Treadmill exercise reduces spinal cord injury-induced apoptosis by activating the PI3K/Akt pathway in rats.

abstract：:In the present study, the changes in the retinal nerve fiber layer (RNFL) thickness associated with Leber's hereditary optic neuropathy (LHON) were examined by Cirrus high definition-optical coherence tomography (OCT), and the correlation between the RNFL thickness and the best corrected visual acuity (BCVA) was evalu...

journal_title：Experimental and therapeutic medicine

authors： Zhang Y,Huang H,Wei S,Qiu H,Gong Y,Li H,Dai Y,Jiang Z,Liu Z

更新日期：2014-02-01 00:00:00

abstract：:The incidence of oral squamous cell carcinoma (OSCC) is continuously increasing while its survival rate has not notably improved. There is a pressing need for improved understanding of the genetic regulation of OSCC tumorigenesis and progression. In this study, the function of miR-448 in the regulation of OSCC growth ...

journal_title：Experimental and therapeutic medicine

authors： Shen L,Liu L,Ge L,Xie L,Liu S,Sang L,Zhan T,Li H

更新日期：2016-10-01 00:00:00

abstract：:A number of microRNAs (miRs) have been revealed to be involved in the development of osteoporosis, including postmenopausal osteoporosis. The aim of the present study was to investigate miR-135a-5p expression and the cellular function of miR-135a-5p and its underlying mechanism in postmenopausal osteoporosis. miR-135a...

journal_title：Experimental and therapeutic medicine

authors： Shi X,Zhang Z

更新日期：2019-10-01 00:00:00

abstract：:Previous studies have indicated pro-tumor functions of macrophages in tumor progression in different types of malignant tumors. The detailed mechanisms of cell-cell interaction between macrophages and tumor cells have been investigated by means of in vitro co-culture experiments. The present study developed magnetite ...

journal_title：Experimental and therapeutic medicine

authors： Komohara Y,Kawauchi R,Makiyama E,Mikami K,Horlad H,Fujiwara Y,Kida T,Takeya M,Niidome T

更新日期：2017-08-01 00:00:00

abstract：:The present study investigated the clinical characteristics and diagnosis of modern laryngeal tuberculosis (TB). A total of 61 patients that were pathologically diagnosed with laryngeal TB between 1998 and 2012 were retrospectively analyzed using laryngoscopy methods. The primary symptoms of laryngeal TB observed in t...

journal_title：Experimental and therapeutic medicine

authors： Zhao N,Zhang Y,Li K

更新日期：2017-11-01 00:00:00

abstract：:Resveratrol, a naturally occurring polyphenolic phytoalexin antioxidant compound present in grapes and red wine, has been reported to induce various biochemical responses. It has been shown to possess anti-aging, anti-inflammatory and anti-proliferative activities in several cell types. However, the effects of resvera...

journal_title：Experimental and therapeutic medicine

authors： Eo SH,Cho HS,Kim SJ

更新日期：2014-03-01 00:00:00

abstract：:This study was designed to assess the relationship between changes in peripheral inflammatory factors of patients complicated with non-alcoholic fatty liver disease (NAFLD) undergoing coronary artery bypass grafting (CABG) before and after operation, and their prognosis. A total of 68 patients with stable angina pecto...

journal_title：Experimental and therapeutic medicine

authors： Wang L,Li Y,Gong X

更新日期：2018-01-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) may lead to physical and pathological damage and has been a focus of research for decades. Evaluating tensile damage caused by deformation in ICH is an important component of damage assessment for correct diagnosis and treatment. Traditional research on ICH paid little attention to quant...

journal_title：Experimental and therapeutic medicine

authors： Ren P,Wang BC,Wang YZ,Hao SL,Guo TW,Li XF

更新日期：2018-12-01 00:00:00

abstract：:Icariin, a flavonoid isolated from traditional oriental herbal medicines, has been demonstrated to exhibit several health benefits in animal models and in humans. The aim of the present study was to investigate the effect of Icariin on hyperglycemia in type 2 diabetes mellitus (T2DM) in rats. A model of diabetes was e...

journal_title：Experimental and therapeutic medicine

authors： Li X,Wang YX,Shi P,Liu YP,Li T,Liu SQ,Wang CJ,Wang LX,Cao Y

更新日期：2020-04-01 00:00:00

abstract：:The present study aimed to investigate the effects of levodopa (LEV) on cellular apoptosis in a rabbit model of steroid-associated necrosis of the femoral head (SANFH). A total of 44 healthy adult Chinese rabbits were randomly divided into three groups: Group A (n=15), administered a combination of lipopolysaccharide ...

journal_title：Experimental and therapeutic medicine

authors： Xi H,Tao W,Jian Z,Sun X,Gong X,Huang L,Dong T

更新日期：2017-01-01 00:00:00

abstract：:The aim of this study was to investigate and analyze the effects of human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) on the recovery of neurological function and telomerase reverse transcriptase (TERT) expression in brain tissue of rats with cerebral ischemia-reperfusion injury. A total of 100 healthy adu...

journal_title：Experimental and therapeutic medicine

authors： Huang X,Zhang S,Li F,Zhou Y,Wang X,Fu G,Ma X

更新日期：2017-12-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus, which causes coronavirus disease 2019 (COVID-19) and affects children less frequently than adults. According to Professor Vana Papaevangelou, Professor of Paediatrics at the University of Athens School of Medicine, children comprise o...

journal_title：Experimental and therapeutic medicine

authors： Mammas IN,Theodoridou M,Spandidos DA

更新日期：2020-12-01 00:00:00

abstract：:The role of apolipoprotein E (Apo E) gene polymorphisms in the etiology of recurrent pregnancy loss (RPL) is not clearly understood. We evaluated this polymorphism in unexplained pregnancy losses in a group of Turkish women. In our prospective case-control study, 45 well-characterized RPL cases were examined for their...

journal_title：Experimental and therapeutic medicine

authors： Korkmazer E,Ustunyurt E,Tekin B,Cilingir O

更新日期：2013-05-01 00:00:00

abstract：:The aim of this study was to analyze the techniques for intraocular lens (IOL) implantation in patients with coloboma of the iris. A retrospective cohort study was used to analyze the degree of iris coloboma and the characteristics of the crystalline lens in 56 patients with iris coloboma. The patients with a lesser d...

journal_title：Experimental and therapeutic medicine

authors： Li J,Li Y,Hu Z,Kong L

更新日期：2014-06-01 00:00:00

abstract：:Diagnostic value between IL-17 combined with IL-18 and CT angiography in carotid atherosclerosis was evaluated. A total of 158 patients with suspected carotid artery stenosis in People's Hospital of Dongying from March 2014 to April 2017 were selected as the subjects. One hundred and two patients with carotid atherosc...

journal_title：Experimental and therapeutic medicine

authors： Suo F,Jiang F,Fang X,Ma A,Ma L

更新日期：2019-02-01 00:00:00

abstract：:Recent studies have demonstrated that melatonin significantly decreased all studied acute pancreatitis-associated inflammatory parameters, in addition to reducing apoptosis and necrosis associated with pancreatic injury. However, the effect of melatonin on gut barrier dysfunction and bacterial translocation has not be...

journal_title：Experimental and therapeutic medicine

authors： Sun X,Shao Y,Jin Y,Huai J,Zhou Q,Huang Z,Wu J

更新日期：2013-12-01 00:00:00

abstract：:Cnidium officinale Makino and Capsella bursa-pastoris are used as traditional herbs with diverse medicinal effects, including the inhibition of inflammation, reduction of blood pressure and as diuretics, however, the anti-cancer effects of C. officinale Makino and C. bursa-pastoris are poorly defined. The aims of this...

journal_title：Experimental and therapeutic medicine

authors： Lee KE,Shin JA,Hong IS,Cho NP,Cho SD

更新日期：2013-03-01 00:00:00

abstract：:Extramedullary T-lymphoblastic blast crisis of chronic myelogenous leukemia (CML) is uncommon and the prognosis is poor. It was usually misdiagnosed as the co-existence of T-lymphoblastic lymphoma (T-LBL) and CML. In the present study, we report a patient with CML, who developed extramedullary T-lymphoblastic blast cr...

journal_title：Experimental and therapeutic medicine

authors： Zeng DF,Chang C,Li JP,Kong PY,Zhang X,Gao L

更新日期：2015-03-01 00:00:00

abstract：:Angioimmunoblastic T cell lymphoma (AITL)-associated hemophagocytic lymphohistiocytosis (HLH) rarely occurs with annular erythema multiforme-like rashes. The present case report describes a patient who was misdiagnosed with erythema multiforme at an early stage of the disease due to annular erythema multiforme-like er...

journal_title：Experimental and therapeutic medicine

authors： Zhang L,Tong C,Tan Y,Peng S,He Y,Wang T

更新日期：2018-09-01 00:00:00

abstract：:The aim of the present study was to screen differentially co-expressed genes and the involved transcription factors (TFs) and microRNAs (miRNAs) in venous thromboembolism (VTE). Microarray data of GSE19151 were downloaded from Gene Expression Omnibus, including 70 patients with VTE and 63 healthy controls. Principal c...

journal_title：Experimental and therapeutic medicine

authors： Ming Z,Ding W,Yuan R,Jin J,Li X

更新日期：2016-06-01 00:00:00

abstract：:Female athletes may experience difficulties in achieving pregnancy due to athletic amenorrhea (AA); however, the underlying mechanisms of AA remain unknown. The present study focuses on the mitochondrial alteration and its function in detecting the possible mechanism of AA. An AA rat model was established by excessive...

journal_title：Experimental and therapeutic medicine

authors： Xiong RH,Wen SL,Wang Q,Zhou HY,Feng S

更新日期：2018-01-01 00:00:00

abstract：:Schwann cell proliferation and differentiation is critical for the remyelination of injured peripheral nerves. Ferulic acid (FA) is a widely used antioxidant agent with neuroprotective properties. However, the potentially beneficial effects of FA on Schwann cells are unknown. Therefore, the present study was designed ...

journal_title：Experimental and therapeutic medicine

authors： Zhu X,Li K,Guo X,Wang J,Xiang Y

更新日期：2016-09-01 00:00:00

abstract：:The present study reports the case of a 33-year-old male who presented with Terson syndrome with no cerebral hemorrhage secondary to traumatic brain injury (TBI). A computed tomography scan of the patient, who had sustained an impact injury to the right occipital region, showed no cerebral lesion. Ophthalmoscopy clear...

journal_title：Experimental and therapeutic medicine

authors： Jing XB,Sun LQ

更新日期：2014-01-01 00:00:00

abstract：:Sodium 4-phenylbutyrate (PBA) exerts therapeutic effects in a wide range of pathologies. A previous study by the present authors revealed that intraperitoneal administration of PBA suppresses the onset of dextran sulfate sodium (DSS)-induced colitis in mice. In the present study, the effects of orally administered PBA...

journal_title：Experimental and therapeutic medicine

authors： Ono K,Nimura S,Hideshima Y,Nabeshima K,Nakashima M

更新日期：2017-12-01 00:00:00

abstract：:The aim of the present study was to investigate the expression and role of transforming growth factor (TGF)-β1/phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3KC3) in the peripheral blood in patients with hypertension. A total of 28 patients with primary hypertension and 20 healthy control subjects were inc...

journal_title：Experimental and therapeutic medicine

authors： Zhang Q,Liu H,Yang J

更新日期：2019-03-01 00:00:00

abstract：:Metabolic acidosis has been proved to be a risk factor for the progression of chronic kidney disease, but its relation to acute kidney injury (AKI) has not been investigated. In general, a diagnosis of metabolic acidosis is based on arterial blood gas (ABG) analysis, but the diagnostic role of carbon dioxide combining...

journal_title：Experimental and therapeutic medicine

authors： Hu J,Wang Y,Geng X,Chen R,Xu X,Zhang X,Lin J,Teng J,Ding X

更新日期：2017-05-01 00:00:00

abstract：:The present study aimed to investigate changes of T-regulatory (Treg) and T-helper (Th)17 cells as well as cytokines in peripheral blood of children with acute bronchitis, and to explore the roles of these cells in the pathogenesis of acute bronchitis. A total of 126 children who had presented at Renji Hospital (Shang...

journal_title：Experimental and therapeutic medicine

authors： Tu Z,Xue H,Chen W,Cao L,Zhang W

更新日期：2017-10-01 00:00:00

abstract：:Effects of ivabradine hydrochloride (Iva) and trimetazidine on myocardial fibrosis (MF) in rats with chronic heart failure (CHF) werφe explored. Fifty Wistar rats were randomly divided into sham operation, model, Iva, trimetazidine and combined drug group with 10 rats each. All rats except those in sham operation grou...

journal_title：Experimental and therapeutic medicine

authors： Ma D,Xu T,Cai G,Wu X,Lei Z,Liu X,Li J,Yang N

更新日期：2019-09-01 00:00:00

abstract：:Various types of complications arising from intravenous indwelling needles have become a challenge in clinical care. It is urgent to seek a simple and cost-effective method for prevention and treatment of phlebitis. We investigated the roles of mirabilite in preventing and treating phlebitis caused by intravenous indw...

journal_title：Experimental and therapeutic medicine

authors： Lu Y,Hao C,He W,Tang C,Shao Z

更新日期：2018-01-01 00:00:00

abstract：:The aim of the present study was to evaluate the expression and effect of rat mitofusin-2 (rMfn2) in the ovaries and other organs in rats. Rat models were developed by the intraovarian microinjection of an rMfn2-overexpressing lentiviral vector. Lenti-green fluorescent protein (GFP)-rMfn2 was microinjected into rat ov...

journal_title：Experimental and therapeutic medicine

authors： Hu X,Lei X,Wang J,Pan H,Li C,Yao Z

更新日期：2014-09-01 00:00:00