Decorin inhibits the proliferation of HepG2 cells by elevating the expression of transforming growth factor-β receptor II.

abstract：:The aim of the present study was to investigate the functional status of dendritic cells (DCs) in nasal polyps (NP) and their interactions with T lymphocytes. The interactions between DC and T lymphocytes in the pathogenesis of NP was also studied. The expression of cluster of differentiation (CD)1a and CD83 in NP was...

journal_title：Experimental and therapeutic medicine

authors： Lin X,Zhuang X,Li C,Wang X

更新日期：2018-06-01 00:00:00

abstract：:The aim of the present study was to investigate the expression of estrogen receptor β (ERβ) in triple-negative and triple-positive breast cancer patients, and evaluate its utility as a prognostic factor. Between January 2000 and December 2010, primary tumor tissue samples were collected from 234 subjects, including 10...

journal_title：Experimental and therapeutic medicine

authors： Guo L,Zhu Q,Aisimutuola M,Yilamu D,Liu S,Jakulin A

更新日期：2015-06-01 00:00:00

abstract：:E-cadherin is a key cell adhesion molecule implicated in tumor suppression that is frequently altered in hepatocellular carcinoma (HCC), particularly in hepatitis B virus-related tumors. Here, we report that the epigenetic drugs 5-azacytidine and trichostatin A up-regulated E-cadherin expression in HCC cells. The depl...

journal_title：Experimental and therapeutic medicine

authors： Qiu X,Qiao F,Su X,Zhao Z,Fan H

更新日期：2010-05-01 00:00:00

abstract：:The presence of an occluded culprit artery or collaterals in non-ST-segment elevation myocardial infarction (NSTEMI) is relatively common; however, limited data are available regarding their clinical significance. The aim of the current study was to determine the clinical characteristics of occluded culprit arteries a...

journal_title：Experimental and therapeutic medicine

authors： Hwang HJ,Park CB,Cho JM,Jin ES,Sohn IS,Kim DH,Kim CJ

更新日期：2018-10-01 00:00:00

abstract：:The therapeutic effect of saikosaponin a (SSa) on hyperlipidemic pancreatitis (HP) is not completely understood. The aim of the present study was to investigate the therapeutic effect and the underlying mechanism of SSa using a rat model of HP. Following successful establishment of the HP rat model, different doses of...

journal_title：Experimental and therapeutic medicine

authors： Feng P,Xu Y,Tong B,Tong X,Bian Y,Zhao S,Shen H

更新日期：2020-02-01 00:00:00

abstract：:The global incidence of melanoma is increasing. Mortality from melanoma is influenced primarily by metastasis in advanced stages of the disease. Current treatments are largely ineffective; thus, novel gene delivery approaches that target tumor-specific markers may be useful for the treatment of melanoma. Systemic admi...

journal_title：Experimental and therapeutic medicine

authors： Saavedra-Alonso S,Zapata-Benavides P,Chavez-Escamilla AK,Manilla-Muñoz E,Zamora-Avila DE,Franco-Molina MA,Rodriguez-Padilla C

更新日期：2016-12-01 00:00:00

abstract：:Curcumin is a natural polyphenol with powerful antioxidant and anti-inflammatory properties. The present study evaluated the protective effect of curcumin on myocardial injury in rats as well as the mechanisms underlying these effects, and examined the expression of nuclear factor-κB (NF-κB), peroxisome proliferator-a...

journal_title：Experimental and therapeutic medicine

authors： Lv FH,Yin HL,He YQ,Wu HM,Kong J,Chai XY,Zhang SR

更新日期：2016-12-01 00:00:00

abstract：:The objective of this study was to investigate the effects of leukotriene B4 (LTB4) on the expression of interleukin-32 (IL-32) interferon-γ (IFN-γ) and chemokine monocyte chemoattractant protein (MCP-1) and macrophage inhibitory protein (MIP-1α) in rheumatoid arthritis (RA). The rat model of RA collagen induced-arthr...

journal_title：Experimental and therapeutic medicine

authors： Bi D,Bi D,Zhong M,Zhang H,Jin S,Ma S,Luo H

更新日期：2017-10-01 00:00:00

abstract：:The aim of this study was to investigate and analyze the effects of human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) on the recovery of neurological function and telomerase reverse transcriptase (TERT) expression in brain tissue of rats with cerebral ischemia-reperfusion injury. A total of 100 healthy adu...

journal_title：Experimental and therapeutic medicine

authors： Huang X,Zhang S,Li F,Zhou Y,Wang X,Fu G,Ma X

更新日期：2017-12-01 00:00:00

abstract：:The aim of the present study was to analyze the mechanism by which nerve growth factor (NGF) promotes callus formation in mice with tibial fracture. NGF transgenic homozygotic mice and NGF wild homozygotic mice were selected to construct non-stabilized fracture model of tibia. The mice were sacrificed on days 7, 14 an...

journal_title：Experimental and therapeutic medicine

authors： Sang XG,Wang ZY,Cheng L,Liu YH,Li YG,Qin T,Di K

更新日期：2017-04-01 00:00:00

abstract：:Multiple cellular components are involved in the complex pathological process following central nervous system (CNS) injury, including neurons, glial cells and endothelial cells. Previous studies and neurotherapeutic clinical trials have assessed the molecular mechanisms that underlie neuronal cell death following CNS...

journal_title：Experimental and therapeutic medicine

authors： Yang JS,Wei HX,Chen PP,Wu G

更新日期：2018-03-01 00:00:00

abstract：:The current study aimed to investigate the effect of sepsis on rat serotonin (5-HT) responses and cardiac action potentials. A total of 20 rats were randomly divided into a sepsis and control group (each, n=10). Rat hearts were harvested and perfused using the Langendorff method 18-h after the induction of sepsis, whi...

journal_title：Experimental and therapeutic medicine

authors： Liu ZJ,Liu H,Wu C,Xue K

更新日期：2019-09-01 00:00:00

abstract：:Ischemia/reperfusion (I/R) injury during liver resection or transplantation for the treatment of hepatocellular carcinoma (HCC) may increase the risk of metastasis. Peroxisome proliferator-activated receptor-γ (PPARγ) activation has been observed to exert a protective effect against hepatic I/R injury. However, whethe...

journal_title：Experimental and therapeutic medicine

authors： Liu YI,Liu Z,Chen Y,Xu K,Dong J

更新日期：2016-02-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of feeder layers composed of various ratios of mouse embryonic fibroblasts (MEFs) and human foreskin fibroblasts (hFFs) on the growth of human embryonic stem cells (hESCs). In addition, the secretion levels of basic fibroblast growth factor (bFGF) by the feed...

journal_title：Experimental and therapeutic medicine

authors： Yang H,Qiu Y,Zeng X,Ding Y,Zeng J,Lu K,Li D

更新日期：2016-06-01 00:00:00

abstract：:This study aimed to investigate the correlations between the detection rate of mural coronary artery (MCA) by 128-slice CT and the MCA compression extent in systole with myocardial bridge (MB) length and thickness. A retrospective analysis was conducted for 580 patients receiving multislicespiral CT coronary angiograp...

journal_title：Experimental and therapeutic medicine

authors： Niu YJ,Zhang XL,Cao AD,Leng B

更新日期：2013-03-01 00:00:00

abstract：:The aim of the present study was to isolate, culture and characterize sheep metanephric mesenchymal stem cells (MMSCs). The MMSCs were isolated from the kidney tissue of six-week-old sheep fetus. This study investigated whether primary MMSCs could be grown for 26 passages and expressed Oct-4, which is involved in the ...

journal_title：Experimental and therapeutic medicine

authors： Ji M,Bai C,Li L,Fan Y,Ma C,Li X,Guan W

更新日期：2016-12-01 00:00:00

abstract：:Phthalates are confirmed to have toxic effects on the reproductive system and are likely to have further damaging actions in humans. The present study explored the molecular mechanisms of the toxic effect of mono-(2-ethylhexyl) phthalate (MEHP) on mouse Sertoli cells. Cell apoptosis and proliferation assays were used ...

journal_title：Experimental and therapeutic medicine

authors： Wang L,Dou T,Li S,Liu Y

更新日期：2019-04-01 00:00:00

abstract：:Drug eruption is a major problem of adverse drug reactions and may present as variform clinical manifestations. Toxic epidermal necrolysis (TEN) and acute generalized exanthematous pustulosis (AGEP) are relatively rare severe drug eruptions. It has rarely been reported that AGEP overlaps or mimics TEN, while no purule...

journal_title：Experimental and therapeutic medicine

authors： Liu LF,Yan JL,Wang JY,Chen JS,Cai SQ,Lao LM,Zheng M

更新日期：2013-04-01 00:00:00

abstract：:Arteriovenous fistula (AVF) thrombosis is a common complication in patients undergoing hemodialysis, and early intervention is required. Urokinase has been used as a thrombolytic agent for declotting the thrombosed access. However, the optimal route for infusing urokinase remains to be determined. In the present retro...

journal_title：Experimental and therapeutic medicine

authors： Wan Z,Xiang R,Wang H,Zhong Q,Tu B

更新日期：2019-05-01 00:00:00

abstract：:This study aimed to investigate the effects of hypoxia on the proliferation, mineralization and ultrastructure of human periodontal ligament fibroblasts (HPLFs) at various times in vitro in order to further study plateau-hypoxia-induced periodontal disease. HPLFs (fifth passage) cultured by the tissue culture method w...

journal_title：Experimental and therapeutic medicine

authors： Zhang HY,Liu R,Xing YJ,Xu P,Li Y,Li CJ

更新日期：2013-12-01 00:00:00

abstract：:Atherosclerosis is caused by various factors, and Glabridin may have protective effects on the cardiovascular system. The purpose of the present study was to evaluate the effects of Glabridin on atherosclerosis and evaluate whether Glabridin attenuates arteriosclerosis and endothelial permeability by suppressing the m...

journal_title：Experimental and therapeutic medicine

authors： Wang G,Sun G,Wang Y,Yu P,Wang X,Zhou B,Zhu H

更新日期：2019-01-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) accumulation and hypertrophy are common in vascular disorders, and inflammation has a crucial role in the development of these diseases. To investigate the effect of inflammation on the neurotransmission of VSMC, bioinformatic analysis was performed, following next generation sequenc...

journal_title：Experimental and therapeutic medicine

authors： Gan S,Qiu S,Feng Y,Zhang Y,Qian Q,Wan Z,Tang J

更新日期：2017-04-01 00:00:00

abstract：:Professor Alan Michael Weindling, Emeritus Professor of Perinatal Medicine at the University of Liverpool in the UK, is one of the pioneers of modern neonatal care worldwide with an enormous contribution to the care of premature babies in the city of Liverpool. During the last 3 decades, his contributions focused on t...

journal_title：Experimental and therapeutic medicine

authors： Mammas IN,Spandidos DA

更新日期：2018-09-01 00:00:00

abstract：:The Global Registry of Acute Coronary Events (GRACE) risk score and the mean platelet volume to lymphocyte count ratio (MPVLR) can be used independently to predict adverse outcomes in patients with acute coronary syndromes. However, the level of MPVLR in relation to the GRACE score, and whether a combination of these ...

journal_title：Experimental and therapeutic medicine

authors： Chen X,Shao M,Zhang T,Zhang W,Meng Y,Zhang H,Hai H,Li G

更新日期：2020-06-01 00:00:00

abstract：:The present study aimed to construct a rat model of rheumatoid arthritis (RA) to evaluate changes in pathology, the expression of inflammatory factors and regulation of signaling pathways. The protective effect of tetrandrine (Tet) on tissue lesions induced by RA was also investigated. A total of 60 Wistar rats (100-2...

journal_title：Experimental and therapeutic medicine

authors： Li X,Wu Z,He B,Zhong W

更新日期：2018-09-01 00:00:00

abstract：:Lung adenocarcinoma (LACA) is the leading cause of cancer-associated death worldwide. The present study intended to identify DNA methylation patterns that may serve as diagnostic and prognostic biomarkers for LACA. Data on DNA methylation and the survival data of the patients of LACA were obtained from The Cancer Geno...

journal_title：Experimental and therapeutic medicine

authors： Zheng R,Xu H,Mao W,Du Z,Wang M,Hu M,Gu X

更新日期：2020-01-01 00:00:00

abstract：:The present case report describes a case of infantile myofibromatosis (IM) with a pseudo-ulcerated plaque on the right side of the back of a fetus, detected in the 38th week of gestation using prenatal ultrasound. The fetus was examined weekly by ultrasound to measure the size of the mass. At birth, the scarlet mass w...

journal_title：Experimental and therapeutic medicine

authors： Zhang F,Cheng D,Wu M,Ge L,Ma X

更新日期：2014-12-01 00:00:00

abstract：:Bisphenol A (BPA) is an environmental pollutant that is widely produced throughout the world. It is primarily used in the manufacture of polycarbonate plastics, epoxy resins, paints and dental materials. BPA has been reported to promote hepatotoxicity and cardiotoxicity. The antioxidant activity of sesame lignans is w...

journal_title：Experimental and therapeutic medicine

authors： Eweda SM,Newairy ASA,Abdou HM,Gaber AS

更新日期：2020-01-01 00:00:00

abstract：:Ginsenoside Rg3 has been demonstrated to inhibit tumor cell proliferation and angiogenesis. However, its effect on liver tumors when administered via the hepatic artery has not been investigated. The purpose of this study was to evaluate the therapeutic effect of hepatic artery administration of Rg3 combined with tran...

journal_title：Experimental and therapeutic medicine

authors： Yu Y,Zhang C,Liu L,Li X

更新日期：2013-03-01 00:00:00

abstract：:Previous clinical trials have investigated the effect of glucocorticoid therapy in acute respiratory distress syndrome (ARDS), with controversial results, particularly with regard to the early administration of low dose glucocorticoid. The present meta-analysis aimed to assess whether the application of glucocorticoid...

journal_title：Experimental and therapeutic medicine

authors： Yang ZG,Lei XL,Li XL

更新日期：2017-04-01 00:00:00