Abstract：
:In vivo reflectance confocal microscopy (RCM) is a modern, non-invasive imaging technique, which allows for real-time examination of the upper layers of the skin at a resolution similar to that of classic microscopy. In addition, it has the advantage of real-time evaluation of blood flow and dynamic monitoring of cutaneous changes while preserving tissue integrity. The present study reported on the in vivo RCM technique as an objective method for the noninvasive assessment of psoriasis vulgaris that is potentially applicable in clinical studies and in monitoring the evolution of lesions under treatment. In psoriasis lesions, RCM virtual horizontal sections at the level of the dermo-epidermal junction featured numerous and prominent dermal papillae that were not surrounded by bright rings of basal cells. Micromorphological examination of the lesions using this technique revealed that mean values of the section area, the perimeter and the Feret's diameter of the dermal papillae were significantly higher in psoriatic lesions than in normal skin. An increased number of capillary vessels per lesional dermal papilla as compared to healthy skin was observed. Furthermore, micromorphological parameters of dermal capillaries were increased in psoriatic skin. These observations point to the utility of in vivo RCM as a promising technique for the non-invasive diagnosis of psoriasis vulgaris, for monitoring the evolution of lesions at a micromorphological level under various treatments and for gaining a better understanding of the pathophysiological processes that occur in the evolution of this disease.
journal_name
Exp Ther Medjournal_title
Experimental and therapeutic medicineauthors
Batani A,Brănișteanu DE,Ilie MA,Boda D,Ianosi S,Ianosi G,Caruntu Cdoi
10.3892/etm.2017.5542subject
Has Abstractpub_date
2018-02-01 00:00:00pages
1241-1246issue
2eissn
1792-0981issn
1792-1015pii
ETM-0-0-5542journal_volume
15pub_type
杂志文章abstract：:Cytomegalovirus (CMV) infection is the most common congenital infection worldwide, and remains a significant cause of the neurological deficiency and sensory deafness in developed countries. Maternal primary infection, reactivation or reinfection during pregnancy may lead to fetal infection and congenital CMV syndrome...
journal_title：Experimental and therapeutic medicine
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abstract：:GATA4, a member of the GATA family, serves a key function in several types of cancer, including hepatoblastoma, gastric cancer and breast cancer. However, the function of GATA4 in nasopharyngeal cancer (NPC) is largely unknown. The present study revealed that GATA4 was upregulated in NPC tissue samples and the NPC cel...
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abstract：:[This corrects the article DOI: 10.3892/etm.2018.6297.]. ...
journal_title：Experimental and therapeutic medicine
pub_type： 杂志文章,已发布勘误
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更新日期：2017-07-01 00:00:00
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journal_title：Experimental and therapeutic medicine
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更新日期：2011-09-01 00:00:00
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journal_title：Experimental and therapeutic medicine
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journal_title：Experimental and therapeutic medicine
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更新日期：2017-10-01 00:00:00
abstract：:MiR-216a-5p has been acknowledged as an oncogene and is known to be involved in the progression and metastasis of numerous cancer subtypes. However, the potential role of miR-216a-5p in renal cell carcinoma (RCC) remains to be elucidated. In the present study, reverse transcription-quantitative polymerase chain reacti...
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更新日期：2018-12-01 00:00:00
abstract：:Allicin has been reported to inhibit cancer cell proliferation, induce cell apoptosis and enhance the accumulation of reactive oxygen species. However, it has remained elusive whether allicin improves multidrug resistance in thyroid cancer cells through modulating autophagy. The present study demonstrated that combine...
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abstract：:The primarily metabolic abnormality in type 2 diabetes mellitus (T2DM) is the defect in gluconeogenesis and glucose uptake. Itraconazole (ITCZ) is a traditional azole drug with anti-fungal and anticancer properties. However, limited attention has been directed towards the contribution of ITCZ to hepatic gluconeogenesi...
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更新日期：2020-11-01 00:00:00
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