Abstract:
:Lung cancer is among the most common causes of cancer-related mortality. It has a high mortality rate and resistance to chemotherapy due to its high metastatic potential. Naringenin, a bioactive compound identified in several fruits, displays anti-inflammatory and antitumor effects. Furthermore, naringenin mitigates the migration of several human cancer cell types. However, the effects of naringenin on lung cancer remain unclear. The current study investigated the mechanisms of naringenin on the migration of lung cancer A549 cells. The results indicate that significant alteration in A549 cell proliferation was observed in response to naringenin (0-300 µM) treatment for 24 and 48 h. Furthermore, a dose-dependent migration inhibition of A549 in the presence of naringenin was observed by healing and transwell migration assays. In addition, a zymography assay revealed that naringenin exhibited a concentration-dependent inhibition of matrix metalloproteinase (MMP)-2 and -9 activities. Furthermore, naringenin also inhibited the activities of AKT in a dose-dependent manner. These observations indicated that naringenin inhibited the migration of lung cancer A549 cells through several mechanisms, including the inhibition of AKT activities and reduction of MMP-2 and -9 activities.
journal_name
Exp Ther Medjournal_title
Experimental and therapeutic medicineauthors
Chang HL,Chang YM,Lai SC,Chen KM,Wang KC,Chiu TT,Chang FH,Hsu LSdoi
10.3892/etm.2016.3994subject
Has Abstractpub_date
2017-02-01 00:00:00pages
739-744issue
2eissn
1792-0981issn
1792-1015pii
ETM-0-0-3994journal_volume
13pub_type
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