miR-448 downregulates MPPED2 to promote cancer proliferation and inhibit apoptosis in oral squamous cell carcinoma.

abstract：:Valvular heart disease (VHD) is caused by either damage or defect in one of the four heart valves, aortic, mitral, tricuspid or pulmonary. Defects in these valves can be congenital or acquired. Age, gender, tobacco use, hypercholesterolemia, hypertension, and type II diabetes contribute to the risk of disease. VHD is ...

journal_title：Experimental and therapeutic medicine

authors： Zeng YI,Sun R,Li X,Liu M,Chen S,Zhang P

更新日期：2016-04-01 00:00:00

abstract：:The aim of the present study was to investigate the function of microRNA-146b on myocardial infarction and the mechanism. An MTT assay, Annexin V/propidium iodide (PI) apoptosis assay, ELISA kits, western blot analysis and a caspase-3/8 activity assay were used to measure cell growth, vascular apoptosis inflammatory f...

journal_title：Experimental and therapeutic medicine

authors： Zhao L,Yang XR,Han X

更新日期：2019-02-01 00:00:00

abstract：:The aim of this meta-analysis was to investigate the accuracy of subtraction computed tomography angiography (CTA) for diagnosing intracranial aneurysms. A systematic literature search up to January 1, 2013 was performed in PubMed. Two independent reviewers selected 8 studies that compared subtraction CTA with digital...

journal_title：Experimental and therapeutic medicine

authors： Feng TY,Han XF,Lang R,Wang F,Wu Q

更新日期：2016-05-01 00:00:00

abstract：:The aim of the present study was to determine the preventive effect of the traditional Chinese medicine, Dendrobium candidum Wall ex Lindl. (D. candidum), on CCl4-induced hepatic damage in mice. The CCl4-induced hepatic damage mice were treated with D. candidum, and the serum levels of aspartate aminotransferase (AST)...

journal_title：Experimental and therapeutic medicine

authors： Li GJ,Sun P,Wang Q,Qian Y,Zhu K,Zhao X

更新日期：2014-09-01 00:00:00

abstract：:Previous studies have demonstrated that Hedyotis diffusa Willd (HDW), a traditional Chinese herbal medicine, exhibits potent anticancer activity in models of colorectal cancer (CRC). Aggressive forms of CRC exhibit resistance to widely used chemotherapeutic drugs, including the antimetabolite, 5-fluorouracil (5-FU); h...

journal_title：Experimental and therapeutic medicine

authors： Li Q,Wang X,Shen A,Zhang Y,Chen Y,Sferra TJ,Lin J,Peng J

更新日期：2015-11-01 00:00:00

abstract：:Matrix metalloproteases (MMPs) are a family of zinc-dependent endopeptidases that degrade extracellular matrix proteins. MMP-1 and MMP-2 are produced by endothelial cells and are involved in specific vascular pathologies, including atherosclerosis and aortal aneurysm. One of the most important differences between thes...

journal_title：Experimental and therapeutic medicine

authors： Siemianowicz K,Gminski J,Goss M,Francuz T,Likus W,Jurczak T,Garczorz W

更新日期：2010-11-01 00:00:00

abstract：:Point mutations in oncogenes and tumor suppressor genes occur at early stages in the carcinogenic process. Point mutations in ras family oncogenes are the most common mutational events in several types of human cancer, and are available as molecular markers for the detection of cancer cells in carcinogenicity bioassay...

journal_title：Experimental and therapeutic medicine

authors： Yano Y,Yano T,Kinoshita A,Matoba A,Hasuma T,Wanibuchi H,Morimura K,Otani S,Fukushima S

更新日期：2010-07-01 00:00:00

abstract：:In vivo reflectance confocal microscopy (RCM) is a modern, non-invasive imaging technique, which allows for real-time examination of the upper layers of the skin at a resolution similar to that of classic microscopy. In addition, it has the advantage of real-time evaluation of blood flow and dynamic monitoring of cuta...

journal_title：Experimental and therapeutic medicine

authors： Batani A,Brănișteanu DE,Ilie MA,Boda D,Ianosi S,Ianosi G,Caruntu C

更新日期：2018-02-01 00:00:00

abstract：:The role of apolipoprotein E (Apo E) gene polymorphisms in the etiology of recurrent pregnancy loss (RPL) is not clearly understood. We evaluated this polymorphism in unexplained pregnancy losses in a group of Turkish women. In our prospective case-control study, 45 well-characterized RPL cases were examined for their...

journal_title：Experimental and therapeutic medicine

authors： Korkmazer E,Ustunyurt E,Tekin B,Cilingir O

更新日期：2013-05-01 00:00:00

abstract：:Opioids and α2-agonists have been used as epidural adjuvants in local anesthetics for a long time, but the effect of the combination of opioids and α2-agonists as epidural adjuvants is not completely understood. In the present study, the combination of dexmedetomidine (Dex) and sufentanil as adjuvants to ropivacaine f...

journal_title：Experimental and therapeutic medicine

authors： Li G,Xiao Y,Qi X,Wang H,Wang X,Sun J,Li Y,Li Y

更新日期：2020-07-01 00:00:00

abstract：:As a strategy to prevent the well-known immunosuppressant effects of cyclophosphamide (CY), the immunomodulatory activity of the polysaccharide isolated from Urtica macrorrhiza Hand.-Mazz. (UMHMPS) was investigated in the present study. The chemical properties of UMHMPS, including total carbohydrates, uronic acid, pro...

journal_title：Experimental and therapeutic medicine

authors： Wang Z,Li Y,Wang C,Xia H,Liang Y,Li Z

更新日期：2019-09-01 00:00:00

abstract：:The present report describes the clinical course and treatment of a Mooren-like ulcer associated with abuse of topical anesthetics and dexamethasone. A 38-year-old male physician treated himself with lidocaine, tetracaine and dexamethasone (DEX) eye drops for severe pain and decline of vision in both eyes. After six m...

journal_title：Experimental and therapeutic medicine

authors： Wu H,Hu Y,Shi XR,Xu F,Jiang CY,Huang R,Jia H

更新日期：2016-07-01 00:00:00

abstract：:Embelin is a small-molecule inhibitor extracted from plants of the Myrsinaceae family demonstrating specific inhibition of the X-linked inhibitor of apoptosis protein (XIAP) to affect the proliferation and apoptosis of various types of tumor cells. However, the mechanism of action for this effect remains unclear. The ...

journal_title：Experimental and therapeutic medicine

authors： Taghiyev A,Sun D,Gao ZM,Liang R,Wang L

更新日期：2012-10-01 00:00:00

abstract：:Donor organ rejection remains a significant problem. The present study aimed to assess whether transferring a donor's major histocompatibility complex (MHC) genes to the recipient could mitigate rejection in organ transplantation. Seven loci of MHC genes from donor mice were amplified and ligated into vectors; the vec...

journal_title：Experimental and therapeutic medicine

authors： Li T,Zhang W,Xu Q,Li S,Tong X,Ding J,Li H,Hou S,Xu Z,Jablons DM,You L

更新日期：2018-06-01 00:00:00

abstract：:The application of biomarkers in melanoma prognosis has been well recognized. However the ability of a single biomarker to predict melanoma patient outcome is usually limited. We previously examined the expression of ten biomarkers (Bim, BRG1, BRMS1, CTHRC1, ING4, NQO1, NF-κB-p50, PUMA, SNF5 and SOX4) in melanomas. To...

journal_title：Experimental and therapeutic medicine

authors： Li J,Zhang Z,Li G

更新日期：2011-01-01 00:00:00

abstract：:Ginsenoside Rg3 has been demonstrated to inhibit tumor cell proliferation and angiogenesis. However, its effect on liver tumors when administered via the hepatic artery has not been investigated. The purpose of this study was to evaluate the therapeutic effect of hepatic artery administration of Rg3 combined with tran...

journal_title：Experimental and therapeutic medicine

authors： Yu Y,Zhang C,Liu L,Li X

更新日期：2013-03-01 00:00:00

abstract：:Neuroblastoma is a common tumor in childhood and exhibits heterogeneity and malignant progression. MYCN expression and amplification profiles are frequently correlated with the efficacy of therapy. Arsenic trioxide and imatinib mesylate (STI-571) have been suggested as promising therapeutic agents for neuroblastoma, w...

journal_title：Experimental and therapeutic medicine

authors： Kim KJ,Jung JM,Cho JY,Woo SY,Cho KA,Ryu KH,Yoo ES

更新日期：2011-05-01 00:00:00

abstract：:Gamboge, the dried resin secreted by Garcinia maingayii (gambogic tree), was previously demonstrated to exert anti-inflammatory effects. The present study examined the effects of gambogic acid, the major active constituent of gamboge, on myocardial infarction (MI) and inflammation in a rat model and explored the possi...

journal_title：Experimental and therapeutic medicine

authors： Na D,Aijie H,Bo L,Zhilin M,Long Y

更新日期：2018-02-01 00:00:00

abstract：:Human osteoarthritis (OA) has been reclassified as a systemic musculoskeletal disorder involving activation of the innate and adaptive immune systems. Elevated pro-inflammatory cytokines may serve a key function in the development of the disease. 1,25-Dihydroxyvitamin D3 and dexamethasone (vitD3/Dex) may inhibit infla...

journal_title：Experimental and therapeutic medicine

authors： Wang G,Zhang J,Fang Y,Cao W,Xu B,Chen X

更新日期：2019-01-01 00:00:00

abstract：:Scarred uterus is caused by cesarean section surgery, and this condition affects further gestation and delivery in patients. Previous evidence suggested that resveratrol, a polyphenol compound, presents beneficial outcomes for patients with scarred uterus. Therefore, the aim of the present study was to analyze the eff...

journal_title：Experimental and therapeutic medicine

authors： Ma H,Qiao Z

更新日期：2018-06-01 00:00:00

abstract：:Following spinal cord injury in rats, FK506 is able to protect local nerve tissue, promote neural regeneration, reduce neuronal apoptosis and accelerate the recovery of spinal cord functions. Nerve growth factor (NGF) is important in the regulation of central and peripheral nerve cell regeneration, growth differentiat...

journal_title：Experimental and therapeutic medicine

authors： Chen G,Zhang Z,Wang S,Lv D

更新日期：2013-10-01 00:00:00

abstract：:Previous studies have suggested that 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside (TSG) prevents progression of non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet. The present study aimed to evaluate whether TSG could reverse NAFLD induced by a methionine and choline-deficient (MCD) diet and identi...

journal_title：Experimental and therapeutic medicine

authors： Han M,Zhang T,Gu W,Yang X,Zhao R,Yu J

更新日期：2018-08-01 00:00:00

abstract：:Infantile neuroaxonal dystrophy (INAD) is a rare neurodegenerative disorder. Phospholipase A2 group VI (PLA2G6) gene mutations have been identified in the majority of individuals with INAD. The present case report is on a Chinese female pediatric patient (age, 18 months) diagnosed with INAD with deafness. To date, onl...

journal_title：Experimental and therapeutic medicine

authors： Wang B,Wu,Tang J

更新日期：2018-08-01 00:00:00

abstract：:Drug eruption is a major problem of adverse drug reactions and may present as variform clinical manifestations. Toxic epidermal necrolysis (TEN) and acute generalized exanthematous pustulosis (AGEP) are relatively rare severe drug eruptions. It has rarely been reported that AGEP overlaps or mimics TEN, while no purule...

journal_title：Experimental and therapeutic medicine

authors： Liu LF,Yan JL,Wang JY,Chen JS,Cai SQ,Lao LM,Zheng M

更新日期：2013-04-01 00:00:00

abstract：:Cardiac fibrosis is a hallmark of cardiac remodeling associated with nearly all forms of heart disease. Clinically, no effective therapeutic drugs aim to inhibit cardiac fibrosis, owing to the complex etiological heterogeneity and pathogenesis of this disease. A two-in-one protein structure, a ubiquitous expression pr...

journal_title：Experimental and therapeutic medicine

authors： Hu F,Li M,Han F,Zhang Q,Zeng Y,Zhang W,Cheng X

更新日期：2021-02-01 00:00:00

abstract：:The effects of different cytochrome P450 2C19 (CYP2C19) genotypes on the prognosis of clopidogrel resistance in patients complicated with atrial fibrillation taking clopidogrel after percutaneous coronary intervention (PCI) were investigated. Eighty patients who were complicated with atrial fibrillation and treated wi...

journal_title：Experimental and therapeutic medicine

authors： Zhang Q,Zhong Z,Li B,Liao Z,Zhao P,Ye Z,He X,Wang H,Chen W,Huang J

更新日期：2018-10-01 00:00:00

abstract：:3-Hydroxy-3-methylglutaric aciduria (3-HMG, OMIN 246450) is a rare autosomal recessive metabolic disorder caused by a deficiency of 3-hydroxy-3-methylglutaryl-CoA lyase, a key enzyme in leucine metabolism and ketone body synthesis. Acute episodes of 3-HMG may be triggered by fasting or infection, and symptoms include ...

journal_title：Experimental and therapeutic medicine

authors： Hao X,Wang J,Liu S,Chen Y,Zhang Y,Hao Y

更新日期：2016-06-01 00:00:00

abstract：:In recent years accumulating evidence has indicated that tocotrienol exhibits an oxidation resistance function, decreased cholesterol function, inhibits cancer function and has unique physiological functions, including anti-inflammatory, anti-apoptotic and anti-oxidative properties. The present study investigated the ...

journal_title：Experimental and therapeutic medicine

authors： Xun C,Mamat M,Guo H,Mamati P,Sheng J,Zhang J,Xu T,Liang W,Cao R,Sheng W

更新日期：2017-07-01 00:00:00

abstract：:Chronic inducible urticaria (CIndU) is a subgroup of chronic urticaria which can cause severe quality of life impairment by their refractory forms. The recommended treatment approach in CindU is the same as that for chronic spontaneous urticaria (CSU). However, CIndU seem to be more resistant to standard doses of H1 a...

journal_title：Experimental and therapeutic medicine

authors： Bumbăcea RS,Deaconu CG,Berghea EC

更新日期：2019-08-01 00:00:00

abstract：:The aim of this study was to use proteomic and transcriptomic approaches to examine differences in protein and gene expression in maternal plasma between normal and preeclamptic pregnancies. Preeclampsia and control groups were compared with respect to the expression of CD34 and CD133 genes by quantitative polymerase ...

journal_title：Experimental and therapeutic medicine

authors： Sahin H,Gunel T,Benian A,Onay Ucar E,Guralp O,Kilic A

更新日期：2015-08-01 00:00:00