Abstract:
:Although cryptococcal meningitis (CM) typically occurs in immunocompromised hosts, immunocompetent humans are susceptible to CM. In humans with an intact immune system, CM presents with signs and symptoms typical of meningitis, including fever, headache and neck stiffness. The present study reported the case of a female immunocompetent patient who presented visual blurring in both eyes and bilateral papilledema for ~1 month. Following hospital admission, the patient was diagnosed with optic nerve inflammation and was treated with intravenous methylprednisolone and oral prednisone. However, the initial symptoms failed to improve and the patient developed a headache. The microscopic examination and India ink test performed using the cerebrospinal fluid of the patient showed the presence of Cryptococcus neoformans. Following combined treatment with amphotericin B and fluconazole, the patient made a full recovery with total resolution of the initial symptoms. This case demonstrates that CM in immunocompetent patients may initially include eye symptoms, which may result in a delayed diagnosis of CM.
journal_name
Exp Ther Medjournal_title
Experimental and therapeutic medicineauthors
Li J,Wang P,Ye L,Wang Y,Zhang X,Yu Sdoi
10.3892/etm.2016.3440subject
Has Abstractpub_date
2016-08-01 00:00:00pages
1119-1124issue
2eissn
1792-0981issn
1792-1015pii
ETM-0-0-3440journal_volume
12pub_type
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