Antitumor effects of imatinib mesylate and synergistic cytotoxicity with an arsenic compound in neuroblastoma cell lines.

abstract：:Endotoxin tolerance is an immunohomeostatic reaction to reiterant lipopolysaccharide (LPS) exposure that maintains a state of altered responsiveness in immune cells, resulting in the inhibition of the pro-inflammatory response and the resolution of inflammation. Microglia constitutes the first line of defense against ...

journal_title：Experimental and therapeutic medicine

authors： Sun X,Sun J,Shao X,Feng J,Yan J,Qin Y

更新日期：2018-06-01 00:00:00

abstract：:Chemotherapy-induced anorexia (CIA), which may lead to severe nutrition-associated problems, is a common complication associated with anti-cancer therapies. In the present study, the anti-anorexigenic effect of electroacupuncture (EA) was explored through assessing a change in appetite-associated peptides and c-Fos ex...

journal_title：Experimental and therapeutic medicine

authors： Kang KS,Huh W,Bang Y,Choi HJ,Baek JY,Song JH,Kang JW,Kim TH

更新日期：2019-04-01 00:00:00

abstract：:Diffuse ganglioneuromatosis (DG) of the gastrointestinal tract is a rare condition that is closely associated with neurofibromatosis type 1 and multiple endocrine neoplasia type 2B. The occurrence of DG with multiple schwannomas, which, of the GI tract, usually affect the stomach, is considerably more rare. The presen...

journal_title：Experimental and therapeutic medicine

authors： Lu C,Qiu Y,Lu X,Li G,Bu H

更新日期：2015-03-01 00:00:00

abstract：:The aim of the present study was to identify genes under the effect of transforming growth factor-β (TGF-β1), high glucose (HG) and glucosamine (GlcN) in MES-13 mesangial cells and elucidate the molecular mechanisms of diabetic nephropathy (DN). The gene expression datasets GSE2557 and GSE2558 were downloaded from the...

journal_title：Experimental and therapeutic medicine

authors： Mou X,Zhou DY,Liu YH,Liu K,Zhou D

更新日期：2019-06-01 00:00:00

abstract：:Metastatic breast cancer is one of the most common metastatic tumors. Although studies have validated the role of β-inducible gene-h3 (βig-h3) in human biology and disease, the detailed mechanisms mediated by βig-h3 in breast carcinoma metastasis remain unclear. Thus, the present study investigated the role and potent...

journal_title：Experimental and therapeutic medicine

authors： Zhang J,Li Z

更新日期：2018-03-01 00:00:00

abstract：:Aggressive behavior is one of the main characteristics of different psychiatric disorders such as: personality disorders (antisocial personality disorder, borderline personality disorder), schizophrenia, intermittent explosive disorder, post-traumatic stress disorder, bipolar disorder, depression, alcohol/substance in...

journal_title：Experimental and therapeutic medicine

authors： Trifu SC,Tudor A,Radulescu I

更新日期：2020-10-01 00:00:00

abstract：:Posterior communicating artery (PCoA) in patients with posterior circulation ischemia (PCI) was quantitatively studied using phase contrast magnetic resonance angiography (PC-MRA). Fifty-one cases who received PC-MRA were included in the study, and divided into the research and control groups. The mean flow volume, me...

journal_title：Experimental and therapeutic medicine

authors： Zhou W,Lu M,Li J,Chen F,Hu Q,Yang S

更新日期：2019-01-01 00:00:00

abstract：:Phosphocitrate (PC) and its analogue, PC-β ethyl ester, inhibit articular cartilage degeneration in Hartley guinea pigs. However, the underlying molecular mechanisms remain unclear. The present study aimed to investigate the hypothesis that PC exerted its disease-modifying effect on osteoarthritis (OA), in part, by in...

journal_title：Experimental and therapeutic medicine

authors： Sun Y,Kiraly AJ,Cox M,Mauerhan DR,Hanley EN Jr

更新日期：2018-04-01 00:00:00

abstract：:Kidney morphology has been used to estimate renal functions. The present study investigated the usefulness of kidney length and renal parenchymal volume (RPV) measured using three-dimensional ultrasonography (3-D USG) in estimating renal pathological findings, and the outcome in patients with nephropathy who underwent...

journal_title：Experimental and therapeutic medicine

authors： Xu J,Hwang SI,Lee HJ,Chin HJ

更新日期：2018-02-01 00:00:00

abstract：:Macrophage autophagy has a protective role in the development of atherosclerosis; however, it turns dysfunctional in advanced lesions with an increase in p62/sequestosome-1 protein. Little is known about the role and significance of p62 accumulation in atherosclerosis. The present study investigated the association be...

journal_title：Experimental and therapeutic medicine

authors： Ning H,Liu D,Yu X,Guan X

更新日期：2017-12-01 00:00:00

abstract：:The aim of this study was to validate the feasibility of modified frontolateral partial laryngectomy without tracheotomy using animal experiments. The glottic area before and after surgery of 6 excised canine larynges and 10 canine larynges in vivo were compared to observe whether the glottic area following modified f...

journal_title：Experimental and therapeutic medicine

authors： Xu H,Dong P,Sun Z,Xie J

更新日期：2013-02-01 00:00:00

abstract：:Action potential (AP) contours vary considerably between the fibers of normal adult and aged left atria. The underlying ionic and molecular mechanisms that mediate these differences remain unknown. The aim of the present study was to investigate whether the L-type calcium current (ICa.L) and the L-type Ca2+ channel of...

journal_title：Experimental and therapeutic medicine

authors： Gan TY,Qiao W,Xu GJ,Zhou XH,Tang BP,Song JG,Li YD,Zhang J,Li FP,Mao T,Jiang T

更新日期：2013-10-01 00:00:00

abstract：:Expression levels and clinical significance of matrix metalloproteinase-1 (MMP1), MMP-2 and inflammatory factors in the serum of patients with deep venous thrombosis (DVT) of lower extremity were investigated. Fifty untreated DVT patients were selected as the DVT group, and 50 patients undergoing health examination we...

journal_title：Experimental and therapeutic medicine

authors： Zhang T,Li Q,Wang L,Li G

更新日期：2019-01-01 00:00:00

abstract：:Uncommon causes of nail failures and surgical reinterventions were determined. The study included 23 osteoporotic patients, 13 of whom followed a fast recovery program with early walking (FWB group). The other 10 patients were not allowed full weight bearing until 6 weeks (NFWB group). The T-score was determined befor...

journal_title：Experimental and therapeutic medicine

authors： Dragosloveanu Ş,Dragosloveanu CDM,Stanca HT,Cotor DC,Dragosloveanu CI,Stoica CI

更新日期：2020-12-01 00:00:00

abstract：:Red cell distribution width (RDW) has been found to be a novel prognostic biomarker in patients with coronary artery disease (CAD); however, the association between RDW and the risk of heart events in patients with CAD is yet to be fully elucidated. Thus, the aim of the present study was to determine whether an elevat...

journal_title：Experimental and therapeutic medicine

authors： Li W,Li X,Wang M,Ge X,Li F,Huang B,Peng J,Li G,Lu L,Yu Z,Ma J,Xu L,Jin M,Si H,Wan R

更新日期：2015-04-01 00:00:00

abstract：:Acyclovir has been a frequently used antiviral agent in the clinical treatment of leukemia, acute encephalitis, malignant tumor and herpes simplex. The adverse effects of this drug have been widely described in clinical practice. In the present study, a case of a 35-year-old female patient diagnosed with herpes simple...

journal_title：Experimental and therapeutic medicine

authors： Zhang Y,Cong Y,Teng Y

更新日期：2016-12-01 00:00:00

abstract：:Shikonin (SK), a naturally occurring naphthoquinone, exhibits antitumor activity. However, its precise mechanisms of action are unknown. In the present study, the effects of SK on NCI-H460 human lung cancer cells were investigated. It was found that SK reduced cell viability and induced apoptosis in the NCI-H460 cells...

journal_title：Experimental and therapeutic medicine

authors： Qu D,Chen YU,Xu XM,Zhang M,Zhang YI,Li SQ

更新日期：2015-04-01 00:00:00

abstract：:The present study aimed to investigate the therapeutic effects of Euterpe oleracea Mart. (EO) on alcoholic liver diseases (ALD). A total of 30 Wistar rats were randomly divided into three groups (10 rats per group), including alcohol group (alcohol intake), EO group (alcohol + EO puree intake) and control group (disti...

journal_title：Experimental and therapeutic medicine

authors： Zhou J,Zhang J,Wang C,Qu S,Zhu Y,Yang Z,Wang L

更新日期：2018-01-01 00:00:00

abstract：:Numerous studies have demonstrated that microRNAs (miRNAs) are dysregulated in esophageal squamous cell carcinoma (ESCC). Changes in miRNA expression may be associated with ESCC formation and progression. Therefore, the identification of ESCC-associated miRNAs may facilitate the development of effective therapeutic ap...

journal_title：Experimental and therapeutic medicine

authors： Zhen C,Huang J,Lu J

更新日期：2019-12-01 00:00:00

abstract：:The aim of this study was to investigate whether resolvin E1 (RvE1) protects against hepatic fibrosis in a murine model of liver fibrosis induced by Schistosoma japonicum infection. A total of 30 pathogen-free Kunming mice were randomly and equally divided into three groups: Control (uninfected, untreated), model (inf...

journal_title：Experimental and therapeutic medicine

authors： Qiu W,Guo K,Yi L,Gong Y,Huang L,Zhong W

更新日期：2014-06-01 00:00:00

abstract：:This study aimed to investigate the influence of intrathecal injection with dexmedetomidine on the behavioral ability and analgesic effects of rat models with chronic neuropathic pain. It also discusses the role that the expression of protein kinase C (PKC) in the spinal dorsal horn plays in the analgesic mechanism of...

journal_title：Experimental and therapeutic medicine

authors： Li X,Zhang W

更新日期：2018-11-01 00:00:00

abstract：:Curcumin is a natural polyphenol with powerful antioxidant and anti-inflammatory properties. The present study evaluated the protective effect of curcumin on myocardial injury in rats as well as the mechanisms underlying these effects, and examined the expression of nuclear factor-κB (NF-κB), peroxisome proliferator-a...

journal_title：Experimental and therapeutic medicine

authors： Lv FH,Yin HL,He YQ,Wu HM,Kong J,Chai XY,Zhang SR

更新日期：2016-12-01 00:00:00

abstract：:This study aimed to investigate the effects of hypoxia on the proliferation, mineralization and ultrastructure of human periodontal ligament fibroblasts (HPLFs) at various times in vitro in order to further study plateau-hypoxia-induced periodontal disease. HPLFs (fifth passage) cultured by the tissue culture method w...

journal_title：Experimental and therapeutic medicine

authors： Zhang HY,Liu R,Xing YJ,Xu P,Li Y,Li CJ

更新日期：2013-12-01 00:00:00

abstract：:The aim of the study was to investigate the effects of high-volume continuous renal replacement therapy (HV-CRRT) on procalcitonin (PCT), tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4), IL-6, IL-8 and IL-10 in acute pancreatitis complicated by acute renal failure. Eighty-six patients with acute pancreatitis com...

journal_title：Experimental and therapeutic medicine

authors： Liu C,Li M,Cao S,Wang J,Huang X,Zhong W

更新日期：2017-10-01 00:00:00

abstract：:The aim of the present study was to investigate the expression levels and clinical significance of Toll-like receptor (TLR) 3 and 4 in peripheral blood mononuclear cells (PBMCs) collected from children with Henoch-Schönlein purpura (HSP) nephritis. The randomized controlled trial was conducted between August 2011 and ...

journal_title：Experimental and therapeutic medicine

authors： Chang H,Yu DS,Liu XQ,Zhang QY,Cheng N,Zhang SQ,Qu ZH

更新日期：2014-06-01 00:00:00

abstract：:The present study was designed to evaluate the effects of steady and fluctuant inhibition of acetylcholinesterase (AChE) activity on neurotrophic factors in the hippocampus of juvenile mice. Steady inhibition of AChE activity was induced by an intramuscular injection of huperizine A (HupA) sustained-release microspher...

journal_title：Experimental and therapeutic medicine

authors： Li C,Wang T,Jiang N,Yu P,DU Y,Ren R,Fu F

更新日期：2012-02-01 00:00:00

abstract：:The curative effect of minimally invasive surgery on palmar and foot hyperhidrosis and its influence on serum-related cytokines and immunoglobulins were investigated. Seventy-six patients with palmar and foot hyperhidrosis admitted to Yunnan University Hospital from August 2014 to July 2016 were selected and randomly ...

journal_title：Experimental and therapeutic medicine

authors： Li WX,Li YK,Lin HT

更新日期：2018-04-01 00:00:00

abstract：:The use of intravenous dexmedetomidine during surgery has been shown to suppress inflammatory cytokines peri-operatively. It has also been demonstrated that dexmedetomidine may benefit cognitive function in elderly patients following surgery; however, it is not clear whether dexmedetomidine reduces postoperative cogni...

journal_title：Experimental and therapeutic medicine

authors： Li Y,He R,Chen S,Qu Y

更新日期：2015-11-01 00:00:00

abstract：:Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS2) deficiency is a metabolic disorder caused by mutations in the HMGCS2 gene. The present study describes the identification of four cases of HMGCS2 deficiency in Japan. Hepatomegaly and severe metabolic acidosis were observed in all cases. Fatty liver was id...

journal_title：Experimental and therapeutic medicine

authors： Ago Y,Otsuka H,Sasai H,Abdelkreem E,Nakama M,Aoyama Y,Matsumoto H,Fujiki R,Ohara O,Akiyama K,Fukui K,Watanabe Y,Nakajima Y,Ohnishi H,Ito T,Fukao T

更新日期：2020-11-01 00:00:00

abstract：:Previous research has shown that breathing exercises may improve the prognosis and health status in patients with lung cancer by enhancing pulmonary function and quality of life (QOL). However, individually published results are inconclusive. The aim of the present meta-analysis was to evaluate the clinical value of b...

journal_title：Experimental and therapeutic medicine

authors： Liu W,Pan YL,Gao CX,Shang Z,Ning LJ,Liu X

更新日期：2013-04-01 00:00:00