T-regulatory cells from patients with rheumatoid arthritis retain suppressor functions in vitro.

abstract：:Pulmonary arterial hypertension (PAH) is a progressive disease with a high mortality rate. Previous studies have revealed the important function of the β3 adrenergic receptor (β3-AR) in cardiovascular diseases, and the potential beneficial effects of numerous β3-AR agonists on pulmonary vasodilation. Conversely, a num...

journal_title：Experimental and therapeutic medicine

authors： Sun J,Cheng J,Ding X,Chi J,Yang J,Li W

更新日期：2020-01-01 00:00:00

abstract：:The associations between the aortic dimensions (of the aortic sinus, aortic annulus and aortic arch) and physiological variables have not been established in the Chinese population. The present study examined the associations among physiological variables to determine the aortic root and arch dimensions echocardiograp...

journal_title：Experimental and therapeutic medicine

authors： Wang YL,Wang QL,Wang L,Wu YB,Wang ZB,Cameron J,Liang YL

更新日期：2013-02-01 00:00:00

abstract：:MicroRNAs (miRs) are have been demonstrated to serve important functions in the genesis of human cancer, including colorectal cancer (CRC). The role of miR-6852 in CRC remains unknown. In this study, it was demonstrated that miR-6852 was underexpressed in CRC tissues compared with adjacent normal tissues. Moreover, th...

journal_title：Experimental and therapeutic medicine

authors： Cui BH,Hong X

更新日期：2018-08-01 00:00:00

abstract：:UNBS5162, a naphthalimide derivative, has a strong anticancer effect and low clinical hematological toxicity. UNBS5162 has been shown to have an anticancer effect in numerous cancer types, except triple negative breast cancer (TNBC). To explore this issue, TNBC MDA-MB-231 cells were selected, and the effect of UNBS516...

journal_title：Experimental and therapeutic medicine

authors： Yue X,Li M,Chen D,Xu Z,Sun S

更新日期：2018-11-01 00:00:00

abstract：:The aim of the present study was to evaluate the clinical efficacy and safety of intravitreal ranibizumab injections for the treatment of macular choroidal neovascularization (CNV) caused by pathological myopia. Between one and four intravitreal injections of ranibizumab were administered to 61 eyes from 61 patients w...

journal_title：Experimental and therapeutic medicine

authors： Ji L,Lv W,Xiao Y,Xu Z,Zhang X,Zhang W

更新日期：2015-09-01 00:00:00

abstract：:The proliferation and migration of Schwann cells (SCs) are key events in the process of peripheral nerve repair. This is required to promote the growth of SCs and is a challenge during the treatment of peripheral nerve injury. Baicalin is a natural herb-derived flavonoid compound, which has been reported to possess ne...

journal_title：Experimental and therapeutic medicine

authors： Zuo W,Wu H,Zhang K,Lv P,Xu F,Jiang W,Zheng L,Zhao J

更新日期：2017-07-01 00:00:00

abstract：:The present case report describes a case of infantile myofibromatosis (IM) with a pseudo-ulcerated plaque on the right side of the back of a fetus, detected in the 38th week of gestation using prenatal ultrasound. The fetus was examined weekly by ultrasound to measure the size of the mass. At birth, the scarlet mass w...

journal_title：Experimental and therapeutic medicine

authors： Zhang F,Cheng D,Wu M,Ge L,Ma X

更新日期：2014-12-01 00:00:00

abstract：:Esophageal submucosal tumors are occasionally detected incidentally during a gastrointestinal survey. In the present study, a case of esophageal leiomyoma is reported, which was incidentally detected by chest radiography during an annual survey of mass-screening for lung cancer. The patient underwent a laparoscopic lo...

journal_title：Experimental and therapeutic medicine

authors： Tadano S,Kondo T,Watanabe M,Takayashiki N,Shiozawa T,Ohara G,Kagohashi K,Kurishima K,Satoh H

更新日期：2014-12-01 00:00:00

abstract：:The present study aimed to evaluate the prognostic value of venous-arterial CO2 to arterial-venous O2 (Cv-aCO2/Da-vO2) for patients with septic shock treated by fluid resuscitation. A total of 108 cases who received fluid resuscitation for septic shock at the Intensive Care Unit were retrospectively screened according...

journal_title：Experimental and therapeutic medicine

authors： Zang H,Shen X,Wang S,He Z,Cheng H

更新日期：2019-11-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/etm.2015.2860.]. ...

journal_title：Experimental and therapeutic medicine

authors： Liu Y,Xiao J,Shi X,Hao G,Chen Q,Zhou J,Wei X

更新日期：2019-04-01 00:00:00

abstract：:Emodin, an anthraquinone derivative isolated mainly from the root and rhizome of the medicinal plant Rheum palmatum L., was found to exert anticancer effects on various cultured cancer cells. Phosphatase of regenerating liver-3 (PRL-3), a novel gene, has been known to play an important role in the promotion of cellula...

journal_title：Experimental and therapeutic medicine

authors： Sun ZH,Bu P

更新日期：2012-06-01 00:00:00

abstract：:A 58-year-old female exhibited the onset of symmetrical sensory abnormalities of the face and extremities. The neurological examination revealed normal muscle strength with abated or absent tendon reflexes. The patient experienced symmetrical glove- and stocking-type pinprick sensations in the distal extremities and a...

journal_title：Experimental and therapeutic medicine

authors： Zhang J,Liu N,Zhang ZC,Zheng RZ,Li Q

更新日期：2014-12-01 00:00:00

abstract：:β-elemene is a novel, plant-derived anticancer drug, which has been used to target multiple solid tumor types. Hyperthermia is an adjuvant therapeutic modality to treat cancer. However, the underlying mechanisms associated with the efficacy of these two treatments are largely unknown. The aim of the present study was ...

journal_title：Experimental and therapeutic medicine

authors： Wu Z,Wang T,Zhang Y,Zheng Z,Yu S,Jing S,Chen S,Jiang H,Ma S

更新日期：2017-06-01 00:00:00

abstract：:The Chinese population are at an increased risk of autoimmune hepatitis (AIH). The aims of this study were to determine the demographic and clinical features of AIH in China. A total of 83 patients with AIH diagnosed by the revised scoring system were re-analyzed, and the clinical presentations among the different age...

journal_title：Experimental and therapeutic medicine

authors： Peng M,Li Y,Zhang M,Jiang Y,Xu Y,Tian Y,Peng F,Gong G

更新日期：2014-01-01 00:00:00

abstract：:The present study aimed to investigate the effect of NVP-BEP800, a novel heat shock protein (Hsp) 90 inhibitor of the 2-aminothieno[2,3-d]pyrimidine class, in combination with radiation on glioblastoma cells. T98G human glioblastoma cells were treated with dimethyl sulfoxide (DMSO), NVP-BEP800, NVP-BEP800 in combinati...

journal_title：Experimental and therapeutic medicine

authors： Wu J,Wang W,Shao Q,Xiao G,Cheng J,Yuan Y,Zhang M

更新日期：2014-09-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a prominent public health issue that has a significant negative impact on patients and their family members. It is the leading cause of mortality and disability among young (below 50 years old) individuals. Intracranial hypertension (ICH) remains the single most difficult therapeutic ch...

journal_title：Experimental and therapeutic medicine

authors： Chen JH,Xu YN,Ji M,Li PP,Yang LK,Wang YH

更新日期：2018-05-01 00:00:00

abstract：:The present study reported a case of portopulmonary hypertension (POPH) that was secondary to underlying liver cirrhosis in a 58-year-old woman, who was successfully treated with low-dose tolvaptan. The patient had suffered from refractory peripheral edema and electrolyte abnormalities, including severe hypokalemia, u...

journal_title：Experimental and therapeutic medicine

authors： Ogihara Y,Yamada N,Dohi K,Matsuda A,Ota S,Ishikura K,Nakamura M,Ito M

更新日期：2017-01-01 00:00:00

abstract：:This study aimed to assess the effect on solid tumors of mild temperature hyperthermia (MTH) combined with hexamethylenetetramine (HMTA) or tirapazamine (TPZ). Squamous cell carcinoma (SCC VII) tumor-bearing mice were continuously administered 5-bromo-2'-deoxyuridine (BrdU) to label intratumor proliferating (P) cells....

journal_title：Experimental and therapeutic medicine

authors： Masunaga SI,Tano K,Nakamura J,Watanabe M,Kashino G,Suzuki M,Kinashi Y,Ono K

更新日期：2010-01-01 00:00:00

abstract：:Driving under the influence of alcohol and/or psychoactive substances increases the risk of severe, even fatal motor vehicle accidents. The aim of this descriptive study was to present the impact of alcohol and/or psychoactive substances on fatal road traffic accidents (RTAs) during the period 2011-2017. For this purp...

journal_title：Experimental and therapeutic medicine

authors： Papalimperi AH,Athanaselis SA,Mina AD,Papoutsis II,Spiliopoulou CA,Papadodima SA

更新日期：2019-09-01 00:00:00

abstract：:Temozolomide (TMZ) resistance is a complication of treatment of glioma, and new strategies are urgently required to overcome chemoresistance in glioma cells. In the present study, it was demonstrated that tripartite motif-containing 31 (TRIM31) was abnormally upregulated in glioma tissues and cell lines compared with ...

journal_title：Experimental and therapeutic medicine

authors： Fan MD,Zhao XY,Qi JN,Jiang Y,Liu BY,Dun ZP,Zhang R,Wang CW,Pang Q

更新日期：2020-08-01 00:00:00

abstract：:The aim of the study was to investigate the effect of stromal cell-derived factor-1 (SDF-1) on myocardial apoptosis and cardiac function recovery in rats with acute myocardial infarction (AMI) and the mechanism of the Toll-like receptor (TLR)-4/nuclear factor-κB (NF-κB) signaling pathway. A total of 64 healthy male F3...

journal_title：Experimental and therapeutic medicine

authors： Liu Y,Gao S,Wang Z,Yang Y,Huo H,Tian X

更新日期：2016-11-01 00:00:00

abstract：:The objective of this study was to investigate the effect of seven days of feed restriction (between days 42 and 49) on the morphology of the small intestine in experimental rabbit models. Sixty weaned Hyplus rabbits (35 days old) were included in the experiment and split into three groups of 20 rabbits. The first con...

journal_title：Experimental and therapeutic medicine

authors： Makovicky P,Tumova E,Volek Z,Makovicky P,Vodicka P

更新日期：2014-11-01 00:00:00

abstract：:The aim of the present study was to examine the effects of atorvastatinon p38 phosphorylation and cardiac remodeling after myocardial infarction in rats. A total of 43 rats were randomly divided into the control, sham operation, post-modeling medication (medication) and post-modeling non-medication (non-medication) gr...

journal_title：Experimental and therapeutic medicine

authors： Li M,Liu F,Sang M,Sun X,Li L,Wang X

更新日期：2018-08-01 00:00:00

abstract：:The aim of this study was to establish and to optimize the preparation technology of whole blood internal quality control (IQC) products for blood transfusion compatibility testing. Several B-type RhD-negative blood samples collected from healthy donors were mixed. Two groups of whole blood IQC products, namely, the p...

journal_title：Experimental and therapeutic medicine

authors： Yu Y,Ma C,Feng Q,Chen X,Guan X,Zhang X,Chen L,Lin Z,Pan J,Zhang T,Luo Q,Wang D

更新日期：2013-05-01 00:00:00

abstract：:Long non-coding RNA (lncRNA) maternally expressed 3 (MEG3) has been reported to be a key component in cancer biology. Preliminary microarray data from a previous study indicated that lncRNA MEG3 expression was altered in plasma of patients with sepsis. The present study found that the plasma levels of lncRNA MEG3 were...

journal_title：Experimental and therapeutic medicine

authors： Chen K,Shi X,Jin Y,Wang F,Shen Q,Xu W

更新日期：2019-11-01 00:00:00

abstract：:We report a case of a 10-year-old female patient who survived ring-sling complex without surgery. The patient had congenital wheezing from the neonatal period and was treated after a tentative diagnosis of infantile asthma. The patient suffered from allergy and was hospitalized several times due to severe wheezing, an...

journal_title：Experimental and therapeutic medicine

authors： Fukuda H,Imataka G,Drago F,Maeda K,Yoshihara S

更新日期：2017-09-01 00:00:00

abstract：:Malignant melanoma is the most aggressive neoplasm, with severe metastatic potential. microRNAs represent a class of endogenously expressed, small non-coding RNAs that regulate gene expression. As a consequence, the translation of these mRNAs is inhibited or they are destabilized resulting in downregulation of the enc...

journal_title：Experimental and therapeutic medicine

authors： Yamazaki H,Chijiwa T,Inoue Y,Abe Y,Suemizu H,Kawai K,Wakui M,Furukawa D,Mukai M,Kuwao S,Saegusa M,Nakamura M

更新日期：2012-05-01 00:00:00

abstract：:Coronary artery disease (CAD) is a leading cause of death, and microRNAs (miRNAs) are widely involved in physiological and pathological processes of CAD. We chose the targetscore method calculated via the variational Bayesian Gaussian mixture model (VB-GMM) as the prediction method of target genes. By observing the de...

journal_title：Experimental and therapeutic medicine

authors： Ma XL,Yang X,Fan R

更新日期：2019-03-01 00:00:00

abstract：:Phosphocitrate (PC) and its analogue, PC-β ethyl ester, inhibit articular cartilage degeneration in Hartley guinea pigs. However, the underlying molecular mechanisms remain unclear. The present study aimed to investigate the hypothesis that PC exerted its disease-modifying effect on osteoarthritis (OA), in part, by in...

journal_title：Experimental and therapeutic medicine

authors： Sun Y,Kiraly AJ,Cox M,Mauerhan DR,Hanley EN Jr

更新日期：2018-04-01 00:00:00

abstract：:The aim of the study was to investigate the possibility of human umbilical cord mesenchymal stem cells (UC-MSCs) surviving and differentiating into hepatocyte-like cells in partially hepatectomized model rats. MSCs were isolated from human umbilical cord and cultured with collagenase digestion. Cell surface markers we...

journal_title：Experimental and therapeutic medicine

authors： Chen Z,Kuang Q,Lao XJ,Yang J,Huang W,Zhou D

更新日期：2016-09-01 00:00:00