Tocotrienol alleviates inflammation and oxidative stress in a rat model of spinal cord injury via suppression of transforming growth factor-β.

abstract：:We report a case of a 10-year-old female patient who survived ring-sling complex without surgery. The patient had congenital wheezing from the neonatal period and was treated after a tentative diagnosis of infantile asthma. The patient suffered from allergy and was hospitalized several times due to severe wheezing, an...

journal_title：Experimental and therapeutic medicine

authors： Fukuda H,Imataka G,Drago F,Maeda K,Yoshihara S

更新日期：2017-09-01 00:00:00

abstract：:Limited studies have focused on mental symptoms (anxiety and depression) and their impact on quality of life (QoL) in patients with pulmonary hypertension (PH). The objective of the present study was to assess the prevalence of anxiety and depression and their association with QoL in patients with pulmonary arterial h...

journal_title：Experimental and therapeutic medicine

authors： Zhou X,Shi H,Yang Y,Zhang Z,Zhai Z,Wang C

更新日期：2020-04-01 00:00:00

abstract：:The present study examined the expression of microRNA (miRNA or miR)-204 in pulp tissues, blood and saliva from pediatric patients with pulpitis and an underlying Helicobacter pylori (Hp) infection in the stomach, and the mechanism of the associated regulation by miR-204 was assessed. A total of 26 children with pulpi...

journal_title：Experimental and therapeutic medicine

authors： Zhou S,Xu J

更新日期：2019-07-01 00:00:00

abstract：:Flos Chrysanthemi Indici (CI) is a traditional medicinal plant used in the treatment of inflammatory diseases. However, the pharmacological role of CI in metabolic diseases, especially in diseases induced by insulin metabolism disorders, remains poorly understood. In the present study, Drosophila melanogaster (Drosoph...

journal_title：Experimental and therapeutic medicine

authors： Bai Y,Li K,Shao J,Luo Q,Jin LH

更新日期：2018-09-01 00:00:00

abstract：:Nuclear receptor related-1 protein (Nurr1) is a novel orphan member of the nuclear receptor superfamily (the NR4A family) involved in tumorigenesis. The aim of the present study was to investigate the expression and possible function of Nurr1 in pancreatic ductal adenocarcinoma (PDAC). The expression pattern of Nurr1 ...

journal_title：Experimental and therapeutic medicine

authors： Ji L,Gong C,Ge L,Song L,Chen F,Jin C,Zhu H,Zhou G

更新日期：2017-02-01 00:00:00

abstract：:The present study aimed to investigate the effect of the traditional Chinese medicine Qingre Baidu mixture (QBM) on the regulation of various parameters, including the morphology of bacterial biofilms, the bacterial density sensing system, the self-induction of the molecule autoinducer (AI)-2 and the hypoxia-inducible...

journal_title：Experimental and therapeutic medicine

authors： Shan W,Wang Y,Zhang Z,Xing J,Xu J,Xiao W,Shen Y,Guo S,Que H

更新日期：2019-05-01 00:00:00

abstract：:The present study was conducted to investigate the effects of minocycline on the expression of selected transcriptional and translational profiles in the rat spinal cord following sciatic nerve (SNR) transection and microsurgical coaptation. The mRNA and protein expression levels of B cell lymphoma-2 (Bcl-2), Bcl-2-as...

journal_title：Experimental and therapeutic medicine

authors： Keilhoff G,Lucas B,Uhde K,Fansa H

更新日期：2016-05-01 00:00:00

abstract：:Cardiovascular diseases are among the primary causes of decreased quality of life as well as mortality of hemodialysis patients with end-stage renal disease. The aim of the present study was to evaluate the predictive value of the red blood cell distribution width (RDW)-to-platelet ratio (RPR) and neutrophil-to-lympho...

journal_title：Experimental and therapeutic medicine

authors： Zhu X,Li G,Li S,Gong Z,Liu J,Song S

更新日期：2020-08-01 00:00:00

abstract：:The present study performed a meta-analysis of randomized controlled trials in multiple sclerosis (MS) patients to evaluate the efficacy and safety of anti-B-cell monoclonal antibodies (mAbs). To the best of our knowledge, no previous meta-analysis has evaluated this. Relevant studies published until March 2015 were r...

journal_title：Experimental and therapeutic medicine

authors： Xie Q,Li X,Sun J,Yuan B,Li Y,Wang L,Wang M

更新日期：2017-06-01 00:00:00

abstract：:Obstructive sleep apnoea (OSA) is a very common sleep and breathing disorder that occurs in worldwide. It is important to develop a more effective treatment for OSA to overcome lung cell apoptosis during intermittent hypoxia (IH). A mitochondrial separation protein inhibitor (Mdivi-1) has been demonstrated to be a pow...

journal_title：Experimental and therapeutic medicine

authors： Zhao D,Yin CY,Ye XW,Wan ZF,Zhao DG,Zhang XY

更新日期：2019-03-01 00:00:00

abstract：:microRNA (miRNA) expression profiles of gastric cancer (GC) and adjacent healthy gastric mucosa tissue were used to search for differentially expressed miRNAs, identifying downregulated miRNA-490-3p in GC. The present study aimed to investigate the cellular function of miRNA-490-3p and its underlying mechanism in the ...

journal_title：Experimental and therapeutic medicine

authors： Yu H,Sun J,Jiang S,Xu Y

更新日期：2019-02-01 00:00:00

abstract：:To suppress the invasion of hepatocellular carcinoma (HCC) cells into surrounding connective tissues during metastasis, we investigated the usefulness of sorafenib. In order to search for model cell lines, cell numbers were counted to reveal cell lines with the potential to proliferate in serum-free media. Cell prolif...

journal_title：Experimental and therapeutic medicine

authors： Tomizawa M,Shinozaki F,Sugiyama T,Yamamoto S,Sueishi M,Yoshida T

更新日期：2010-09-01 00:00:00

abstract：:The aim of the present study was to examine whether the expression of focal adhesion kinase (FAK) is altered in the eutopic endometrium of female patients with adenomyosis, as compared with that of females without adenomyosis. The expression of FAK was assessed by immunohistochemical, western blot and reverse transcri...

journal_title：Experimental and therapeutic medicine

authors： Mu L,Chen W,Ma Y,Zheng W

更新日期：2015-11-01 00:00:00

abstract：:Compared to other diseases, early or atypical spinal tuberculosis (TB) is prone to being misdiagnosed due to the lack of specific clinical manifestations and misleading negative results of various laboratory analyses and imaging examinations. Various methods for diagnosing spinal TB have become research hotspots. Rece...

journal_title：Experimental and therapeutic medicine

authors： Pu F,Feng J,Yang L,Zhang L,Xia P

更新日期：2019-11-01 00:00:00

abstract：:Activated T cells rely on aerobic glycolysis and glutaminolysis in order to proliferate and differentiate into effector cells. Therefore, intervention in these metabolic pathways inhibits proliferation. The aim of the present study was to evaluate the effects of Krebs' cycle inhibition at the level of malate dehydroge...

journal_title：Experimental and therapeutic medicine

authors： Eleftheriadis T,Pissas G,Antoniadi G,Liakopoulos V,Stefanidis I

更新日期：2015-11-01 00:00:00

abstract：:Osteopontin (OPN), a secreted phosphorylated glycoprotein, has been found to be involved in carcinogenesis, progression and metastasis of several types of cancers. The aim of the present study was to investigate the immunohistochemical expression of OPN in colorectal carcinoma (CRC) and its relationship with clinicopa...

journal_title：Experimental and therapeutic medicine

authors： Li J,Yang GZ,Zhu ZM,Zhou ZY,Li L

更新日期：2012-04-01 00:00:00

abstract：:Previous studies have demonstrated that Hedyotis diffusa Willd (HDW), a traditional Chinese herbal medicine, exhibits potent anticancer activity in models of colorectal cancer (CRC). Aggressive forms of CRC exhibit resistance to widely used chemotherapeutic drugs, including the antimetabolite, 5-fluorouracil (5-FU); h...

journal_title：Experimental and therapeutic medicine

authors： Li Q,Wang X,Shen A,Zhang Y,Chen Y,Sferra TJ,Lin J,Peng J

更新日期：2015-11-01 00:00:00

abstract：:Monosialotetrahexosylganglioside sodium (GM1) is widely used in the treatment of central and peripheral neurological injuries. In addition to its neuroprotective activity, GM1 exerts protective effects on brain microvascular endothelial cells, although the mechanisms underlying these effects remain unclear. The aim of...

journal_title：Experimental and therapeutic medicine

authors： Zhao H,Li X,Li G,Sun BO,Ren L,Zhao C

更新日期：2015-09-01 00:00:00

abstract：:The intermingling of two malignant neoplasms within the same cutaneous tumor is rare. No consensus has been reached for a clear definition and categorization. In the current study, we describe a cutaneous neoplasm; a squamomelanocytic tumor (SMT) with histological features combining those of a squamous cell carcinoma ...

journal_title：Experimental and therapeutic medicine

authors： Wang HY,Zhang XB,Su RJ,Wang CB,Liu X

更新日期：2013-03-01 00:00:00

abstract：:A long-acting β2-agonist (LABA) combined with an inhaled corticosteroid (ICS) is frequently prescribed as initial therapy in steroid-naïve asthma patients because of its effective control of symptoms and improvement of pulmonary function. However, it is unclear which patients will be responsive to LABAs and whether br...

journal_title：Experimental and therapeutic medicine

authors： Ohwada A,Inami K,Onuma E,Matsumoto-Yamazaki M,Atsuta R,Takahashi K

更新日期：2011-07-01 00:00:00

abstract：:The study aims to investigate the clinical significance of regulating the expression of 25-hydroxyvitamin D (25-OH-VD) via microRNA (miRNA)-376c in the occurrence and development of preeclampsia (PE) in pregnant women. Peripheral blood and placental tissues were collected from pregnant women in 4 groups, including 67 ...

journal_title：Experimental and therapeutic medicine

authors： Li J,Du J,Wang Z,Wang C,Bai J,Zhang S

更新日期：2018-09-01 00:00:00

abstract：:Transmembrane protein 174 (TMEM174) is a type III transmembrane protein with no clear signal peptide. The N and C terminals are located inside the cell. Our previous study demonstrated high expression of TMEM174 in the kidney and its potential involvement in renal cancer based on its capacity to stimulate cell prolife...

journal_title：Experimental and therapeutic medicine

authors： Hu F,Meng Y,Gou L,Zhang X

更新日期：2013-11-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of decorin (DCN) on the proliferation of human hepatoma HepG2 cells and the involvement of transforming growth factor-β (TGF-β) signaling pathway. A vector containing DCN was transfected into HepG2 cells with the use of Lipofectamine 2000. Cell proliferation ...

journal_title：Experimental and therapeutic medicine

authors： Liu Y,Wang X,Wang Z,Ju W,Wang D

更新日期：2016-10-01 00:00:00

abstract：:Chronic antibody-mediated rejection (ABMR) is a major cause of the transplant renal interstitial fibrosis and transplanted kidney epithelial cell transdifferentiation is one of the main mechanisms. The transforming growth factor (TGF)-β1/integrin-linked kinase (ILK) signaling pathway has a significant role in the epit...

journal_title：Experimental and therapeutic medicine

authors： Yan Q,Luo H,Wang B,Sui W,Zou G,Chen H,Zou H

更新日期：2017-05-01 00:00:00

abstract：:The effect of hepatitis B immune globulin (HBIG) combined with hepatitis B vaccine on blocking hepatitis B virus (HBV) transmission between mother and infant and its effect on immune cells were studied. Ninety newborn infants confirmed to be HBV surface antigen (HBsAg)-positive were divided equally into three groups. ...

journal_title：Experimental and therapeutic medicine

authors： Gong J,Liu X

更新日期：2018-01-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus, which causes coronavirus disease 2019 (COVID-19) and affects children less frequently than adults. According to Professor Vana Papaevangelou, Professor of Paediatrics at the University of Athens School of Medicine, children comprise o...

journal_title：Experimental and therapeutic medicine

authors： Mammas IN,Theodoridou M,Spandidos DA

更新日期：2020-12-01 00:00:00

abstract：:E-cadherin is a key cell adhesion molecule implicated in tumor suppression that is frequently altered in hepatocellular carcinoma (HCC), particularly in hepatitis B virus-related tumors. Here, we report that the epigenetic drugs 5-azacytidine and trichostatin A up-regulated E-cadherin expression in HCC cells. The depl...

journal_title：Experimental and therapeutic medicine

authors： Qiu X,Qiao F,Su X,Zhao Z,Fan H

更新日期：2010-05-01 00:00:00

abstract：:Chronic hepatitis B virus (CHB) infection is a burden on global healthcare and is associated with a higher risk of serious sequelae, including cirrhosis and hepatocellular carcinoma. The clinical application of entecavir as a treatment for CHB has produced positive outcomes, and so is an attractive form of pharmacolog...

journal_title：Experimental and therapeutic medicine

authors： Gai XD,Wu WF

更新日期：2017-10-01 00:00:00

abstract：:The aim of the present study was to evaluate the clinical efficacy and safety of intravitreal ranibizumab injections for the treatment of macular choroidal neovascularization (CNV) caused by pathological myopia. Between one and four intravitreal injections of ranibizumab were administered to 61 eyes from 61 patients w...

journal_title：Experimental and therapeutic medicine

authors： Ji L,Lv W,Xiao Y,Xu Z,Zhang X,Zhang W

更新日期：2015-09-01 00:00:00

abstract：:The aim of the present study was to evaluate the protective effects and safety aspects of recombinant human brain natriuretic peptide (rhBNP) on cardiac functions of patients undergoing open-heart surgery during perioperative period. In total, 150 patients undergoing open heart surgery in the Second Hospital of Shando...

journal_title：Experimental and therapeutic medicine

authors： Xu Y,Li Y,Bao W,Qiu S

更新日期：2018-03-01 00:00:00