Purulent bullous epidermal necrolysis: A potential new clinical pattern of drug eruption.

abstract：:Cnidium officinale Makino and Capsella bursa-pastoris are used as traditional herbs with diverse medicinal effects, including the inhibition of inflammation, reduction of blood pressure and as diuretics, however, the anti-cancer effects of C. officinale Makino and C. bursa-pastoris are poorly defined. The aims of this...

journal_title：Experimental and therapeutic medicine

authors： Lee KE,Shin JA,Hong IS,Cho NP,Cho SD

更新日期：2013-03-01 00:00:00

abstract：:The present study aimed to investigate the capabilities of the cardiovascular virtual endoscopy (VE) system in diagnosing tetralogy of Fallot (TOF) and performing measurements. A total of 37 patients underwent two-dimensional echocardiography (2-DE) and multi-detector computed tomography (MDCT) examinations. The obtai...

journal_title：Experimental and therapeutic medicine

authors： Yao LP,Zhang L,Mei J,Ding FB,Li HM,Ding M,Yang X,Li XM,Sun K

更新日期：2018-02-01 00:00:00

abstract：:This study investigated optimal pathways for preeclampsia (PE) utilizing the network-based guilt by association (GBA) algorithm. The inference method consisted of four steps: preparing differentially expressed genes (DEGs) between PE patients and normal controls from gene expression data; constructing co-expression ne...

journal_title：Experimental and therapeutic medicine

authors： Ruan Y,Li Y,Liu Y,Zhou J,Wang X,Zhang W

更新日期：2019-05-01 00:00:00

abstract：:Pancreatic cancer is one of the most lethal types of cancer, and curative resection is only applicable to potentially limited cases due to early metastasis and local invasion. This study reports the influence of CXCL12 and its receptor CXCR4 on the progression of pancreatic cancer and highlights the correlation betwee...

journal_title：Experimental and therapeutic medicine

authors： Zhong W,Chen W,Zhang D,Sun J,Li Y,Zhang J,Gao Y,Zhou W,Li S

更新日期：2012-09-01 00:00:00

abstract：:The application value of conventional ultrasound and ultrasonic elastography (UE) in preoperative diagnosis and combined diagnosis of malignant anus neoplasms was investigated. One hundred and twenty patients, whose mass was detected by digital rectal examination, were examined using UE and conventional ultrasound bef...

journal_title：Experimental and therapeutic medicine

authors： Zhu Y,Deng S,Zhang Y,Jiang Q

更新日期：2018-03-01 00:00:00

abstract：:Abnormalities in insulin hormone levels leads to a hyperglycemic condition of diabetic mellitus. Hyperglycemia seriously induces organ and system destructions. The excessive accumulation of collagen fiber deposits occurs in inflammatory and reorganization processes of chronic liver diseases in type I insulin-dependent...

journal_title：Experimental and therapeutic medicine

authors： Komolkriengkrai M,Nopparat J,Vongvatcharanon U,Anupunpisit V,Khimmaktong W

更新日期：2019-08-01 00:00:00

abstract：:The incidence of oral squamous cell carcinoma (OSCC) is continuously increasing while its survival rate has not notably improved. There is a pressing need for improved understanding of the genetic regulation of OSCC tumorigenesis and progression. In this study, the function of miR-448 in the regulation of OSCC growth ...

journal_title：Experimental and therapeutic medicine

authors： Shen L,Liu L,Ge L,Xie L,Liu S,Sang L,Zhan T,Li H

更新日期：2016-10-01 00:00:00

abstract：:Melatonin is a darkness hormone secreted by the pineal gland, which serves a role in idiopathic oligoasthenoteratozoospermia (iOAT). The present study aimed to evaluate the seminal plasma and serum melatonin levels of 50 patients with iOAT and 50 normal fertile controls and the effects of exposure to light at night on...

journal_title：Experimental and therapeutic medicine

authors： H Hassan M,A El-Taieb M,N Fares N,M Fayed H,Toghan R,M Ibrahim H

更新日期：2020-07-01 00:00:00

abstract：:The aim of this study was to explore the effect of electroacupuncture (EA) on immune function in patients undergoing supratentorial craniotomy. We also examined whether point specificity in EA was present. The study involved 29 patients undergoing craniotomy. The patients were divided into three groups: a control (C, ...

journal_title：Experimental and therapeutic medicine

authors： Li G,Li S,Wang B,An L

更新日期：2013-09-01 00:00:00

abstract：:Cardiovascular disease is the main cause of morbidity and mortality in end-stage renal disease (ESRD) patients. Recent population based epidemiological studies demonstrated a correlation between reduced renal function and risk for all causes and cardiovascular mortality, 50% of patients dying before the commencement o...

journal_title：Experimental and therapeutic medicine

authors： Timofte D,Dragoș D,Balcangiu-Stroescu AE,Tănăsescu MD,Gabriela Bălan D,Răducu L,Tulin A,Stiru O,Ionescu D

更新日期：2020-07-01 00:00:00

abstract：:The associations between the aortic dimensions (of the aortic sinus, aortic annulus and aortic arch) and physiological variables have not been established in the Chinese population. The present study examined the associations among physiological variables to determine the aortic root and arch dimensions echocardiograp...

journal_title：Experimental and therapeutic medicine

authors： Wang YL,Wang QL,Wang L,Wu YB,Wang ZB,Cameron J,Liang YL

更新日期：2013-02-01 00:00:00

abstract：:Achondroplasia (ACH) is a hereditary dwarfism caused by the disturbed proliferation and differentiation of growth plate chondrocytes, followed by impaired endochondral bone growth. ACH is caused by mutations in the gene encoding the transmembrane receptor, fibroblast growth factor receptor 3 (FGFR3). In total, >90% of...

journal_title：Experimental and therapeutic medicine

authors： Liu J,Tang X,Cheng J,Wang L,Yang X,Wang Y

更新日期：2015-05-01 00:00:00

abstract：:Ischemia-reperfusion (I/R) injury of the kidneys is commonly encountered in the clinic. The present study assessed the efficacy of simvastatin in preventing I/R-induced renal injury in a rat model and investigated the corresponding molecular mechanisms. Rats were divided into 3 groups, including a sham, I/R and I/R + ...

journal_title：Experimental and therapeutic medicine

authors： Zhang Y,Rong S,Feng Y,Zhao L,Hong J,Wang R,Yuan W

更新日期：2017-11-01 00:00:00

abstract：:The activation of monocytes and macrophages is associated with steroid-resistant (SR) asthma. Interleukin-35 (IL-35) is an important anti-inflammatory cytokine, but its regulatory effects on monocytes in patients with SR asthma is not fully understood. Based on clinical response to oral prednisolone, 34 patients with ...

journal_title：Experimental and therapeutic medicine

authors： Qian L,Xu D,Xue F,Li M,Wang X,Liu G

更新日期：2020-05-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of S-adenosyl methionine (SAMe) on infectious premature inflammatory factors and uterine contraction, and to further explore its mechanism of action via the transient receptor protein 3 (TRPC3)/protein kinase Cβ (PKCβ)/C-kinase-activated protein phosphatase-1...

journal_title：Experimental and therapeutic medicine

authors： Ge J,Han T,Li X,Shan L,Zhang J,Hong Y,Xia Y,Wang J,Hou M

更新日期：2018-07-01 00:00:00

abstract：:Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are an effective treatment for advanced non-small cell lung cancer. The objective of the present study was to compare the efficacy of gefitinib and erlotinib in patients with pulmonary adenocarcinoma, whose tumor EGFR mutation status was known. Pu...

journal_title：Experimental and therapeutic medicine

authors： Wu WS,Chen YM,Tsai CM,Shih JF,Chiu CH,Chou KT,Lai SL,Wu CH,Luo YH,Huang CY,Lee YC,Perng RP,Whang-Peng J

更新日期：2012-02-01 00:00:00

abstract：:The present study aimed to investigate the expression of the forkhead box protein M1 (FOXM1) in the placenta of patients with preeclampsia, and its effect on trophoblasts. A total of 28 patients with preeclampsia and 30 patients without preeclampsia (controls) who underwent cesarean section and were admitted to the Af...

journal_title：Experimental and therapeutic medicine

authors： Cui X,Xu J,Ji Y,Song X,Wang J,Zhang L,Yang S,Ye Y

更新日期：2018-07-01 00:00:00

abstract：:Guillain-Barré syndrome is a type of acute inflammatory neuropathy that causes ataxia and is associated with the IgG anti-GM1 antibody. However, the pathogenic role of the IgG anti-GM1 antibody and calcium channels in neuromuscular junctions (NMJs) remains unclear. Thus, the aim of the present study was to investigate...

journal_title：Experimental and therapeutic medicine

authors： Hotta S,Nakatani Y,Kambe T,Abe K,Masuda Y,Utsumomiya I,Taguchi K

更新日期：2015-08-01 00:00:00

abstract：:Ozone (O3) as a major air pollutant is widely recognized for causing pathological changes of the airway system. However, it is not clear whether O3 exposure of bronchial epithelial cells (BECs) influences the proliferation and collagen synthesis of submucosal fibroblasts and contributes to the pathogenesis of airway r...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Tan M,Ouyang H,Deng L

更新日期：2018-06-01 00:00:00

abstract：:Doxorubicin (DOX), a potent and widely used anticancer agent, can give rise to severe cardiotoxicity that limits its clinical use by inducing oxidative stress. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the central regulator of cellular responses to electrophilic/oxidative stress, which serves a critical ro...

journal_title：Experimental and therapeutic medicine

authors： Guo Z,Yan M,Chen L,Fang P,Li Z,Wan Z,Cao S,Hou Z,Wei S,Li W,Zhang B

更新日期：2018-10-01 00:00:00

abstract：:A mutation in the IIb sodium phosphate transporter SLC34A2 gene has recently been described in pulmonary alveolar microlithiasis (PAM) patients. Experiments in this study were aimed at confirming the role of the gene product in PAM by comparing phosphorylated products in extracellular fluid of alveolar epithelial cell...

journal_title：Experimental and therapeutic medicine

authors： Ma T,Qu D,Yan B,Zhang Q,Ren J,Hu Y

更新日期：2018-01-01 00:00:00

abstract：:Arteriovenous fistula (AVF) thrombosis is a common complication in patients undergoing hemodialysis, and early intervention is required. Urokinase has been used as a thrombolytic agent for declotting the thrombosed access. However, the optimal route for infusing urokinase remains to be determined. In the present retro...

journal_title：Experimental and therapeutic medicine

authors： Wan Z,Xiang R,Wang H,Zhong Q,Tu B

更新日期：2019-05-01 00:00:00

abstract：:The aim of the present study was to investigate the expression levels and clinical significance of Toll-like receptor (TLR) 3 and 4 in peripheral blood mononuclear cells (PBMCs) collected from children with Henoch-Schönlein purpura (HSP) nephritis. The randomized controlled trial was conducted between August 2011 and ...

journal_title：Experimental and therapeutic medicine

authors： Chang H,Yu DS,Liu XQ,Zhang QY,Cheng N,Zhang SQ,Qu ZH

更新日期：2014-06-01 00:00:00

abstract：:It is occasionally observed that patients without contrast-induced nephropathy (CIN) develop kidney injury within 1-6 months after coronary angiography (CAG), termed delayed CIN or delayed kidney injury (DKI) following CAG. The present study aimed to investigate the associated risk factors of delayed CIN and its possi...

journal_title：Experimental and therapeutic medicine

authors： Wang F,Peng C,Zhang G,Zhao Q,Xuan C,Wei M,Wang N

更新日期：2016-07-01 00:00:00

abstract：:As a strategy to prevent the well-known immunosuppressant effects of cyclophosphamide (CY), the immunomodulatory activity of the polysaccharide isolated from Urtica macrorrhiza Hand.-Mazz. (UMHMPS) was investigated in the present study. The chemical properties of UMHMPS, including total carbohydrates, uronic acid, pro...

journal_title：Experimental and therapeutic medicine

authors： Wang Z,Li Y,Wang C,Xia H,Liang Y,Li Z

更新日期：2019-09-01 00:00:00

abstract：:The present study aimed to investigate the clinical characteristics of von Hippel-Lindau (VHL) disease and the clinical significance of VHL gene detection. The clinical materials of patients with VHL disease were collected from 3 different families between May 1985 and October 2017. A systematic pedigree study and VHL...

journal_title：Experimental and therapeutic medicine

authors： Lin G,Zhao Y,Zhang Z,Zhang H

更新日期：2020-08-01 00:00:00

abstract：:Resistance to platinum-based chemotherapy frequently poses a serious problem in the treatment of head and neck squamous cell carcinoma. In this study, we isolated cisplatin-resistant cells from a head and neck squamous cell carcinoma cell line. The mismatch repair (MMR) system is known as one of the cisplatin-resistan...

journal_title：Experimental and therapeutic medicine

authors： Adachi M,Ijichi K,Hasegawa Y,Nakamura H,Ogawa T,Kanematsu N

更新日期：2010-01-01 00:00:00

abstract：:The objective of this study was to investigate the effect of seven days of feed restriction (between days 42 and 49) on the morphology of the small intestine in experimental rabbit models. Sixty weaned Hyplus rabbits (35 days old) were included in the experiment and split into three groups of 20 rabbits. The first con...

journal_title：Experimental and therapeutic medicine

authors： Makovicky P,Tumova E,Volek Z,Makovicky P,Vodicka P

更新日期：2014-11-01 00:00:00

abstract：:The present study is a retrospective analysis of 11 cases with severe acute liver failure combined with multiple organ dysfunction syndrome (MODS) performed during the period June, 2012 to December, 2014. After part of plasmapheresis with plasma filtration adsorption combined with continuous hemodiafiltration treatmen...

journal_title：Experimental and therapeutic medicine

authors： Li M,Wang Z,Wang Y,Du C,Li S,Shi Z,Lu B

更新日期：2016-10-01 00:00:00

abstract：:The diagnostic value of detection of serum β-human chorionic gonadotropin (β-HCG) and Chlamydia trachomatis immunoglobulin G (CT-IgG) combined with transvaginal ultrasonography in early tubal pregnancy was investigated. A total of 55 patients with early tubal pregnancy were selected as the tubal pregnancy group, while...

journal_title：Experimental and therapeutic medicine

authors： Xin H,Liu W,Li P

更新日期：2018-07-01 00:00:00