Adenovirus Ad-p53AIP1-mediated gene therapy and its regulation of p53-MDM2 interactions.

abstract：:Chronic rhinosinusitis (CRS) is a heterogeneous disease, with varying immunological and histopathological features. The CC chemokine ligand 19 (CCL19) can stimulate T cells and antigen-presenting cells into secondary lymphoid node formation, as observed in allergic rhinitis, inflammatory bowel disease and other inflam...

journal_title：Experimental and therapeutic medicine

authors： Zou Y,Wang Y,Wang SB,Kong YG,Xu YU,Tao ZZ,Chen SM

更新日期：2016-01-01 00:00:00

abstract：:The aim of the present study was to develop an animal model of pulmonary fat embolism (PFE) caused by femoral intramedullary procedures, and to investigate the initial changes in the hemodynamics, cytokines and risk factors of PFE. Sixteen dogs were randomly divided into two groups: Group A (intramedullary reaming and...

journal_title：Experimental and therapeutic medicine

authors： Zhou F,Ji J,Song Q,Peng Z,Zhang G,Wang Y

更新日期：2013-08-01 00:00:00

abstract：:Gastrointestinal (GI) mucormycosis is a rare and life-threatening invasive fungal infection. GI mucormycosis occur in all parts of the alimentary tract, with the stomach being the most common site. Diabetes mellitus and other types of conditions associated with immunodeficiency, including hematologic malignancies, sol...

journal_title：Experimental and therapeutic medicine

authors： Lee SH,Son YG,Sohn SS,Ryu SW

更新日期：2014-08-01 00:00:00

abstract：:Bone cancer pain commonly occurs when tumors originating in the breast, prostate or lung metastasize to long bones, spinal vertebrae and/or the pelvis. However, the underlying mechanisms of bone cancer pain remain largely unknown. The present study aimed to determine the role of spinal tumor necrosis factor-α (TNF-α) ...

journal_title：Experimental and therapeutic medicine

authors： Yang Y,Zhang J,Gao Q,Bo J,Ma Z

更新日期：2017-05-01 00:00:00

abstract：:Pancreatic necrosectomy (PN) following percutaneous catheter drainage (PCD) is an effective method of treating patients with necrotizing pancreatitis, however, the predictive factors for PN after PCD have not yet been identified. A total of 74 patients with suspected infected necrotizing pancreatitis (INP) and peripan...

journal_title：Experimental and therapeutic medicine

authors： Cao X,Cao F,Li A,Gao X,Wang XH,Liu DG,Fang Y,Guo DH,Li F

更新日期：2017-11-01 00:00:00

abstract：:The action mechanism of long non-coding ribonucleic acid-homeobox transcript antisense ribonucleic acid (lncRNA-HOTAIR) in the regulation of the Wnt signaling pathway on the drug resistance of non-small cell lung cancer was investigated. Forty eight patients with non-small cell lung cancer, who were treated with cispl...

journal_title：Experimental and therapeutic medicine

authors： Guo F,Cao Z,Guo H,Li S

更新日期：2018-06-01 00:00:00

abstract：:Cyclooxygenase (COX)-2 inhibitors are widely used for postoperative pain control in clinical practice. However, it is unknown whether spinal sensitization is involved in the analgesic effects of COX-2 inhibitors on surgical pain. Extracellular signal-regulated kinase (ERK) in the spinal cord is implicated in various t...

journal_title：Experimental and therapeutic medicine

authors： Guo YJ,Shi XD,Fu D,Yang Y,Wang YP,Dai RP

更新日期：2013-07-01 00:00:00

abstract：:One of the most prevalent diseases affecting humans are those which affect the oral cavity. Several diseases can affect the mouth, such as oral cancer, dental caries, Lichen Planus and, of course, periodontal disease with its variants. This review discusses gingivitis, periodontitis and peri-implantitis with a brief f...

journal_title：Experimental and therapeutic medicine

authors： Mann J,Bernstein Y,Findler M

更新日期：2020-02-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) may lead to physical and pathological damage and has been a focus of research for decades. Evaluating tensile damage caused by deformation in ICH is an important component of damage assessment for correct diagnosis and treatment. Traditional research on ICH paid little attention to quant...

journal_title：Experimental and therapeutic medicine

authors： Ren P,Wang BC,Wang YZ,Hao SL,Guo TW,Li XF

更新日期：2018-12-01 00:00:00

abstract：:The T790M mutational basis of treatment failure, following treatment via alteration of the epidermal growth factor receptor (EGFR) pathway, is a well-known anomaly in patients with non-small cell lung cancer (NSCLC). The T790M mutation activates the kinase domain, causing tyrosine kinase inhibitors, such as gefitinib,...

journal_title：Experimental and therapeutic medicine

authors： Zang SZ,Yang YR,Zhao SS,Li YX,Gao XY,Zhong CL

更新日期：2017-05-01 00:00:00

abstract：:The aim of the present study was to investigate the protective effects of sodium ferulate (SF) on HT22 hippocampal cells under a high glucose concentration. Cells were cultured in normal glucose (25 mM D-glucose) or high glucose (50 mM D-glucose) with various concentrations of SF (50, 100, 250 or 500 µM) for 0, 48 and...

journal_title：Experimental and therapeutic medicine

authors： Zhao J,Liu L,Zhang L,Lv J,Guo X,Li X,Zhao T

更新日期：2019-09-01 00:00:00

abstract：:The present report describes the clinical course and treatment of a Mooren-like ulcer associated with abuse of topical anesthetics and dexamethasone. A 38-year-old male physician treated himself with lidocaine, tetracaine and dexamethasone (DEX) eye drops for severe pain and decline of vision in both eyes. After six m...

journal_title：Experimental and therapeutic medicine

authors： Wu H,Hu Y,Shi XR,Xu F,Jiang CY,Huang R,Jia H

更新日期：2016-07-01 00:00:00

abstract：:Gastric ulcer is one of the most common chronic gastrointestinal diseases characterized by a significant defect in the mucosal barrier. Helicobacter pylori (H. pylori) infection and the frequent long-term use of non-steroidal anti-inflammatory drugs are major factors involved in gastric ulcer development. Acid inhibit...

journal_title：Experimental and therapeutic medicine

authors： Khoder G,Al-Menhali AA,Al-Yassir F,Karam SM

更新日期：2016-07-01 00:00:00

abstract：:The aim of the present study was to investigate the correlation between the protein expression of A-kinase anchor protein 95 (AKAP95), cyclin D3 and AKT with pathological indicators in lung cancer tissues. Immunohistochemistry was used to detect the protein expression levels of the proteins in 51 lung cancer tissue sa...

journal_title：Experimental and therapeutic medicine

authors： Yu X,Yuan Y,Zhi X,Teng B,Chen X,Huang Q,Chen Y,Guan Z,Zhang Y

更新日期：2015-09-01 00:00:00

abstract：:This study aimed to assess the effect on solid tumors of mild temperature hyperthermia (MTH) combined with hexamethylenetetramine (HMTA) or tirapazamine (TPZ). Squamous cell carcinoma (SCC VII) tumor-bearing mice were continuously administered 5-bromo-2'-deoxyuridine (BrdU) to label intratumor proliferating (P) cells....

journal_title：Experimental and therapeutic medicine

authors： Masunaga SI,Tano K,Nakamura J,Watanabe M,Kashino G,Suzuki M,Kinashi Y,Ono K

更新日期：2010-01-01 00:00:00

abstract：:In the present study, we analyzed schizophrenia (SCZ)-related genome-wide association studies (GWAS) to identify genes and pathways associated with SCZ. We identified 1,098 common genes (1,098/9,468) and 20 shared KEGG pathways (both P<0.01) by integrating candidate genes from the European and American SCZ-related GWA...

journal_title：Experimental and therapeutic medicine

authors： Wang Z,Li P,Wu T,Zhu S,Deng L,Cui G

更新日期：2018-12-01 00:00:00

abstract：:Apoptosis occurring secondary to spinal cord injury (SCI) causes further neural damage and functional loss. In this study, a rat model was used to investigate the effect of treadmill exercise on SCI-induced apoptosis and expression of neurotrophic factors. To produce SCI, a contusion injury (10 g × 25 mm) was applied ...

journal_title：Experimental and therapeutic medicine

authors： Jung SY,Kim DY,Yune TY,Shin DH,Baek SB,Kim CJ

更新日期：2014-03-01 00:00:00

abstract：:Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is broadly expressed on the majority of immune cells; however, the biological role of LAIR in solid tumors has yet to be elucidated. In the present study, using immunohistochemical staining analysis, the expression of LAIR-1 in human cervical cancer (HCC) an...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Zhang X,Miao F,Cao Y,Xue J,Cao Q,Zhang X

更新日期：2016-12-01 00:00:00

abstract：:Primary congenital glaucoma (PCG) is one of the primary causes of blindness in children and is characterized by congenital trabecular meshwork and anterior chamber angle dysplasia. While being a rare condition, PCG severely impairs the quality of life of affected patients. However, the pathogenesis of PCG remains to b...

journal_title：Experimental and therapeutic medicine

authors： Ling C,Zhang D,Zhang J,Sun H,Du Q,Li X

更新日期：2020-08-01 00:00:00

abstract：:Resveratrol, a naturally occurring polyphenolic phytoalexin antioxidant compound present in grapes and red wine, has been reported to induce various biochemical responses. It has been shown to possess anti-aging, anti-inflammatory and anti-proliferative activities in several cell types. However, the effects of resvera...

journal_title：Experimental and therapeutic medicine

authors： Eo SH,Cho HS,Kim SJ

更新日期：2014-03-01 00:00:00

abstract：:The aim of this study was to investigate the surgical methods and efficacies for cervicothoracolumbar spinal schwannoma (CSS). A total of 52 patients who had undergone treatment for schwannoma were retrospectively analyzed. Two methods were employed for the surgical resection of the thoracic and lumbar schwannomas: Ty...

journal_title：Experimental and therapeutic medicine

authors： Deng Q,Tian Z,Sheng W,Guo H,Dan ME

更新日期：2015-12-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/etm.2015.2631.]. ...

journal_title：Experimental and therapeutic medicine

authors： Wong AP,Kalinovsky T,Niedzwiecki A,Rath M

更新日期：2020-02-01 00:00:00

abstract：:Diabetes mellitus promotes atrial structural remodeling, thereby producing atrial arrhythmogenicity. Atrial arrhythmia can substantially increase the risk of premature death. The aim of this study was to investigate the role of Ras homolog gene family, member A (RhoA)/Rho associated coiled-coil forming protein kinase ...

journal_title：Experimental and therapeutic medicine

authors： Chen J,Li Q,Dong R,Gao H,Peng H,Wu Y

更新日期：2014-09-01 00:00:00

abstract：:Sepsis is a highly complex and often fatal syndrome which varies widely in its clinical manifestations, and therapies that target the underlying uncontrolled immune status in sepsis are needed. The failure of preclinical approaches to provide significant sepsis survival benefit in the clinic is often attributed to ina...

journal_title：Experimental and therapeutic medicine

authors： Stevens NE,Nash CH,Fraser CK,Kuchel TR,Maiden MJ,Chapman MJ,Diener KR,Hayball JD

更新日期：2019-11-01 00:00:00

abstract：:The aim of the present study was to explore the effect of baicalin on liver hypoxia/reoxygenation (H/R) injury and the possible mechanism involved. A cellular H/R model was established and cells were treated with 50, 100 and 200 µmol/l baicalin. Following reoxygenation for 6 h, cell viability, lactate dehydrogenase (L...

journal_title：Experimental and therapeutic medicine

authors： Liu F,Zhang J,Qian J,Wu G,Ma Z

更新日期：2018-08-01 00:00:00

abstract：:Spinal cord injury (SCI) may lead to a devastating and permanent loss of neurological function, which may place a great economic burden on the family of the patient and society. Methods for reducing the death of neuronal cells, inhibiting immune and inflammatory reactions, and promoting the growth of axons in order to...

journal_title：Experimental and therapeutic medicine

authors： Ji W,Hu S,Zhou J,Wang G,Wang K,Zhang Y

更新日期：2014-03-01 00:00:00

abstract：:Acellular dermal matrices (ADMs) are increasingly used for the restoration of soft-tissue defects of the oral cavity due to their ability to facilitate faster healing and reduce scar formation without rejection. However, few studies have focused on the histopathology and biological mechanisms involved in their use. Th...

journal_title：Experimental and therapeutic medicine

authors： Xu X,Cui N,Wang E

更新日期：2018-03-01 00:00:00

abstract：:Compared to other diseases, early or atypical spinal tuberculosis (TB) is prone to being misdiagnosed due to the lack of specific clinical manifestations and misleading negative results of various laboratory analyses and imaging examinations. Various methods for diagnosing spinal TB have become research hotspots. Rece...

journal_title：Experimental and therapeutic medicine

authors： Pu F,Feng J,Yang L,Zhang L,Xia P

更新日期：2019-11-01 00:00:00

abstract：:Enamel matrix derivative (EMD) is a commercially available protein extract, mainly comprising amelogenins. A number of other polypeptides have been identified in EMD, mostly growth factors, which promote cementogenesis and osteogenesis during the regeneration processes through the regulation of cell proliferation, dif...

journal_title：Experimental and therapeutic medicine

authors： Wyganowska-Świątkowska M,Urbaniak P,Nohawica MM,Kotwicka M,Jankun J

更新日期：2015-06-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/etm.2016.3317.]. ...

journal_title：Experimental and therapeutic medicine

authors：

更新日期：2016-09-01 00:00:00