ROS induces epithelial-mesenchymal transition via the TGF-β1/PI3K/Akt/mTOR pathway in diabetic nephropathy.

abstract：:Neuroblastoma is a common tumor in childhood and exhibits heterogeneity and malignant progression. MYCN expression and amplification profiles are frequently correlated with the efficacy of therapy. Arsenic trioxide and imatinib mesylate (STI-571) have been suggested as promising therapeutic agents for neuroblastoma, w...

journal_title：Experimental and therapeutic medicine

authors： Kim KJ,Jung JM,Cho JY,Woo SY,Cho KA,Ryu KH,Yoo ES

更新日期：2011-05-01 00:00:00

abstract：:The underlying mechanisms of arterial remodeling (AR) remain unclear. Studies have indicated that decellularized scaffolds stimulate the differentiation of fibroblasts into myofibroblasts and promote the accumulation of the extracellular matrix (ECM). In the present study, the impact of ECM changes following AR on vas...

journal_title：Experimental and therapeutic medicine

authors： Xin H,Wang Z,Wu S,Wang P,Tao X,Xu C,You L

更新日期：2019-07-01 00:00:00

abstract：:The present study is a retrospective analysis of 11 cases with severe acute liver failure combined with multiple organ dysfunction syndrome (MODS) performed during the period June, 2012 to December, 2014. After part of plasmapheresis with plasma filtration adsorption combined with continuous hemodiafiltration treatmen...

journal_title：Experimental and therapeutic medicine

authors： Li M,Wang Z,Wang Y,Du C,Li S,Shi Z,Lu B

更新日期：2016-10-01 00:00:00

abstract：:Tools to define the active ingredients and flavors of Traditional Chinese Medicines (TCMs) are limited by long analysis times, complex sample preparation and a lack of multiplexed analysis. The aim of the present study was to optimize and validate an electronic tongue (E-tongue) methodology to analyze the bitterness o...

journal_title：Experimental and therapeutic medicine

authors： Li X,Gao X,Liu R,Wang J,Wu Z,Zhang L,Li H,Gui X,Kang B,Shi J

更新日期：2016-11-01 00:00:00

abstract：:Silk fibroin (SF), chitosan (CS) and nano-hydroxyapatite (nHA) possess excellent biocompatibility, thus, these were used to construct a SF/CS/nHA composite scaffold. Previously published results identified that this material exhibited satisfactory physical and chemical properties, and therefore qualified as a repair m...

journal_title：Experimental and therapeutic medicine

authors： Ye P,Yu B,Deng J,She RF,Huang WL

更新日期：2017-12-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) with variant translocations is rare. The patient of the present case report, a 2-year-old male with a microgranular variant of APL carrying der(17) ins(17;15) translocation, exhibited fever and epistaxis. The complete blood count showed marked leukocytosis with 72% atypical promyeloc...

journal_title：Experimental and therapeutic medicine

authors： Guan H,Liu J,Guo X,Wu C,Yu H

更新日期：2015-09-01 00:00:00

abstract：:Pediatric or childhood obesity is the most prevalent nutritional disorder among children and adolescents worldwide. Approximately 43 million individuals are obese, 21-24% children and adolescents are overweight, and 16-18% of individuals have abdominal obesity. The prevalence of obesity is highest among specific ethni...

journal_title：Experimental and therapeutic medicine

authors： Xu S,Xue Y

更新日期：2016-01-01 00:00:00

abstract：:The anticancer properties of epigallocatechin-3-gallate (EGCG) are documented in the treatment of several types of cancer; however, there is no relevant evidence for its efficacy in the treatment of renal cell carcinoma (RCC). In the present study, the therapeutic effects of EGCG in vitro were investigated, with parti...

journal_title：Experimental and therapeutic medicine

authors： Chen SJ,Yao XD,Peng BO,Xu YF,Wang GC,Huang J,Liu M,Zheng JH

更新日期：2016-04-01 00:00:00

abstract：:The rabbit VX2 hepatic tumor model has been widely used for the investigation of liver cancer. The present study was designed to compare two inoculation methods in order to identify an improved modality for establishing rabbit hepatic tumors. A total of 44 rabbits were randomly divided into 2 groups. All inoculations ...

journal_title：Experimental and therapeutic medicine

authors： Sun JH,Zhang YL,Nie CH,Yu XB,Xie HY,Zhou L,Zheng SS

更新日期：2012-03-01 00:00:00

abstract：:Diabetic keratopathy is an ocular complication that occurs with diabetes. In the present study, the effect of diabetic keratopathy on corneal optical density, central corneal thickness, and corneal endothelial cell count was investigated. One hundred and eighty diabetic patients (360 eyes) were enrolled in the study d...

journal_title：Experimental and therapeutic medicine

authors： Gao F,Lin T,Pan Y

更新日期：2016-09-01 00:00:00

abstract：:The pain-depression dyad is becoming widespread in the clinic and is attracting increasing attention. A previous study by our group found that 100-Hz electro-acupuncture (EA), but not 2-, 50- and 2/100-Hz EA, was effective against the reserpine-induced pain-depression dyad. This finding is in contrast to the fact that...

journal_title：Experimental and therapeutic medicine

authors： Wu YY,Jiang YL,He XF,Zhao XY,Shao XM,Sun J,Shen Z,Shou SY,Wei JJ,Ye JY,Yan SS,Fang JQ

更新日期：2017-07-01 00:00:00

abstract：:The present study aimed to determine whether nimotuzumab enhances the effect of radiochemotherapy in malignant gliomas. Patients (n=41) with malignant gliomas were divided into 20 cases (treatment group) in which nimotuzumab plus radiochemotherapy were offered and 21 cases (control group) in which placebo and radioche...

journal_title：Experimental and therapeutic medicine

authors： Hong J,Peng Y,Liao Y,Jiang W,Wei R,Huo L,Han Z,Duan C,Zhong M

更新日期：2012-07-01 00:00:00

abstract：:Diagnostic value between IL-17 combined with IL-18 and CT angiography in carotid atherosclerosis was evaluated. A total of 158 patients with suspected carotid artery stenosis in People's Hospital of Dongying from March 2014 to April 2017 were selected as the subjects. One hundred and two patients with carotid atherosc...

journal_title：Experimental and therapeutic medicine

authors： Suo F,Jiang F,Fang X,Ma A,Ma L

更新日期：2019-02-01 00:00:00

abstract：:Jiawei Shenqi-wan (JSQW), which comprises Shenqi-wan and two additional medicinal herbs, has been widely used for the treatment of various growth impairments, including cerebral palsy. In the present study, JSQW was administered to hypoxic-ischemic Sprague-Dawley rats that underwent treadmill training from 4-7 weeks o...

journal_title：Experimental and therapeutic medicine

authors： Kim HN,Pak ME,Shin MJ,Kim SY,Shin YB,Yun YJ,Shin HK,Choi BT

更新日期：2017-05-01 00:00:00

abstract：:The C-X-C Motif Chemokine Receptor 4/C-X-C Motif Chemokine Ligand 12 (CXCR4/CXCL12) axis has been implicated in the pathogenesis of pulmonary fibrosis. However, the mechanisms governing this remain to be determined. The current study demonstrated that human lung fibroblasts (HLFs) exhibit high CXCL12 expression and al...

journal_title：Experimental and therapeutic medicine

authors： Li F,Xu X,Geng J,Wan X,Dai H

更新日期：2020-03-01 00:00:00

abstract：:This study aimed to explore and evaluate the tolerability and antiviral activity of pegylated recombinant human consensus interferon-α (PEG-CIFN) in adults with hepatitis C virus (HCV) infection. A total of 48 adult subjects chronically infected with HCV were divided into five groups, which were treated separately wit...

journal_title：Experimental and therapeutic medicine

authors： Ding YH,Liu B,Zhang X,Sun L,Zhang H,Luo H,Sun YF,Liu CJ,Zhang Q,Cao YC,Chen H,Niu JQ

更新日期：2017-01-01 00:00:00

abstract：:Endometriosis (EM) is a common benign gynecological disorder. The present study aimed to investigate the potential role of propofol, a commonly used intravenous anesthetic agent, in the pathogenesis of EM. The EM cell line CRL-7566 was used in the present study. CRL-7566 cells were first treated with various concentra...

journal_title：Experimental and therapeutic medicine

authors： Feng S,Sun Y

更新日期：2018-10-01 00:00:00

abstract：:The present study aimed to analyze the imaging, clinical and pathological features of fungal infection involvement in primary biliary cirrhosis (PBC) by retrospectively analyzing and reviewing the features of two patients with fungal infection involvement in PBC. Both patients were female. One patient had a confirmed ...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Zhao Z,Lu H,Zhang J,Huang F

更新日期：2017-02-01 00:00:00

abstract：:A previous study by our group found that electro-acupuncture (EA) at the Shenting (DU24) and Baihui (DU20) acupoints ameliorates cognitive impairment in rats with cerebral ischemia-reperfusion (I/R) injury. However, the precise mechanism of action has remained largely unknown. The present study investigated whether br...

journal_title：Experimental and therapeutic medicine

authors： Lin R,Li X,Liu W,Chen W,Yu K,Zhao C,Huang J,Yang S,Peng H,Tao J,Chen L

更新日期：2017-09-01 00:00:00

abstract：:The aim of the present study was to screen differentially co-expressed genes and the involved transcription factors (TFs) and microRNAs (miRNAs) in venous thromboembolism (VTE). Microarray data of GSE19151 were downloaded from Gene Expression Omnibus, including 70 patients with VTE and 63 healthy controls. Principal c...

journal_title：Experimental and therapeutic medicine

authors： Ming Z,Ding W,Yuan R,Jin J,Li X

更新日期：2016-06-01 00:00:00

abstract：:Mitochondrial factor and cell cytokines play important roles in the incidence of vascular dementia (VD), but their correlations with inflammatory and mitochondrial factors and the role of both in the kidney essence deficiency pattern and phlegm turbidity blocking orifice pattern are not clear. This study was aimed at ...

journal_title：Experimental and therapeutic medicine

authors： Sun L

更新日期：2018-01-01 00:00:00

abstract：:In patients with chronic kidney disease (CKD), hypertension (HP) is associated with the development of left ventricular (LV) diastolic dysfunction. However, the impact of antihypertensive treatment on LV diastolic function has not been well studied in CKD patients. Recently, two-dimensional speckle-tracking echocardio...

journal_title：Experimental and therapeutic medicine

authors： Li KL,Wang RX,Dai M,Lu J,Xue J,Yang XJ

更新日期：2015-05-01 00:00:00

abstract：:Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS2) deficiency is a metabolic disorder caused by mutations in the HMGCS2 gene. The present study describes the identification of four cases of HMGCS2 deficiency in Japan. Hepatomegaly and severe metabolic acidosis were observed in all cases. Fatty liver was id...

journal_title：Experimental and therapeutic medicine

authors： Ago Y,Otsuka H,Sasai H,Abdelkreem E,Nakama M,Aoyama Y,Matsumoto H,Fujiki R,Ohara O,Akiyama K,Fukui K,Watanabe Y,Nakajima Y,Ohnishi H,Ito T,Fukao T

更新日期：2020-11-01 00:00:00

abstract：:Effects of antithrombotic agents on the bleeding risk after transurethral resection of the prostate (TURP) were assessed in patients with benign prostatic hyperplasia (BPH). Controlled clinical trials on the effects of perioperative anticoagulant therapy on postoperative bleeding in BPH patients published during Janua...

journal_title：Experimental and therapeutic medicine

authors： He Q,Yu Y,Gao F

更新日期：2020-10-01 00:00:00

abstract：:The activation of tunica albuginea myofibroblasts (MFs) serves an essential role in Peyronie's disease (PD). Increasing evidence has reported that adipose tissue-derived stem cells (ADSCs) have been demonstrated to attenuate the symptoms of PD in animal models. However, the mechanisms of the antifibrotic effects of AD...

journal_title：Experimental and therapeutic medicine

authors： Jiang H,Gao Q,Che X,Zhu L,Zhang Z,Chen Y,Dai Y

更新日期：2017-11-01 00:00:00

abstract：:Tanshinone IIA (TSIIA) is a major component of Salvia miltiorrhiza, a Chinese herb that exhibits a therapeutic effect on polycystic ovary syndrome (PCOS). The present study replicated PCOS via the neonatal treatment of estradiol in mice. Estrous cycles, body and ovarian weight, serum levels of testosterone and estradi...

journal_title：Experimental and therapeutic medicine

authors： Jin J,Hu QY,Xu WW,Zhu WJ,Liu B,Liu J,Wang W,Zhou HF

更新日期：2019-05-01 00:00:00

abstract：:Homeobox protein Nxk-2.5 (Nkx2.5) is a homeobox transcription factor that promotes chamber-like myocardial gene expression. Data from a previous genome-wide association study suggested that Nkx2.5 may be associated with the genetic variation that underlies atrial fibrillation (AF). Nkx2.5 loss of function has been dem...

journal_title：Experimental and therapeutic medicine

authors： Chen J,Xu S,Li W,Wu L,Wang L,Li Y,Zhou W

更新日期：2019-12-01 00:00:00

abstract：:Opioids and α2-agonists have been used as epidural adjuvants in local anesthetics for a long time, but the effect of the combination of opioids and α2-agonists as epidural adjuvants is not completely understood. In the present study, the combination of dexmedetomidine (Dex) and sufentanil as adjuvants to ropivacaine f...

journal_title：Experimental and therapeutic medicine

authors： Li G,Xiao Y,Qi X,Wang H,Wang X,Sun J,Li Y,Li Y

更新日期：2020-07-01 00:00:00

abstract：:The aim of the present study was to examine the effect of CCAAT enhancer binding protein β (C/EBPβ) on human breast cancer cells. The plasmids pCDH-C/EBPβ and pLKO.1-shC/EBPβ were constructed and were infected into MDA-MB-468 cells, to provide C/EBPβ overexpressing and C/EBPβ knockdown cells, respectively. Cell viabil...

journal_title：Experimental and therapeutic medicine

authors： Cao J,Wang M,Wang T

更新日期：2017-08-01 00:00:00

abstract：:Discoid lateral meniscus of the knee causes a high morbidity in China. Since the traditional treatment to open the capsule and resect the meniscus often results in arthritis, it is now believed that a discoid lateral meniscus should be treated with arthroscopy to preserve part of the meniscus. The current study aimed ...

journal_title：Experimental and therapeutic medicine

authors： Cao H,Zhang Y,Qian W,Cheng XH,Ke Y,Guo XP

更新日期：2012-11-01 00:00:00