Effects of curcumin on the apoptosis of cardiomyocytes and the expression of NF-κB, PPAR-γ and Bcl-2 in rats with myocardial infarction injury.

abstract：:Hyperlipidemia is a risk factor of kidney damage that can lead to chronic kidney disease. Studies have shown that exercise reduces kidney damage; however, the specific mechanisms underlying the protective effects of exercise remain unclear. For 12 weeks, 8-week-old male apolipoprotein E-deficient (ApoE-/-) mice were r...

journal_title：Experimental and therapeutic medicine

authors： Qian C,Yang Q,Guo L,Zhu H,You X,Liu H,Sun Y

更新日期：2021-02-01 00:00:00

abstract：:Tumor-infiltrating lymphocytes (TILs) are produced by resecting tumor tissue and growing and expanding ex vivo large quantities of autologous T cells. Once the TILs are ready for infusion, the patient undergoes a non-myeloablative lympho-depleting course of chemotherapy and subsequent TIL infusion with high-dose bolus...

journal_title：Experimental and therapeutic medicine

authors： Zippel DB,Besser M,Shapira R,Ben-Nun A,Goitein D,Davidson T,Treves AJ,Markel G,Schachter J,Papa MZ

更新日期：2012-05-01 00:00:00

abstract：:Doxorubicin (DOX), a potent and widely used anticancer agent, can give rise to severe cardiotoxicity that limits its clinical use by inducing oxidative stress. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the central regulator of cellular responses to electrophilic/oxidative stress, which serves a critical ro...

journal_title：Experimental and therapeutic medicine

authors： Guo Z,Yan M,Chen L,Fang P,Li Z,Wan Z,Cao S,Hou Z,Wei S,Li W,Zhang B

更新日期：2018-10-01 00:00:00

abstract：:The aim of the present study was to elucidate the underlying mechanism of antitumor activity of gambogic acid (GA) in colon cancer. Human colon cancer SW620 cells were divided into five treatment groups, including no-treatment control (NC), low dose GA (10 µg/ml), medium dose GA (50 µg/ml), high dose GA (100 µg/ml) an...

journal_title：Experimental and therapeutic medicine

authors： Zhou Z,Ma J

更新日期：2019-10-01 00:00:00

abstract：:Infantile neuroaxonal dystrophy (INAD) is a rare neurodegenerative disorder. Phospholipase A2 group VI (PLA2G6) gene mutations have been identified in the majority of individuals with INAD. The present case report is on a Chinese female pediatric patient (age, 18 months) diagnosed with INAD with deafness. To date, onl...

journal_title：Experimental and therapeutic medicine

authors： Wang B,Wu,Tang J

更新日期：2018-08-01 00:00:00

abstract：:Engineered nanoparticles (NPs) have been increasingly used in numerous fields over the last decade. In particular, iron oxide NPs (Fe2O3NPs) and silver NPs (AgNPs) have contributed to the current increase in NP usage. However, the possible side effects of increased NP exposure remain not fully elucidated. The present ...

journal_title：Experimental and therapeutic medicine

authors： Yousef MI,Abuzreda AA,Kamel MA

更新日期：2019-12-01 00:00:00

abstract：:Rutin has a variety of pharmacological actions, including radical reactivity, and protective activity against lipid peroxidation, viruses and acute pancreatitis; thus, it may be used as a treatment for many diseases. The present study aimed to investigate whether rutin inhibits coronary heart disease through extracell...

journal_title：Experimental and therapeutic medicine

authors： Lv L,Yao Y,Zhao G,Zhu G

更新日期：2018-01-01 00:00:00

abstract：:Scabies is a contagious skin disease that causes extremely itching. It is a parasitic disease caused by the mite Sarcoptes scabiei and characterized by polymorphous lesions. Vesicular and bullous lesions in cases of scabies are rather rare. Bullous scabies has a pemphigoid presentation. Crusted scabies, also known as ...

journal_title：Experimental and therapeutic medicine

authors： Su WJ,Fang S,Chen AJ,Shan K

更新日期：2015-10-01 00:00:00

abstract：:Women with endometrial cancer often undergo hysteroscopy during their diagnostic work-up. Whether or not the duration of hysteroscopy affects the rate of positive peritoneal cells and the duration of recurrence-free survival is unknown. In a retrospective multi-centre study, the records of 552 patients with endometria...

journal_title：Experimental and therapeutic medicine

authors： Tempfer C,Froese G,Buerkle B,Polterauer S,Grimm C,Concin N,Hofstetter G,Weigert M,Oehler MK

更新日期：2011-09-01 00:00:00

abstract：:Obstructive salivary gland diseases are common conditions that arise following the disruption of the secretary ductal system and usually results in the swelling and pain of the affected gland(s). There has been an increase in the use of sialendoscopy for the treatment and diagnosis of obstructive salivary gland infect...

journal_title：Experimental and therapeutic medicine

authors： Ding YF,Tseng H,Su CH,Tai CC,Wu YY,Haung CJ,Lee CS,Hung SH

更新日期：2019-04-01 00:00:00

abstract：:Pancreatic necrosectomy (PN) following percutaneous catheter drainage (PCD) is an effective method of treating patients with necrotizing pancreatitis, however, the predictive factors for PN after PCD have not yet been identified. A total of 74 patients with suspected infected necrotizing pancreatitis (INP) and peripan...

journal_title：Experimental and therapeutic medicine

authors： Cao X,Cao F,Li A,Gao X,Wang XH,Liu DG,Fang Y,Guo DH,Li F

更新日期：2017-11-01 00:00:00

abstract：:The aim of the present study was to evaluate the expression and effect of rat mitofusin-2 (rMfn2) in the ovaries and other organs in rats. Rat models were developed by the intraovarian microinjection of an rMfn2-overexpressing lentiviral vector. Lenti-green fluorescent protein (GFP)-rMfn2 was microinjected into rat ov...

journal_title：Experimental and therapeutic medicine

authors： Hu X,Lei X,Wang J,Pan H,Li C,Yao Z

更新日期：2014-09-01 00:00:00

abstract：:The diagnostic criteria of osteoporosis were established based on bone mineral density (BMD). Therefore, BMD measured by dual energy X-ray absorptiometry has been recognized as the gold standard to diagnose osteoporosis. However, discrepancies between fracture risk and BMD have been recognized. Bone is composed of col...

journal_title：Experimental and therapeutic medicine

authors： Suzuki Y,Maruyama-Nagao A,Sakuraba K,Kawai S

更新日期：2017-05-01 00:00:00

abstract：:The aim of the present study was to elucidate differentially expressed proteins in lesional tissues of psoriasis vulgaris (PV) and normal tissues. Lesional skin tissues were collected from PV patients, along with normal skin tissues from healthy individuals. The protein content of the samples was extracted and then se...

journal_title：Experimental and therapeutic medicine

authors： Dai Y,Zhang Q,Jiang Y,Yin L,Zhang X,Chen Y,Cai X

更新日期：2017-10-01 00:00:00

abstract：:The aim of this study was to compare the results of immunohistochemistry (IHC) assays evaluated by human examiners with the results evaluated by computerized image analysis, and to compare the computerized image analysis results among three automated IHC assays, namely the BioGenex, Dako and Ventana assays. All slides...

journal_title：Experimental and therapeutic medicine

authors： Arihiro K,Oda M,Ogawa K,Tominaga K,Kaneko Y,Shimizu T,Ohnishi S,Oda M,Kurita Y,Taira Y,Fujii M,Tanaka M

更新日期：2010-11-01 00:00:00

abstract：:The present investigation explored the in vitro culture, isolation and characterization of hair follicle cell differentiation from umbilical cord blood mesenchymal stem cells (MSCs). Flow cytometry was used to obtain MSCs from the isolation and purification of human umbilical cord blood MSCs. Culture suspension of hai...

journal_title：Experimental and therapeutic medicine

authors： Bu ZY,Wu LM,Yu XH,Zhong JB,Yang P,Chen J

更新日期：2017-07-01 00:00:00

abstract：:Synovitis, acne, palmoplantar pustulosis, hyperostosis and osteitis syndrome (SAPHO) is a rare syndrome that affects the skin, bones and joints. Diagnosis of SAPHO syndrome is established on clinical appearance and imaging features. The present case report described the imaging features of three cases of SAPHO with st...

journal_title：Experimental and therapeutic medicine

authors： Duan N,Chen X,Liu Y,Wang J,Wang Z

更新日期：2016-10-01 00:00:00

abstract：:Kidney morphology has been used to estimate renal functions. The present study investigated the usefulness of kidney length and renal parenchymal volume (RPV) measured using three-dimensional ultrasonography (3-D USG) in estimating renal pathological findings, and the outcome in patients with nephropathy who underwent...

journal_title：Experimental and therapeutic medicine

authors： Xu J,Hwang SI,Lee HJ,Chin HJ

更新日期：2018-02-01 00:00:00

abstract：:The aim of the present study was to establish a stem cell line for multi-mode imaging (in vivo fluorescence imaging, magnetic resonance imaging and 99mTc single-photon emission computed tomography) and to study the biological activity, stemness, proliferative activity and differentiation ability of superparamagnetic i...

journal_title：Experimental and therapeutic medicine

authors： Meng Y,Liu H,Bian N,Gong J,Zhong X,Huang C,Liang W,Xu H

更新日期：2018-09-01 00:00:00

abstract：:Serum thymidine kinase 1 (STK1) is a reliable proliferation marker in most solid tumors, including gastric cancer. The aim of this study was to evaluate whether STK1 levels are related to the tumor response to chemotherapy and survival in advanced gastric cancer. The results showed that the average STK1 level in patie...

journal_title：Experimental and therapeutic medicine

authors： Liu Y,Ling Y,Qi Q,Tang Y,Xu J,Tong Z,Sheng G,Yang Q,Pan Y

更新日期：2011-11-01 00:00:00

abstract：:The aim of the present study was to investigate the roles of matrix metalloproteinase 14 (MMP-14) in corneal inflammatory lymphangiogenesis. The expression of MMP-14 in vivo was detected by immunohistochemistry, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot assays, under vario...

journal_title：Experimental and therapeutic medicine

authors： Du HT,Liu P

更新日期：2016-10-01 00:00:00

abstract：:The host response to spinal cord injury (SCI) can lead to an ischemic environment that can induce cell death. Therapeutic interventions using neurotrophic factors have focused on the prevention of such reactions in order to reduce this cell death. Vascular endothelial growth factor (VEGF) is a potent angiogenic and va...

journal_title：Experimental and therapeutic medicine

authors： Yu H,Lin B,He Y,Zhang W,Xu Y

更新日期：2015-05-01 00:00:00

abstract：:Dimethyl carbonate (DMC) is a widely used industrial chemical, which may be increasingly used in the future. However, its toxicity profile remains largely unknown. The present study was designed to investigate the effects of DMC exposure on the ovaries and the effect of autophagy activation on follicular development. ...

journal_title：Experimental and therapeutic medicine

authors： Tang Z,Zhang Z,Tang Y,Qi L,Yang F,Wang Z

更新日期：2017-12-01 00:00:00

abstract：:The programmed death-1 (PD-1)/PD-ligand 1 (PD-L1) signaling pathway is a negative regulatory mechanism that inhibits T cell proliferation and cytokine production. Soluble PD-1 (sPD-1) and soluble PD-L1 (sPD-L1), are also involved in regulation of the PD-1/PD-L1 signaling pathway. In the present study, the expression l...

journal_title：Experimental and therapeutic medicine

authors： Li Y,Xiao Y,Su M,Zhang R,Ding J,Hao X,Ma Y

更新日期：2016-01-01 00:00:00

abstract：:Pulmonary mucormycosis, a relatively rare pulmonary fungal disease, is difficult to diagnose and lacks effective treatment. The present study reports the case of a 64-year-old patient who was treated successfully for pulmonary mucormycosis in Xuan Wu Hospital. The patient presented with low-grade fever and a productiv...

journal_title：Experimental and therapeutic medicine

authors： Luo Z,Zhang L

更新日期：2017-10-01 00:00:00

abstract：:Although thrombocytosis has been reported in a variety of cancer types, the standard of thrombocytosis in gastric cancer (GC) and the association between thrombocytosis and the clinicopathological features of patients with GC remain unclear. In the present study, 1,763 GC patients were retrospectively filtered by preo...

journal_title：Experimental and therapeutic medicine

authors： Hu C,Chen R,Chen W,Pang W,Xue X,Zhu G,Shen X

更新日期：2014-07-01 00:00:00

abstract：:Melatonin is a darkness hormone secreted by the pineal gland, which serves a role in idiopathic oligoasthenoteratozoospermia (iOAT). The present study aimed to evaluate the seminal plasma and serum melatonin levels of 50 patients with iOAT and 50 normal fertile controls and the effects of exposure to light at night on...

journal_title：Experimental and therapeutic medicine

authors： H Hassan M,A El-Taieb M,N Fares N,M Fayed H,Toghan R,M Ibrahim H

更新日期：2020-07-01 00:00:00

abstract：:Forkhead box P3 (FOXP3), which is a transcription factor, has a primary role in the development and function of regulatory T cells, and thus contributes to homeostasis of the immune system. A previous study generated a cell-permeable fusion protein of mouse FOXP3 conjugated to a protein transduction domain (PTD-mFOXP3...

journal_title：Experimental and therapeutic medicine

authors： Liu X,Wang J,Wang H,Zhou C,Yu Q,Yin L,Wu W,Xia S,Shao Q

更新日期：2017-02-01 00:00:00

abstract：:Effect of etanercept and infliximab on bone metabolism indexes in patients with ankylosing spondylitis (AS) were evaluated. The clinical data of 80 patients with ankylosing spondylitis admitted to Affiliated Hospital of Hebei University of Engineering from June 2015 to March 2016 were selected. There were 39 patients ...

journal_title：Experimental and therapeutic medicine

authors： Wang C,Li W

更新日期：2020-01-01 00:00:00

abstract：:Breast cancer remains a worldwide public-health issue. Novel drugs that increase the sensitivity and reduce the toxic side effects of chemotherapeutic agents are urgently required. The present study investigated the effect and mechanism of the short-term intermittent administration of an anticancer bioactive peptide (...

journal_title：Experimental and therapeutic medicine

authors： Li X,Gao B,Su X

更新日期：2020-09-01 00:00:00