions of the retinoids (vitamin A and its derivatives), which are essential for human health and survival due to their extensive involvement in numerou...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2011.242

    authors: Perraud A,Nouaille M,Akil H,Petit D,Labrousse F,Jauberteau MO,Mathonnet M

    更新日期:2011-05-01 00:00:00

  • LncRNA NEAT1 promotes apoptosis and inflammation in LPS-induced sepsis models by targeting miR-590-3p.

    abstract::Sepsis is a complication of infection caused by disease or trauma. Increasing evidence have shown that long noncoding RNAs (lncRNAs) are involved in the regulation of sepsis. However, the mechanism of lncRNA nuclear enriched abundant transcript 1 (NEAT1) in the regulation of sepsis progression remains to be elucidated...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2020.9079

    authors: Liu L,Liu F,Sun Z,Peng Z,You T,Yu Z

    更新日期:2020-10-01 00:00:00

  • Ciliary sulcus implantation of intraocular lens in manual small incision cataract surgery complicated by large posterior capsule rupture.

    abstract::The present study aimed to evaluate the safety and efficiency of ciliary sulcus implantation of intraocular lens (IOL) in patients that had undergone manual small incision cataract surgery (MSICS) complicated by large posterior capsule rupture (LPCR). A total of 11 eyes taken from 11 patients in Brazzaville, Republic ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.7074

    authors: Zhao J,Yu J,Wang T,Mban B

    更新日期:2019-02-01 00:00:00

  • Identification of genes associated with the effect of inflammation on the neurotransmission of vascular smooth muscle cell.

    abstract::Vascular smooth muscle cell (VSMC) accumulation and hypertrophy are common in vascular disorders, and inflammation has a crucial role in the development of these diseases. To investigate the effect of inflammation on the neurotransmission of VSMC, bioinformatic analysis was performed, following next generation sequenc...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4138

    authors: Gan S,Qiu S,Feng Y,Zhang Y,Qian Q,Wan Z,Tang J

    更新日期:2017-04-01 00:00:00

  • Bronchopulmonary dysplasia: Pathogenesis and treatment.

    abstract::Bronchopulmonary dysplasia (BPD) is a form of chronic lung disease of infancy, which mostly affects premature infants with significant morbidity and mortality. Premature infants who require to be treated for conditions including respiratory distress syndrome have a higher risk of developing BPD. In spite of the improv...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章,评审

    doi:10.3892/etm.2018.6780

    authors: Pasha AB,Chen XQ,Zhou GP

    更新日期:2018-12-01 00:00:00

  • Treatment of a central venous perforation caused by dialysis intubation using coils and cyanoacrylate glue: A case report.

    abstract::Central venous catheter is one of the most commonly used vascular therapies in patients receiving hemodialysis and vascular perforation is a rare but serious complication. The present study reports on a case of a 64-year-old female who developed massive hemothorax and hemorrhagic shock after long-term dialysis due to ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2019.7923

    authors: Zhou CZ,Liu KC,Wang P,Ren W,Lv WF

    更新日期:2019-10-01 00:00:00

  • Multimodal imaging findings of SAPHO syndrome with no skin lesions: A report of three cases and review of the literature.

    abstract::Synovitis, acne, palmoplantar pustulosis, hyperostosis and osteitis syndrome (SAPHO) is a rare syndrome that affects the skin, bones and joints. Diagnosis of SAPHO syndrome is established on clinical appearance and imaging features. The present case report described the imaging features of three cases of SAPHO with st...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2016.3689

    authors: Duan N,Chen X,Liu Y,Wang J,Wang Z

    更新日期:2016-10-01 00:00:00

  • Facile mechanical shaking method is an improved isolation approach for islet preparation and transplantation.

    abstract::Successful islet isolation is crucial for islet transplantation and cell treatment for type 1 diabetes. Current isolation methods are able to obtain 500-1,000 islets per rat, which results in a waste of ≥50% of total islets. In the present study, a facile mechanical shaking method for improving islet yield (up to 1,50...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2016.3844

    authors: Yin N,Chen T,Yu Y,Han Y,Yan F,Zheng Z,Chen Z

    更新日期:2016-12-01 00:00:00

  • Extra-articular tenosynovial chondromatosis of the left ring finger in a 23-year-old man: A case report and literature review.

    abstract::Tenosynovial chondromatosis is an extra-articular version of articular synovial chondromatosis and a relatively rare condition that can affect the tendon sheath, bursa, or joint synovial tissue. Tenosynovial chondromatosis is rarely reported in the literature and is often misdiagnosed. In the present study, a case of ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2015.2687

    authors: Chen YX,Lu YX,Zhuang ZE,Li ZY

    更新日期:2015-10-01 00:00:00

  • Comparison of clinical efficacy of metoprolol combined with irbesartan and hydrochlorothiazide and non-invasive ventilator in the emergency treatment of patients with severe heart failure.

    abstract::Clinical efficacy of metoprolol combined with irbesartan and hydrochlorothiazide and non-invasive ventilator in the emergency treatment of patients with severe heart failure (HF) was investigated. A retrospective analysis of the medical records of 124 patients with severe HF admitted to Binzhou Medical University Hosp...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.6828

    authors: Zhang F,Zhou G,Guo L,Lu F,Zhou G

    更新日期:2018-12-01 00:00:00

  • Ellagic acid promotes A549 cell apoptosis via regulating the phosphoinositide 3-kinase/protein kinase B pathway.

    abstract::The present study aimed to evaluate the anti-cancer effect of ellagic acid in human non-small cell lung cancer (NSCLC) A549 cells and to reveal the potential underlying mechanism. The effects of ellagic acid on the cell proliferation of A549 cells were determined by MTT assay. Cell cycle and apoptosis were measured wi...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.6193

    authors: Liu Q,Liang X,Niu C,Wang X

    更新日期:2018-07-01 00:00:00

  • Downregulation of phosphatase of regenerating liver-3 is involved in the inhibition of proliferation and apoptosis induced by emodin in the SGC-7901 human gastric carcinoma cell line.

    abstract::Emodin, an anthraquinone derivative isolated mainly from the root and rhizome of the medicinal plant Rheum palmatum L., was found to exert anticancer effects on various cultured cancer cells. Phosphatase of regenerating liver-3 (PRL-3), a novel gene, has been known to play an important role in the promotion of cellula...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2012.516

    authors: Sun ZH,Bu P

    更新日期:2012-06-01 00:00:00

  • Inhibition of mTOR promotes hyperthermia sensitivity in SMMC-7721 human hepatocellular carcinoma cell line.

    abstract::The mammalian target of rapamycin (mTOR) is a critical mediator of the phosphoinositide 3-kinase/protein kinase B/mTOR signaling pathway, and mTOR activity is induced following heat shock. Thermotherapy is used to treat hepatocellular carcinoma (HCC). However, the role of mTOR in modulating thermosensitivity in HCC ha...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2016.2979

    authors: Wang QL,Liu BO,Li XJ,Hu KP,Zhao K,Ye XM

    更新日期:2016-03-01 00:00:00

  • Electrospun collagen/poly(L-lactic acid-co-ε-caprolactone) scaffolds for conjunctival tissue engineering.

    abstract::Conjunctival injuries are general but intractable ocular surface diseases, the sequelae of which are particularly challenging to treat. A promising therapy for conjunctival injuries is to employ biodegradable scaffolds to deliver conjunctival epithelial cells for repairing damaged or diseased conjunctiva. In the prese...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.5073

    authors: Yao Q,Zhang W,Hu Y,Chen J,Shao C,Fan X,Fu Y

    更新日期:2017-11-01 00:00:00

  • Development of a poly-L-lactide salivary duct stent.

    abstract::Obstructive salivary gland diseases are common conditions that arise following the disruption of the secretary ductal system and usually results in the swelling and pain of the affected gland(s). There has been an increase in the use of sialendoscopy for the treatment and diagnosis of obstructive salivary gland infect...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2019.7308

    authors: Ding YF,Tseng H,Su CH,Tai CC,Wu YY,Haung CJ,Lee CS,Hung SH

    更新日期:2019-04-01 00:00:00

  • Effect of neuromedin U on allergic airway inflammation in an asthma model.

    abstract::Asthma is a major inflammatory airway disease with high incidence and mortality rates. The Global Initiative for Asthma released a report called 'The Global Burden of Asthma' in 2004. However, the specific pathogenesis of asthma remains unclear. An increasing number of studies have demonstrated that neuromedin U (NMU)...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章,评审

    doi:10.3892/etm.2019.8283

    authors: Ren X,Dong F,Zhuang Y,Wang Y,Ma W

    更新日期:2020-02-01 00:00:00

  • Overexpression of long non-coding RNA zinc finger antisense 1 in acute myeloid leukemia cell lines influences cell growth and apoptosis.

    abstract::The association between long non-coding RNA zinc finger antisense 1 (ZFAS1) and acute myeloid leukemia (AML) has not yet been investigated. The present study aimed to assess the potential role of ZFAS1 in AML cell proliferation and apoptosis. The expression of ZFAS1 mRNA in various AML cell lines (HL-60, KG-1, ML-1 an...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4535

    authors: Guo H,Wu L,Zhao P,Feng A

    更新日期:2017-07-01 00:00:00

  • Effects of matrine on the proliferation and apoptosis of vincristine-resistant retinoblastoma cells.

    abstract::Matrine is an active component of Leguminosae plants and is thought to exhibit anti-tumor effects. However, the effects of matrine on drug-resistant cancer have not been fully elucidated. The present study aimed to investigate the effects of matrine on vincristine (VCR)-resistant retinoblastoma (RB) cells and to asses...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2020.8992

    authors: Zhao B,Li B,Liu Q,Gao F,Zhang Z,Bai H,Wang Y

    更新日期:2020-09-01 00:00:00

  • Long-term survival results and prognostic factors of early gastric cancer.

    abstract::In spite of the favorable prognosis of early gastric cancer (EGC), recurrence or second primary cancers present in certain patients after curative surgery. It is crucial to identify who are at high risk and when. In the present study, 323 patients with EGC who underwent curative surgery were studied. A total of 22 pat...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2011.323

    authors: Huang B,Wang Z,Xing C,Sun Z,Zhao B,Xu H

    更新日期:2011-11-01 00:00:00

  • IGF-1 and VEGF can be used as prognostic indicators for patients with uterine fibroids treated with uterine artery embolization.

    abstract::The aim of the present study was to investigate the association between serum vascular endothelial growth factor (VEGF) and insulin-like growth factor 1 (IGF-1) levels and the prognosis of patients with uterine fibroids following uterine artery embolization (UAE) treatment. A total of 70 patients with uterine fibroids...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2015.2924

    authors: Mu Y,He J,Yan R,Hu X,Liu H,Hao Z

    更新日期:2016-02-01 00:00:00

  • MMP-9 and TIMP-1 in placenta of hypertensive disorder complicating pregnancy.

    abstract::Expression and characteristics of matrix metalloproteinase-9 (MMP-9) and TIMP metallopeptidase inhibitor-1 (TIMP-1) in the placenta of pregnancy induced hypertension (PIH) were detected in Uygur to analyze its correlation with PIH, and to provide a theoretical basis for clinical work. Ninety cases of placental tissue ...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2019.7591

    authors: Zhang Y,Li P,Guo Y,Liu X,Zhang Y

    更新日期:2019-07-01 00:00:00

  • Correlation of vitamin D receptor with bronchial asthma in children.

    abstract::This study was designed to investigate the correlation of vitamin D receptor (VDR) gene polymorphism with bronchial asthma in children. Seventy patients admitted to Daqing Longnan Hospital and diagnosed as bronchial asthma for the first time from April 2015 to May 2017 were selected as observation group. Patients rece...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.5739

    authors: Hou C,Zhu X,Chang X

    更新日期:2018-03-01 00:00:00

  • Dose-dependent effect of Curcuma longa for the treatment of Parkinson's disease.

    abstract::Curcuma longa is a plant that belongs to the ginger family, Zingiberaceae. It has been used in Siddha medicine for thousands of years in Asia. Parkinson's disease (PD) is a degenerative disorder of the central nervous system that affects the motor system of the brain. Death of dopamine-producing cells in the substanti...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4225

    authors: Ma XW,Guo RY

    更新日期:2017-05-01 00:00:00

  • Tetrandrine alleviates symptoms of rheumatoid arthritis in rats by regulating the expression of cyclooxygenase-2 and inflammatory factors.

    abstract::The present study aimed to construct a rat model of rheumatoid arthritis (RA) to evaluate changes in pathology, the expression of inflammatory factors and regulation of signaling pathways. The protective effect of tetrandrine (Tet) on tissue lesions induced by RA was also investigated. A total of 60 Wistar rats (100-2...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2018.6498

    authors: Li X,Wu Z,He B,Zhong W

    更新日期:2018-09-01 00:00:00

  • Overactivated autophagy contributes to steroid-induced avascular necrosis of the femoral head.

    abstract::Steroid-induced avascular necrosis of the femoral head (SANFH) is a mainly bilateral complication of steroid therapy that involves extensive necrosis, and frequently occurs in young and middle-aged individuals, with a high disability rate. Autophagy is an intracellular lysosomal degradation process occurring in numero...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2017.4508

    authors: Li X,Li YS,Li LJ,Xie X,Yang Y,Deng ZH,Zeng C,Lei GH

    更新日期:2017-07-01 00:00:00

  • Ultrasonic features of papillary thyroid microcarcinoma and non-microcarcinoma.

    abstract::The present study analyzed the ultrasonic features of papillary thyroid microcarcinoma (PTMC) and papillary thyroid non-microcarcinoma (non-PTMC) with the aim of improving the diagnostic value of ultrasonography. The ultrasonic features of 328 patients with papillary thyroid carcinoma (PTC), as confirmed by pathology,...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2014.1910

    authors: Zhang XL,Qian LX

    更新日期:2014-10-01 00:00:00

  • Successful treatment of invasive gastric mucormycosis in a patient with alcoholic liver cirrhosis: A case report.

    abstract::Gastrointestinal (GI) mucormycosis is a rare and life-threatening invasive fungal infection. GI mucormycosis occur in all parts of the alimentary tract, with the stomach being the most common site. Diabetes mellitus and other types of conditions associated with immunodeficiency, including hematologic malignancies, sol...

    journal_title:Experimental and therapeutic medicine

    pub_type: 杂志文章

    doi:10.3892/etm.2014.1753

    authors: Lee SH,Son YG,Sohn SS,Ryu SW

    更新日期:2014-08-01 00:00:00