Menaquinone-4 modulates the expression levels of calcification-associated factors to inhibit calcification of rat aortic vascular smooth muscle cells in a dose-dependent manner.

abstract：:Coronary artery disease (CAD) is the first cause of morbidity and mortality worldwide. An important goal is to diagnose patients in early stages, in order to reduce acute cardiovascular events. The angiotensin-converting enzyme (ACE) is an important element for the cardiovascular system, through its actions on hydro-s...

journal_title：Experimental and therapeutic medicine

authors： Vladeanu MC,Bojan IB,Bojan A,Iliescu D,Badescu MC,Badulescu OV,Badescu M,Georgescu CA,Ciocoiu M

更新日期：2020-10-01 00:00:00

abstract：:Patients with spontaneous isolated superior mesenteric artery (SMA) dissection (SISMAD) usually present with acute or chronic abdominal pain and are admitted to the emergency or digestive diseases department to undergo auxiliary examinations, typically abdominal plain CT or contrast-enhanced CT (CECT). Plain CT is the...

journal_title：Experimental and therapeutic medicine

authors： Tan Z,Jin Q,Fan W,Han P,Li X

更新日期：2021-01-01 00:00:00

abstract：:The current study aimed to investigate the effect of sepsis on rat serotonin (5-HT) responses and cardiac action potentials. A total of 20 rats were randomly divided into a sepsis and control group (each, n=10). Rat hearts were harvested and perfused using the Langendorff method 18-h after the induction of sepsis, whi...

journal_title：Experimental and therapeutic medicine

authors： Liu ZJ,Liu H,Wu C,Xue K

更新日期：2019-09-01 00:00:00

abstract：:The activation of tunica albuginea myofibroblasts (MFs) serves an essential role in Peyronie's disease (PD). Increasing evidence has reported that adipose tissue-derived stem cells (ADSCs) have been demonstrated to attenuate the symptoms of PD in animal models. However, the mechanisms of the antifibrotic effects of AD...

journal_title：Experimental and therapeutic medicine

authors： Jiang H,Gao Q,Che X,Zhu L,Zhang Z,Chen Y,Dai Y

更新日期：2017-11-01 00:00:00

abstract：:The aim of the present study was to investigate the association between serum vascular endothelial growth factor (VEGF) and insulin-like growth factor 1 (IGF-1) levels and the prognosis of patients with uterine fibroids following uterine artery embolization (UAE) treatment. A total of 70 patients with uterine fibroids...

journal_title：Experimental and therapeutic medicine

authors： Mu Y,He J,Yan R,Hu X,Liu H,Hao Z

更新日期：2016-02-01 00:00:00

abstract：:Aberrant methylation of gene promoter regions is one of the mechanisms for inactivation of tumor suppressor genes in human malignancies. In this study, the methylation pattern of 24 tumor suppressor genes was analyzed in 75 samples of ovarian cancer using the methylation-specific multiplex ligation-dependent probe amp...

journal_title：Experimental and therapeutic medicine

authors： Ozdemir F,Altinisik J,Karateke A,Coksuer H,Buyru N

更新日期：2012-12-01 00:00:00

abstract：:In Traditional Chinese Medicine, Polygonum multiflorum (PM) is known for its anti-aging properties. A previous study by our group showed that extracts of PM were able to prevent and treat bone loss in vivo, and the active components emodin and 2,3,5,4,-tetrahydroxystilbene-2-O-β-glucoside (TSG) promoted the osteogenic...

journal_title：Experimental and therapeutic medicine

authors： Zhou M,Li J,Wu J,Yang Y,Zeng X,Lv X,Cui L,Yao W,Liu Y

更新日期：2017-09-01 00:00:00

abstract：:Here, we present a case of post-operative liver metastases from pancreatic head cancer in a patient with leukocytopenia, who was safely treated by hepatic arterial infusion (HAI) chemotherapy consisting of gemcitabine and 5-FU. The patient was a 61-year-old woman who underwent pancreaticoduodenectomy for pancreatic he...

journal_title：Experimental and therapeutic medicine

authors： Tajima H,Ohta T,Kitagawa H,Sakai S,Makino I,Hayashi H,Nakagawara H,Onishi I,Takamura H,Ninomiya I,Fushida S,Tani T,Fujimura T,Kayahara M,Koda W,Minami T,Ryu Y,Sanada J,Matsui O

更新日期：2010-11-01 00:00:00

abstract：:Meibomian gland dysfunction (MGD) is a major cause of dry eye, and the purpose of the present study was to evaluate the differences between dry eye patients with MGD and controls using a novel noninvasive ocular surface analyzer. A total of 33 dry eye patients with MGD and 31 controls were enrolled in the present stud...

journal_title：Experimental and therapeutic medicine

authors： Qi Y,Zhang C,Zhao S,Huang Y,Yang R

更新日期：2017-06-01 00:00:00

abstract：:The aim of the present study was to evaluate the diagnostic value of ultrasound (US) elastography in differentiating between benign and malignant peripheral lung lesions (PLLs). This retrospective study included 91 consecutive patients with 91 PLLs. Conventional US, strain elastography (SE), acoustic radiation force i...

journal_title：Experimental and therapeutic medicine

authors： Wei H,Lu Y,Ji Q,Zhou H,Zhou X

更新日期：2018-08-01 00:00:00

abstract：:The aim of the present study was to evaluate and compare the effects of single- and two-dose low-level laser therapy (LLLT) on the postoperative swelling, trismus and pain of patients undergoing extraction of impacted mandibular third molars. In addition, edema was volumetrically measured with a 3dMD face system. A to...

journal_title：Experimental and therapeutic medicine

authors： Koparal M,Kucuk AO,Alan H,Asutay F,Avci M

更新日期：2018-04-01 00:00:00

abstract：:The present study aimed to evaluate the clinical efficacy of hyperbaric oxygen (HBO) treatment for depression in the convalescent stage following cerebral hemorrhage. A total of 60 cases of patients with depression in the convalescent stage following cerebral hemorrhage (2-6 months) were randomly divided into the trea...

journal_title：Experimental and therapeutic medicine

authors： Cao H,Ju K,Zhong L,Meng T

更新日期：2013-06-01 00:00:00

abstract：:The DNA methylation inhibitor 5-aza-2'-deoxycytidine (5-aza-CdR) is widely used as an anticancer drug for the treatment of leukemia and solid tumors. Gastric cancer (GC) patients who were positive for caudal type homeobox transcription factor 2 (CDX2) expression showed a higher survival rate compared with those who we...

journal_title：Experimental and therapeutic medicine

authors： Zhang JF,Zhang JG,Kuai XL,Zhang H,Jiang W,Ding WF,Li ZL,Zhu HJ,Mao ZB

更新日期：2013-03-01 00:00:00

abstract：:The association between Helicobacter pylori (H. pylori) infection and metabolic syndrome (MetS) determined in different cohorts from different countries is currently inconclusive. In the majority of previous studies, H. pylori infection was diagnosed based on the presence of H. pylori IgG antibody in the serum. Howeve...

journal_title：Experimental and therapeutic medicine

authors： Yu Y,Cai J,Song Z,Wang J,Wu L

更新日期：2019-06-01 00:00:00

abstract：:The aim of the present study was to determine the optimal intensity of anticoagulation therapy in elderly patients with paroxysmal atrial fibrillation (PAF), using aspirin and varied concentrations of warfarin. Elderly patients with PAF (n=1,162) who met the inclusion criteria of the study and were at middle or high-r...

journal_title：Experimental and therapeutic medicine

authors： Chen X,Wan R,Jiang W,Zhang H,Zhen R,Ying Q,Li W,Qian H,Wei F,Xu Z,Tang J,Lei H,Zhou Y

更新日期：2013-08-01 00:00:00

abstract：:The incidence of oral squamous cell carcinoma (OSCC) is continuously increasing while its survival rate has not notably improved. There is a pressing need for improved understanding of the genetic regulation of OSCC tumorigenesis and progression. In this study, the function of miR-448 in the regulation of OSCC growth ...

journal_title：Experimental and therapeutic medicine

authors： Shen L,Liu L,Ge L,Xie L,Liu S,Sang L,Zhan T,Li H

更新日期：2016-10-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/etm.2018.6297.]. ...

journal_title：Experimental and therapeutic medicine

authors： Jia L,Wang L,Liu W,Qian G,Jiang X,Zhang Z

更新日期：2018-12-01 00:00:00

abstract：:Malignant hyperthermia (MH) is a rare life threatening inherited disorder that is triggered by drugs used for general anesthesia in susceptible persons. The symptoms include rapid increase of body temperature and severe muscle contractions. The present study includes 3 cases of MH and highlights the timely identificat...

journal_title：Experimental and therapeutic medicine

authors： Pan T,Ji W,Nie M,Li Y

更新日期：2016-11-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a prominent public health issue that has a significant negative impact on patients and their family members. It is the leading cause of mortality and disability among young (below 50 years old) individuals. Intracranial hypertension (ICH) remains the single most difficult therapeutic ch...

journal_title：Experimental and therapeutic medicine

authors： Chen JH,Xu YN,Ji M,Li PP,Yang LK,Wang YH

更新日期：2018-05-01 00:00:00

abstract：:The diagnostic criteria of osteoporosis were established based on bone mineral density (BMD). Therefore, BMD measured by dual energy X-ray absorptiometry has been recognized as the gold standard to diagnose osteoporosis. However, discrepancies between fracture risk and BMD have been recognized. Bone is composed of col...

journal_title：Experimental and therapeutic medicine

authors： Suzuki Y,Maruyama-Nagao A,Sakuraba K,Kawai S

更新日期：2017-05-01 00:00:00

abstract：:The aim of this study was to evaluate the clinical value of multidetector-row computed tomography (MDCT) and magnetic resonance imaging (MRI) in the diagnosis and treatment of complex fractures of the tibial plateau. A total of 71 patients with complex fractures of the tibial plateau (estimated Schatzker classificatio...

journal_title：Experimental and therapeutic medicine

authors： Xu Y,Li Q,Su P,Shen T,Zhu Y

更新日期：2014-01-01 00:00:00

abstract：:microRNA (miRNA) expression profiles of gastric cancer (GC) and adjacent healthy gastric mucosa tissue were used to search for differentially expressed miRNAs, identifying downregulated miRNA-490-3p in GC. The present study aimed to investigate the cellular function of miRNA-490-3p and its underlying mechanism in the ...

journal_title：Experimental and therapeutic medicine

authors： Yu H,Sun J,Jiang S,Xu Y

更新日期：2019-02-01 00:00:00

abstract：:The aim of this study was to establish and to optimize the preparation technology of whole blood internal quality control (IQC) products for blood transfusion compatibility testing. Several B-type RhD-negative blood samples collected from healthy donors were mixed. Two groups of whole blood IQC products, namely, the p...

journal_title：Experimental and therapeutic medicine

authors： Yu Y,Ma C,Feng Q,Chen X,Guan X,Zhang X,Chen L,Lin Z,Pan J,Zhang T,Luo Q,Wang D

更新日期：2013-05-01 00:00:00

abstract：:The aim of the present study was to track in vivo the distribution and survival of adipose-derived mesenchymal stem cells (ASCs) transplanted into female BALB/c nude mice following simulated childbirth injury, using green fluorescent protein and luciferase dual labeling, bioluminescent imaging (BLI) and histological e...

journal_title：Experimental and therapeutic medicine

authors： Dai M,Xu P,Hou M,Teng Y,Wu Q

更新日期：2015-02-01 00:00:00

abstract：:Obstructive sleep apnoea (OSA) is a very common sleep and breathing disorder that occurs in worldwide. It is important to develop a more effective treatment for OSA to overcome lung cell apoptosis during intermittent hypoxia (IH). A mitochondrial separation protein inhibitor (Mdivi-1) has been demonstrated to be a pow...

journal_title：Experimental and therapeutic medicine

authors： Zhao D,Yin CY,Ye XW,Wan ZF,Zhao DG,Zhang XY

更新日期：2019-03-01 00:00:00

abstract：:Neuropathic pain (NP) is a common clinical chronic pain with very complex mechanisms. This study explored the function of activated Wnt signaling pathway in NP. A rat model of chronic constriction injury (CCI) was established. Different doses of IWP-2, a Wnt signal inhibitor, were intrathecally injected to observe the...

journal_title：Experimental and therapeutic medicine

authors： Zhao Y,Yang Z

更新日期：2018-10-01 00:00:00

abstract：:Monosialotetrahexosylganglioside sodium (GM1) is widely used in the treatment of central and peripheral neurological injuries. In addition to its neuroprotective activity, GM1 exerts protective effects on brain microvascular endothelial cells, although the mechanisms underlying these effects remain unclear. The aim of...

journal_title：Experimental and therapeutic medicine

authors： Zhao H,Li X,Li G,Sun BO,Ren L,Zhao C

更新日期：2015-09-01 00:00:00

abstract：:Conjunctival injuries are general but intractable ocular surface diseases, the sequelae of which are particularly challenging to treat. A promising therapy for conjunctival injuries is to employ biodegradable scaffolds to deliver conjunctival epithelial cells for repairing damaged or diseased conjunctiva. In the prese...

journal_title：Experimental and therapeutic medicine

authors： Yao Q,Zhang W,Hu Y,Chen J,Shao C,Fan X,Fu Y

更新日期：2017-11-01 00:00:00

abstract：:One of the critical factors for predicting the success of percutaneous catheter drainage (PCD) is the mean CT density of collection. A higher CT density suggests more necrotic solid tissue within the collection. In the present study, a novel technique for PCD of the necrotic pancreatic collection with a higher mean CT...

journal_title：Experimental and therapeutic medicine

authors： Gupta P,Koshi S,Samanta J,Mandavdhare H,Sharma V,K Sinha S,Dutta U,Kochhar R

更新日期：2020-09-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a progressive disease with a high mortality rate. Previous studies have revealed the important function of the β3 adrenergic receptor (β3-AR) in cardiovascular diseases, and the potential beneficial effects of numerous β3-AR agonists on pulmonary vasodilation. Conversely, a num...

journal_title：Experimental and therapeutic medicine

authors： Sun J,Cheng J,Ding X,Chi J,Yang J,Li W

更新日期：2020-01-01 00:00:00