Protective effect of senegenin on splenectomy-induced postoperative cognitive dysfunction in elderly rats.

abstract：:The aim of the present study was to investigate the association between polymorphism in the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) in the promoter region of the 5-HTT gene and the pathogenesis of postpartum depression (PPD). Blood samples were collected from 120 female patients with PP...

journal_title：Experimental and therapeutic medicine

authors： Zhang X,Wang L,Huang F,Li J,Xiong L,Xue H,Zhang Y

更新日期：2015-01-01 00:00:00

abstract：:The aim of the present study was to determine the ferulic acid (FA) content of Radix Angelicae Sinensis (AS), Danggui-Buxue-Tang (DBT) and Danggui-Sini-Tang (DST) using the same ultra performance liquid chromatography system and method. FA was eluted using an Acquity BEH C18 column (100×2.1 mm inner diameter; 1.7 μm)....

journal_title：Experimental and therapeutic medicine

authors： Yao JM,Yu LJ,Chen Q,Chen ZQ,Wang DS,Qiu XJ,Zhao LL

更新日期：2014-05-01 00:00:00

abstract：:The aim of the present study was to investigate the expression and role of transforming growth factor (TGF)-β1/phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3KC3) in the peripheral blood in patients with hypertension. A total of 28 patients with primary hypertension and 20 healthy control subjects were inc...

journal_title：Experimental and therapeutic medicine

authors： Zhang Q,Liu H,Yang J

更新日期：2019-03-01 00:00:00

abstract：:The present study aimed to investigate the association between high mobility group protein B1 (HMGB1), transforming growth factor-β1 (TGF-β1), nuclear factor-κB (NF-κB) and chronic allograft nephropathy (CAN) and to identify the clinical significance of HMGB1, TGF-β1, NF-κB on patients with CAN. Between September 2012...

journal_title：Experimental and therapeutic medicine

authors： Zhao SQ,Xue ZZ,Wang LZ

更新日期：2017-12-01 00:00:00

abstract：:Atrial remodeling is considered to be any persistent change in atrial structure or function, and is responsible for the development and perpetuation of atrial fibrillation (AF). Oxidative stress and intracellular pH regulation may also be linked to AF; however it remains unclear whether eicosapentaenoic acid (EPA) or ...

journal_title：Experimental and therapeutic medicine

authors： Tong M,Wang J,Ji Y,Chen X,Wang J,Wang S,Ruan L,Cui H,Zhou Y,Zhang Q,Watanabe E

更新日期：2017-09-01 00:00:00

abstract：:Relative changes in B-type natriuretic peptide (BNP) and amino terminal pro-BNP (NT-proBNP) levels may help to assess the risk of congestive heart failure (CHF). However, whether these levels at the time of admission enable the prediction of outcomes with acute exacerbation remains unknown. The current study determine...

journal_title：Experimental and therapeutic medicine

authors： Dai Y,Yang J,Takagi A,Konishi H,Miyazaki T,Masuda H,Shimada K,Miyauchi K,Daida H

更新日期：2017-08-01 00:00:00

abstract：:The abnormal expression of miRNAs (miRs) has previously been reported in respiratory syncytial virus (RSV) disease. However, to the best of our knowledge, the expression of miR-140-5p in patients with an RSV infection has never been explored. Reverse transcription-quantitative polymerase chain reaction was performed t...

journal_title：Experimental and therapeutic medicine

authors： Zhang Y,Shao L

更新日期：2018-08-01 00:00:00

abstract：:It has been widely reported that the serum anion gap is significantly associated with mortality in intensive care unit (ICU); however, it remains unknown whether the association is present in aortic aneurysm (AA) patients. The present study aimed to investigate the association between the admission serum anion gap and...

journal_title：Experimental and therapeutic medicine

authors： Chen Q,Chen Q,Li L,Lin X,Chang SI,Li Y,Tian Z,Liu W,Huang K

更新日期：2018-09-01 00:00:00

abstract：:The present study aimed to investigate changes in the levels of metabolites and appetite control factors caused by different dietary interventions in Sprague Dawley (SD) rats. A total of 35 male SD rats were weaned and immediately randomly assigned to five groups. The control group was given ad libitum access to a nor...

journal_title：Experimental and therapeutic medicine

authors： Lin B,Liu Y,Zhang W,Zou W

更新日期：2020-09-01 00:00:00

abstract：:The aim of the present study was to investigate whether magnolol, the essential component of the traditional Chinese medicine, Magnolia officinalis, can pass through liver X receptor α (LXRα), to subsequently play an important role in the lipid metabolic balance. Using a HepG2 human hepatoma cell line, mammalian cellu...

journal_title：Experimental and therapeutic medicine

authors： Xie NA,Hu C,Guo A,Liang H,DU P,Yin G

更新日期：2015-05-01 00:00:00

abstract：:Kawasaki disease (KD) is the leading cause of acquired heart disease in pediatric patients in developed countries. Coronary artery aneurysms and myocardial infarction may occur if the disease remains untreated. An estimated 10-20% of KD patients do not respond to intravenous gamma globulin (IVIG), and thus, alternativ...

journal_title：Experimental and therapeutic medicine

authors： Dai N,Zhao C,Kong Q,Li D,Cai Z,Wang M

更新日期：2019-05-01 00:00:00

abstract：:The aim of the present study was to clarify the association between lipid metabolism and the atherosclerosis in early-stage chronic renal failure at the molecular level and to explore the efficacy of decorin on chronic renal failure. Sprague Dawley rats receiving 5/6 nephrectomy and Sham surgery were divided into cont...

journal_title：Experimental and therapeutic medicine

authors： Ma HB,Wang R,Yu KZ,Yu C

更新日期：2015-02-01 00:00:00

abstract：:Platelet-rich plasma (PRP) is blood plasma containing a high number of platelets that release growth factors for wound healing and tissue regeneration. In the present study, the feasibility of improving PRP therapy by using chitosan that exhibits high platelet activation ability was investigated. A total of 13 chitosa...

journal_title：Experimental and therapeutic medicine

authors： Hattori H,Ishihara M

更新日期：2017-03-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus, which causes coronavirus disease 2019 (COVID-19) and affects children less frequently than adults. According to Professor Vana Papaevangelou, Professor of Paediatrics at the University of Athens School of Medicine, children comprise o...

journal_title：Experimental and therapeutic medicine

authors： Mammas IN,Theodoridou M,Spandidos DA

更新日期：2020-12-01 00:00:00

abstract：:Curcuma longa is a plant that belongs to the ginger family, Zingiberaceae. It has been used in Siddha medicine for thousands of years in Asia. Parkinson's disease (PD) is a degenerative disorder of the central nervous system that affects the motor system of the brain. Death of dopamine-producing cells in the substanti...

journal_title：Experimental and therapeutic medicine

authors： Ma XW,Guo RY

更新日期：2017-05-01 00:00:00

abstract：:Chronic hepatitis B virus (CHB) infection is a burden on global healthcare and is associated with a higher risk of serious sequelae, including cirrhosis and hepatocellular carcinoma. The clinical application of entecavir as a treatment for CHB has produced positive outcomes, and so is an attractive form of pharmacolog...

journal_title：Experimental and therapeutic medicine

authors： Gai XD,Wu WF

更新日期：2017-10-01 00:00:00

abstract：:Previous studies have demonstrated that Hedyotis diffusa Willd (HDW), a traditional Chinese herbal medicine, exhibits potent anticancer activity in models of colorectal cancer (CRC). Aggressive forms of CRC exhibit resistance to widely used chemotherapeutic drugs, including the antimetabolite, 5-fluorouracil (5-FU); h...

journal_title：Experimental and therapeutic medicine

authors： Li Q,Wang X,Shen A,Zhang Y,Chen Y,Sferra TJ,Lin J,Peng J

更新日期：2015-11-01 00:00:00

abstract：:Gardenia fruit has been used in traditional Chinese medicine for thousands of years. A previous study by the present authors indicated that the ethanol extract of gardenia fruits (EEG) primarily contains eight constituents. In the present study, the potential effects of EEG on unilateral ureteral obstruction (UUO)-ind...

journal_title：Experimental and therapeutic medicine

authors： Li X,Ma M,Zhang X,Deng L,Wang Y,Bian Z,Cai S,Peng B,Yang J,Chen Y

更新日期：2017-08-01 00:00:00

abstract：:The present study was designed to test the hypothesis that butylphthalide protects the brain of Alzheimer's disease (AD) model rats by inhibiting apoptosis. Ninety Sprague-Dawley rats were randomly divided into drug, control and blank groups of 30 rats in each. The rats in the drug and control groups were treated to i...

journal_title：Experimental and therapeutic medicine

authors： Song FX,Wang L,Liu H,Wang YL,Zou Y

更新日期：2017-06-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of urantide on the expression status of C-reactive protein (CRP) and the inflammatory cytokines monocyte chemotactic protein (MCP)-1 and transforming growth factor (TGF)-β in the aortas of rats with atherosclerosis (AS), and to identify its underlying mechani...

journal_title：Experimental and therapeutic medicine

authors： Zhao J,Xie LD,Song CJ,Mao XX,Yu HR,Yu QX,Ren LQ,Shi Y,Xie YQ,Li Y,Liu SS,Yang XH

更新日期：2014-06-01 00:00:00

abstract：:The present study aimed to explore the potential of combined treatment with mesenchymal stem cells (MSCs) and danshen for angiogenesis and bone regeneration in a rabbit model of avascular necrosis of femoral head (ANFH). A rabbit model of ANFH was established using the Shwartzman reaction with methylprednisolone and E...

journal_title：Experimental and therapeutic medicine

authors： Wu Y,Zhang C,Wu J,Han Y,Wu C

更新日期：2019-07-01 00:00:00

abstract：:Vascular calcification (VC) caused by chronic kidney disease (CKD)-mineral and bone disorder is a common complication of CKD. Recent studies have demonstrated that menaquinone-4 (MK-4) is negativly associated with VC in patients with CKD. Furthermore, we have previously shown that runt-related transcription factor 2 (...

journal_title：Experimental and therapeutic medicine

authors： Cui L,Xu J,Zhang J,Zhang M,Zhang S,Bai Y

更新日期：2018-10-01 00:00:00

abstract：:Environmental exposure, including a high-fat diet (HFD), contributes to the high prevalence of colorectal cancer by changing the composition of the intestinal microbiota. However, data examining the interaction between dietary habits and intestinal microbiota of the Chinese population is sparse. We assessed dietary ha...

journal_title：Experimental and therapeutic medicine

authors： Qian L,Gao R,Hong L,Pan C,Li H,Huang J,Qin H

更新日期：2018-08-01 00:00:00

abstract：:Flos Chrysanthemi Indici (CI) is a traditional medicinal plant used in the treatment of inflammatory diseases. However, the pharmacological role of CI in metabolic diseases, especially in diseases induced by insulin metabolism disorders, remains poorly understood. In the present study, Drosophila melanogaster (Drosoph...

journal_title：Experimental and therapeutic medicine

authors： Bai Y,Li K,Shao J,Luo Q,Jin LH

更新日期：2018-09-01 00:00:00

abstract：:This study aimed to investigate the influence of intrathecal injection with dexmedetomidine on the behavioral ability and analgesic effects of rat models with chronic neuropathic pain. It also discusses the role that the expression of protein kinase C (PKC) in the spinal dorsal horn plays in the analgesic mechanism of...

journal_title：Experimental and therapeutic medicine

authors： Li X,Zhang W

更新日期：2018-11-01 00:00:00

abstract：:An accessory middle cerebral artery (AMCA), which mainly acts in the collateral circulation of the middle cerebral artery (MCA), is a rare anatomic malformation. Similar to other intracranial vessels, cerebrovascular disease can occur in the AMCA. However, the development of an arteriovenous malformation (AVM) in the ...

journal_title：Experimental and therapeutic medicine

authors： Li K,Guo Y,Qu L,Xu B,Xu K,Yu J

更新日期：2018-09-01 00:00:00

abstract：:Previous research has shown that breathing exercises may improve the prognosis and health status in patients with lung cancer by enhancing pulmonary function and quality of life (QOL). However, individually published results are inconclusive. The aim of the present meta-analysis was to evaluate the clinical value of b...

journal_title：Experimental and therapeutic medicine

authors： Liu W,Pan YL,Gao CX,Shang Z,Ning LJ,Liu X

更新日期：2013-04-01 00:00:00

abstract：:Gamboge, the dried resin secreted by Garcinia maingayii (gambogic tree), was previously demonstrated to exert anti-inflammatory effects. The present study examined the effects of gambogic acid, the major active constituent of gamboge, on myocardial infarction (MI) and inflammation in a rat model and explored the possi...

journal_title：Experimental and therapeutic medicine

authors： Na D,Aijie H,Bo L,Zhilin M,Long Y

更新日期：2018-02-01 00:00:00

abstract：:The present study assessed the effects of γ-aminobutyric acid (GABA) from β-cells on glucose levels and glucagon secretion, and identified channels via which glucagon secretion is initiated. An in vivo experiment was performed containing three groups: Intrapancreatic artery infusion of GABA alone, GABA plus insulin or...

journal_title：Experimental and therapeutic medicine

authors： Yu T,Jiang Z,Liu L,Fan Z

更新日期：2018-03-01 00:00:00

abstract：:A major consequence of obstructive jaundice (OJ) in clinical practice is the development of severe liver injury, and at present, no effective treatments have been developed to protect against it. Preconditioning with damage-associated molecular pattern (DAMP) molecules has been demonstrated to protect multiple organs ...

journal_title：Experimental and therapeutic medicine

authors： Zhou YX,Ni Y,Liu YB,Liu X

更新日期：2014-07-01 00:00:00