Nimotuzumab prolongs survival in patients with malignant gliomas: A phase I/II clinical study of concomitant radiochemotherapy with or without nimotuzumab.

abstract：:Aortic valve (AoV) stenosis is the third most common cardiovascular disease. The pathogenesis of AoV stenosis is associated with an inflammatory process where MMPs serve important roles. The aim of the present study was to determine the association between matrix metalloproteinases (MMPs), tissue inhibitors of metallo...

journal_title：Experimental and therapeutic medicine

authors： Lurins J,Lurina D,Svirskis S,Nora-Krukle Z,Tretjakovs P,Mackevics V,Lejnieks A,Rapisarda V,Baylon V

更新日期：2019-04-01 00:00:00

abstract：:Chronic antibody-mediated rejection (ABMR) is a major cause of the transplant renal interstitial fibrosis and transplanted kidney epithelial cell transdifferentiation is one of the main mechanisms. The transforming growth factor (TGF)-β1/integrin-linked kinase (ILK) signaling pathway has a significant role in the epit...

journal_title：Experimental and therapeutic medicine

authors： Yan Q,Luo H,Wang B,Sui W,Zou G,Chen H,Zou H

更新日期：2017-05-01 00:00:00

abstract：:The aim of the present study was to investigate the expression levels of estrogen receptor (ER) α and β and human epidermal growth factor receptor-2 (Her-2), as well as the distribution of breast cancer molecular subtypes in Uygur and Han breast cancer patients. Cancer tissues were collected and analyzed from 709 brea...

journal_title：Experimental and therapeutic medicine

authors： Guo L,Hou X,Dilimina Y,Wang B

更新日期：2014-05-01 00:00:00

abstract：:The Global Registry of Acute Coronary Events (GRACE) risk score and the mean platelet volume to lymphocyte count ratio (MPVLR) can be used independently to predict adverse outcomes in patients with acute coronary syndromes. However, the level of MPVLR in relation to the GRACE score, and whether a combination of these ...

journal_title：Experimental and therapeutic medicine

authors： Chen X,Shao M,Zhang T,Zhang W,Meng Y,Zhang H,Hai H,Li G

更新日期：2020-06-01 00:00:00

abstract：:Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene have previously been associated with a predisposition to pituitary adenomas. However, to the best of our knowledge, mutations in AIP that relate specifically to sporadic non-functioning pituitary adenomas (NFPAs) have yet to be reported. Therefo...

journal_title：Experimental and therapeutic medicine

authors： Hu Y,Yang J,Chang Y,Ma S,Qi J

更新日期：2016-03-01 00:00:00

abstract：:Delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) is a serious complication that occurs several days or weeks after carbon monoxide (CO) intoxication. This study identified computed tomography (CT) findings in the prediction of DEACMP development. Adults with CO poisoning admitted to Beijing Chaoya...

journal_title：Experimental and therapeutic medicine

authors： Du X,Gu H,Hao F,Gao L,Wang J,Sun C,Zhang H,Ma P,Zhang X,Hu W

更新日期：2019-04-01 00:00:00

abstract：:Central venous catheter is one of the most commonly used vascular therapies in patients receiving hemodialysis and vascular perforation is a rare but serious complication. The present study reports on a case of a 64-year-old female who developed massive hemothorax and hemorrhagic shock after long-term dialysis due to ...

journal_title：Experimental and therapeutic medicine

authors： Zhou CZ,Liu KC,Wang P,Ren W,Lv WF

更新日期：2019-10-01 00:00:00

abstract：:Alteration of behavior and PSD proteins in cerebral cortex and hippocampal synaptosome in the Alzheimer's disease (AD) mouse model were determined. AD was established by intraperitoneal injection of streptozotocin (STZ) in neonatal mice (intraperitoneal AD group) or intracerebroventricular injection of STZ in adult mi...

journal_title：Experimental and therapeutic medicine

authors： Zhang Y,Ding R,Wang S,Ren Z,Xu L,Zhang X,Zhao J,Ding Y,Wu Y,Gong Y

更新日期：2018-09-01 00:00:00

abstract：:Recent studies have demonstrated that melatonin significantly decreased all studied acute pancreatitis-associated inflammatory parameters, in addition to reducing apoptosis and necrosis associated with pancreatic injury. However, the effect of melatonin on gut barrier dysfunction and bacterial translocation has not be...

journal_title：Experimental and therapeutic medicine

authors： Sun X,Shao Y,Jin Y,Huai J,Zhou Q,Huang Z,Wu J

更新日期：2013-12-01 00:00:00

abstract：:Activated T cells rely on aerobic glycolysis and glutaminolysis in order to proliferate and differentiate into effector cells. Therefore, intervention in these metabolic pathways inhibits proliferation. The aim of the present study was to evaluate the effects of Krebs' cycle inhibition at the level of malate dehydroge...

journal_title：Experimental and therapeutic medicine

authors： Eleftheriadis T,Pissas G,Antoniadi G,Liakopoulos V,Stefanidis I

更新日期：2015-11-01 00:00:00

abstract：:In Traditional Chinese Medicine, Polygonum multiflorum (PM) is known for its anti-aging properties. A previous study by our group showed that extracts of PM were able to prevent and treat bone loss in vivo, and the active components emodin and 2,3,5,4,-tetrahydroxystilbene-2-O-β-glucoside (TSG) promoted the osteogenic...

journal_title：Experimental and therapeutic medicine

authors： Zhou M,Li J,Wu J,Yang Y,Zeng X,Lv X,Cui L,Yao W,Liu Y

更新日期：2017-09-01 00:00:00

abstract：:A male 46 year-old patient was admitted to the Emergency Intensive Care Unit of Qinghai Provincial People's Hospital (Xining, China) in December 2008 with complaints of a headache and fever that had lasted for three days. In addition, the patient had experienced two general convulsions accompanied with consciousness d...

journal_title：Experimental and therapeutic medicine

authors： Zhang B,Wang L

更新日期：2016-11-01 00:00:00

abstract：:Osteonecrosis is a condition that frequently affects patients with systemic lupus erythematosus (SLE). However, reports on severe multifocal osteonecrosis involving more than three anatomical sites in patients with SLE are scarce. The present study describes a case of SLE with multifocal osteonecrosis involving all fo...

journal_title：Experimental and therapeutic medicine

authors： Sun S,Wang Q,Gong Y,Qi X,Liu J

更新日期：2019-10-01 00:00:00

abstract：:Cisplatin (DDP) is a commonly used chemotherapy drug; however, the side effects associated with its use, particularly acute kidney injury (AKI), limit its clinical application. Puerarin is a natural flavonoid extracted from the Chinese medical herb Radix puerariae, which has been reported to alleviate DDP-induced neph...

journal_title：Experimental and therapeutic medicine

authors： Wu Z,Li C,Li Q,Li J,Lu X

更新日期：2020-10-01 00:00:00

abstract：:microRNAs (miRNAs) are small, non-coding RNAs of endogenous origin. They have been increasingly shown to have aberrant expression in a number of tumor types. miR-192, -194 and -215 have not been comprehensively investigated using a large number of cases in colorectal cancer (CRC). We extracted total RNA from 107 CRC t...

journal_title：Experimental and therapeutic medicine

authors： Chiang Y,Song Y,Wang Z,Liu Z,Gao P,Liang J,Zhu J,Xing C,Xu H

更新日期：2012-03-01 00:00:00

abstract：:Eukaryotic translation initiation factor (EIF) 5A2 exerts important functions that regulate the development and progression of cancers. The present study aimed to investigate the expression of EIF5A2 in prostate cancer (PCa) and its association with biological and prognostic significance. EIF5A2 mRNA and protein level...

journal_title：Experimental and therapeutic medicine

authors： Lu J,Zhao HW,Chen Y,Wei JH,Chen ZH,Feng ZH,Huang Y,Chen W,Luo JH,Fang Y

更新日期：2019-05-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are involved in bone formation in the embryo, bone repair and remodeling. The differentiation of these cells is a complex multistep pathway that involves discrete cellular transitions and is similar to that which occurs during hematopoiesis. MSCs have self-renewal capacity without differe...

journal_title：Experimental and therapeutic medicine

authors： Shima WN,Ali AM,Subramani T,Mohamed Alitheen NB,Hamid M,Samsudin AR,Yeap SK

更新日期：2015-06-01 00:00:00

abstract：:The aim of the present study was to determine whether chlorogenic acid (CA) is able to modulate cadmium (Cd)-induced oxidative brain damage. Cd-treated rats displayed numerous pathological effects, including the inhibition of acetylcholinesterase, elevated lipid peroxidation, the depletion of enzymatic and non-enzymat...

journal_title：Experimental and therapeutic medicine

authors： Hao ML,Pan N,Zhang QH,Wang XH

更新日期：2015-05-01 00:00:00

abstract：:In the present study, the risk factors for systemic air embolism as a complication of percutaneous CT-guided lung biopsy were explored. Data from 2,026 percutaneous CT-guided lung biopsy procedures were retrospectively analyzed. All cases were divided into a concurrent air embolism group and a control group, depending...

journal_title：Experimental and therapeutic medicine

authors： Liu SH,Fu Q,Yu HL,Yang Q,Hu YB,Zhang ZX,Zhang BP,Zhang CY

更新日期：2020-01-01 00:00:00

abstract：:Dysregulation of microRNAs serves a crucial role in the chemosensitivity to cisplatin (DDP) in ovarian cancer (OVC). The abnormal expression of microRNA (miR)-654-3p has been reported in several types of human cancer. However, the association between miR-654-3p and cisplatin resistance in human OVC remains unclear. Th...

journal_title：Experimental and therapeutic medicine

authors： Niu YC,Tong J,Shi XF,Zhang T

更新日期：2020-08-01 00:00:00

abstract：:The current published data on p53 expression and its predictive value in the risk of malignant gastrointestinal stromal tumors (GIST) has are inconclusive. To derive a more precise estimation of the correlation between p53 and the biological behavior of GIST, a meta-analysis was performed. Studies were identified by s...

journal_title：Experimental and therapeutic medicine

authors： Zong L,Chen P,Jiang J,Wang L,Li QG

更新日期：2012-01-01 00:00:00

abstract：:Effects of paraquat (PQ) on interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in macrophages were investigated. Different concentrations of PQ were added to mouse macrophage RAW264.7 for culture. According to different concentrations of PQ, mice were divided into micro concentration (0.01 mmol/l), low concentra...

journal_title：Experimental and therapeutic medicine

authors： Huang J,Ning N,Zhang W

更新日期：2019-03-01 00:00:00

abstract：:Vitiligo is an acquired pigmentary disorder characterized by the loss of skin color and functional melanocytes. The pathogenesis of vitiligo remains unclear, which means that effective clinical treatment is difficult. However, if melanocyte linkage-specific genes are identified in vitiligo lesions, the appropriate tre...

journal_title：Experimental and therapeutic medicine

authors： Xu W,Wang X

更新日期：2019-06-01 00:00:00

abstract：:The hypoxia-reoxygenation process of obstructive sleep apnea (OSA) may cause oxidative stress injury of the kidney, but the molecular mechanisms are not clear. The present study aimed to investigate whether high mobility group box 1 protein (HMGB1) and its subsequent inflammatory pathway served a role in kidney injury...

journal_title：Experimental and therapeutic medicine

authors： Zhang C,Dong H,Chen F,Wang Y,Ma J,Wang G

更新日期：2019-01-01 00:00:00

abstract：:The excessive production of inflammatory cytokines during invasive infection primarily mediates the pathophysiology of sepsis. To improve the survival of septic patients, many selective or mediator-specific anti-inflammatory agents have been developed. Saikosaponin A (SsA), a triterpenoid saponin isolated from Radix B...

journal_title：Experimental and therapeutic medicine

authors： Zhao H,Li S,Zhang H,Wang G,Xu G,Zhang H

更新日期：2015-08-01 00:00:00

abstract：:Identifying the predominant microbial species in patients with ethmoidal sinusitis is conducive to its successful treatment. The aim of the present study was to determine the microbial composition and the predominant fungal and bacterial species in patients with ethmoidal sinusitis. A sample was obtained from 3 patien...

journal_title：Experimental and therapeutic medicine

authors： Zhang J,He S,Li Y,Lv M,Wei H,Qu B,Zheng Y,Hu C

更新日期：2018-11-01 00:00:00

abstract：:Honokiol, a potent radical scavenger, has been demonstrated to ameliorate cerebral infarction following ischemia/reperfusion (I/R) injury. However, its effects on myocardial I/R injury remain unclear. The present study aimed to examine the effects of honokiol on myocardial I/R injury and to investigate its potential c...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Zhang ZZ,Wu Y,Zhan J,He XH,Wang YL

更新日期：2013-01-01 00:00:00

abstract：:Although cryptococcal meningitis (CM) typically occurs in immunocompromised hosts, immunocompetent humans are susceptible to CM. In humans with an intact immune system, CM presents with signs and symptoms typical of meningitis, including fever, headache and neck stiffness. The present study reported the case of a fema...

journal_title：Experimental and therapeutic medicine

authors： Li J,Wang P,Ye L,Wang Y,Zhang X,Yu S

更新日期：2016-08-01 00:00:00

abstract：:The mortality and disability rate of patients with ruptured anterior communicating artery (AComA) aneurysm after bleeding is high. Even with the most advanced treatment methods, the incidence of complications remains high. The purpose of the present study was to determine the efficacy of microsurgery via supraorbital ...

journal_title：Experimental and therapeutic medicine

authors： Bhattarai R,Liang C,Chen C,Wang H,Huang T,Ning X,Guo Y

更新日期：2020-09-01 00:00:00

abstract：:Previous studies have demonstrated that Hedyotis diffusa Willd (HDW), a traditional Chinese herbal medicine, exhibits potent anticancer activity in models of colorectal cancer (CRC). Aggressive forms of CRC exhibit resistance to widely used chemotherapeutic drugs, including the antimetabolite, 5-fluorouracil (5-FU); h...

journal_title：Experimental and therapeutic medicine

authors： Li Q,Wang X,Shen A,Zhang Y,Chen Y,Sferra TJ,Lin J,Peng J

更新日期：2015-11-01 00:00:00