Cbl-b-regulated extracellular signal-regulated kinase signaling is involved in the shikonin-induced apoptosis of lung cancer cells in vitro.

abstract：:The aim of the present study was to investigate the application of 3D printing (3DP) rapid prototyping (RP) technique-assisted percutaneous fixation in the treatment of femoral intertrochanteric fracture (ITF) using proximal femoral nail anti-rotation (PFNA). A total of 39 patients with unstable ITF were included in t...

journal_title：Experimental and therapeutic medicine

authors： Zheng SN,Yao QQ,Mao FY,Zheng PF,Tian SC,Li JY,Yu YF,Liu S,Zhou J,Hu J,Xu Y,Tang K,Lou Y,Wang LM

更新日期：2017-10-01 00:00:00

abstract：:The aim of the present study was to investigate the effect of Forkhead family transcription factor P3 (Foxp3) knockdown on the function of cluster of differentiation (CD)4+CD25+ regulatory T cell (Tregs) and the tumor growth of a hepatocellular carcinoma (HCC) mouse model. CD4+CD25+ Tregs and CD4+CD25- T cells were so...

journal_title：Experimental and therapeutic medicine

authors： Shi C,Zhang Y,Yang H,Dong T,Chen Y,Xu Y,Yang X,Liu P

更新日期：2018-01-01 00:00:00

abstract：:The aim of this study was to analyze the concentration changes of nuclear factor-κB (NF-κB) and the related inflammatory factors of pre-treatment and post-treatment in children with viral encephalitis, to examine the mechanism of NF-κB in the pathogenesis of child viral encephalitis. Twenty-two children with severe vi...

journal_title：Experimental and therapeutic medicine

authors： Zhang D,Zheng N,Liu X

更新日期：2017-06-01 00:00:00

abstract：:The present study aimed to investigate the expression of microRNA (miRNA or miR)-186 in tumor tissue, blood and urine from patients with bladder cancer. The mechanism by which miR-186 regulates the invasion and metastasis of bladder cancer was also assessed. A total of 76 patients who underwent surgical resection of b...

journal_title：Experimental and therapeutic medicine

authors： He X,Ping J,Wen D

更新日期：2017-10-01 00:00:00

abstract：:Our study retrospectively investigated the expression of forkhead/winged helix transcription factor (Foxp3) in renal tissue and clinical features of patients with hepatitis B virus (HBV)-associated glomerulonephritis (HBV-GN). A total of 58 patients with HBV-GN were assigned to group A; 45 serum and renal tissue HBsAg...

journal_title：Experimental and therapeutic medicine

authors： Zhao W,Ma Y,Wang M,Shi C,Sun J,Chu K,Liu C

更新日期：2017-11-01 00:00:00

abstract：:Herpes Zoster (HZ) is reported as the most prevalent viral infection in patients with systemic lupus erythematosus (SLE). The aim of the present study was to investigate the clinical features, complications, and potential risk factors of HZ in patients with SLE from Southern China. A retrospective study was performed ...

journal_title：Experimental and therapeutic medicine

authors： Chen D,Li H,Xie J,Zhan Z,Liang L,Yang X

更新日期：2017-12-01 00:00:00

abstract：:The diaphragm is an important respiratory organ. The aim of this study was to quantitatively evaluate the longitudinal deformation of the right hemidiaphragm in normal subjects using two-dimensional strain ultrasound speckle tracking. Twenty-one healthy subjects were enrolled in this study. GE Healthcare Vivid E9 equi...

journal_title：Experimental and therapeutic medicine

authors： Ye X,Xiao H,Bai W,Liang Y,Chen M,Zhang S

更新日期：2013-08-01 00:00:00

abstract：:The ChrT gene encodes a chromate reductase enzyme which catalyzes the reduction of Cr(VI). The chromate reductase is also known as flavin mononucleotide (FMN) reductase (FMN_red). The aim of the present study was to clone the full-length ChrT DNA from Serratia sp. CQMUS2 and analyze the deduced amino acid sequence and...

journal_title：Experimental and therapeutic medicine

authors： Deng P,Tan X,Wu Y,Bai Q,Jia Y,Xiao H

更新日期：2015-03-01 00:00:00

abstract：:Arteriovenous fistula (AVF) thrombosis is a common complication in patients undergoing hemodialysis, and early intervention is required. Urokinase has been used as a thrombolytic agent for declotting the thrombosed access. However, the optimal route for infusing urokinase remains to be determined. In the present retro...

journal_title：Experimental and therapeutic medicine

authors： Wan Z,Xiang R,Wang H,Zhong Q,Tu B

更新日期：2019-05-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/etm.2018.6297.]. ...

journal_title：Experimental and therapeutic medicine

authors： Jia L,Wang L,Liu W,Qian G,Jiang X,Zhang Z

更新日期：2018-12-01 00:00:00

abstract：:This study investigated changes in the level of serum 25-OH vitamin D [25-hydroxyvitamin D, 25(OH)D] in patients with non-alcoholic fatty liver disease (NAFLD) and the correlation between the severity of NAFLD and 25(OH)D. A retrospective analysis was performed on 385 NAFLD patients (NAFLD group) admitted to the Zhong...

journal_title：Experimental and therapeutic medicine

authors： Cai J,Zhang Z,Liu J,Xiao X,Wang C,Deng M,Chen L

更新日期：2020-03-01 00:00:00

abstract：:This prospective study explored the link between values of C-reactive protein (CRP) in patients with SpA (ankylosing spondylitis, psoriatic arthritis, reactive arthritis, or arthritis-related inflammatory bowel disease) and functional disability in order to derive an algorithm that may predict functional disability ba...

journal_title：Experimental and therapeutic medicine

authors： Catan L,Boariu M,Amaricai E,Popa D,Puenea G,Drăgoi M,Stratul Ș,Drăgoi RG

更新日期：2021-01-01 00:00:00

abstract：:Chronic exposure of workers to powder containing crystalline silica (Silicon dioxide; SiO2) can lead to chronic lung diseases (lung cancer, silicosis, etc.). Aim of this study was to evaluate the exposure of Greek construction workers to SiO2 and describe their pulmonary function. The study involved 86 outdoor and und...

journal_title：Experimental and therapeutic medicine

authors： Keramydas D,Bakakos P,Alchanatis M,Papalexis P,Konstantakopoulos I,Tavernaraki K,Dracopoulos V,Papadakis A,Pantazi E,Chelidonis G,Chaidoutis E,Constantinidis TC,Tsitsimpikou C,Kavantzas N,Patsouris E,Tsarouhas K,Spandidos

更新日期：2020-08-01 00:00:00

abstract：:The prognostic and predictive value of pre-treatment serum levels of carcinoembryonic antigen (CEA) and cytokeratin-19 fragments (CYFRA 21-1) were assessed in advanced non-small cell lung cancer (NSCLC) patients treated with gefitinib or erlotinib. Pre-treatment CEA and CYFRA 21-1 levels were measured in 123 advanced ...

journal_title：Experimental and therapeutic medicine

authors： Jung M,Kim SH,Lee YJ,Hong S,Kang YA,Kim SK,Chang J,Rha SY,Kim JH,Kim DJ,Cho BC

更新日期：2011-07-01 00:00:00

abstract：:Cell-based adoptive immunotherapy for the treatment of various cancer types has attracted the attention of scientists. However, due to the absence of unitary standard protocols to produce large quantities of clinical-grade effector cells, it remains challenging to translate the experimental findings into clinical appl...

journal_title：Experimental and therapeutic medicine

authors： Yu H,Chen W,Li C,Lin D,Liu J,Yang Z,Yang J,Sun Y,Ma D

更新日期：2017-12-01 00:00:00

abstract：:The present study aimed to investigate the effects of levodopa (LEV) on cellular apoptosis in a rabbit model of steroid-associated necrosis of the femoral head (SANFH). A total of 44 healthy adult Chinese rabbits were randomly divided into three groups: Group A (n=15), administered a combination of lipopolysaccharide ...

journal_title：Experimental and therapeutic medicine

authors： Xi H,Tao W,Jian Z,Sun X,Gong X,Huang L,Dong T

更新日期：2017-01-01 00:00:00

abstract：:Implementation of comprehensive rehabilitation therapy in postoperative care of patients with cholangiocarcinoma was studied to explore its impact on patients' quality of life. Two hundred and nineteen patients with cholangiocarcinoma who underwent surgery in Yidu Central Hospital of Weifang from April 2014 to June 20...

journal_title：Experimental and therapeutic medicine

authors： Liu S,Zhou L,An L

更新日期：2019-04-01 00:00:00

abstract：:The aim of the present study was to investigate the possible mechanism of Janus kinase (JAK)-signal transduction and activator of transcription (STAT)/PSMβ3 signaling in the occurrence of asthenozoospermia. We examined seminal fluid samples from 30 cases of asthenozoospermia and 30 healthy controls. Sperm was collecte...

journal_title：Experimental and therapeutic medicine

authors： Li J,Zhang L,Li B

更新日期：2017-01-01 00:00:00

abstract：:Asthma is one of the diseases that demonstrates a wide range of variation in its clinical expression, in addition to an important heterogeneity in the pathophysiological mechanisms present in each case. The ever-increasing knowledge of the molecular signalling routes and the development of the Bio Immune(G)ene Medicin...

journal_title：Experimental and therapeutic medicine

authors： Glady G

更新日期：2018-06-01 00:00:00

abstract：:Single-port laparoscopic technology is effective in minimally invasive surgery. However, this technology requires expensive instrumentation. In the present study, an alternative minimally invasive technique, periumbilical laparoscopic surgery through triple channels using common instrumentation, is introduced. Increas...

journal_title：Experimental and therapeutic medicine

authors： Ge JY,Wang L,Zou H,Zhang XW

更新日期：2013-04-01 00:00:00

abstract：:Asthma in children poses a threat to their health, but the mechanism remains to be elucidated. The present study investigated the mechanism by which the interleukin (IL)-22/IL-22 receptor 1 (IL-22R1) signaling pathway regulates subepithelial fibrosis in children with asthma. A total of 41 children with asthma and 12 h...

journal_title：Experimental and therapeutic medicine

authors： Liu J,Shang B,Bai J

更新日期：2020-09-01 00:00:00

abstract：:Oxidative stress and apoptosis serve an essential role in cisplatin-induced cardiotoxicity, which limits its clinical use, and increases the risk of cardiovascular disease. As a natural drug, the antioxidant and antitumor effects of cyanidin have been recognized, but its protective effect on cisplatin-induced cardiomy...

journal_title：Experimental and therapeutic medicine

authors： Qian P,Yan LJ,Li YQ,Yang HT,Duan HY,Wu JT,Fan XW,Wang SL

更新日期：2018-02-01 00:00:00

abstract：:Cisplatin (DDP) is a commonly used chemotherapy drug; however, the side effects associated with its use, particularly acute kidney injury (AKI), limit its clinical application. Puerarin is a natural flavonoid extracted from the Chinese medical herb Radix puerariae, which has been reported to alleviate DDP-induced neph...

journal_title：Experimental and therapeutic medicine

authors： Wu Z,Li C,Li Q,Li J,Lu X

更新日期：2020-10-01 00:00:00

abstract：:Pulmonary embolism may escape prompt diagnosis since clinical symptoms and signs are nonspecific. The occurrence of syncope as the sole initial symptom in a previously healthy patient with no predisposing factors to embolism and no hemodynamic instability is extremely rare, which may have been a factor in the delayed ...

journal_title：Experimental and therapeutic medicine

authors： Jiang AG,Lu HY

更新日期：2013-05-01 00:00:00

abstract：:The aim of this study was to investigate the effect of ouabain (EO) on myocardial remodeling. Twenty-two adult male Sprague-Dawley rats were randomly divided into two groups: the rats in the EO group (n=12) were intraperitoneally injected with EO daily and those in the control group (n=10) were injected with physiolog...

journal_title：Experimental and therapeutic medicine

authors： Ren Y,Zhang M,Zhang T,Huang R

更新日期：2013-07-01 00:00:00

abstract：:Therapy using acellular spinal cord (ASC) scaffolds seeded with bone marrow stromal cells (BMSCs) has previously been shown to restore function of the damaged spinal cord and improve functional recovery in a rat model of acute hemisected spinal cord injury (SCI). The aim of the present study was to determine whether B...

journal_title：Experimental and therapeutic medicine

authors： Wang YH,Chen J,Zhou J,Nong F,Lv JH,Liu J

更新日期：2017-01-01 00:00:00

abstract：:The aim of the present study was to characterize the effects of early growth response factor-1 DNA enzyme (EDRz) in a rat abdominal aortic aneurysm (AAA) model to determine the mechanism by which EDRz inhibits AAA and affects the formation of AAA by regulating the activity of matrix metalloproteinase (MMP)-2 and MMP-9...

journal_title：Experimental and therapeutic medicine

authors： Wang S,Dong H,Liu C,Xu G,Hu X,Fan Y,Chen L

更新日期：2018-07-01 00:00:00

abstract：:Primary lung enteric adenocarcinoma is a rare type of invasive lung carcinoma. Its morphology and immunohistochemistry are those of colorectal carcinoma, but there is no associated primary colorectal carcinoma. The present study describes the case of a 53-year-old female who presented with an irritating cough and a ma...

journal_title：Experimental and therapeutic medicine

authors： Lin LI,Xu CW,Zhang BO,Liu RR,Ge FJ,Zhao CH,Jia RU,Qin QH,Stojsic J,Wang Y,Xu JM

更新日期：2016-01-01 00:00:00

abstract：:The purpose of this study was to compare the results of delivering low doses of growth factor iteratively (20 μg x5) via a reservoir system with results obtained following a single administration of 100 μg of growth factor. The delivery systems using gelatin microspheres (GMS) facilitate the controlled release of drug...

journal_title：Experimental and therapeutic medicine

authors： Nitta N,Nitta-Seko A,Sonoda A,Watanabe S,Tsuchiya K,Murata K,Tabata Y

更新日期：2012-08-01 00:00:00

abstract：:Asthma is a major inflammatory airway disease with high incidence and mortality rates. The Global Initiative for Asthma released a report called 'The Global Burden of Asthma' in 2004. However, the specific pathogenesis of asthma remains unclear. An increasing number of studies have demonstrated that neuromedin U (NMU)...

journal_title：Experimental and therapeutic medicine

authors： Ren X,Dong F,Zhuang Y,Wang Y,Ma W

更新日期：2020-02-01 00:00:00