Orphan nuclear receptor Nurr1 as a potential novel marker for progression in human pancreatic ductal adenocarcinoma.

abstract：:Relative changes in B-type natriuretic peptide (BNP) and amino terminal pro-BNP (NT-proBNP) levels may help to assess the risk of congestive heart failure (CHF). However, whether these levels at the time of admission enable the prediction of outcomes with acute exacerbation remains unknown. The current study determine...

journal_title：Experimental and therapeutic medicine

authors： Dai Y,Yang J,Takagi A,Konishi H,Miyazaki T,Masuda H,Shimada K,Miyauchi K,Daida H

更新日期：2017-08-01 00:00:00

abstract：:Hyponatremia is a risk factor associated with poor prognosis in patients with heart failure (HF) with reduced ejection fraction. However, whether hyponatremia has a similar role in patients with HF with preserved ejection fraction (HFpEF) has remained controversial. Therefore, the present study aimed to investigate th...

journal_title：Experimental and therapeutic medicine

authors： Su Y,Ma M,Zhang H,Pan X,Zhang X,Zhang F,Lv Y,Yan C

更新日期：2020-11-01 00:00:00

abstract：:The new enzyme-targeting radiosensitization treatment, Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas, type II (KORTUC II), markedly enhances the radiotherapeutic effect of treatment for various types of locally advanced malignant neoplasms. Patients who had declined surgical treatment and systemic chemoth...

journal_title：Experimental and therapeutic medicine

authors： Hitomi J,Kubota K,Ogawa Y,Hamada N,Murata Y,Nishioka A

更新日期：2010-09-01 00:00:00

abstract：:The present study investigated the effect of the phytochemical genistein on the proliferation and differentiation of MCF-7 and 3T3-L1 cells via the regulation of estrogen receptor-α (ERα) expression and the induction of apoptosis. When MCF-7 human breast cancer cells were treated with 50, 100, 150 and 200 μM genistein...

journal_title：Experimental and therapeutic medicine

authors： Choi EJ,Jung JY,Kim GH

更新日期：2014-08-01 00:00:00

abstract：:Many studies have focused on the identification of therapeutic targets for the treatment of certain types of cancer. Wogonin is a natural flavonoid compound that exhibits a potent anti-cancer effect. The underlying mechanism of wogonin may therefore reveal an effective way to identify novel therapeutic targets. In the...

journal_title：Experimental and therapeutic medicine

authors： Wang SJ,Zhao JK,Ren S,Sun WW,Zhang WJ,Zhang JN

更新日期：2019-01-01 00:00:00

abstract：:The oxidation of tyrosine to 3-nitrotyrosine is irreversible, and due to this characteristic, 3-nitrotyrosine is used as a marker for oxidative stress in a range of diverse chronic and degenerative diseases. It has been established that the yeast Debaryomyces hansenii (D. hansenii) can assimilate free 3-nitrotyrosine ...

journal_title：Experimental and therapeutic medicine

authors： Calderón-Torres CM,Sarabia-Curz L,Ledesma-Soto Y,Murguía-Romero M,Terrazas LI

更新日期：2019-05-01 00:00:00

abstract：:The study aims to investigate the clinical significance of regulating the expression of 25-hydroxyvitamin D (25-OH-VD) via microRNA (miRNA)-376c in the occurrence and development of preeclampsia (PE) in pregnant women. Peripheral blood and placental tissues were collected from pregnant women in 4 groups, including 67 ...

journal_title：Experimental and therapeutic medicine

authors： Li J,Du J,Wang Z,Wang C,Bai J,Zhang S

更新日期：2018-09-01 00:00:00

abstract：:The objective of this study was to investigate the effect of seven days of feed restriction (between days 42 and 49) on the morphology of the small intestine in experimental rabbit models. Sixty weaned Hyplus rabbits (35 days old) were included in the experiment and split into three groups of 20 rabbits. The first con...

journal_title：Experimental and therapeutic medicine

authors： Makovicky P,Tumova E,Volek Z,Makovicky P,Vodicka P

更新日期：2014-11-01 00:00:00

abstract：:LipoxinA4 (LXA4) is a well-known key mediator of endogenous anti-inflammation and of the resolution of inflammation. Considerable oxidative stress occurs during inflammation due to the generation of reactive oxidative species (ROS). Moreover, high levels of uric acid (UA) contribute to endothelial cell dysfunction, wh...

journal_title：Experimental and therapeutic medicine

authors： Zhou Y,You H,Zhang A,Jiang X,Pu Z,Xu G,Zhao M

更新日期：2020-08-01 00:00:00

abstract：:The purpose of this study was to compare the results of delivering low doses of growth factor iteratively (20 μg x5) via a reservoir system with results obtained following a single administration of 100 μg of growth factor. The delivery systems using gelatin microspheres (GMS) facilitate the controlled release of drug...

journal_title：Experimental and therapeutic medicine

authors： Nitta N,Nitta-Seko A,Sonoda A,Watanabe S,Tsuchiya K,Murata K,Tabata Y

更新日期：2012-08-01 00:00:00

abstract：:Diabetes may affect myocardial fibrosis through oxidative stress. Trimetazidine (TMZ) is an anti-anginal agent. The present study aimed to determine the modulatory effect of TMZ on reactive oxygen species (ROS) and connective tissue growth factor (CTGF) expression and to evaluate the potential of TMZ to improve diasto...

journal_title：Experimental and therapeutic medicine

authors： Zhao Y,Li S,Quan E,Zhang H,Wu Y,Luo Y,Peng L,Wang J,Zhu J,Liu J

更新日期：2019-08-01 00:00:00

abstract：:The underlying mechanisms of arterial remodeling (AR) remain unclear. Studies have indicated that decellularized scaffolds stimulate the differentiation of fibroblasts into myofibroblasts and promote the accumulation of the extracellular matrix (ECM). In the present study, the impact of ECM changes following AR on vas...

journal_title：Experimental and therapeutic medicine

authors： Xin H,Wang Z,Wu S,Wang P,Tao X,Xu C,You L

更新日期：2019-07-01 00:00:00

abstract：:The aim of this study was to explore the effect of electroacupuncture (EA) on immune function in patients undergoing supratentorial craniotomy. We also examined whether point specificity in EA was present. The study involved 29 patients undergoing craniotomy. The patients were divided into three groups: a control (C, ...

journal_title：Experimental and therapeutic medicine

authors： Li G,Li S,Wang B,An L

更新日期：2013-09-01 00:00:00

abstract：:The complex network of etiological factors, signals and tissue responses involved in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) cannot be successfully targeted by a single therapeutic agent. Multimodal approaches to the therapy of CP/CPPS have been and are currently being tested, as in the frame of com...

journal_title：Experimental and therapeutic medicine

authors： Magri V,Marras E,Restelli A,Wagenlehner FM,Perletti G

更新日期：2015-03-01 00:00:00

abstract：:In vivo reflectance confocal microscopy (RCM) is a modern, non-invasive imaging technique, which allows for real-time examination of the upper layers of the skin at a resolution similar to that of classic microscopy. In addition, it has the advantage of real-time evaluation of blood flow and dynamic monitoring of cuta...

journal_title：Experimental and therapeutic medicine

authors： Batani A,Brănișteanu DE,Ilie MA,Boda D,Ianosi S,Ianosi G,Caruntu C

更新日期：2018-02-01 00:00:00

abstract：:Pulmonary carcinoid tumors represent bronchopulmonary neuroendocrine neoplasms which might synthetize serotonin, histamine, bombesin or other types of hormones responsible for the development of a broad spectrum of signs and symptoms, known as carcinoid syndrome. Data of 98 patients submitted to surgery for bronchial ...

journal_title：Experimental and therapeutic medicine

authors： Savu C,Melinte A,Lukadi JL,Mirvald C,Savu C,Belu E,Diaconu C,Iliescu L,Balescu I,Stiru O,Bratu O,Gorecki G,Bacalbasa N

更新日期：2020-12-01 00:00:00

abstract：:The present study investigated the role of runt-related transcription factor 2 (Runx2) in regulating the differentiation of human dental pulp stem cells (hDPSCs) into odontoblasts under the mediation of the Rho/Rho-associated protein kinase (ROCK) signaling pathway. hDPSCs and human bone marrow mesenchymal stem cells ...

journal_title：Experimental and therapeutic medicine

authors： Huang X,Chen X,Chen H,Xu D,Lin C,Peng B

更新日期：2018-05-01 00:00:00

abstract：:The aim of the present study was to explore the effects and mechanisms of insulin on mitochondrial oxidative stress in septic acute kidney injury (AKI). Male Sprague Dawley rats were divided randomly into four groups: Control group, sham surgery group, cecal ligation and puncture (CLP) group, and CLP plus insulin grou...

journal_title：Experimental and therapeutic medicine

authors： Chen GD,Zhang JL,Chen YT,Zhang JX,Wang T,Zeng QY

更新日期：2018-04-01 00:00:00

abstract：:Coronary artery disease (CAD) is the first cause of morbidity and mortality worldwide. An important goal is to diagnose patients in early stages, in order to reduce acute cardiovascular events. The angiotensin-converting enzyme (ACE) is an important element for the cardiovascular system, through its actions on hydro-s...

journal_title：Experimental and therapeutic medicine

authors： Vladeanu MC,Bojan IB,Bojan A,Iliescu D,Badescu MC,Badulescu OV,Badescu M,Georgescu CA,Ciocoiu M

更新日期：2020-10-01 00:00:00

abstract：:Adipose stem cell-conditioned medium may promote human dermal fibroblast (HDF) proliferation and migration by activating paracrine peptides during the re-epithelization phase of wound healing. Human antimicrobial peptide LL-37 is upregulated in the skin epithelium as part of the normal response to injury. The effects ...

journal_title：Experimental and therapeutic medicine

authors： Yang EJ,Bang SI

更新日期：2017-07-01 00:00:00

abstract：:The aim of the present study was to determine how Endostar inhibits tumor angiogenesis and increases radiation sensitivity when combined with radiotherapy. In vitro studies were conducted to analyze the expression levels of transforming growth factor-β1 (TGF-β1), hypoxia-inducible factor 1 (HIF-1α) and basic fibroblas...

journal_title：Experimental and therapeutic medicine

authors： Wu Y,Zheng Y,Shen Z,Ge W,Xie Y,Li C

更新日期：2014-04-01 00:00:00

abstract：:Sepsis is a serious condition characterized by an infectious process that induces a severe systemic inflammatory response. In this study, the effects of gemfibrozil (GFZ) on the inflammatory response associated with abdominal sepsis were investigated using a rat model of cecal-ligation and puncture (CLP). Male Wistar ...

journal_title：Experimental and therapeutic medicine

authors： Cámara-Lemarroy CR,Guzman-DE LA Garza FJ,Cordero-Perez P,Ibarra-Hernandez JM,Muñoz-Espinosa LE,Fernandez-Garza NE

更新日期：2015-03-01 00:00:00

abstract：:Previous research has shown that breathing exercises may improve the prognosis and health status in patients with lung cancer by enhancing pulmonary function and quality of life (QOL). However, individually published results are inconclusive. The aim of the present meta-analysis was to evaluate the clinical value of b...

journal_title：Experimental and therapeutic medicine

authors： Liu W,Pan YL,Gao CX,Shang Z,Ning LJ,Liu X

更新日期：2013-04-01 00:00:00

abstract：:The aim of the study was to investigate the effect of stromal cell-derived factor-1 (SDF-1) on myocardial apoptosis and cardiac function recovery in rats with acute myocardial infarction (AMI) and the mechanism of the Toll-like receptor (TLR)-4/nuclear factor-κB (NF-κB) signaling pathway. A total of 64 healthy male F3...

journal_title：Experimental and therapeutic medicine

authors： Liu Y,Gao S,Wang Z,Yang Y,Huo H,Tian X

更新日期：2016-11-01 00:00:00

abstract：:The present study aimed to investigate the practicability and clinical value of applying laparotomy biliary lithotomy forceps to laparoscopic bile duct exploration (LCBDE) for the surgical treatment of incarcerated calculi. A total of 63 patients were diagnosed with cholecystolithiasis and choledocholithiasis. The pre...

journal_title：Experimental and therapeutic medicine

authors： Jiang H,Wang SY,Jin XL,Jin JC,Gu HB,Zhang FM

更新日期：2016-10-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/etm.2018.6297.]. ...

journal_title：Experimental and therapeutic medicine

authors： Jia L,Wang L,Liu W,Qian G,Jiang X,Zhang Z

更新日期：2018-12-01 00:00:00

abstract：:The present study aimed to apply the best single-energy (SE) scanning in energy spectrum computed tomography (CT) to evaluate the usefulness of lower extremity arterial angiography imaging in patients with lower extremity arterial occlusive disease. A total of 64 patients diagnosed with lower extremity arterial occlus...

journal_title：Experimental and therapeutic medicine

authors： Wang G,Zhao D,Ling Z,Wang H,Yu S,Zhang J

更新日期：2019-08-01 00:00:00

abstract：:Resistance to platinum-based chemotherapy frequently poses a serious problem in the treatment of head and neck squamous cell carcinoma. In this study, we isolated cisplatin-resistant cells from a head and neck squamous cell carcinoma cell line. The mismatch repair (MMR) system is known as one of the cisplatin-resistan...

journal_title：Experimental and therapeutic medicine

authors： Adachi M,Ijichi K,Hasegawa Y,Nakamura H,Ogawa T,Kanematsu N

更新日期：2010-01-01 00:00:00

abstract：:The novel orally available inhibitor of the molecular chaperone heat shock protein 90 (Hsp90), BIIB021, induces the apoptosis of various types of tumor cell in vitro and in vivo. However, the effects and mechanisms of this agent on myelodysplastic syndrome (MDS) cell lines remain unknown. The aim of this study was to ...

journal_title：Experimental and therapeutic medicine

authors： Lin S,Li J,Zhou W,Qian W,Wang B,Chen Z

更新日期：2014-06-01 00:00:00

abstract：:A male 46 year-old patient was admitted to the Emergency Intensive Care Unit of Qinghai Provincial People's Hospital (Xining, China) in December 2008 with complaints of a headache and fever that had lasted for three days. In addition, the patient had experienced two general convulsions accompanied with consciousness d...

journal_title：Experimental and therapeutic medicine

authors： Zhang B,Wang L

更新日期：2016-11-01 00:00:00