Expression and clinical significance of serum amyloid A and interleukin-6 in patients with acute exacerbation of chronic obstructive pulmonary disease.

abstract：:Uterine cervical adenocarcinoma has a poor clinical prognosis when compared with squamous cell carcinoma. Therefore, the development of new treatment strategies for uterine cervical adenocarcinoma is necessary. Src is a proto-oncogene that is important in cancer progression. Dasatinib is a Src inhibitor that has been ...

journal_title：Experimental and therapeutic medicine

authors： Takiguchi E,Nishimura M,Mineda A,Kawakita T,Abe A,Irahara M

更新日期：2017-11-01 00:00:00

abstract：:The aim of the present study was to investigate the protective effects of sodium ferulate (SF) on HT22 hippocampal cells under a high glucose concentration. Cells were cultured in normal glucose (25 mM D-glucose) or high glucose (50 mM D-glucose) with various concentrations of SF (50, 100, 250 or 500 µM) for 0, 48 and...

journal_title：Experimental and therapeutic medicine

authors： Zhao J,Liu L,Zhang L,Lv J,Guo X,Li X,Zhao T

更新日期：2019-09-01 00:00:00

abstract：:The aim of the present study was to investigate the expression profiles of cyclooxygenase (COX)-2 and microRNA (miRNA)-143 in the tumor tissue and blood samples of patients with osteosarcoma, and their involvement in the disease pathogenesis. Tumor tissue and blood samples were obtained from 46 patients with osteosarc...

journal_title：Experimental and therapeutic medicine

authors： Fang Y,Zhang Z,Wang Q,Zhao J

更新日期：2015-06-01 00:00:00

abstract：:The Global Registry of Acute Coronary Events (GRACE) risk score and the mean platelet volume to lymphocyte count ratio (MPVLR) can be used independently to predict adverse outcomes in patients with acute coronary syndromes. However, the level of MPVLR in relation to the GRACE score, and whether a combination of these ...

journal_title：Experimental and therapeutic medicine

authors： Chen X,Shao M,Zhang T,Zhang W,Meng Y,Zhang H,Hai H,Li G

更新日期：2020-06-01 00:00:00

abstract：:Embelin is a small-molecule inhibitor extracted from plants of the Myrsinaceae family demonstrating specific inhibition of the X-linked inhibitor of apoptosis protein (XIAP) to affect the proliferation and apoptosis of various types of tumor cells. However, the mechanism of action for this effect remains unclear. The ...

journal_title：Experimental and therapeutic medicine

authors： Taghiyev A,Sun D,Gao ZM,Liang R,Wang L

更新日期：2012-10-01 00:00:00

abstract：:Paeoniflorin serves important cellular roles, exerting anti-cancer, anti-inflammatory and anti-pulmonary fibrosis effects and possesses immune-modulatory properties. However, the exact role of paeoniflorin in the pathogenesis of osteoarthritis (OA) remains unclear. The aim of the present study was to investigate the e...

journal_title：Experimental and therapeutic medicine

authors： Hu PF,Sun FF,Jiang LF,Bao JP,Wu LD

更新日期：2018-08-01 00:00:00

abstract：:Opioids are commonly used in cancer pain management. The present study aimed to investigate the occurrence of endocrine dysfunction in patients with cancer pain treated with opioids. The study included 20 patients with cancer-associated pain. All data were obtained from malignant tumors diagnosed and followed up at th...

journal_title：Experimental and therapeutic medicine

authors： Merdin A,Merdin FA,Gündüz Ş,Bozcuk H,Coşkun HŞ

更新日期：2016-05-01 00:00:00

abstract：:The aim of the present study was to investigate the electrophysiological properties of transient receptor potential melastatin 7 (TRPM7) channels in the cell membranes of cardiac fibroblasts (CFs). CFs obtained from Sprague-Dawley rats were treated with six different concentrations of angiotensin (Ang) II for 12 h. Th...

journal_title：Experimental and therapeutic medicine

authors： Zhou Y,Yi X,Wang T,Li M

更新日期：2015-05-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/etm.2018.6297.]. ...

journal_title：Experimental and therapeutic medicine

authors： Jia L,Wang L,Liu W,Qian G,Jiang X,Zhang Z

更新日期：2018-12-01 00:00:00

abstract：:The present study retrospectively analyzed 19 patients diagnosed with paraquat (PQ) poisoning with the aim to investigate the effect of activated charcoal hemoperfusion on renal function and PQ elimination. The results indicated that 7 patients died and 12 survived. Non-oliguric renal failure occurred in all of the 7 ...

journal_title：Experimental and therapeutic medicine

authors： Sun L,Yan PB,Zhang Y,Wei LQ,Li GQ

更新日期：2018-03-01 00:00:00

abstract：:The aim of this study was to investigate the effect of ouabain (EO) on myocardial remodeling. Twenty-two adult male Sprague-Dawley rats were randomly divided into two groups: the rats in the EO group (n=12) were intraperitoneally injected with EO daily and those in the control group (n=10) were injected with physiolog...

journal_title：Experimental and therapeutic medicine

authors： Ren Y,Zhang M,Zhang T,Huang R

更新日期：2013-07-01 00:00:00

abstract：:Obesity and β-cell dysfunction due to oxidative stress impact the pathogenesis of type 2 diabetes mellitus. We co-cultured 3T3L1 adipocytes and islet cells in the presence or absence of the antioxidant α-lipoic acid (LA) and assayed the effects of the adipocytes and LA on the secretion of insulin by the islet cells an...

journal_title：Experimental and therapeutic medicine

authors： Wang Y,Dong W,Ding X,Wang F,Wang Y,Chen X,Yu L,Li X,Zhang A,Peng Y

更新日期：2012-09-01 00:00:00

abstract：:Chronic myelogenous leukemia (CML) is a condition characterized by a balanced genetic translocation, t (9;22) (q34;q11.2), which leads to a fusion of the Abelson oncogene (ABL) from chromosome 9q34 with the breakpoint cluster region (BCR) gene on chromosome 22q11.2. This rearrangement is referred to as the Philadelphi...

journal_title：Experimental and therapeutic medicine

authors： Shen X,Zhang M,Shen Y,Shi W,Liu W,Wei WU

更新日期：2015-10-01 00:00:00

abstract：:The main function of adipocyte fatty acid-binding protein (A-FABP) is to regulate fatty acid metabolism as its molecular chaperone. The clinical significance of A-FABP in hypoxic-ischemic brain damage (HIBD) neonates is not yet clear. Free fatty acid (FFA) in cerebral cortex increases along with hypoxia ischemia degre...

journal_title：Experimental and therapeutic medicine

authors： Li M,Jiang L,Zhang H,Wang D,Zhang M,Zhang L

更新日期：2016-08-01 00:00:00

abstract：:The aim of the present study was to investigate the effect of γ-aminobutyric acid transporter-1 (GAT-1) on the anxiety-like behaviors and cognitive function in knockout mice. In total, 20 adult male mice were divided into two groups, namely the GAT-1 knockout (GAT-1-/-) and wild-type (WT) groups. The open field test, ...

journal_title：Experimental and therapeutic medicine

authors： Gong X,Shao Y,Li B,Chen L,Wang C,Chen Y

更新日期：2015-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate the expression of targeted genes in a post-transcriptional manner. Increasing evidence indicates that miRNAs play important roles in cancer pathogenesis, including apoptosis, proliferation and differentiation, as oncogenes or tumor suppressors. Previo...

journal_title：Experimental and therapeutic medicine

authors： Shen ZY,Zhang ZZ,Liu H,Zhao EH,Cao H

更新日期：2014-06-01 00:00:00

abstract：:The present study examined the effectiveness of the method of inversing the distal clavicle anatomic locking plate to treat medial-end clavicle fractures. This involved retrospectively analyzing six cases of medial-end clavicle fractures treated using the method of inversing the distal clavicle anatomic locking plate ...

journal_title：Experimental and therapeutic medicine

authors： Xie WP,Zhang YK,Chen YH,Wang SL,Xu HH,Bi RX

更新日期：2018-12-01 00:00:00

abstract：:A major consequence of obstructive jaundice (OJ) in clinical practice is the development of severe liver injury, and at present, no effective treatments have been developed to protect against it. Preconditioning with damage-associated molecular pattern (DAMP) molecules has been demonstrated to protect multiple organs ...

journal_title：Experimental and therapeutic medicine

authors： Zhou YX,Ni Y,Liu YB,Liu X

更新日期：2014-07-01 00:00:00

abstract：:Gamboge, the dried resin secreted by Garcinia maingayii (gambogic tree), was previously demonstrated to exert anti-inflammatory effects. The present study examined the effects of gambogic acid, the major active constituent of gamboge, on myocardial infarction (MI) and inflammation in a rat model and explored the possi...

journal_title：Experimental and therapeutic medicine

authors： Na D,Aijie H,Bo L,Zhilin M,Long Y

更新日期：2018-02-01 00:00:00

abstract：:Hypophosphatasia (HPP) is a rare hereditary systemic disease that is characterized by defective bone and/or dental mineralization, and is caused by mutations in the alkaline phosphatase gene (ALPL). The present study investigated the ALPL mutation in a Chinese Han family with HPP and studied the pathogenesis of the mu...

journal_title：Experimental and therapeutic medicine

authors： Huang H,Wang J,Liang Y,Wei X,Guo D,Sun H,Zhang X,Xu X,Xiong F

更新日期：2020-12-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of target-controlled infusion (TCI) of propofol and remifentanil combined with dexmedetomidine on functional endoscopic sinus surgery (FESS) bleeding and surgical field. 62 patients scheduled to undergo FESS were randomly divided into experimental group (intr...

journal_title：Experimental and therapeutic medicine

authors： Ding DF,Wu LF,Wang P,Jiang YX,Luo YW,Dai ZL,Zhang XP,Li YL

更新日期：2017-11-01 00:00:00

abstract：:Opioids and α2-agonists have been used as epidural adjuvants in local anesthetics for a long time, but the effect of the combination of opioids and α2-agonists as epidural adjuvants is not completely understood. In the present study, the combination of dexmedetomidine (Dex) and sufentanil as adjuvants to ropivacaine f...

journal_title：Experimental and therapeutic medicine

authors： Li G,Xiao Y,Qi X,Wang H,Wang X,Sun J,Li Y,Li Y

更新日期：2020-07-01 00:00:00

abstract：:Tanshinone IIA (TSIIA) is a major component of Salvia miltiorrhiza, a Chinese herb that exhibits a therapeutic effect on polycystic ovary syndrome (PCOS). The present study replicated PCOS via the neonatal treatment of estradiol in mice. Estrous cycles, body and ovarian weight, serum levels of testosterone and estradi...

journal_title：Experimental and therapeutic medicine

authors： Jin J,Hu QY,Xu WW,Zhu WJ,Liu B,Liu J,Wang W,Zhou HF

更新日期：2019-05-01 00:00:00

abstract：:Eukaryotic translation initiation factor (EIF) 5A2 exerts important functions that regulate the development and progression of cancers. The present study aimed to investigate the expression of EIF5A2 in prostate cancer (PCa) and its association with biological and prognostic significance. EIF5A2 mRNA and protein level...

journal_title：Experimental and therapeutic medicine

authors： Lu J,Zhao HW,Chen Y,Wei JH,Chen ZH,Feng ZH,Huang Y,Chen W,Luo JH,Fang Y

更新日期：2019-05-01 00:00:00

abstract：:An early and accurate diagnosis of pulmonary thromboembolism (PTE) remains challenging. The present study aimed to evaluate the diagnostic value of platelet-derived microparticles in PTE based on a population study. A total of 102 patients with PTE, 102 healthy controls and 40 patients suspected with PTE were enrolled...

journal_title：Experimental and therapeutic medicine

authors： Wang M,Fu Y,Xu L,Xiao L,Yue Y,Liu S,Huang Q,Li S,Li Y

更新日期：2018-10-01 00:00:00

abstract：:The present study aimed to determine the expression of microRNA (miRNA or miR)-145 in hypertrophic scars at the tissue and cellular levels, and to investigate its biological functions and mechanism of action. A total of 36 patients who were diagnosed with hypertrophic scar were included in the present study. Reverse t...

journal_title：Experimental and therapeutic medicine

authors： Wang S,Li C,Yu Y,Qiao J

更新日期：2019-11-01 00:00:00

abstract：:An accessory middle cerebral artery (AMCA), which mainly acts in the collateral circulation of the middle cerebral artery (MCA), is a rare anatomic malformation. Similar to other intracranial vessels, cerebrovascular disease can occur in the AMCA. However, the development of an arteriovenous malformation (AVM) in the ...

journal_title：Experimental and therapeutic medicine

authors： Li K,Guo Y,Qu L,Xu B,Xu K,Yu J

更新日期：2018-09-01 00:00:00

abstract：:The aim of this meta-analysis was to investigate the accuracy of subtraction computed tomography angiography (CTA) for diagnosing intracranial aneurysms. A systematic literature search up to January 1, 2013 was performed in PubMed. Two independent reviewers selected 8 studies that compared subtraction CTA with digital...

journal_title：Experimental and therapeutic medicine

authors： Feng TY,Han XF,Lang R,Wang F,Wu Q

更新日期：2016-05-01 00:00:00

abstract：:Sodium 4-phenylbutyrate (PBA) exerts therapeutic effects in a wide range of pathologies. A previous study by the present authors revealed that intraperitoneal administration of PBA suppresses the onset of dextran sulfate sodium (DSS)-induced colitis in mice. In the present study, the effects of orally administered PBA...

journal_title：Experimental and therapeutic medicine

authors： Ono K,Nimura S,Hideshima Y,Nabeshima K,Nakashima M

更新日期：2017-12-01 00:00:00

abstract：:Enamel matrix derivative (EMD) is a commercially available protein extract, mainly comprising amelogenins. A number of other polypeptides have been identified in EMD, mostly growth factors, which promote cementogenesis and osteogenesis during the regeneration processes through the regulation of cell proliferation, dif...

journal_title：Experimental and therapeutic medicine

authors： Wyganowska-Świątkowska M,Urbaniak P,Nohawica MM,Kotwicka M,Jankun J

更新日期：2015-06-01 00:00:00